Critical Reviews in Food Science and Nutrition,
Journal Year:
2021,
Volume and Issue:
63(20), P. 4274 - 4287
Published: Nov. 30, 2021
We
aimed
to
summarize
the
associations
between
food
sources
of
fructose
and
cardiovascular
diseases
(CVD),
cancer,
all-cause
mortality
risk
using
a
systematic
review
meta-analysis.
searched
PubMed,
Scopus,
Web
Science
up
November
2020.
included
cohort
studies
that
investigated
relationship
(all-cause,
CVD,
specific
total
site-specific
cancers)
intake
≥1
source
(fruit,
fruit
juice,
breakfast
cereals,
sugar-sweetened
beverages
(SSBs),
sweets,
yogurt)
in
general
adult
population.
Summary
hazard
ratios
95%
CIs
were
estimated
random-effects
model
for
linear
nonlinear
relationships.
Findings
indicated
each
100
g/d
increase
was
associated
with
8-13%
lower
CVDs,
stroke,
gastrointestinal,
lung
cancer
mortality.
For
mortality,
there
beneficial
200
fruit,
then
plateaued.
ischemic
heart
disease
300
followed
by
slight
increase.
Ingestion
cereals
sweets
also
yogurt,
non-linear
marginal
decrease
found.
yogurt
14%
CVD
Every
60
sweet
linked
5%
Contrariwise,
every
250
SSBs
7–10%
higher
In
conclusion,
found
and/or
risk.
Fruit
had
an
inverse
link
Conversely,
harmful
mortality.Registry
number:
CRD42019144956
Obesity
and
diabetes
are
established
comorbidities
for
COVID-19.
Adipose
tissue
demonstrates
high
expression
of
ACE2
which
SARS-
CoV-2
exploits
to
enter
host
cells.
This
makes
adipose
a
reservoir
SARS-CoV-2
viruses
thus
increases
the
integral
viral
load.
Acute
infection
results
in
downregulation.
relative
deficiency
can
lead
disturbances
other
systems
controlled
by
ACE2,
including
renin-angiotensin
system.
will
be
further
increased
case
pre-conditions
with
already
compromised
functioning
these
systems,
such
as
patients
obesity
diabetes.
Here,
we
propose
that
interactions
virally-induced
and/or
leads
synergistic
impairment
endothelial
gut
barrier
function.
The
appearance
bacteria
their
products
lungs
obese
diabetic
promotes
between
bacterial
pathogens,
resulting
more
severe
lung
injury
Heliyon,
Journal Year:
2023,
Volume and Issue:
9(8), P. e18896 - e18896
Published: Aug. 1, 2023
The
excessive
intake
of
fructose
in
the
regular
human
diet
could
be
related
to
global
increases
metabolic
disorders.
Sugar-sweetened
soft
drinks,
mostly
consumed
by
children,
adolescents,
and
young
adults,
are
main
source
added
fructose.
Dietary
high-fructose
can
increase
intestinal
permeability
circulatory
endotoxin
changing
gut
barrier
function
microbial
composition.
Excess
transports
liver
then
triggers
inflammation
as
well
de
novo
lipogenesis
leading
hepatic
steatosis.
Fructose
also
induces
fat
deposition
adipose
tissue
stimulating
expression
lipogenic
genes,
thus
causing
abdominal
adiposity.
Activation
inflammatory
pathway
target
tissues
is
thought
contribute
suppression
insulin
signaling
producing
systemic
resistance.
Moreover,
there
some
evidence
that
high
negatively
affects
both
male
female
reproductive
systems
may
lead
infertility.
This
review
addresses
dietary
high-fructose-induced
deteriorations
obvious,
especially
permeability,
microbiota,
accumulation,
signaling,
function.
recognition
detrimental
effects
development
relevant
new
public
health
policies
necessary
order
prevent
diet-related
Renal Failure,
Journal Year:
2025,
Volume and Issue:
47(1)
Published: Feb. 5, 2025
To
explore
the
risk
factors
for
uric
acid-lowering
therapy-resistant
gout
(UALT-RG)
and
its
relationships
with
estimated
glomerular
filtration
rate
(eGFR),
body
roundness
index
(BRI),
visceral
adiposity
(VAI)
via
2007-2018
National
Health
Nutrition
Examination
Survey
(NHANES)
data.
We
calculated
BRI
using
waist
circumference
standing
height;
VAI
triglycerides
(TGs),
high-density
lipoprotein
cholesterol
(HDL-C),
mass
(BMI);
eGFR
from
serum
creatinine
levels.
also
collected
explored
of
eGFR,
BRI,
UALT-RG
univariable
multivariable
weighted
logistic
regression,
trend
analysis,
restricted
cubic
splines.
Among
1,811
patients
gout,
∼9.08%
had
UALT-RG;
these
were
more
likely
to
have
obesity,
comorbid
diabetes
(36%
[27-47%]
vs.
25%
[22-28%])
or
impaired
kidney
function
(eGFR
<
60
mL/min/1.73
m2,
34.5%
[27-43%]
22.5%
[20-26%]);
be
former
smokers;
take
colchicine
(10%
[5.6-19%]
4.3%
[2.8-6.7%]).
Logistic
regression
analysis
suggested
that
an
elevated
decreased
independent
potential
screening
indicators
UALT-RG.
Restricted
spline
revealed
a
negative
linear
between
(p-overall
0.0001)
significant
positive
correlation
0.0001).
An
increased
may
assessment
in
U.S.
adults.
It
is
necessary
monitor
urate
levels
closely
conduct
early
multidisciplinary
comanagement
when
obesity
chronic
disease
stages
3-5.
International Journal of Molecular Sciences,
Journal Year:
2020,
Volume and Issue:
21(18), P. 6902 - 6902
Published: Sept. 20, 2020
Oxidative
stress
(OxS)
is
the
cause
and
consequence
of
metabolic
syndrome
(MetS),
incidence
economic
burden
which
increasing
each
year.
OxS
triggers
dysregulation
signaling
pathways
associated
with
metabolism
epigenetics,
including
microRNAs,
are
biomarkers
disorders.
In
this
review,
we
aimed
to
summarize
current
knowledge
regarding
interplay
between
microRNAs
in
MetS
its
components.
We
searched
PubMed
Google
Scholar
most
relevant
studies.
Collected
data
suggested
that
different
sources
(e.g.,
hyperglycemia,
insulin
resistance
(IR),
hyperlipidemia,
obesity,
proinflammatory
cytokines)
change
expression
numerous
organs
involved
regulation
glucose
lipid
endothelium.
Dysregulated
either
directly
or
indirectly
affect
and/or
activity
molecules
antioxidative
(SIRT1,
FOXOs,
Keap1/Nrf2)
along
effector
enzymes
GPx-1,
SOD1/2,
HO-1),
ROS
producers
NOX4/5),
as
well
genes
connected
inflammation,
sensitivity,
metabolism,
thus
promoting
progression
imbalance.
MicroRNAs
appear
be
important
epigenetic
modifiers
managing
delicate
redox
balance,
mediating
pro-
antioxidant
biological
impacts.
Summarizing,
may
promising
therapeutic
targets
ameliorating
repercussions
MetS.
Frontiers in Endocrinology,
Journal Year:
2022,
Volume and Issue:
13
Published: March 2, 2022
Background
Hyperuricemia
(HUA)
is
a
metabolic
anomaly
with
an
increased
incidence
rate,
causing
global
medical
burden.
Several
studies
have
confirmed
that
obesity
and
insulin
resistance
(IR)
are
the
risk
factors
for
HUA.
Reports
on
predictive
power
of
different
indices
HUA
limited.
This
study
aimed
to
compare
association
between
general,
abdominal,
visceral
markers
IR-triglyceride
glucose
(TyG)
index
serum
uric
acid
(SUA)
assess
ability
these
predict
Methods
A
total
2243
participants
were
recruited
from
Barkol
County
Hospital
surrounding
township
hospitals
in
Xinjiang.
Obesity
indices,
including
atherogenic
plasma,
cardiometabolic
index,
adiposity
lipid
accumulation
product
body
shape
roundness
waist
circumference,
waist-to-height
ratio,
mass
TyG
divided
into
four
quartiles.
Moreover,
partial
correlations
logistic
regression
used
analyze
SUA.
The
area
under
curve
(AUC)
receiver
operating
characteristic
curves
value
Results
After
controlling
confounding
variables,
was
stronger
than
both
males
females.
odds
ratios
(ORs)
highest
quartile
2.098
(95%
confidence
interval,
1.555–2.831)
7.788
CI,
3.581–16.937)
For
males,
AIP,
CMI,
VAI,
LAP
able
discriminate
HUA,
showed
AUC
0.586
0.557–0.614;
P
<
0.001).
females,
all
except
BMI,
can
CMI
0.737
0.691–0.782;
Meanwhile,
had
relatively
high
0.728
0.682–0.773;
Conclusion
significantly
related
superior
identifying
checkup
population
Xinjiang,
China.
Journal of Clinical Hypertension,
Journal Year:
2022,
Volume and Issue:
25(1), P. 78 - 85
Published: Dec. 27, 2022
Previous
studies
focused
on
the
relationships
between
Serum
Uric
Acid
(SUA)
and
lipids
have
found
an
association
mainly
with
triglycerides.
Furthermore,
previous
adiposity
indices
been
evaluation
of
Visceral
Adiposity
Index
(VAI).
The
present
study
was
aimed
at
providing
within
same
population
a
systematic
SUA,
employing
both
classic
cutoff
for
hyperuricemia
newly
one
identified
by
Right
Heart
Health
(URRAH)
study.
We
analyzed
data
collected
in
1892
subjects
Pressioni
Arteriose
Monitorate
E
loro
Associazioni
(PAMELA)
available
lipid
profile
variables
necessary
to
calculate
VAI,
Cardio-Metabolic
(CMI)
Lipid
Accumulation
Product
(LAP).
At
linear
regression
model
(corrected
confounders)
SUA
correlated
all
values
(with
strongest
β
triglycerides)
indices.
When
two
different
cutoffs
were
compared,
URRAH
significantly
related
atherogenic
(OR
1.207
LDL
1.33
non-HDL,
P
<
0.001)
while
this
not
case
one.
Regarding
displays
highest
OR
as
compared
In
conclusions,
reported
better
relate
lipoprotein
(LDL
non-HDL)
when
opposite
has
indexes
where
cut-off
seems
performance.
Among
indexes,
LAP
relationship
hyperuricemia.
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(7), P. 939 - 939
Published: March 25, 2024
Worldwide,
childhood
obesity
cases
continue
to
rise,
and
its
prevalence
is
known
increase
the
risk
of
non-communicable
diseases
typically
found
in
adults,
such
as
cardiovascular
disease
type
2
diabetes
mellitus.
Thus,
comprehending
multiple
causes
build
healthier
approaches
revert
this
scenario
urgent.
Obesity
development
strongly
associated
with
high
fructose
intake
since
excessive
consumption
highly
lipogenic
sugar
leads
white
fat
accumulation
adipose
tissue
(WAT)
inflammation,
oxidative
stress,
dysregulated
adipokine
release.
Unfortunately,
global
has
increased
dramatically
recent
years,
which
fact
that
not
always
evident
consumers,
it
commonly
added
a
sweetener
food
sugar-sweetened
beverages
(SSB).
Therefore,
here,
we
discuss
impact
on
biology,
contribution
obesity,
current
strategies
for
reducing
and/or
free
intake.
To
achieve
reductions,
conclude
important
population
access
reliable
information
about
ingredients
via
labels.
Consumers
also
need
scientific
education
understand
potential
health
risks
themselves
their
children.