Green Silver Nanoparticles Promote Inflammation Shutdown in Human Leukemic Monocytes DOI Open Access
Mariafrancesca Cascione, Loris Rizzello, D. Manno

et al.

Materials, Journal Year: 2022, Volume and Issue: 15(3), P. 775 - 775

Published: Jan. 20, 2022

The use of silver nanoparticles (Ag NPs) in the biomedical field deserves a mindful analysis possible inflammatory response which could limit their clinic. Despite anti-cancer properties Ag NPs having been widely demonstrated, there are still few studies concerning involvement activation specific pathways. outcome depends on synthetic route used production, toxic reagents employed. In this work, we compared two types NPs, obtained by different chemical routes: conventional synthesis using sodium citrate and green protocol based leaf extracts as source reduction capping agents. A careful physicochemical characterization was carried out showing spherical stable with an average size between 20 nm 35 for respectively. Then, evaluated ability to induce inflammation Human Leukemic Monocytes (THP-1) differentiated into M0 macrophages 1 µM 2 concentrations (corresponded 0.1 µg/mL 0.2 respectively) two-time points (24 h 48 h). Our results showed clear difference Nuclear Factor κB (NF-κb) activation, Interleukins 6-8 (IL-6, IL-8) secretion, Tumor Necrosis Factor-α (TNF-α) Cyclooxygenase-2 (COX-2) expression exerted kinds NPs. Green were definitely tolerated induced all factors mentioned above. Subsequently, exposure breast cancer cell line (MCF-7) that they exhibited antitumor activity like ones, but surprisingly, MCF-10A (not tumoral cells) did not cause significant decrease viability.

Language: Английский

Study on Mechanical Properties, Optical Properties, Cytotoxicity of TiO2-HAP Nanoparticles-Modified PMMA and Photodynamically Assisted Antibacterial Activity Against Candida Albicans in Vitro DOI Creative Commons
Youbo Liu, Z. K. Wang,

Xiangrui Liu

et al.

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 2695 - 2709

Published: March 1, 2025

The high recurrence rate of denture stomatitis may be related to the strong resistance fungi. Therefore, method providing biomaterials with antifungal properties is an attractive solution for improving microbial control. Against drug Candida albicans, this study aim elucidate photocatalytic antibacterial effect TiO2-HAP nanocomposite-modified PMMA on albicans through in vitro experiments, and evaluate potential impact mechanical properties, optical cytotoxicity contact angle modified PMMA, provide a scientific basis development base resins minimum percentage additives. In study, nanoparticles were mixed self-polymerized different mass ratios, 0%wt was control group. Various methods used characterize TiO2-HAP. Subsequently, changes samples measured, Cell Counting Kit-8 (CCK-8) cell live-death staining detect human gingival fibroblasts (HGFs) vitro. specimens evaluated. activity against studied using biofilm accumulation test scanning electron microscopy. nanocomposites have acceptable structure. When addition amount 1.0%wt, material showed peak properties. additional less than 1%wt, patient still aesthetically no significant at doses below 2%wt. While containing only 1%wt up 94% efficiency under visible light. it inferred that optimal antimicrobial materials are achieved by adding without causing

Language: Английский

Citations

0
Addressing the silent killer: Nanotechnology for preventing oral bacteria-induced cardiovascular risks DOI
Santosh Mallikarjun Bhavi,

Akshata Choudhari Padti,

Bothe Thokchom

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: 9(1)

Published: March 4, 2025

Tooth extraction, while essential for oral health, can contribute to systemic complications, particularly increasing cardiovascular risk due bacterial translocation and inflammation. Periodontal disease, a major cause of tooth loss, exacerbates this by serving as reservoir pathogenic bacteria that enter the bloodstream during extractions. This review explores mechanisms linking post-extraction infections diseases evaluates role nanotechnology in mitigating these risks. Advances antimicrobial nanoparticles, nanodrug delivery systems, biosensors offer promising solutions infection control targeted drug delivery. These innovations enhance healing potentially reducing However, challenges remain optimizing material biocompatibility, ensuring clinical efficacy, addressing translational hurdles. underscores need interdisciplinary research integrate into dental practice, ultimately improving both health outcomes.

Language: Английский

Citations

0
The Influence of Nanoparticles on the Mechanical and Biological Properties of Temporary Acrylics DOI Creative Commons
Mirac Berke Topcu Ersöz, Esra Nur Avukat, Emre Mumcu

et al.

Acta Odontologica Turcica, Journal Year: 2025, Volume and Issue: 42(2), P. 75 - 79

Published: May 5, 2025

Objective: The aim of this study was to evaluate the flexural strength (FS) and antifungal properties autopolymerised polymethylmethacrylate (PMMA) reinforced with zirconium oxide (ZrO2) hydroxyapatite (HA) nanoparticles (NPs). Materials Methods: ZrO2 HA-NPs were incorporated into cold cured PMMA at a rate 1%. 65×10×3 mm specimens prepared for FS 2×10 disc Candida albicans (C. Albicans) adhesion test (n=10). Surface roughness recorded each specimen via profilometer. 3-point bending, tests performed. Statistical analysis done One-way variance Post-Hoc Bonferroni tests. (p<0.05) Results: Based on findings, addition NPs resulted in decrease FS. In comparison other groups, (55.47 ± 9.40) showed significant (p<0.05). addition, C. significantly reduced by (16.5 5.8) control group Conclusion: ZrO2-NPs temporary acrylic prevented adhesion, while impact remains elusive.

Language: Английский

Citations

0
Nanoparticle-modified PMMA to prevent denture stomatitis: a systematic review DOI
Amanda Aparecida Maia Neves Garcia, Carolina Yoshi Campos Sugio, Lucas José de Azevedo‐Silva

et al.

Archives of Microbiology, Journal Year: 2021, Volume and Issue: 204(1)

Published: Dec. 24, 2021

Language: Английский

Citations

20
Green Silver Nanoparticles Promote Inflammation Shutdown in Human Leukemic Monocytes DOI Open Access
Mariafrancesca Cascione, Loris Rizzello, D. Manno

et al.

Materials, Journal Year: 2022, Volume and Issue: 15(3), P. 775 - 775

Published: Jan. 20, 2022

The use of silver nanoparticles (Ag NPs) in the biomedical field deserves a mindful analysis possible inflammatory response which could limit their clinic. Despite anti-cancer properties Ag NPs having been widely demonstrated, there are still few studies concerning involvement activation specific pathways. outcome depends on synthetic route used production, toxic reagents employed. In this work, we compared two types NPs, obtained by different chemical routes: conventional synthesis using sodium citrate and green protocol based leaf extracts as source reduction capping agents. A careful physicochemical characterization was carried out showing spherical stable with an average size between 20 nm 35 for respectively. Then, evaluated ability to induce inflammation Human Leukemic Monocytes (THP-1) differentiated into M0 macrophages 1 µM 2 concentrations (corresponded 0.1 µg/mL 0.2 respectively) two-time points (24 h 48 h). Our results showed clear difference Nuclear Factor κB (NF-κb) activation, Interleukins 6-8 (IL-6, IL-8) secretion, Tumor Necrosis Factor-α (TNF-α) Cyclooxygenase-2 (COX-2) expression exerted kinds NPs. Green were definitely tolerated induced all factors mentioned above. Subsequently, exposure breast cancer cell line (MCF-7) that they exhibited antitumor activity like ones, but surprisingly, MCF-10A (not tumoral cells) did not cause significant decrease viability.

Language: Английский

Citations

13