Medicinal Research Reviews,
Journal Year:
2023,
Volume and Issue:
44(1), P. 235 - 274
Published: July 24, 2023
Aging,
a
fundamental
physiological
process
influenced
by
innumerable
biological
and
genetic
pathways,
is
an
important
driving
factor
for
several
aging-associated
disorders
like
diabetes
mellitus,
osteoporosis,
cancer,
neurodegenerative
diseases
including
Alzheimer's
Parkinson's
diseases.
In
the
modern
era,
mechanisms
associated
with
aging
have
been
deeply
studied.
Treatment
therapeutics
age-related
also
made
considerable
advances;
however,
effective
long-lasting
treatment,
nutritional
therapy
particularly
dietary
polyphenols
from
natural
origin
are
endorsed.
These
(e.g.,
apigenin,
baicalin,
curcumin,
epigallocatechin
gallate,
kaempferol,
quercetin,
resveratrol,
theaflavin),
many
other
phytochemicals
target
certain
molecular,
mechanisms.
The
most
common
pathways
of
age-associated
mitogen-activated
protein
kinase,
reactive
oxygen
species
production,
nuclear
kappa
light
chain
enhancer
activated
B
cells
signaling
metal
chelation,
c-Jun
N-terminal
inflammation.
Polyphenols
slow
down
course
help
in
combatting
age-linked
disorders.
This
exemplified
form
clinical
trials
on
specific
various
With
this
context
mind,
review
reveals
new
insights
to
process,
consequently
reduce
some
classic
age
such
as
aforementioned,
targeting
activities
origin.
Nutrients,
Journal Year:
2022,
Volume and Issue:
14(5), P. 1107 - 1107
Published: March 6, 2022
Major
depressive
disorder
(MDD)
is
an
incapacitating
condition
characterized
by
loss
of
interest,
anhedonia
and
low
mood,
which
affects
almost
4%
people
worldwide.
With
rising
prevalence,
it
considered
a
public
health
issue
that
economic
productivity
heavily
increases
costs
alone
or
as
comorbidity
for
other
pandemic
non-communicable
diseases
(such
obesity,
cardiovascular
disease,
diabetes,
inflammatory
bowel
diseases,
etc.).
What
even
more
noteworthy
the
double
number
women
suffering
from
MDD
compared
to
men.
In
fact,
this
sex-related
ratio
has
been
contemplated
since
men
have
different
sexual
hormone
oscillations,
where
meet
significant
changes
depending
on
age
range
moment
life
(menstruation,
premenstruation,
pregnancy,
postpartum,
menopause…),
seem
be
associated
with
susceptibility
symptoms.
For
instance,
decreased
estrogen
level
promotes
activation
serotonin
transporters.
Nevertheless,
hormones
are
not
only
triggers
alter
neurotransmission
monoamines
neuropeptides.
Actually,
dietary
habits
and/or
nutritional
requirements
specific
moments
severely
affect
pathophysiology
in
women.
context,
present
review
aims
descriptively
collect
information
regarding
role
malnutrition
onset
course,
focusing
female
patient
especially
macro-
micronutrient
deficiencies
(amino
acids,
ω3
polyunsaturated
fatty
acids
(ω3
PUFAs),
folate,
vitamin
B12,
D,
minerals…),
besides
providing
evidence
future
intervention
programs
sex-gender
perspective
hopefully
improves
mental
quality
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(21), P. 12958 - 12958
Published: Oct. 26, 2022
In
recent
years,
there
has
been
considerable
research
showing
that
coffee
consumption
seems
to
be
beneficial
human
health,
as
it
contains
a
mixture
of
different
bioactive
compounds
such
chlorogenic
acids,
caffeic
acid,
alkaloids,
diterpenes
and
polyphenols.
Neurodegenerative
diseases
(NDs)
are
debilitating,
non-curable
associated
with
impaired
central,
peripheral
muscle
nervous
systems.
Several
studies
demonstrate
neuroinflammation
mediated
by
glial
cells—such
microglia
astrocytes—is
critical
factor
contributing
neurodegeneration
causes
the
dysfunction
brain
homeostasis,
resulting
in
progressive
loss
structure,
function,
number
neuronal
cells.
This
happens
over
time
leads
damage
physical
impairment.
The
most
known
chronic
NDs
represented
Alzheimer’s
disease
(AD),
Parkinson’s
(PD),
multiple
sclerosis
(MS),
amyotrophic
lateral
(ALS)
Huntington’s
(HD).
According
epidemiological
studies,
regular
is
lower
risk
neurodegenerative
diseases.
this
review,
we
summarize
latest
about
potential
effects
caffeine
disorders
prevention
discuss
role
controlled
delivery
systems
maintaining
high
plasma
concentrations
for
an
extended
time.
Foods,
Journal Year:
2023,
Volume and Issue:
12(14), P. 2721 - 2721
Published: July 17, 2023
Caffeine
is
a
metabolite
derived
from
purine
nucleotides,
typically
accounting
for
2–5%
of
the
dry
weight
tea
and
1–2%
coffee.
In
coffee
plants,
main
synthesis
pathway
caffeine
four-step
sequence
consisting
three
methylation
reactions
one
nucleosidase
reaction
using
xanthine
as
precursor.
bacteria,
degradation
occurs
mainly
through
pathways
N-demethylation
C-8
oxidation.
However,
study
fully
systematically
summarizing
metabolism
application
in
microorganisms
has
not
been
established
elsewhere.
present
study,
we
provide
review
biosynthesis,
microbial
degradation,
gene
expression,
degradation.
The
aims
to
further
elaborate
mechanism
by
explore
development
prospects
this
field.
Medicinal Research Reviews,
Journal Year:
2023,
Volume and Issue:
44(1), P. 235 - 274
Published: July 24, 2023
Aging,
a
fundamental
physiological
process
influenced
by
innumerable
biological
and
genetic
pathways,
is
an
important
driving
factor
for
several
aging-associated
disorders
like
diabetes
mellitus,
osteoporosis,
cancer,
neurodegenerative
diseases
including
Alzheimer's
Parkinson's
diseases.
In
the
modern
era,
mechanisms
associated
with
aging
have
been
deeply
studied.
Treatment
therapeutics
age-related
also
made
considerable
advances;
however,
effective
long-lasting
treatment,
nutritional
therapy
particularly
dietary
polyphenols
from
natural
origin
are
endorsed.
These
(e.g.,
apigenin,
baicalin,
curcumin,
epigallocatechin
gallate,
kaempferol,
quercetin,
resveratrol,
theaflavin),
many
other
phytochemicals
target
certain
molecular,
mechanisms.
The
most
common
pathways
of
age-associated
mitogen-activated
protein
kinase,
reactive
oxygen
species
production,
nuclear
kappa
light
chain
enhancer
activated
B
cells
signaling
metal
chelation,
c-Jun
N-terminal
inflammation.
Polyphenols
slow
down
course
help
in
combatting
age-linked
disorders.
This
exemplified
form
clinical
trials
on
specific
various
With
this
context
mind,
review
reveals
new
insights
to
process,
consequently
reduce
some
classic
age
such
as
aforementioned,
targeting
activities
origin.
