Can the ketogenic diet improve our dreams? Effect of very low-calorie ketogenic diet (VLCKD) on sleep quality

Journal of Translational Medicine, Journal Year: 2023, Volume and Issue: 21(1)

Published: July 18, 2023

Abstract Background Obesity is a condition that often associated with sleep disorders, including reduced quality (SQ). Very low calorie ketogenic diet (VLCKD) has proven to be effective in the management of obesity and metabolic disorders. However, little still known about effects this promising nutritional protocol on SQ. Thus, purpose study was investigate short-term effect VLCKD SQ women overweight/obesity if any changes, identify predictive factor through modified Methods Were consecutively enrolled total 324 subjects, who met inclusion criteria accepted adhere VLCKD. Assessment status, anthropometric measurements (height, weight, waist circumference), bioelectrical impedance analysis (phase-sensitive system, 50 kHz BIA 101 RJL, Akern Bioresearch, Florence, Italy Akern), high sensitivity C reactive protein levels (hs-CRP), were carried out at baseline after 31 days active stage evaluated using validated questionnaire Pittsburgh Sleep Quality Index (PSQI). Results In addition expected general improvement parameters body composition, improved significantly SQ, as demonstrated by all included PSQI (p < 0.001). Both VLCKD, score BMI, circumference, fat mass, free mass 0.001 for all) hs-CRP = 0.023). PhA negatively only ∆% positively correlated 0.001), 0.031). multiple regression represented predictor changes Finally, ROC analysis, threshold value > − 8.4% predicted Conclusion conclusion, determines an overweight obesity, mostly mediated reduction related protocol. Graphical

Language: Английский

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Hypertrophy and ER Stress Induced by Palmitate Are Counteracted by Mango Peel and Seed Extracts in 3T3-L1 Adipocytes

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(6), P. 5419 - 5419

Published: March 12, 2023

A diet rich in saturated fatty acids (FAs) has been correlated with metabolic dysfunction and ROS increase the adipose tissue of obese subjects. Thus, reducing hypertrophy oxidative stress can represent a strategy to counteract obesity obesity-related diseases. In this context, present study showed how peel seed extracts mango (Mangifera indica L.) reduced lipotoxicity induced by high doses sodium palmitate (PA) differentiated 3T3-L1 adipocytes. Mango (MPE) (MSE) significantly lowered PA-induced fat accumulation lipid droplet (LDs) triacylglycerol (TAGs) content We that MPE MSE activated hormone-sensitive lipase, key enzyme TAG degradation. addition, down-regulated adipogenic transcription factor PPARγ as well AMPK consequent inhibition acetyl-CoA-carboxylase (ACC). Notably, PA increased endoplasmic reticulum (ER) markers GRP78, PERK CHOP, enhanced reactive oxygen species (ROS) These effects were accompanied reduction cell viability induction apoptosis. Interestingly, counteracted ER production. level anti-oxidant Nrf2 its targets MnSOD HO-1. Collectively, these results suggest intake extract-enriched foods association correct lifestyle could exert beneficial obesity.

Language: Английский

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Low-carbohydrate and ketogenic diets: a scoping review of neurological and inflammatory outcomes in human studies and their relevance to chronic pain

Nutrition Research Reviews, Journal Year: 2022, Volume and Issue: 36(2), P. 295 - 319

Published: April 19, 2022

Abstract Dietary restriction of carbohydrate has been demonstrated to be beneficial for nervous system dysfunction in animal models and may human chronic pain. The purpose this review is assess the impact a low-carbohydrate/ketogenic diet on adult function inflammatory biomarkers inform nutritional research An electronic database search was carried out May 2021. Publications were screened prospective with dietary intake <130 g per day duration ≥2 weeks. Studies categorised into those reporting neurological outcomes extracted analysis other outcomes. Both groups again reported biomarkers. From 1548 studies, there 847 studies included. Sixty-four 83% showing improvement. Five hundred twenty-three had different focus (metabolic n = 394, sport/performance 51, cancer 33, general 30, non-neuro 12, or gastrointestinal 4). second screen identified sixty-three biomarkers, 71% reduction inflammation. overall results suggest favourable outcome from carbohydrates. sensitisation inflammation occur pain, indicate it improved by low-carbohydrate therapy. More clinical trials within population are required build few that have done.

Language: Английский

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Crosstalk between dietary patterns, obesity and nonalcoholic fatty liver disease

World Journal of Gastroenterology, Journal Year: 2022, Volume and Issue: 28(27), P. 3314 - 3333

Published: July 14, 2022

The prevalence of nonalcoholic fatty liver disease (NAFLD) is rising worldwide, paralleling the epidemic obesity. a key organ for metabolism proteins, fats and carbohydrates. Various types carbohydrates in isocaloric diets differently influence fat accumulation parenchyma. Therefore, nutrition can manage hepatic cardiometabolic complications NAFLD. Even moderately reduced caloric intake, which leads to weight loss 5%-10% initial body weight, effective improving steatosis surrogate markers status. Among dietary patterns, Mediterranean diet mostly prevents onset Furthermore, this also most recommended treatment NAFLD patients. However, clinical trials based on interventions patients are sparse. Since there only few studies examining clinically advanced stages NAFLD, such as active fibrotic steatohepatitis, optimal these must still be determined. In narrative review, we aimed critically summarize associations between different obesity prevention/risk describe specific interventions' impacts adults with provide an updated overview recommendations that clinicians potentially need apply their daily practice.

Language: Английский

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Supplementation with medium-chain fatty acids increases body weight loss during very low-calorie ketogenic diet: a retrospective analysis in a real-life setting

Journal of Translational Medicine, Journal Year: 2023, Volume and Issue: 21(1)

Published: Jan. 16, 2023

Abstract Background Very low-calorie ketogenic diet (VLCKD) has shown to significantly reduce body weight and fat mass, as well inflammation. These effects are supported by nutritional ketosis, which triggers the utilization of ketone an energy source. Medium-chain fatty acids (MCTs) might serve potential enhancers bodies production with a greater effect on loss. Nevertheless, no clinical studies have evaluated MCTs supplementation in addition VLCKD. Therefore, present study aimed evaluate whether can induce reduction during phase Methods In this retrospective study, 263 women overweight/obesity (body mass index, BMI: 35.7 ± 5.3 kg/m 2 ) aged 37.5 14.2 years followed one these dietary protocols for 45 days: (a) Control group, 83 participants (31.6%) (VLCKD without MCTs), (b) VLCKD + 86 (32.7%) (MCTs − 20 g/day- starting from first day active phase), (c) earlyMCTs, 94 (35.7%) g/day-starting 5 days before beginning phase. Anthropometric measures, composition, c-reactive protein (CRP) concentrations were collected at end (45 days) intervention. Results decreased weight, BMI, waist circumference compared control earlyMCTs group. A two-fold decrease increase muscle observed group As inflammation, hs-CRP (assessed absolute percent change) lower ( p = 0.009) 0.011) than logistic regression model showed that likelihood improvement BMI classes (OR: 1.85, 95% CI 1.02–3.36) also after adjusting confounding factors. Conclusion (20 g/day) may be useful tool enhance beneficial mass. particular, facilitate ketosis thus contributing effectiveness

Language: Английский

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