Gut Microbiota Dysbiosis in Celiac Disease, Exploring the Probiotic Solution DOI Creative Commons

Hadeer Mohammed Ali,

Z Mohammed,

Oruba Khalid Abbas

et al.

Iraqi Journal of Community Medicine, Journal Year: 2025, Volume and Issue: 38(2), P. 96 - 102

Published: March 31, 2025

Abstract The gut microbiome significantly influences human health and disease, especially autoimmune disorders. During illness, the microbiota (GM) composition changes (dysbiosis), leading to disrupted communication between immune cells microbiota, which can cause infections activate Gut bacteria are isolated from their host by a physical barrier, such as epithelium lining or skin. Bacterial components lipopolysaccharides bacterial antigens may stimulate an inflammatory response activating stimulating cells. Numerous variables influence intestinal including diet, age, geographical location, mode of delivery, antibiotic probiotic consumption, various medical conditions. Celiac disease (CD) is immune-mediated enteropathy that exhibits gluten sensitivity induces upon consumption. Children with CD typically exhibit abdominal distension, diarrhea, failure thrive. Extraintestinal signs include anemia, tiredness, arthritis, infertility, liver failure, neuropathy, schizophrenia, autism. This review provides potential explanation GMs role in CD.

Language: Английский

Modulating Microbiota as a New Strategy for Breast Cancer Prevention and Treatment DOI Creative Commons
Huixin Wu, Sebanti Ganguly, Trygve O. Tollefsbol

et al.

Microorganisms, Journal Year: 2022, Volume and Issue: 10(9), P. 1727 - 1727

Published: Aug. 27, 2022

Breast cancer (BC) is the most common in women United States. There has been an increasing incidence and decreasing mortality rate of BC cases over past several decades. Many risk factors are associated with BC, such as diet, aging, personal family history, obesity, some environmental factors. Recent studies have shown that healthy individuals patients different microbiota composition, indicating microbiome a new factor for BC. Gut breast alterations prognosis. This review will evaluate altered populations gut, tissue, milk patients, well mechanisms interactions between modulation Probiotics prebiotics commercially available dietary supplements to alleviate side-effects therapies. They also shape population human gut microbiome. evaluates novel means modulating by nutritional treatment probiotics emerging promising strategies prevention The mechanistic role probiotic partially depend on estrogen metabolism, systematic immune regulation, epigenetics regulation.

Language: Английский

Citations

35
Microbiome Assisted Tumor Microenvironment: Emerging Target of Breast Cancer DOI
Rama Rao Malla,

Rakshmitha Marni,

Seema Kumari

et al.

Clinical Breast Cancer, Journal Year: 2021, Volume and Issue: 22(3), P. 200 - 211

Published: Sept. 12, 2021

Language: Английский

Citations

38
A straightforward access to trifluoromethylated natural products through late-stage functionalization DOI
Heping Li, Xiang‐Hong He, Cheng Peng

et al.

Natural Product Reports, Journal Year: 2022, Volume and Issue: 40(5), P. 988 - 1021

Published: Oct. 7, 2022

This review summarizes the applications of late-stage strategies in direct trifluoromethylation natural products past ten years, with particular emphasis on reaction model each method.

Language: Английский

Citations

28
The Chemo-Gut Pilot Study: Associations between Gut Microbiota, Gastrointestinal Symptoms, and Psychosocial Health Outcomes in a Cross-Sectional Sample of Young Adult Cancer Survivors DOI Creative Commons
Julie Deleemans, Faye Chleilat, Raylene A. Reimer

et al.

Current Oncology, Journal Year: 2022, Volume and Issue: 29(5), P. 2973 - 2994

Published: April 21, 2022

Chemotherapy adversely affects the gut microbiota, inducing dysbiosis, and negatively impacts gastrointestinal (GI) psychosocial health during treatment, but little is known about long-term effects or how these factors are related. Methods: This cross-sectional pilot study investigated of chemotherapy on GI symptoms, outcomes in cancer survivors aged 18–39 years old, compared to healthy controls. Gut microbial diversity composition were assessed from stool samples using 16S rRNA gene sequencing. Results: Survivors (n = 17) controls 18) participated. Mean age at diagnosis was 31 (±5.3). time off treatment 16.9 months (±16.4). had more severe poorer health, increased relative abundance Selenomondales, Veilloneliaceae, Intestinibacter. In survivors, Lachnospiraceae, Ruminococcaceae Intestinibacter correlated with while diarrhea positively Lachnospiraceae. Results statistically significant. ≤6 post-treatment lower alpha than >6 (p 0.04) 0.19). Conclusion: small exploratory demonstrates potential dysbiosis which may be associated symptoms. Larger trials concurrently longitudinally examining needed.

Language: Английский

Citations

23
Stachydrine represses the proliferation and enhances cell cycle arrest and apoptosis of breast cancer cells via PLA2G2A/DCN axis DOI
Zhen Zhai,

Tianlong Mu,

Lina Zhao

et al.

Chemical Biology & Drug Design, Journal Year: 2024, Volume and Issue: 103(1)

Published: Jan. 1, 2024

Abstract Considering the therapeutic efficacy of Stachydrine on breast cancer (BC), this study aims to decipher relevant mechanism. The effects BC cell viability, proliferation and apoptosis were firstly investigated. Then, Bioinformatics was applied sort out candidate interacting with as well its expression downstream target in BC. Relative expressions genes interest proliferation‐ apoptosis‐related factors cells quantified through quantitative reverse‐transcription PCR western blot appropriate. As a result, inhibited proliferation, down‐regulated proliferating nuclear antigen CyclinD1, enhanced cycle arrest apoptosis, up‐regulated levels Cleaved caspase‐3 caspase‐9 cells. Phospholipase A2 Group IIA (PLA2G2A) predicted be lowly expressed PLA2G2A silencing reversed while overexpression reinforced Stachydrine. Decorin (DCN) also counteracted yet overexpressed strengthened promoting DCN level. Collectively, inhibits growth promote via PLA2G2A/DCN axis.

Language: Английский

Citations

6
Control of Redox Homeostasis by Short-Chain Fatty Acids: Implications for the Prevention and Treatment of Breast Cancer DOI Creative Commons
Carmen González‐Bosch, Patricia A. Zunszain, Giovanni E. Mann

et al.

Pathogens, Journal Year: 2023, Volume and Issue: 12(3), P. 486 - 486

Published: March 19, 2023

Breast cancer is the leading cause of death among women worldwide, and certain subtypes are highly aggressive drug resistant. As oxidative stress linked to onset progression cancer, new alternative therapies, based on plant-derived compounds that activate signaling pathways involved in maintenance cellular redox homeostasis, have received increasing interest. Among bioactive dietary considered for prevention treatment flavonoids, such as quercetin, carotenoids, lycopene, polyphenols, resveratrol stilbenes, isothiocyanates, sulforaphane. In healthy cells, these phytochemicals exhibit antioxidant, anti-apoptotic anti-inflammatory properties through intracellular epigenetic regulation. Short-chain fatty acids (SCFAs), produced by intestinal microbiota obtained from diet, also anti-proliferative related their activity-and thus key cell homeostasis. There evidence supporting an antioxidant role SCFAs, mainly butyrate, modulators Nrf2-Keap1 involving inhibition histone deacetylases (HDACs) and/or Nrf2 nuclear translocation. Incorporation SCFAs nutritional pharmacological interventions changes composition microbiota, which has been shown be relevant treatment. this review, we focused impact development treatment, with special emphasis breast cancer.

Language: Английский

Citations

12
The immunoregulatory role of gut microbiota in the incidence, progression, and therapy of breast cancer DOI Creative Commons

Kaiyang Xue,

Jiawei Li, Ruijie Huang

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: July 5, 2024

Breast cancer (BrCa) is the most prevalent malignant tumor in women and one of leading causes female mortality. Its occurrence progression are influenced by various factors, including genetics, environment, lifestyle, hormones. In recent years, gut microbiota has been identified as a significant factor affecting BrCa. The refers to collective population microorganisms human gastrointestinal tract. Gut closely associated with health disease development, participating crucial physiological functions such digestion, metabolism, immune response, neural regulation. It found influence treatment BrCa through variety mechanisms. This article aims review immunomodulatory role development

Language: Английский

Citations

4
Effect of Chemotherapy on the Gut Microbiome of Breast Cancer Patients During the First Year of Treatment DOI Creative Commons
Anna H. Wu, Cheryl Vigen, Chiu-Chen Tseng

et al.

Breast Cancer Targets and Therapy, Journal Year: 2022, Volume and Issue: Volume 14, P. 433 - 451

Published: Dec. 1, 2022

Introduction: There is accumulating information of the effects chemotherapy and weight changes on gut microbiome breast cancer patients. Methods: In this 1-year follow-up study, we investigated 33 patients who donated fecal samples at baseline after completion treatment. We compared alpha diversity mean taxa abundance absolute (final-baseline) by treatment (16 neoadjuvant [neoADJ], 13 adjuvant [ADJ], 4 no [noC]) specific agent using Wilcoxon rank sum negative binomial mixed model (NBMM) analysis. Results: All four measures changed in association with treatment; they increased neoADJ (+16.4% OTU p = 0.03; +51.6% Chao1 +7.0% Shannon index 0.02; +11.0% PD whole tree 0.09) but not ADJ noC group (ADJ+noC). The difference change between groups was statistically significant (p vs. ADJ+noC =0.04). values 0.03– 0.003 were observed for five taxa. NBMM analysis, differed (Bonferroni-adjusted ≤ 0.0007) two Bacteroidetes ( g_Alistipes , f _S24-7 ) Firmicutes (g_Catenibacterium, g_Eubacterium ). analysis results remained unchanged adjustment changes. Alpha also found receipt agents. Consistent increases among those treated TCHP (OTU 0.009; 0.05) AC, Taxol or Herceptin. Those Herceptin showed Verrucomicrobia (g_Akkermansia) decreases Bacteroidetes(g _ Alistipes ); differences significant. Conclusion: Results from pilot longitudinal study support an effect chemotherapy, particularly even Further investigations are needed to confirm these findings larger studies longer assess impact patient outcome. Keywords: neoadjuvant, microbiome, diversity,

Language: Английский

Citations

17
Interactions between the tumor microbiota and breast cancer DOI Creative Commons
Hua Guo

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 14

Published: Jan. 24, 2025

Breast cancer is the most common malignancy in women worldwide. Changes microbiota and their metabolites affect occurrence development of breast cancer; however, specific mechanisms are not clear. Gut microbes influence by regulating tumor immune response, estrogen metabolism, chemotherapy, immunotherapy effects. It was previously thought that there were no microorganisms tissue, but it now can outcome disease. This review builds on existing research to comprehensively analyze role gut intratumoral metastasis cancer. We also explore potential function as biomarkers for prognosis therapeutic highlighting need further clarify causal relationship between hope provide new ideas directions methods treatment.

Language: Английский

Citations

0
Microbiome-mediated immune modulation in tumor microenvironment DOI
John O. Richards,

Eleanor L. Davis,

L. Shakila

et al.

International review of cell and molecular biology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0