The metabolic characteristics and changes of chondrocytes in vivo and in vitro in osteoarthritis

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: May 24, 2024

Osteoarthritis (OA) is an intricate pathological condition that primarily affects the entire synovial joint, especially hip, hand, and knee joints. This results in inflammation synovium osteochondral injuries, ultimately causing functional limitations joint dysfunction. The key mechanism responsible for maintaining articular cartilage function chondrocyte metabolism, which involves energy generation through glycolysis, oxidative phosphorylation, other metabolic pathways. Some studies have shown chondrocytes OA exhibit increased glycolytic activity, leading to elevated lactate production decreased matrix synthesis. In cartilage, display alterations mitochondrial such as ATP stress, can contribute deterioration. Chondrocyte metabolism also anabolic processes extracellular substrate generation. During OA, undergo considerable changes different aspects, homeostasis Numerous been carried out provide tangible therapies by using various models vivo vitro targeting although there are still certain limitations. With growing evidence indicating essential role of disease etiology, this literature review explores characteristics presence both . To insight into complex reprogramming crucial during progression, we investigate dynamic interaction between pathways, lipid function. addition, highlights prospective future research directions novel approaches diagnosis treatment. Adopting a multifaceted strategy, our aims offer comprehensive understanding intricacies within with ultimate goal identifying therapeutic targets capable modulating treatment OA.

Language: Английский

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Therapeutic effects of resveratrol on epigenetic mechanisms in age‐related diseases: A comprehensive review

Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(5), P. 2347 - 2360

Published: Feb. 29, 2024

Abstract Recently, various studies have shown that epigenetic changes are associated with aging and age‐related diseases. Both animal human models revealed processes involved in mechanisms. These happen at multiple levels include histone modification, DNA methylation, noncoding RNA expression. Consequently, the organization of chromatin accessibility lead to regulation gene With increasing awareness pivotal function epigenetics process, researchers' attention has been drawn how these can be modified prevent, stop, or reverse aging, senescence, Among agents affect epigenetic, polyphenols well‐known phytochemicals found fruits, vegetables, plants. Polyphenols modify epigenetic‐related mechanisms diseases conditions, such as metabolic disorders, obesity, neurodegenerative diseases, cancer, cardiovascular Resveratrol (RSV) is a member stilbene subgroup which derived from plants, grapes, apples, blueberries. Therefore, herein, we aim summarize RSV affects different change aging‐related Furthermore, discuss its roles Alzheimer's, Parkinson's, osteoporosis,

Language: Английский

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Deciphering the Power of Resveratrol in Mitophagy: From Molecular Mechanisms to Therapeutic Applications

Phytotherapy Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 4, 2025

Resveratrol (RES), a natural polyphenolic compound, has garnered significant attention for its therapeutic potential in various pathological conditions. This review explores how RES modulates mitophagy-the selective autophagic degradation of mitochondria essential maintaining cellular homeostasis. promotes the initiation and execution mitophagy by enhancing PINK1/Parkin-mediated mitochondrial clearance, reducing reactive oxygen species production, mitigating apoptosis, thereby preserving integrity. Additionally, regulates through activation key molecular targets such as AMP-activated protein kinase (AMPK), mechanistic target rapamycin (mTOR), deacetylases (SIRT1 SIRT3), quality control (MQC) pathways, demonstrating substantial effects multiple disease models. We provide detailed account biosynthetic pharmacokinetics, metabolic characteristics RES, focusing on role modulation implications medical applications. Potential adverse associated with clinical use are also discussed. Despite promising properties, application is limited issues bioavailability pharmacokinetic profiles. Future research should concentrate developing derivatives that precisely modulate mitophagy, unlocking new avenues therapy.

Language: Английский

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Resveratrol—A Promising Therapeutic Agent with Problematic Properties

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(1), P. 134 - 134

Published: Jan. 19, 2025

Resveratrol is a natural polyphenol (stilbenoid), which can be found in grape skin, red wine, blueberries, peanuts and others. The biological properties of resveratrol, particular antioxidant, anti-inflammatory, anticancer, estrogenic, vasorelaxant cardioprotective activity, are the main reason for its importance medicine pharmacy. Despite all advantages, however, there many problems related to this polyphenolic substance, such as low stability, water insolubility, poor bioavailability fast metabolism. For reason, scientists currently searching different approaches dealing with these problematic improving therapeutic usage resveratrol. This review summarizes mechanisms effects determined vitro vivo, limitations drug. article emphasizes new improvement resveratrol delivery, nanoencapsulation, formation nanocrystals, prodrugs structure analogues.

Language: Английский

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Therapeutic potential and underlying mechanisms of phytoconstituents: emphasizing on resveratol, curcumin, quercetin, berberine, and hesperidin in ulcerative colitis

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Language: Английский

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