Gut microbiome predicts cognitive function and depressive symptoms in late life

Molecular Psychiatry, Journal Year: 2024, Volume and Issue: 29(10), P. 3064 - 3075

Published: April 25, 2024

Depression in older adults with cognitive impairment increases progression to dementia. Microbiota is associated current mood and cognition, but the extent which it predicts future symptoms unknown. In this work, we identified microbial features that reflect predict depressive symptoms. Clinical assessments stool samples were collected from 268 participants varying Seventy underwent 2-year follow-up. Microbial community diversity, structure, composition assessed using high-resolution 16 S rRNA marker gene sequencing. We implemented linear regression characterize relationship between microbiome composition, impairment, leveraged elastic net discover or function Greater diversity lower cognition whole sample, greater depression not on antidepressants. Poor relative abundance of Bifidobacterium, while GABA degradation severity. Future decline function, Intestinibacter, glutamate degradation, higher baseline histamine synthesis. increase anxiety, diabetes, Bacteroidota, degradation. Our results suggest dysfunction are unique states an overall biological effect detectable through gut microbiota. The may present a noninvasive readout prognostic tool for psychiatric states.

Language: Английский

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Exploring the Involvement of Gut Microbiota in Cancer Therapy-Induced Cardiotoxicity

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(8), P. 7261 - 7261

Published: April 14, 2023

Trillions of microbes in the human intestinal tract, including bacteria, viruses, fungi, and protozoa, are collectively referred to as gut microbiome. Recent technological developments have led a significant increase our understanding It has been discovered that microbiome affects both health progression diseases, cancer heart disease. Several studies indicated microbiota may serve potential target therapy modulation, by enhancing effectiveness chemotherapy and/or immunotherapy. Moreover, altered composition linked long-term effects therapy; for example, deleterious on microbial diversity can, turn, lead acute dysbiosis serious gastrointestinal toxicity. Specifically, relationship between cardiac diseases patients following is poorly understood. In this article, we provide summary role treatment, while also speculating connection treatment-related changes cardiotoxicity. Through brief review literature, further explore which bacterial families or genera were differentially affected treatment A deeper link cardiotoxicity caused help lower risk critical potentially fatal side effect.

Language: Английский

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Chemotherapy-induced gut microbiome disruption, inflammation, and cognitive decline in female patients with breast cancer

Brain Behavior and Immunity, Journal Year: 2024, Volume and Issue: 120, P. 208 - 220

Published: May 31, 2024

Language: Английский

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Impacts of breast cancer and chemotherapy on gut microbiome, cognitive functioning, and mood relative to healthy controls

Scientific Reports, Journal Year: 2022, Volume and Issue: 12(1)

Published: Nov. 15, 2022

Abstract Women diagnosed with breast cancer undergoing chemotherapy experience cognitive impairment, symptoms of anxiety and depression, physical side effects including disruption in the diversity community composition gut microbiome. To date, there is limited research exploring associations among these specific challenges. The present cross-sectional study explored self-reported functioning, symptoms, microbiome women who were treatment for (BC) compared to cancer-free healthy controls (HC). BC group displayed higher rates dysfunction ( p < 0.001) depressive 0.05) relative HC. There was a significant difference between HC, particularly characterized by decreased abundance mucin-degrading genus Akkermansia HC 0.05). Association models identified group, cognitive, variables 0.001). Overall, that participants experienced differences depression composition, bacteria gut-mucosal barrier, consistent hypothesis impacts woman’s suggesting microbiome-based interventions have potential improving quality life outcomes individuals cancer.

Language: Английский

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Operationalizing Team Science at the Academic Cancer Center Network to Unveil the Structure and Function of the Gut Microbiome

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(6), P. 2040 - 2040

Published: March 17, 2025

Oncologists increasingly recognize the microbiome as an important facilitator of health well a contributor to disease, including, specifically, cancer. Our knowledge etiologies, mechanisms, and modulation states that ameliorate or promote cancer continues evolve. The progressive refinement adoption “omic” technologies (genomics, transcriptomics, proteomics, metabolomics) utilization advanced computational methods accelerate this evolution. academic center network, with its immediate access extensive, multidisciplinary expertise scientific resources, has potential catalyze research. Here, we review our current understanding role gut in prevention, predisposition, response therapy. We underscore promise operationalizing network uncover structure function microbiome; highlight unique microbiome-related expert resources available at City Hope Comprehensive Cancer Center example team science achieve novel clinical discovery.

Language: Английский

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The mutual effect of dietary fiber and polyphenol on gut microbiota: Implications for the metabolic and microbial modulation and associated health benefits

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: 358, P. 123541 - 123541

Published: March 30, 2025

Language: Английский

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The Impact of Health‐Promoting Lifestyle Behaviors on Gut Microbiota in Survivors of Hematological Cancer: A Scoping Review

Cancer Reports, Journal Year: 2025, Volume and Issue: 8(5)

Published: May 1, 2025

ABSTRACT Purpose This scoping review aims to explore the relationship between health‐promoting lifestyle behaviors and gut microbiota in survivors of hematological cancers, including leukemia, lymphoma, multiple myeloma. Given rising incidence these malignancies associated treatment challenges, understanding how factors influence health may provide insights into improving survivorship outcomes. Methods We conducted a comprehensive search across databases, PubMed/Medline, CINAHL, Scopus, following Preferred Reporting Items for Systematic Reviews Meta‐Analysis extension Scoping (PRISMA‐ScR). The strategy incorporated MeSH terms related behaviors, microbiota. Inclusion criteria focused on primary research studies published English that reported results cancers. A total 1717 papers were initially identified, with 16 meeting inclusion after screening relevance. Results identified significant association such as physical activity, nutrition, stress management, composition diversity cancer survivors. findings suggest engaging enhance health, potentially mitigating treatment‐related symptoms overall quality life. Notably, highlighted importance tailored interventions consider individual patient needs preferences. Conclusions underscores critical role influencing among Future should focus longitudinal establish causal relationships mechanisms underlying associations. By promoting healthy choices, healthcare providers can care improve outcomes this population.

Language: Английский

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Exercise and Prebiotic Fiber Provide Gut Microbiota-Driven Benefit in a Survivor to Germ-Free Mouse Translational Model of Breast Cancer

Cancers, Journal Year: 2022, Volume and Issue: 14(11), P. 2722 - 2722

Published: May 31, 2022

The gut microbiota plays a role in shaping overall host health and response to several cancer treatments. Factors, such as diet, exercise, chemotherapy, can alter the microbiota. In present study, Alberta Cancer Exercise (ACE) program was investigated strategy favorably modify of breast survivors who had received chemotherapy. Subsequently, ability post-exercise microbiota, alone or with prebiotic fiber supplementation, influence outcomes interrogated using fecal transplant (FMT) germ-free mice. While experienced little microbial change following ACE, mice, tumor volume trended consistently lower over time mice colonized compared pre-exercise significant differences on days 16 22. Beta diversity analysis revealed that EO771 cell injection Paclitaxel chemotherapy altered communities Enrichment potentially protective microbes found groups. Tumors exhibited more favorable cytokine profiles, including decreased vascular endothelial growth factor (VEGF) levels. Beneficial molecular were augmented supplementation. demonstrated adjuvant action, via an enhanced anti-tumor immune modulated by advantageous shifts.

Language: Английский

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The Association between the Gut Microbiome and Development and Progression of Cancer Treatment Adverse Effects

Cancers, Journal Year: 2023, Volume and Issue: 15(17), P. 4301 - 4301

Published: Aug. 28, 2023

Adverse effects are a common consequence of cytotoxic cancer treatments. Over the last two decades there have been significant advances in exploring relationship between gut microbiome and these adverse effects. Changes were shown multiple clinical studies to be associated with development acute gastrointestinal effects, including diarrhoea mucositis. However, more recent showed that changes may also long-term psychoneurological changes, cachexia, fatigue. Therefore, aim this review was examine literature identify potential contributions associations wide range from

Language: Английский

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Blockade of CCR5 suppresses paclitaxel-induced peripheral neuropathic pain caused by increased deoxycholic acid

Cell Reports, Journal Year: 2023, Volume and Issue: 42(11), P. 113386 - 113386

Published: Nov. 1, 2023

Paclitaxel leads to peripheral neuropathy (paclitaxel-induced [PIPN]) in approximately 50% of cancer patients. At present, there are no effective treatment strategies for PIPN, the mechanisms which also remain unclear. In this study, we performed microbiome and metabolome analysis feces serum from breast patients with different PIPN grades due paclitaxel treatment. Our reveals that levels deoxycholic acid (DCA) highly increased because ingrowth Clostridium species, is associated severe neuropathy. DCA, turn, elevates level C-C motif ligand 5 (CCL5) induces CCL5 receptor (CCR5) overexpression dorsal root ganglion (DRG) through bile Takeda G-protein-coupled (TGR5), contributing neuronal hyperexcitability. Consistent this, administration CCR5 antagonist maraviroc suppresses development neuropathic nociception. These results implicate gut microbiota/bile acids/CCR5 signaling induction thus suggesting a target

Language: Английский

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