Saponins as therapeutic candidates for atherosclerosis

Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(3), P. 1651 - 1680

Published: Feb. 1, 2024

Abstract Drug development for atherosclerosis, the underlying pathological state of ischemic cardiovascular diseases, has posed a longstanding challenge. Saponins, classified as steroid or triterpenoid glycosides, have shown promising therapeutic potential in treatment atherosclerosis. Through an exhaustive examination scientific literature spanning from May 2013 to 2023, we identified 82 references evaluating 37 types saponins terms their prospective impacts on These studies suggest that ameliorate atherosclerosis by regulating lipid metabolism, inhibiting inflammation, suppressing apoptosis, reducing oxidative stress, and modulating smooth muscle cell proliferation migration, well gut microbiota, autophagy, endothelial senescence, angiogenesis. Notably, ginsenosides exhibit significant manifest essential pharmacological attributes, including lipid‐lowering, anti‐inflammatory, anti‐apoptotic, anti‐oxidative stress effects. This review provides comprehensive attributes with particular emphasis role regulation metabolism anti‐inflammatory Thus, may warrant further investigation therapy However, due various reasons such low oral bioavailability, clinical application still needs exploration.

Language: Английский

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Endoplasmic Reticulum Stress and Obesity

Advances in experimental medicine and biology, Journal Year: 2024, Volume and Issue: unknown, P. 373 - 390

Published: Jan. 1, 2024

Language: Английский

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Comprehensive safety and toxicity analysis of 2,2’-Bipyridine derivatives in combating MRSA biofilm formation and persistence

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 24, 2025

Introduction Methicillin-resistant Staphylococcus aureus (MRSA) infections have become arduous to treat due their capacity form biofilms, develop persistence, and exhibit significant antimicrobial resistance. These factors contribute the complexity of managing MRSA highlight urgent need for innovative treatment strategies. Objectives This endeavor aims evaluate safety 2,2’-Bipyridine (2,2’-Bipy) derivatives antimicrobial, anti-biofilm, anti-persister activities in treating Infections. Methods Six were screened ADMET properties tested minimum inhibitory concentrations against various bacterial strains using agar well diffusion broth dilution. Safety studies conducted through hemolysis tests, cell viability assays, vivo acute oral toxicity examinations. Bactericidal mechanisms biofilm disruption effects analyzed crystal violet staining confocal microscopy assays. The murine thigh infection model was also used investigate efficacy. Results All exhibited favorable physicochemical profiles are predicted be safe based on drug-like properties. vitro demonstrated that non-toxic 3T3 L1, confirmed mice at a dose 300 mg/kg non-hemolytic nature rabbit red blood cells. compounds showed potent antibacterial activity bacteria, including resistant strain 831. They inhibited formation eradicated biofilms dose-dependent manner MTCC 737 831, they effectively eliminated persister cells, outperforming reference antibiotic vancomycin. found depolarize mitochondrial membrane accumulate intracellular reactive oxygen species. significantly reduced load model. Conclusion study concluded 2,2’-Bipy possess activity, non-toxic, effective inhibiting killing

Language: Английский

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Mango (Mangifera indica L.) By-products in Food Processing and Health Promotion

Nutrition Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 4, 2025

Abstract The edible and nonedible parts of the mango (Mangifera indica L.) contain vitamins, phytocompounds, fiber, fatty acids. This review highlights uses by-products in food industry their effects on human health. literature offers many new possibilities for usage secondary products industry, such as production functional foods bakery products, addition to potential extraction antioxidants enzymes. Furthermore, due antioxidant anti-inflammatory properties, consumption various by-products, form peel leaf (powder or extract), can improve glycemia, plasma lipid levels, satiety, endothelial function, suggesting that these compounds prevent risk factors cardiovascular complications metabolic syndrome. Clinical trials show discarded fruits leaves be used treat diabetes mellitus, obesity, disorders. Moreover, utilized characteristics foods, may incorporated fat replacers, have leverage agribusiness reduce environmental damage resulting from disposal materials, reducing waste complex chain damage. Mango also produce nutraceutical items. use technologies bring light numerous made contributing development industrial foods. In addition, pharmaceutical cosmetics industries developed. Nutraceutical could lower prices could, therefore, by low-income populations. utilization meets current trend growing market better healthier products. However, more clinical are necessary evaluate effectiveness health, applications.

Language: Английский

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MCL1 Inhibition Overcomes the Aggressiveness Features of Triple-Negative Breast Cancer MDA-MB-231 Cells

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(13), P. 11149 - 11149

Published: July 6, 2023

Triple-Negative Breast Cancer (TNBC) is a particularly aggressive subtype among breast cancers (BCs), characterized by anoikis resistance, high invasiveness, and metastatic potential as well Epithelial–Mesenchymal Transition (EMT) stemness features. In the last few years, our research focused on function of MCL1, an antiapoptotic protein frequently deregulated in TNBC. Here, we demonstrate that MCL1 inhibition A-1210477, specific BH3-mimetic, promotes anoikis/apoptosis MDA-MB-231 cell line, shown via increase proapoptotic markers caspase activation. Our evidence also shows A-1210477 effects Focal Adhesions (FAs) impairing integrin trim survival signaling pathways, such FAK, AKT, ERK, NF-κB, GSK3β-inducing anoikis, thus suggesting putative role regulation FA dynamics. Interestingly, accordance with these results, observed reduction migratory invasiveness capabilities confirmed decrease metalloproteinases (MMPs) levels following treatment. Moreover, EMT characteristics demonstrated downregulation Vimentin, MUC1, DNMT1, surprising re-expression E-Cadherin, possible mesenchymal-like phenotype reversion. addition, makers OCT3/4, SOX2, NANOG, CD133, EpCAM, CD49f. findings support idea could be crucial to reduce aggressiveness, minimize features distinguish

Language: Английский

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Lipid droplets in pathogen infection and host immunity

Acta Pharmacologica Sinica, Journal Year: 2023, Volume and Issue: 45(3), P. 449 - 464

Published: Nov. 22, 2023

Language: Английский

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A Deadly Liaison between Oxidative Injury and p53 Drives Methyl-Gallate-Induced Autophagy and Apoptosis in HCT116 Colon Cancer Cells

Antioxidants, Journal Year: 2023, Volume and Issue: 12(6), P. 1292 - 1292

Published: June 16, 2023

Methyl gallate (MG), which is a gallotannin widely found in plants, polyphenol used traditional Chinese phytotherapy to alleviate several cancer symptoms. Our studies provided evidence that MG capable of reducing the viability HCT116 colon cells, while it was be ineffective on differentiated Caco-2 model polarized cells. In first phase treatment, promoted both early ROS generation and endoplasmic reticulum (ER) stress, sustained by elevated PERK, Grp78 CHOP expression levels, as well an upregulation intracellular calcium content. Such events were accompanied autophagic process (16-24 h), where prolonging time (48 h) exposure led cellular homeostasis collapse apoptotic cell death with DNA fragmentation p53 γH2Ax activation. data demonstrated crucial role MG-induced mechanism played p53. Its level, increased precociously (4 MG-treated tightly intertwined oxidative injury. Indeed, addition N-acetylcysteine (NAC), scavenger, counteracted increase, effect viability. Moreover, accumulation into nucleus its inhibition pifithrin-α (PFT-α), negative modulator transcriptional activity, enhanced autophagy, LC3-II level inhibited death. These findings provide new clues potential action possible anti-tumor phytomolecule for treatment.

Language: Английский

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Foodomics-Based Approaches Shed Light on the Potential Protective Effects of Polyphenols in Inflammatory Bowel Disease

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(19), P. 14619 - 14619

Published: Sept. 27, 2023

Inflammatory bowel disease (IBD) is a chronic and progressive inflammatory disorder affecting the gastrointestinal tract (GT) caused by wide range of genetic, microbial, environmental factors. IBD characterized inflammation decreased gut microbial diversity, dysbiosis, with lower number beneficial bacteria concomitant increase in pathogenic species. It well known that dysbiosis closely related to induction oxidative stress, latter an imbalance between reactive oxygen species (ROS) production cellular antioxidant capacity, leading ROS accumulation. are responsible for intestinal epithelium damage increased permeability found patients, their reduction could represent potential therapeutic strategy limit progression alleviate its symptoms. Recent evidence has highlighted dietary polyphenols, natural antioxidants, can maintain redox equilibrium GT, preventing damage, radical responses. Here, we suggest relatively new foodomics approaches, together technologies promoting antioxidative properties including novel delivery systems, chemical modifications, combination strategies, may provide critical insights determine clinical value polyphenols therapy comprehensive perspective implementing antioxidants as candidate treatment.

Language: Английский

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Foodomics-based Approaches Shed Light on the Potential Protective Effects of Polyphenols in Inflammatory Bowel Disease

Published: Aug. 25, 2023

Inflammatory Bowel Disease (IBD) is a chronic and progressive inflammatory disorder affecting the gastrointestinal tract (GT) caused by wide range of genetic, microbial, environmental factors. IBD characterized inflammation, decreased gut microbial diversity dysbiosis, with lower amount beneficial bacteria concomitant increase pathogenic species. It well known that dysbiosis closely related to induction inflammation oxidative stress, this last an imbalance between reactive oxygen species (ROS) production cellular antioxidant capacity leads ROS accumulation. are responsible for intestinal epithelium damage increased permeability found in patients their reduction could represent potential therapeutic strategy limit progression alleviate its symptom. Recent evidence highlighted dietary polyphenols, natural antioxidants, able maintain redox equilibrium GT preventing radical responses. Here, we suggest relatively new foodomics approaches, together technologies promoting antioxidative properties including novel delivery systems, chemical modifications combination strategies, may provide critical insight determine clinical value polyphenols therapy comprehensive perspective implementing antioxidants as candidate treatment.

Language: Английский

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Special Issue: “Inflammatory Signaling Pathways Involved in Gastrointestinal Diseases”

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(2), P. 1287 - 1287

Published: Jan. 20, 2024

Inflammation is a defensive response of the innate and adaptive immune systems against injury and/or harmful microorganisms to restore homeostasis [...]

Language: Английский

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