Science Advances,
Journal Year:
2022,
Volume and Issue:
8(35)
Published: Sept. 2, 2022
Vitiligo
is
an
acquired
skin
depigmentation
disease
involving
multiple
pathogenetic
mechanisms,
which
ultimately
direct
cytotoxic
CD8
+
cells
to
destroy
melanocytes.
Abnormalities
have
been
described
in
several
even
pigmented
as
expression
of
a
functional
inherited
defect.
Keratinocytes
regulate
homeostasis
by
the
assembly
proper
barrier
and
releasing
responding
cytokines
growth
factors.
Alterations
epidermal
proliferation,
differentiation,
lipid
composition
triggers
for
immune
response
activation
vitiligo
not
yet
investigated.
By
applying
cellular
lipidomic
approaches,
we
revealed
deregulated
keratinocyte
differentiation
with
altered
composition,
associated
impaired
energy
metabolism
increased
glycolytic
enzyme
expression.
keratinocytes
secreted
inflammatory
mediators,
further
following
mild
mechanical
stress,
thus
evidencing
activation.
These
findings
identify
intrinsic
alterations
nonlesional
epidermis,
can
be
prime
instigator
local
milieu
that
stimulates
responses
targeting
Cosmetics,
Journal Year:
2021,
Volume and Issue:
8(3), P. 66 - 66
Published: July 16, 2021
The
“modern”
cosmetology
industry
is
focusing
on
research
devoted
to
discovering
novel
neurocosmetic
functional
ingredients
that
could
improve
the
interactions
between
skin
and
nervous
system.
Many
cosmetic
companies
have
started
formulate
products
exhibit
their
activity
cutaneous
system
by
affecting
skin’s
neuromediators
through
different
mechanisms
of
action.
This
review
aims
clarify
definition
neurocosmetics,
describe
features
some
available
market,
with
a
look
at
regulatory
aspect.
attention
for
combating
stress,
explaining
stress
pathways,
which
are
also
correlated
aging.
“Neuro-relaxing”
anti-aging
derived
from
plant
extracts
strategies
combat
inflammatory
responses
related
presented.
Afterwards,
molecular
basis
sensitive
suitable
this
problem
discussed.
With
aim
presenting
major
application
Botox-like
as
first
neurocosmetics
aging
introduced,
its
theory
To
confirm
efficacy
concept
claims
Asthma Research and Practice,
Journal Year:
2021,
Volume and Issue:
7(1)
Published: Dec. 1, 2021
Abstract
Atopic
diseases
are
multifactorial
chronic
disturbances
which
may
evolve
one
into
another
and
have
overlapping
pathogenetic
mechanisms.
dermatitis
is
in
most
cases
the
first
step
towards
development
of
atopic
march
represents
a
major
socio-economic
burden
industrialized
countries.
The
treatment
often
long-lasting
some
with
lower
effectiveness
than
expected.
In
order
to
prevent
march,
links
between
be
understood.
aim
this
review
present
points
outlining
link
asthma,
through
research
medical
literature
from
recent
years.
Stratifying
patient
populations
according
clinical
phenotype
their
disease
specific
measurable
values
(biomarkers)
can
help
establish
main
etiopathogenetic
mechanisms
these
populations.
This
will
add
predictive
value
for
evolution
disease,
allow
use
more
targeted
therapy
stop
comorbidities.
Science Advances,
Journal Year:
2022,
Volume and Issue:
8(35)
Published: Sept. 2, 2022
Vitiligo
is
an
acquired
skin
depigmentation
disease
involving
multiple
pathogenetic
mechanisms,
which
ultimately
direct
cytotoxic
CD8
+
cells
to
destroy
melanocytes.
Abnormalities
have
been
described
in
several
even
pigmented
as
expression
of
a
functional
inherited
defect.
Keratinocytes
regulate
homeostasis
by
the
assembly
proper
barrier
and
releasing
responding
cytokines
growth
factors.
Alterations
epidermal
proliferation,
differentiation,
lipid
composition
triggers
for
immune
response
activation
vitiligo
not
yet
investigated.
By
applying
cellular
lipidomic
approaches,
we
revealed
deregulated
keratinocyte
differentiation
with
altered
composition,
associated
impaired
energy
metabolism
increased
glycolytic
enzyme
expression.
keratinocytes
secreted
inflammatory
mediators,
further
following
mild
mechanical
stress,
thus
evidencing
activation.
These
findings
identify
intrinsic
alterations
nonlesional
epidermis,
can
be
prime
instigator
local
milieu
that
stimulates
responses
targeting
