JCI Insight,
Journal Year:
2021,
Volume and Issue:
7(1)
Published: Dec. 7, 2021
Nonphlogistic
migration
of
macrophages
contributes
to
the
clearance
pathogens
and
apoptotic
cells,
a
critical
step
for
resolution
inflammation
return
homeostasis.
Angiotensin-(1-7)
[Ang-(1-7)]
is
heptapeptide
renin-angiotensin
system
that
acts
through
Mas
receptor
(MasR).
Ang-(1-7)
has
recently
emerged
as
novel
proresolving
mediator,
yet
mechanisms
are
not
fully
determined.
Herein,
stimulated
human
murine
monocytes/macrophages
in
MasR-,
CCR2-,
MEK/ERK1/2-dependent
manner.
Pleural
injection
promoted
nonphlogistic
mononuclear
cell
influx
alongside
increased
levels
CCL2,
IL-10,
macrophage
polarization
toward
regulatory
phenotype.
induction
CCL2
was
also
dependent
on
MasR
MEK/ERK.
Of
note,
upregulated
during
phase
inflammation,
its
pharmacological
inhibition
or
genetic
deficiency
impaired
recruitment
self-resolving
models
LPS
pleurisy
E.
coli
peritonitis.
Inhibition/absence
associated
with
reduced
levels,
phagocytosis
bacteria,
efferocytosis,
delayed
inflammation.
In
summary,
we
have
uncovered
potentially
feature
Ang-(1-7),
namely
cells
favoring
phagocytosis,
Mechanistically,
MasR,
CCR2,
MEK/ERK
pathway.
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: March 22, 2024
Abstract
Transforming
growth
factor
(TGF)-β
is
a
multifunctional
cytokine
expressed
by
almost
every
tissue
and
cell
type.
The
signal
transduction
of
TGF-β
can
stimulate
diverse
cellular
responses
particularly
critical
to
embryonic
development,
wound
healing,
homeostasis,
immune
homeostasis
in
health.
dysfunction
play
key
roles
many
diseases,
numerous
targeted
therapies
have
been
developed
rectify
its
pathogenic
activity.
In
the
past
decades,
large
number
studies
on
signaling
carried
out,
covering
broad
spectrum
topics
health,
disease,
therapeutics.
Thus,
comprehensive
overview
required
for
general
picture
this
field.
review,
we
retrace
research
history
introduce
molecular
mechanisms
regarding
biosynthesis,
activation,
transduction.
We
also
provide
deep
insights
into
functions
physiological
conditions
as
well
pathological
processes.
TGF-β-targeting
which
brought
fresh
hope
treatment
relevant
diseases
are
highlighted.
Through
summary
previous
knowledge
recent
updates,
review
aims
systematic
understanding
attract
more
attention
interest
area.
MedComm,
Journal Year:
2024,
Volume and Issue:
5(3)
Published: March 1, 2024
Abstract
Rheumatoid
arthritis
(RA)
is
a
chronic
autoimmune
disease
characterized
by
the
unresolved
synovial
inflammation
for
tissues‐destructive
consequence,
which
remains
one
of
significant
causes
disability
and
labor
loss,
affecting
about
0.2–1%
global
population.
Although
treatments
with
disease‐modifying
antirheumatic
drugs
(DMARDs)
are
effective
to
control
decrease
bone
destruction,
overall
remission
rates
RA
still
stay
at
low
level.
Therefore,
uncovering
pathogenesis
expediting
clinical
transformation
imminently
in
need.
Here,
we
summarize
immunological
basis,
inflammatory
pathways,
genetic
epigenetic
alterations,
metabolic
disorders
RA,
highlights
on
abnormality
immune
cells
atlas,
epigenetics,
immunometabolism.
Besides
an
overview
first‐line
medications
including
conventional
DMARDs,
biologics,
small
molecule
agents,
discuss
depth
promising
targeted
therapies
under
or
preclinical
trials,
especially
regulators.
Additionally,
prospects
precision
medicine
based
biopsy
RNA‐sequencing
cell
mesenchymal
stem
chimeric
antigen
receptor
T‐cell
also
looked
forward.
The
advancements
innovations
accelerates
progress
treatments.
Journal of Cellular and Molecular Medicine,
Journal Year:
2022,
Volume and Issue:
26(15), P. 4195 - 4209
Published: July 4, 2022
Chronic
inflammation
is
associated
with
the
occurrence
of
several
diseases.
However,
side
effects
anti-inflammatory
drugs
prompt
identification
new
therapeutic
strategies.
Plant-derived
extracellular
vesicles
(PDEVs)
are
gaining
increasing
interest
in
scientific
community
for
their
biological
properties.
We
isolated
PDEVs
from
juice
Citrus
limon
L.
(LEVs)
and
characterized
flavonoid,
limonoid
lipid
contents
through
reversed-phase
high-performance
liquid
chromatography
coupled
to
electrospray
ionization
quadrupole
time-of-flight
mass
spectrometry
(RP-HPLC-ESI-Q-TOF-MS).
To
investigate
whether
LEVs
have
a
protective
role
on
inflammatory
process,
murine
primary
human
macrophages
were
pre-treated
24
h
then
stimulated
lipopolysaccharide
(LPS).
found
that
pre-treatment
decreased
gene
protein
expression
pro-inflammatory
cytokines,
such
as
IL-6,
IL1-β
TNF-α,
reduced
nuclear
translocation
phosphorylation
NF-κB
LPS-stimulated
macrophages.
The
inhibition
activation
was
reduction
ERK1-2
phosphorylation.
Furthermore,
ability
decrease
cytokines
increase
molecules
confirmed
ex
vivo
T
lymphocytes.
In
conclusion,
we
demonstrated
exert
both
vitro
by
inhibiting
ERK1-2/NF-κB
signalling
pathway.
International Journal of Biological Sciences,
Journal Year:
2023,
Volume and Issue:
19(16), P. 5275 - 5289
Published: Jan. 1, 2023
Osteoarthritis
(OA)
is
a
prevalent
joint
disease
commonly
associated
with
aging
and
obesity,
which
can
lead
to
pain,
stiffness,
dysfunction,
disability.
Omentin-1
(also
called
intelectin-1)
newly
discovered
adipokine,
plays
protective
role
in
suppressing
the
secretion
of
pro-inflammatory
cytokines.
Based
on
data
from
Gene
Expression
Omnibus
(GEO)
dataset
clinical
samples
obtained
at
our
institution
revealed,
determined
that
omentin-1
IL-4
(an
anti-inflammatory
cytokine)
levels
were
significantly
lower
OA
patients
than
normal
controls.
was
shown
induce
IL-4-depedent
responses
M2
macrophage
polarization
synovial
fibroblasts
via
PI3K,
ERK,
AMPK
pathways.
Administering
block
cartilage
degradation
bone
erosion
resulting
anterior
cruciate
ligament
transection
by
inhibiting
production
cytokines
promoting
vivo.
Our
findings
indicate
as
promising
therapeutic
avenue
for
treatment
OA.
Gels,
Journal Year:
2025,
Volume and Issue:
11(1), P. 33 - 33
Published: Jan. 3, 2025
Cordyceps
militaris
is
a
medicinal
mushroom
widely
utilized
in
traditional
East
Asian
medicine,
recognized
for
its
diverse
therapeutic
properties.
This
review
explores
the
potential
of
C.
militaris-derived
bioactive
gels
applications
dermatology
and
skincare,
with
particular
focus
on
their
anti-aging
benefits.
In
response
to
rising
incidence
skin
cancers
growing
demand
natural
ingredients,
has
emerged
as
valuable
source
functional
compounds,
including
cordycepin,
polysaccharides,
adenosine.
These
compounds
exhibit
multiple
bioactivities,
apoptosis
induction,
cell
cycle
arrest,
anti-inflammatory
effects,
which
have
been
shown
be
particularly
effective
against
melanoma
other
cancers.
Additionally,
antioxidant
properties
enhance
resilience
by
scavenging
reactive
oxygen
species,
reducing
oxidative
stress,
promoting
collagen
synthesis,
thereby
addressing
health
requirements.
The
incorporating
into
gel-based
formulations
skincare
also
examined,
either
standalone
bioactives
or
combination
synergistic
ingredients.
Emphasis
placed
necessity
clinical
trials
standardization
establish
safety,
efficacy,
reproducibility
such
applications.
By
providing
safer
alternative
synthetic
agents,
represent
promising
advancement
skincare.
