All-in-one: Harnessing multifunctional injectable natural hydrogels for ordered therapy of bacteria-infected diabetic wounds

Chemical Engineering Journal, Journal Year: 2022, Volume and Issue: 439, P. 135691 - 135691

Published: March 9, 2022

Language: Английский

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Copper-based metal–organic frameworks for biomedical applications

Advances in Colloid and Interface Science, Journal Year: 2022, Volume and Issue: 305, P. 102686 - 102686

Published: April 29, 2022

Language: Английский

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Biomedical polymers: synthesis, properties, and applications

Science China Chemistry, Journal Year: 2022, Volume and Issue: 65(6), P. 1010 - 1075

Published: April 24, 2022

Language: Английский

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Micro/nano functional devices fabricated by additive manufacturing

Progress in Materials Science, Journal Year: 2022, Volume and Issue: 131, P. 101020 - 101020

Published: Sept. 13, 2022

Language: Английский

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Antibacterial coatings on orthopedic implants

Materials Today Bio, Journal Year: 2023, Volume and Issue: 19, P. 100586 - 100586

Published: Feb. 15, 2023

With the aging of population and rapid improvement public health medical level in recent years, people have had an increasing demand for orthopedic implants. However, premature implant failure postoperative complications frequently occur due to implant-related infections, which not only increase social economic burden, but also greatly affect patient's quality life, finally restraining clinical use Antibacterial coatings, as effective strategy solve above problems, been extensively studied motivated development novel strategies optimize implant. In this paper, a variety antibacterial coatings recently developed implants were briefly reviewed, with focus on synergistic multi-mechanism multi-functional smart that are more potential use, thereby providing theoretical references further fabrication high-performance satisfying complex needs.

Language: Английский

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Construction of multifunctional wound dressings with their application in chronic wound treatment

Biomaterials Science, Journal Year: 2022, Volume and Issue: 10(15), P. 4058 - 4076

Published: Jan. 1, 2022

Multifunctional wound dressings or smart with pro-angiogenic function, antibacterial properties, anti-inflammatory/antioxidant activity and tissue adhesion for chronic repair.

Language: Английский

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Bioinspired superhydrophobic surfaces, inhibiting or promoting microbial contamination?

Materials Today, Journal Year: 2023, Volume and Issue: 67, P. 468 - 494

Published: July 1, 2023

Language: Английский

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Ultrasound-activated piezo-hot carriers trigger tandem catalysis coordinating cuproptosis-like bacterial death against implant infections

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Feb. 22, 2024

Abstract Implant-associated infections due to the formation of bacterial biofilms pose a serious threat in medical healthcare, which needs effective therapeutic methods. Here, we propose multifunctional nanoreactor by spatiotemporal ultrasound-driven tandem catalysis amplify efficacy sonodynamic and chemodynamic therapy. By combining piezoelectric barium titanate with polydopamine copper, ultrasound-activated piezo-hot carriers transfer easily copper polydopamine. It boosts reactive oxygen species production piezoelectrics, facilitates interconversion between Cu2 + Cu promote hydroxyl radical generation via -catalyzed reactions. Finally, elevated cause membrane structure loosening DNA damage. Transcriptomics metabolomics analysis reveal that intracellular overload restricts tricarboxylic acid cycle, promoting cuproptosis-like death. Therefore, polyetherketoneketone scaffold engineered designed shows excellent antibacterial performance ultrasound stimulation promotes angiogenesis osteogenesis on-demand vivo.

Language: Английский

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A Photo‐Therapeutic Nanocomposite with Bio‐Responsive Oxygen Self‐Supplying Combats Biofilm Infections and Inflammation from Drug‐Resistant Bacteria

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(37)

Published: May 25, 2023

Abstract The use of non‐antibiotic strategies to combat refractory drug‐resistant bacterial infections, especially biofilms and accompanying inflammation, has recently aroused widespread interest. Herein, a photo‐therapeutic nanocomposite with bio‐responsive oxygen (O 2 ) self‐supplying is introduced by integrating manganese dioxide (MnO nanozymes onto photosensitizer (indocyanine green, ICG)‐loaded mesoporous polydopamine nanoparticles (MPDA), namely MI‐MPDA NPs. can activate O generation in the infection microenvironment, thereby effectively alleviating biofilm hypoxia. Under near‐infrared light (NIR) irradiation, continuous supplying further boosts level singlet ( 1 ), enabling robust elimination through ‐potentiated photodynamic/photothermal therapy. Interestingly, down‐regulates factor expression inflammatory signaling pathways MnO ‐mediated reactive species scavenging, which ameliorates condition. Meanwhile, prevents M1‐phenotype switch macrophages from overexpression hypoxia‐inducible factor‐1 α (HIF‐1 prompting macrophage reprogramming toward pro‐regenerative M2‐phenotype. In mouse models subcutaneous implant‐associated caused methicillin‐resistant Staphylococcus aureus (MRSA) burn Pseudomonas aeruginosa biofilms, NIR‐irradiated not only eliminates formed but also alleviates oxidative stress drives cascade reaction immunomodulation‐wound healing. Overall, this strategy provides reliable tool for combating infections inflammation bacteria.

Language: Английский

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Specific Chemiluminescence Imaging and Enhanced Photodynamic Therapy of Bacterial Infections by Hemin‐Modified Carbon Dots

Small, Journal Year: 2023, Volume and Issue: 19(31)

Published: March 25, 2023

Abstract Antibacterial photodynamic therapy (aPDT) is a promising antibiotics‐alternative strategy for bacterial infectious diseases, which features broad‐spectrum antibacterial activity with low risk of inducing resistance. However, clinical applications aPDT are still hindered by the hydrophobicity‐caused inadequate conventional photosensitizers and hypoxic microenvironment infections. To address these problems, herein, developed to achieve specific chemiluminescence (CL) imaging enhanced PDT infections using hemin‐modified carbon dots (H‐CDs). The H‐CDs can be facilely prepared exhibit favorable water solubility, augmented activity, unique peroxidase‐mimicking capacity. Compared free CDs, efficacy significantly due increased electron–hole separation efficiency. Moreover, peroxidase catalytic performance enables not only infection identification via microenvironment‐responsive CL but also oxygen self‐supplied hypoxia‐relief‐enhanced bacteria inactivation effects. Finally, efficiencies validated in both vivo abscess infected wound models. This work may provide an effective platform selective imaging‐guided treatment

Language: Английский

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