Taiwanese Journal of Obstetrics and Gynecology, Journal Year: 2021, Volume and Issue: 60(4), P. 593 - 594
Published: July 1, 2021
Language: Английский
Taiwanese Journal of Obstetrics and Gynecology, Journal Year: 2022, Volume and Issue: 61(6), P. 951 - 959
Published: Nov. 1, 2022
Language: Английский
Citations
46
Heliyon, Journal Year: 2022, Volume and Issue: 8(10), P. e11010 - e11010
Published: Oct. 1, 2022
Language: Английский
Citations
40
Human Reproduction Update, Journal Year: 2024, Volume and Issue: 30(5), P. 614 - 647
Published: June 28, 2024
Chemotherapy-associated ovarian damage (CAOD) is one of the most feared short- and long-term side effects anticancer treatment in premenopausal women. Accumulating detailed data show that different chemotherapy regimens can lead to disturbance hormone levels, reduced or lost fertility, an increased risk early menopause. Previous studies have often focused on direct chemotherapeutic drugs follicles, such as DNA damage-mediated apoptotic death primordial follicle burnout. Emerging evidence has revealed imbalance microenvironment during chemotherapy. The provides nutritional support transportation signals stimulate growth development ovulation, corpus luteum formation. close interaction between follicles determine function. Therefore, designing novel precise strategies manipulate may be a new strategy protect function
Language: Английский
Citations
17
Frontiers in Endocrinology, Journal Year: 2022, Volume and Issue: 13
Published: March 17, 2022
Androgen excess could profoundly lead to follicular dysplasia or atresia, and finally result in polycystic ovary syndrome (PCOS); however, the exact mechanism remains be fully elucidated.PCOS model rats were induced by dehydroepiandrosterone, their fertility was assessed. The ovarian granulosa cells (GCs) from matured follicles of PCOS collected identified immunofluorescence. mitochondrial ultrastructure observed transmission electron microscope function determined detecting adenosine triphosphate (ATP) content mtDNA copy number. Besides, expressions respiratory chain complexes ATP synthases relation analyzed.The successfully induced, reproductive outcomes obviously adverse. GCs layer apparently cut down distinctly destroyed. number greatly reduced, NDUFB8 ATP5j significantly down-regulated without obvious deletion 4834-bp.Androgen damage rat down-regulating expression PCOS.
Language: Английский
Citations
27
International Journal of Environmental Research and Public Health, Journal Year: 2022, Volume and Issue: 19(15), P. 9094 - 9094
Published: July 26, 2022
Polycystic ovary syndrome (PCOS) is a common metabolic problem in women of reproductive age. Evidence suggests pregnant with PCOS may have higher risk the development adverse pregnancy outcomes; however, relationship between pre-pregnancy overweight/obesity and outcomes remains uncertain. We try to clarify subsequent outcomes. Therefore, we conducted this systematic review meta-analysis. used databases obtained from PubMed, Embase, Web Science, Cochrane databases, plus hand-searching, examine association overweightness/obesity inception 4 February 2022. A total 16 cohort studies, including 14 retrospective studies (n = 10,496) another two prospective 818), contributed 11,314 for analysis. The meta-analysis showed significantly increased odds miscarriage rate whose body mass index (BMI) above overweight (OR 1.71 [95% CI 1.38-2.11]) or obese 2.00 1.38-2.90]) under random effect model. tests subgroup difference indicated was consistent, regardless which cut-off (24 25 kg/m2) obesity (28 30 used. With same strategies, found that control group live birth compared those as well 0.79 0.71-0.89], OR 0.78 0.67-0.91]). By contrast, did not find any preterm birth. Based on aforementioned findings, main critical factor contributing worse outcome be an early fetal loss these overweight/obesity. Since were associated outcomes, supposed weight reduction before attempting improve
Language: Английский
Citations
25
Journal of the Chinese Medical Association, Journal Year: 2022, Volume and Issue: 85(10), P. 965 - 971
Published: Sept. 6, 2022
Type 2 diabetes mellitus (T2DM), is a chronic metabolic disease, characterized by the presence of hyperglycemia and insulin resistance. The key treatment strategies for T2DM include modification lifestyle, medications, continuous glucose monitoring. DM patients often have DM-associated morbidities comorbidities; however, disorders musculoskeletal system are neglected, compared to other major systems in patients. Based on sharing similar pathophysiology osteoporosis, it supposed that use antidiabetic agents (ADAs) may not only provide lowering level effect maintenance sugar homeostasis directly delay tissue damage secondary but also offer benefits, such as prevention developing osteoporosis fractures. current review, evidence shows positive correlation between or fracture, effectiveness using ADA subsequent reduction fracture seems be inconclusive. Although benefits bone health uncertain, potential value “To do one get more” therapeutic strategy should always persuaded. At least, an establishment healthy lifestyle work, because improves status resistance subsequently helps control, prevents DM-related micro- macrovascular injury, possibly strengthens general performance system. With stronger support, risk “fall” decreased, associated with fracture. available market does satisfy policy yet, we looking forward seeing continuously advanced technology drug development diabetic hope see their extra-sugar–lowering effects.
Language: Английский
Citations
21
Journal of the Chinese Medical Association, Journal Year: 2021, Volume and Issue: 84(9), P. 813 - 820
Published: Aug. 5, 2021
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (coronavirus disease 2019, COVID-19) is a pandemic with rapidly and widely disseminating to the world. Based on experiences about H1N1, Acute Respiratory Syndrome (SARS) Middle East (MERS) pandemics, pregnant women who are infected disproportionately more likely develop severe illness need hospitalizations, intensive care, finally die of diseases compared those nonpregnant counterparts or without infection. Although than one half COVID-19 asymptomatic, as well their symptoms frequently mild, this observation presents further challenge regarding service provision, prevention, management, in which may result overlooking risk during pregnancy. As predictable, despite much advance critical care recent decades, 2020 pandemic, really at higher progress illness; require hospitalization; such use mechanical ventilation extracorporeal membrane oxygenation (ECMO), most important, COVID-19. The magnitude extend newborn from resultant significantly increasing perinatal neonatal morbidity mortality rates. heightened untoward outcomes emphasizes an urgent national international recommendations guidelines optimize prevention management strategies for Active passive approved effective attempt be Understanding that vulnerable population essential improve novel pandemic. current review part I summarize up-to-date information impact laboratory-confirmed SARS-CoV-2 infection focus clinical presentations pregnancy these SARS-CoV-2.
Language: Английский
Citations
27
Journal of Advanced Research, Journal Year: 2023, Volume and Issue: 65, P. 211 - 226
Published: Dec. 6, 2023
The reportedly high mutation rate of mitochondrial DNA (mtDNA) may be attributed to the absence histone protection and complete repair mechanisms. Mitochondrial heteroplasmy refers coexistence wild-type mutant mtDNA. Most healthy individuals carry a low point load (<1%) in their mtDNA, typically without any discernible phenotypic effects. However, as it exceeds certain threshold, cause onset various diseases. Since ovary is highly energy-intensive organ, relies heavily on function. can potentially contribute variety significant ovarian disorders. Review: In this review, we have elucidated close relationship between mtDNA diseases, summarized novel avenues strategies for potential treatment these Key Scientific Concepts disorders, including polycystic syndrome, premature insufficiency, endometriosis. Current related are untargeted bioavailability. Nanoparticle delivery systems loaded with modulators, replacement/transplantation therapy, mitochondria-targeted gene editing therapy offer promising paths towards more effective treatments despite ongoing challenges.
Language: Английский
Citations
11
Current Opinion in Obstetrics & Gynecology, Journal Year: 2025, Volume and Issue: unknown
Published: April 29, 2025
Purpose of review New concepts have emerged regarding how interrelationships hyperandrogenism and hyperinsulinemia from systemic insulin resistance contribute to the origins polycystic ovary syndrome (PCOS). Although these androgen-insulin are associated with several reproductive metabolic variables, their specific cause effect relationships remain unclear. This examines causal between understand complex interactions phenotypic expression PCOS. Recent findings Clinical interventions for treatments as well in-vitro studies androgen actions on critical target tissues examined why central Summary Bidirectional in normal-weight PCOS women may originally evolved an ancient adaptation simultaneously favor fat storage energy utilization survival reproduction during famine. These now predispose diseases pregnancy complications today’s obesogenic environment and, therefore, require improved preventive healthcare optimize long-term health children.
Language: Английский
Citations
0
Reproductive Biology and Endocrinology, Journal Year: 2023, Volume and Issue: 21(1)
Published: March 3, 2023
Abstract Background Polycystic ovarian syndrome (PCOS) is one of the most common causes infertility in reproductive-age women. However, efficacy and optimal therapeutic strategy for reproductive outcomes are still under debate. We conducted a systematic review network meta-analysis to compare different first-line pharmacological therapies terms women with PCOS infertility. Methods A retrieval databases was conducted, randomized clinical trials (RCTs) interventions infertile were included. The primary pregnancy live birth, secondary miscarriage, ectopic multiple pregnancy. based on Bayesian model performed effects strategies. Results total 27 RCTs 12 included, all tended increase pregnancy, especially pioglitazone (PIO) (log OR 3.14, 95% CI 1.56 ~ 4.70, moderate confidence), clomiphene citrate (CC) + exenatide (EXE) (2.96, 1.07 4.82, confidence) CC metformin (MET) PIO (2.82, 0.99 4.60, confidence). Moreover, MET (2.8, -0.25 6.06, very low could birth when compared placebo, even without significant difference. For outcomes, showed tendency miscarriage (1.44, -1.69 5.28, (-11.25, -33.7 0.57, LZ (-10.44, -59.56 42.11, beneficial decreasing (0.07, -4.26 4.34, neutral effect Subgroup analysis demonstrated no difference between these medications placebo obese participants. Conclusions Most treatments effective improving should be recommended as improve outcomes. none above had PCOS. Trial registration CRD42020183541; 05 July 2020
Language: Английский
Citations
9