Interleukin-17A and Keratinocytes in Psoriasis

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(4), P. 1275 - 1275

Published: Feb. 13, 2020

The excellent clinical efficacy of anti-interleukin 17A (IL-17A) biologics on psoriasis indicates a crucial pathogenic role IL-17A in this autoinflammatory skin disease. accelerates the proliferation epidermal keratinocytes. Keratinocytes produce myriad antimicrobial peptides and chemokines, such as CXCL1, CXCL2, CXCL8, CCL20. Antimicrobial enhance inflammation. is capable upregulating production these chemokines CXCL8 recruit neutrophils CCL20 chemoattracts IL-17A-producing CCR6+ immune cells, which further contributes to forming an IL-17A-rich milieu. This feed-forward process results characteristic histopathological features, hyperproliferation, intraepidermal neutrophilic microabscess, dermal cell infiltration. In review, we focus keratinocyte interaction regarding pathogenesis.

Language: Английский

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Skin Barrier Dysregulation in Psoriasis

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(19), P. 10841 - 10841

Published: Oct. 7, 2021

The skin barrier is broadly composed of two elements-a physical mostly localised in the epidermis, and an immune both dermis epidermis. These systems interact cooperatively to maintain homeostasis overall human health. However, if dysregulated, several diseases may arise. Psoriasis one most prevalent associated with disrupted function. It characterised by formation psoriatic lesions, aberrant differentiation proliferation keratinocytes, excessive inflammation. In this review, we summarize recent discoveries disease pathogenesis, including contribution cells, genetic environmental factors, how they advance current future treatments.

Language: Английский

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Signaling pathways and targeted therapies for psoriasis

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Nov. 27, 2023

Abstract Psoriasis is a common, chronic, and inflammatory skin disease with high burden on individuals, health systems, society worldwide. With the immunological pathologies pathogenesis of psoriasis becoming gradually revealed, therapeutic approaches for this have gained revolutionary progress. Nevertheless, mechanisms less common forms remain elusive. Furthermore, severe adverse effects recurrence upon treatment cessation should be noted addressed during treatment, which, however, has been rarely explored integration preliminary findings. Therefore, it crucial to comprehensive understanding behind pathogenesis, which might offer new insights research lead more substantive progress in expand clinical options treatment. In review, we looked briefly introduce epidemiology, subtypes, pathophysiology, comorbidities systematically discuss signaling pathways involving extracellular cytokines intracellular transmission, as well cross-talk between them. discussion, also paid attention potential metabolic epigenetic molecular mechanistic cascades related its comorbidities. This review outlined current psoriasis, especially targeted therapies novel strategies, mechanism recurrence.

Language: Английский

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Current Concepts of Psoriasis Immunopathogenesis

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(21), P. 11574 - 11574

Published: Oct. 26, 2021

Psoriasis is a recurrent, chronic, immune-mediated, systemic inflammatory disease of the skin, joints, and other organic systems. After atopic dermatitis, chronic stationary psoriasis most common skin disease, affecting an average 2-4% world's population. The carries significant burden due to its numerous comorbidities major impact on patients' social emotional aspects life. According current knowledge, multifactorial that occurs in genetically predisposed individuals under various environmental factors, which trigger immune response disorder with series complex cascades. initiated maintained by mutual interaction innate adaptive cells, primarily dendritic T lymphocytes, keratinocytes, whose leading role alternates at different stages consisting mainly IL-23/Th17 pathway. Inflammatory events result consequent epidermal dermal changes evolution characteristic psoriatic phenotype, respectively. This paper aims present comprehensive overview knowledge genetic etiological immunopathogenesis, cellular cytokine participants pathways this disease.

Language: Английский

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Gut–Skin Axis: Unravelling the Connection between the Gut Microbiome and Psoriasis

Biomedicines, Journal Year: 2022, Volume and Issue: 10(5), P. 1037 - 1037

Published: April 30, 2022

Evidence has shown that gut microbiome plays a role in modulating the development of diseases beyond gastrointestinal tract, including skin disorders such as psoriasis. The gut-skin axis refers to bidirectional relationship between and health. This is regulated through several mechanisms inflammatory mediators immune system. Dysregulation microbiota been seen numerous conditions atopic dermatitis, rosacea, Understanding how are involved regulating health may lead novel therapies for these modulation, particularly In this review, we will compare psoriasis patients healthy control, explain concept effects dysbiosis on physiology. We also review current evidence using probiotics

Language: Английский

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The Brain–Skin Axis in Psoriasis—Psychological, Psychiatric, Hormonal, and Dermatological Aspects

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(2), P. 669 - 669

Published: Jan. 8, 2022

Psoriasis is a chronic inflammatory skin disease with systemic manifestation, in which psychological factors play an important role. The etiology of psoriasis complex and multifactorial, including genetic background environmental such as emotional or physical stress. Psychological stress may also role exacerbation psoriasis, by dysregulation the hypothalamic-pituitary-adrenal (HPA) axis, sympathetic-adrenal-medullary peripheral nervous system, immune system. Skin cells express various neuropeptides hormones response to stress, fully functional analog HPA axis. deterioration psoriatic lesions accompanied increased production mediators, could contribute imbalance neurotransmitters development symptoms depression anxiety. Therefore, deregulation crosstalk between endocrine, paracrine, autocrine signaling pathways contributes clinical manifestations requires multidisciplinary approaches.

Language: Английский

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The Involvement of Oxidative Stress in Psoriasis: A Systematic Review

Antioxidants, Journal Year: 2022, Volume and Issue: 11(2), P. 282 - 282

Published: Jan. 29, 2022

Psoriasis is a chronic, immune-mediated inflammatory dermatosis characterized by the appearance of erythematous plaques, covered white scales, occasionally pruritogenic, and distributed mainly on extensor areas. Oxidative stress defined as an imbalance or transient chronic increase in levels free oxygen/nitrogen radicals, either result exaggerated elevation their production decrease ability to be eliminated antioxidant systems. Although pathogenesis psoriasis remains far from elucidated, there are studies that delineate involvement oxidative this skin disorder. Thus, systematic search was computed PubMed/Medline, Web Science SCOPUS and, total, 1293 potentially eligible articles exploring research question were detected. Following removal duplicates exclusion irrelevant manuscripts based screening titles abstracts (n = 995), 298 original selected for full-text review. Finally, after we applied inclusion criteria, 79 included Overall, data analyzed review point out markers elevated share association with duration severity disease. The concentrations these biomarkers impacted anti-psoriasis therapy. In addition, crosstalk between influenced several polymorphisms arise genes encoding enzymes related redox balance. undisputable, future needed explore utility assessing circulating serum, plasma, urinary and/or studying regulating balance, well how can findings translated into management psoriasis, understanding its evolution.

Language: Английский

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The Immunology of Psoriasis—Current Concepts in Pathogenesis

Clinical Reviews in Allergy & Immunology, Journal Year: 2024, Volume and Issue: 66(2), P. 164 - 191

Published: April 20, 2024

Abstract Psoriasis is one of the most common inflammatory skin diseases with a chronic, relapsing-remitting course. The last decades intense research uncovered pathological network interactions between immune cells and other types in pathogenesis psoriasis. Emerging evidence indicates that dendritic cells, T H 17 keratinocytes constitute pathogenic triad Dendritic produce TNF-α IL-23 to promote cell differentiation toward key psoriatic cytokines IL-17, IFN-γ, IL-22. Their activity results inflammation activation hyperproliferation keratinocytes. In addition, signaling pathways are implicated psoriasis, including 9 22 CD8 + cytotoxic neutrophils, γδ chemokines secreted by them. New insights from high-throughput analysis lesional identified novel populations involved pathogenesis. These studies not only expanded our knowledge about mechanisms response psoriasis but also resulted revolution clinical management patients Thus, understanding crucial for further studies, development therapeutic strategies, patients. aim review was comprehensively present dysregulation an emphasis on recent findings. Here, we described role B monocytes, mast innate lymphoid (ILCs), as well non-immune keratinocytes, fibroblasts, endothelial platelets initiation, development, progression

Language: Английский

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Dendritic cells: The driver of psoriasis

The Journal of Dermatology, Journal Year: 2019, Volume and Issue: 47(2), P. 104 - 113

Published: Dec. 13, 2019

Abstract Psoriasis is a chronic skin inflammatory disorder, the immune mechanism of which has been profoundly elucidated in past few years. The dominance interleukin (IL)‐23/IL‐17 axis significant breakthrough understanding pathogenesis psoriasis, and treatment targeting IL‐23 IL‐17 successfully benefited patients with disease. contains complex network dendritic cells (DC) mainly composed epidermal Langerhans cells, bone marrow‐derived dermal conventional DC, plasmacytoid DC DC. As prominent cellular source α‐interferon, tumor necrosis factor‐α, IL‐12 IL‐23, play pivotal role psoriasis. Thus, pathogenic subsets valid strategy for alleviating preventing psoriasis other DC‐derived diseases. In this review, we survey known

Language: Английский

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The Role of Epigenetic Factors in Psoriasis

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(17), P. 9294 - 9294

Published: Aug. 27, 2021

Psoriasis is a chronic, systemic, immune-mediated disease with an incidence of approximately 2%. The pathogenesis the complex and not yet fully understood. Genetic factors play significant role in disease. In predisposed individuals, multiple trigger may contribute to onset exacerbations symptoms. Environmental (stress, infections, certain medications, nicotinism, alcohol, obesity) psoriasis. addition, epigenetic mechanisms are considered result modulation individual gene expression increased likelihood Studies highlight etiology Epigenetic psoriasis include DNA methylation, histone modifications non-coding RNAs. induce changes under influence chemical histones, which alter chromatin structure activate transcription selected genes, thus leading translation new mRNA without affecting sequence. can regulate at transcriptional (via modification, methylation) posttranscriptional levels microRNAs long RNAs). This study aims present discuss different based on review available literature.

Language: Английский

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