Insects,
Journal Year:
2022,
Volume and Issue:
13(10), P. 918 - 918
Published: Oct. 9, 2022
The
oriental
fruit
fly
Bactrocera
dorsalis
(Hendel)
is
a
destructive
polyphagous
species
that
targets
many
economically
important
fruits
and
vegetables.
primary
control
of
B.
relies
mainly
on
the
use
synthetic
chemicals,
excessive
these
chemicals
has
adverse
effects
both
environment
human
health.
Environmentally
friendly
management
pests
involving
plant
essential
oils
useful
for
controlling
populations
responsible
decreasing
yields
quality
crops.
In
present
study,
we
demonstrate
clove
bud
oil
(CBEO)
strongly
attractive
to
sexually
mature
males.
Mature
males
responded
CBEO
differently
throughout
day;
strongest
response
was
elicited
during
day
decreased
at
dusk.
Virgin
mated
did
not
respond
CBEO.
No
obvious
behaviour
observed
in
two
beneficial
natural
predator
ladybirds.
addition,
cytotoxicity
assessment
demonstrated
nontoxic
normal
mouse
cells.
Based
our
laboratory
experiments,
may
serve
as
promising,
sustainable,
environmentally
attractant
males;
however,
field
experiments
are
needed
confirm
this
hypothesis.
International Journal of Molecular Sciences,
Journal Year:
2021,
Volume and Issue:
22(7), P. 3671 - 3671
Published: April 1, 2021
Eugenol
is
a
phenolic
aromatic
compound
obtained
mainly
from
clove
oil.
Due
to
its
known
antibacterial,
antiviral,
antifungal,
anticancer,
anti-inflammatory
and
antioxidant
properties,
it
has
long
been
used
in
various
areas,
such
as
cosmetology,
medicine,
pharmacology.
However,
high
concentrations
can
be
toxic.
A
dose
of
2.5
mg/kg
body
weight
regarded
safe.
This
paper
reviews
the
current
state
knowledge
regarding
activities
application
eugenol
derivatives
recent
research
these
compounds.
review
based
on
information
concerning
characteristics
articles
PubMed.
remains
great
interest
researchers,
since
multidirectional
action
allows
potential
component
drugs
other
products
with
therapeutic
against
range
diseases.
Journal of Umm Al-Qura University for Applied Sciences,
Journal Year:
2024,
Volume and Issue:
10(3), P. 555 - 566
Published: Feb. 19, 2024
Abstract
Due
to
chronic
inflammation,
elevated
cyclooxygenase
(COX-2)
level
leads
tumorigenesis,
proliferation,
invasion,
angiogenesis
and
metastasis.
Therefore,
suppression
of
COX-2
enzyme
is
a
fascinating
approach
in
cancer
treatment.
In
the
present
study,
natural
product
eugenol
was
modified
develop
new
1,2,4-triazole
derivatives
as
antiCOX-2
antiproliferative
agents.
The
structures
newly
prepared
were
established
using
sophisticated
analytical
techniques.
result
showed
compound
10
be
equipotent
doxorubicin
towards
MDA-MB
231
PC-3
cells
with
IC
50
1.42
5.69
μM,
respectively
potent
inhibitor
0.28
μM.
Compound
also
non
carcinogenic,
mutagenic
good
drug
likeness
property
depicted
by
silico
physicochemical
pharmacokinetic
studies.
docking
results
against
protein
highest
binding
energy
for
which
found
consistent
cytoxicity
results.
conclusion,
could
harness
cell
proliferation
promising
candidate
therapy.
RSC Advances,
Journal Year:
2021,
Volume and Issue:
11(54), P. 34024 - 34035
Published: Jan. 1, 2021
Thymol
and
carvacrol
derivatives
were
synthesised.
Two
of
them
proved
to
be
mildly
active
against
Sf9
insect
cell
line
one
has
presented
selectivity
by
proving
less
toxic
human
cells
than
the
naturally
derived
starting
materials.
Biomolecules,
Journal Year:
2021,
Volume and Issue:
11(9), P. 1325 - 1325
Published: Sept. 7, 2021
Phenols
are
widespread
in
nature,
being
the
major
components
of
several
plants
and
essential
oils.
Natural
phenols’
anti-microbial,
anti-bacterial,
anti-oxidant,
pharmacological
nutritional
properties
are,
nowadays,
well
established.
Hence,
given
their
peculiar
biological
role,
numerous
studies
currently
ongoing
to
overcome
limitations,
as
enhance
activity.
In
this
review,
functionalization
selected
natural
phenols
is
critically
examined,
mainly
highlighting
improved
bioactivity
after
proper
chemical
transformations.
particular,
most
abundant
naturally
occurring
monophenols,
diphenols,
lipidic
phenols,
phenolic
acids,
polyphenols
curcumin
derivatives
explored.
Chemistry & Biodiversity,
Journal Year:
2021,
Volume and Issue:
18(9)
Published: Aug. 4, 2021
Endeavor
to
discover
biorational
natural
products-based
fungicides,
two
series
(26)
of
novel
1-sulfonyloxy/acyloxydihydroeugenol
derivatives
(3a-p
and
5a-j)
were
prepared
assessed
for
their
fungicidal
activity
against
P.
capsici
Leonian,
in
vitro.
Results
revealed
that,
among
all
compounds,
especially
compounds
3a,
5c,
5e
displayed
the
most
potent
anti-oomycete
with
EC50
values
69.33,
68.81,
67.77
mg/L,
respectively.
Overall,
activities
1-acyloxydihydroeugenol
(5a-j)
higher
than
that
1-sulfonyloxydihydroeugenol
(3a-p).
It
is
proved
introduction
acyl
group
at
hydroxy
position
dihydroeugenol
more
beneficial
improve
its
sulfonyl
group.
These
preliminary
results
will
pave
way
further
modification
development
potential
new
fungicides.
Arabian Journal of Chemistry,
Journal Year:
2022,
Volume and Issue:
15(11), P. 104189 - 104189
Published: Aug. 13, 2022
The
quality
of
grains
is
influenced
by
storage
pests,
which
are
not
only
spoilers
stored
grain,
but
also
vectors
human
and
animal
diseases.
Chemical
pesticides
play
an
essential
role
in
the
cultivation
cereals,
however,
due
to
low
degradability
residual
toxicity
synthetic
on
environment
non-target
organisms,
as
well
increasing
resistance
target
organisms
them,
consideration
should
be
given
development
alternative
pest
control
agents.
Compounds
isolated
from
natural
sources
have
emerged
preferred
targets
for
novel
insecticidal
agents
because
their
eco-friendliness,
safety,
effectiveness.
In
this
review,
we
primarily
focus
product
(NPs)
pests.
effective
monomer
components
NPs
anti-insect
mechanisms
were
discussed,
inspiration
models
insect
repellents
described.
This
review
aimed
provide
guidelines
exploitation
utilization
green
efficient
insecticides.
Agronomy,
Journal Year:
2025,
Volume and Issue:
15(3), P. 509 - 509
Published: Feb. 20, 2025
Bioinsecticides
based
on
essential
oils
(EOs)
are
promising
alternatives
for
agricultural
insect
control.
In
this
study,
the
main
compounds
of
Baccharis
macraei
EOs
from
two
geographical
areas
were
identified
using
gas
chromatography–mass
spectrometry
(GC-MS).
The
insecticidal
potential
against
Drosophila
melanogaster,
Tenebrio
molitor,
and
Galleria
mellonella
was
evaluated,
along
with
acetylcholinesterase
(AChE)
inhibition
molecular
docking
analysis.
GC-MS
analysis
revealed
oxygenated
sesquiterpenes,
such
as
spathulenol,
caryophyllene
oxide,
α-cadinol.
EO
Site
1
(S1)
exhibited
activity
lethal
dose
50
(LD50)
values
46.50,
465.76,
241.2
µg/mL
D.
T.
G.
mellonella,
respectively.
2
(S2)
showed
LD50
74.81,
385.62,
195.2
same
pests.
AChE
yielded
inhibitory
concentration
(IC50)
12.8
±
0.13
S1
11.7
0.07
S2.
Molecular
a
strong
binding
energy
between
α-cadinol
AChE.
These
results
highlight
that
B.
effective
serve
natural
alternative
to
traditional
insecticides.
