Frontiers in Aging Neuroscience,
Journal Year:
2022,
Volume and Issue:
14
Published: Oct. 17, 2022
Alzheimer’s
disease
(AD)
is
the
most
prevalent
neurodegenerative
disease,
affecting
more
than
55
million
individuals
worldwide
in
2021.
In
addition
to
“amyloid
hypothesis,”
an
increasing
number
of
studies
have
demonstrated
that
phosphorylated
tau
plays
important
role
AD
pathogenesis.
Both
soluble
oligomers
and
insoluble
aggregates
brain
can
induce
structural
functional
neuronal
damage
through
multiple
pathways,
eventually
leading
memory
deficits
neurodegeneration.
Autophagy
cellular
response
various
stress
stimuli
generally
be
categorized
into
non-selective
selective
autophagy.
Recent
indicated
both
types
autophagy
are
involved
pathology.
Among
several
subtypes
autophagy,
mitophagy,
which
mediates
removal
mitochondria,
has
attracted
attention
because
dysfunctional
mitochondria
been
suggested
contribute
tauopathies.
this
review,
we
summarize
latest
findings
on
bidirectional
association
between
abnormal
proteins
defective
as
well
might
constitute
a
vicious
cycle
induction
Neuroinflammation,
another
feature
pathogenesis
progression
AD,
shown
crosstalk
with
mitophagy.
Additionally,
comprehensively
discuss
relationship
neuroinflammation,
By
elucidating
underlying
molecular
mechanisms
governing
these
pathologies,
highlight
novel
therapeutic
strategies
targeting
mitophagy
such
those
using
rapamycin,
urolithin,
spermidine,
curcumin,
nicotinamide,
actinonin,
for
prevention
treatment
AD.
Aging and Disease,
Journal Year:
2022,
Volume and Issue:
14(3), P. 716 - 716
Published: Nov. 17, 2022
Curcumin,
a
well-known
hydrophobic
polyphenol
extracted
from
the
rhizomes
of
turmeric
(Curcuma
longa
L.),
has
attracted
great
interest
in
last
ten
years
due
to
its
multiple
pharmacological
activities.
A
growing
body
evidence
manifested
that
curcumin
extensive
activities
including
anti-inflammatory,
anti-oxygenation,
lipid
regulation,
antiviral,
and
anticancer
with
hypotoxicity
minor
adverse
reactions.
However,
disadvantages
low
bioavailability,
short
half-life
plasma,
drug
concentration
blood,
poor
oral
absorption
severely
limited
clinical
application
curcumin.
Pharmaceutical
researchers
have
carried
out
plenty
dosage
form
transformations
improve
druggability
achieved
remarkable
results.
Therefore,
objective
this
review
summarizes
research
progress,
problems
improvement
methods
curcumin's
druggability.
By
reviewing
latest
progress
curcumin,
we
believe
broad
prospect
for
wide
range
few
side
effects.
The
deficiencies
lower
bioavailability
could
be
improved
by
transformation.
still
requires
further
study
regarding
underlying
mechanism
trial
verification.
Frontiers in Neuroscience,
Journal Year:
2022,
Volume and Issue:
16
Published: May 16, 2022
The
current
scientific
community
is
facing
a
daunting
challenge
to
unravel
reliable
natural
compounds
with
realistic
potential
treat
neurological
disorders
such
as
Alzheimer’s
disease
(AD).
reported
compounds/drugs
mostly
synthetic
deemed
the
reliability
and
therapeutic
largely
due
their
complexity
off-target
issues.
products
from
nutraceutical
emerge
viable
preventive
therapeutics
fill
huge
gap
in
treating
disorders.
Considering
that
multifactorial
disease,
offer
advantage
of
multitarget
approach,
tagging
different
molecular
sites
human
brain,
compared
single-target
activity
most
drugs
so
far
used
disease.
A
wide
range
plant
extracts
phytochemicals
possess
includes
curcumin,
resveratrol,
epigallocatechin-3-gallate,
morin,
delphinidins,
quercetin,
luteolin,
oleocanthal,
other
huperzine
A,
limonoids,
azaphilones.
Reported
targets
these
include
inhibition
acetylcholinesterase,
amyloid
senile
plaques,
oxidation
products,
inflammatory
pathways,
specific
brain
receptors,
etc.
We
tenaciously
aimed
review
in-depth
applications
against
special
focus
on
diversity
medicinal
plants
phytocompounds
mechanism
action
pathologies.
strongly
believe
phytoconstituents
alone
or
combination
would
be
effective
treatments
lesser
side
effects
currently
available
treatments.
Biomolecules,
Journal Year:
2023,
Volume and Issue:
13(1), P. 183 - 183
Published: Jan. 16, 2023
Type
2
diabetes
(T2D)
and
Alzheimer’s
diseases
(AD)
represent
major
health
issues
that
have
reached
alarming
levels
in
the
last
decades.
Although
growing
evidence
demonstrates
AD
is
a
significant
comorbidity
of
T2D,
there
~1.4–2-fold
increase
risk
developing
among
T2D
patients,
involvement
possible
common
triggers
pathogenesis
these
two
remains
largely
unknown.
Of
note,
recent
mechanistic
insights
suggest
lipotoxicity
could
missing
ring
pathogenetic
mechanisms
linking
to
AD.
Indeed,
obesity,
which
represents
main
cause
lipotoxicity,
has
been
recognized
as
factor
for
both
pathological
conditions.
Lipotoxicity
can
lead
inflammation,
insulin
resistance,
oxidative
stress,
ceramide
amyloid
accumulation,
endoplasmic
reticulum
ferroptosis,
autophagy,
are
shared
biological
events
In
current
review,
we
try
provide
critical
comprehensive
view
molecular
pathways
activated
by
AD,
attempting
summarize
how
drive
future
research
open
way
new
therapeutic
perspectives.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: May 16, 2024
Importance
Research
is
beginning
to
elucidate
the
sophisticated
mechanisms
underlying
microbiota-gut-brain-immune
interface,
moving
from
primarily
animal
models
human
studies.
Findings
support
dynamic
relationships
between
gut
microbiota
as
an
ecosystem
(microbiome)
within
(host)
and
its
intersection
with
host
immune
nervous
systems.
Adding
this
effects
on
epigenetic
regulation
of
gene
expression
further
complicates
strengthens
response.
At
heart
inflammation,
which
manifests
in
a
variety
pathologies
including
neurodegenerative
diseases
such
Alzheimer’s
disease,
Parkinson’s
Multiple
Sclerosis
(MS).
Observations
Generally,
research
date
limited
has
focused
bacteria,
likely
due
simplicity
cost-effectiveness
16s
rRNA
sequencing,
despite
lower
resolution
inability
determine
functional
ability/alterations.
However,
omits
all
other
fungi,
viruses,
phages,
are
emerging
key
members
microbiome.
Much
been
done
pre-clinical
and/or
small
studies
more
developed
parts
world.
The
observed
promising
but
cannot
be
considered
reliable
or
generalizable
at
time.
Specifically,
causal
determined
currently.
More
followed
by
then
little
MS.
data
for
MS
encouraging
this.
Conclusions
relevance
While
still
nascent,
interface
may
missing
link,
hampered
our
progress
understanding,
let
alone
preventing,
managing,
putting
into
remission
diseases.
Relationships
must
first
established
humans,
have
shown
poorly
translate
complex
physiology
environments,
especially
when
investigating
microbiome
where
often
overly
simplistic.
Only
can
robust
conducted
humans
using
mechanistic
model
Aging-related
disorders
pose
significant
challenges
due
to
their
complex
interplay
of
physiological
and
metabolic
factors,
including
inflammation,
oxidative
stress,
mitochondrial
dysfunction.
Curcumin,
a
natural
compound
with
potent
antioxidant
anti-inflammatory
properties,
has
emerged
as
promising
candidate
for
mitigating
these
age-related
processes.
However,
gaps
in
understanding
the
precise
mechanisms
curcumin's
effects
optimal
dosages
different
conditions
necessitate
further
investigation.
This
systematic
review
synthesizes
current
evidence
on
potential
addressing
disorders,
emphasizing
its
impact
cognitive
function,
neurodegeneration,
muscle
health
older
adults.
By
evaluating
safety,
efficacy,
action
curcumin
supplementation,
this
aims
provide
insights
into
therapeutic
promoting
healthy
aging.
A
search
across
three
databases
using
specific
keywords
yielded
2,256
documents,
leading
selection
15
clinical
trials
synthesis.
Here
we
highlight
multifaceted
agent
combating
disorders.
The
findings
suggest
that
could
offer
effective
approach
enhancing
quality
life
aging
individuals.
Further
research
well-designed
are
essential
validate
optimize
use
personalized
medicine
approaches
conditions.
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(16), P. 2721 - 2721
Published: Aug. 15, 2024
Aging-related
disorders
pose
significant
challenges
due
to
their
complex
interplay
of
physiological
and
metabolic
factors,
including
inflammation,
oxidative
stress,
mitochondrial
dysfunction.
Curcumin,
a
natural
compound
with
potent
antioxidant
anti-inflammatory
properties,
has
emerged
as
promising
candidate
for
mitigating
these
age-related
processes.
However,
gaps
in
understanding
the
precise
mechanisms
curcumin’s
effects
optimal
dosages
different
conditions
necessitate
further
investigation.
This
systematic
review
synthesizes
current
evidence
on
potential
addressing
disorders,
emphasizing
its
impact
cognitive
function,
neurodegeneration,
muscle
health
older
adults.
By
evaluating
safety,
efficacy,
action
curcumin
supplementation,
this
aims
provide
insights
into
therapeutic
promoting
healthy
aging.
A
search
across
three
databases
using
specific
keywords
yielded
2256
documents,
leading
selection
15
clinical
trials
synthesis.
Here,
we
highlight
multifaceted
agent
combating
disorders.
The
findings
suggest
that
could
offer
effective
approach
enhancing
quality
life
aging
individuals.
Further
research
well-designed
are
essential
validate
optimize
use
personalized
medicine
approaches
conditions.
ACS Omega,
Journal Year:
2025,
Volume and Issue:
10(6), P. 5148 - 5171
Published: Feb. 3, 2025
Alzheimer's
disease
(AD)
is
an
aging-related
irreversible
neurodegenerative
affecting
mostly
the
elderly
population.
The
main
pathological
features
of
AD
are
extracellular
Aβ
plaques
generated
by
APP
cleavage
through
amyloidogenic
pathway,
intracellular
neurofibrillary
tangles
(NFT)
resulting
from
hyperphosphorylated
tau
proteins,
and
cholinergic
neurodegeneration.
However,
actual
causes
unknown,
but
several
studies
suggest
hereditary
mutations
in
PSEN1
-2,
APOE4,
APP,
TAU
genes
major
perpetrators.
In
order
to
understand
etiology
pathogenesis
AD,
various
hypotheses
proposed.
These
include
following
hypotheses:
amyloid
accumulation,
tauopathy,
inflammation,
oxidative
stress,
mitochondrial
dysfunction,
glutamate/excitotoxicity,
deficiency,
gut
dysbiosis.
Currently
approved
therapeutic
interventions
donepezil,
galantamine,
rivastigmine,
which
cholinesterase
inhibitors
(ChEIs),
memantine,
N-methyl-d-aspartate
(NMDA)
antagonist.
treatment
strategies
focus
on
only
symptomatic
management
attenuating
symptoms
not
regeneration
neurons
or
clearance
Tau.
This
review
focuses
pathophysiology,
novel
targets,
disease-altering
treatments
such
as
α-secretase
modulators,
active
immunotherapy,
passive
natural
antioxidant
products,
nanomaterials,
antiamyloid
therapy,
aggregation
inhibitors,
transplantation
fecal
microbiota
stem
cells,
microtubule
stabilizers
that
clinical
trials
still
under
investigation.
Frontiers in Pharmacology,
Journal Year:
2020,
Volume and Issue:
11
Published: Dec. 14, 2020
Immune
response,
proliferation,
migration
and
angiogenesis
are
juts
a
few
of
cellular
events
that
regulated
by
transforming
growth
factor-β
(TGF-β)
in
cells.
A
number
studies
have
documented
TGF-β
undergoes
abnormal
expression
different
diseases,
e.g.,
diabetes,
cancer,
fibrosis,
asthma,
arthritis,
among
others.
This
has
led
to
great
fascination
into
this
signaling
pathway
developing
agents
with
modulatory
impact
on
TGF-β.
Curcumin,
natural-based
compound,
is
obtained
from
rhizome
roots
turmeric
plant.
It
pharmacological
activities
including
antioxidant,
anti-inflammatory,
anti-tumor,
anti-diabetes
so
on.
Noteworthy,
it
been
demonstrated
curcumin
affects
molecular
pathways
such
as
Wnt/β-catenin,
Nrf2,
AMPK,
mitogen-activated
protein
kinase
In
the
present
review,
we
evaluate
potential
regulation
corelate
therapeutic
impacts
curcumin.
By
modulation
(both
upregulation
down-regulation),
ameliorates
neurological
disorders,
liver
disease,
diabetes
asthma.
Besides,
targets
which
capable
suppressing
proliferation
tumor
cells
invading
cancer
