Age-related bone diseases: Role of inflammaging

Journal of Autoimmunity, Journal Year: 2024, Volume and Issue: 143, P. 103169 - 103169

Published: Feb. 1, 2024

Language: Английский

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Targeting natural antioxidant polyphenols to protect neuroinflammation and neurodegenerative diseases: a comprehensive review

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 24, 2025

Polyphenols, naturally occurring phytonutrients found in plant-based foods, have attracted significant attention for their potential therapeutic effects neurological diseases and neuroinflammation. These compounds possess diverse neuroprotective capabilities, including antioxidant, anti-inflammatory, anti-amyloid properties, which contribute to mitigating the progression of neurodegenerative conditions such as Alzheimer's Disease (AD), Parkinson's (PD), Dementia, Multiple Sclerosis (MS), Stroke, Huntington's (HD). Polyphenols been extensively studied ability regulate inflammatory responses by modulating activity pro-inflammatory genes influencing signal transduction pathways, thereby reducing neuroinflammation neuronal death. Additionally, polyphenols shown promise various cellular signaling pathways associated with viability, synaptic plasticity, cognitive function. Epidemiological clinical studies highlight polyphenol-rich diets decrease risk alleviate symptoms disorders Furthermore, demonstrated through regulation key Akt, Nrf2, STAT, MAPK, play critical roles neuroprotection body's immune response. This review emphasizes growing body evidence supporting combating neurodegeneration neuroinflammation, well enhancing brain health. Despite substantial promising hypotheses, further research investigations are necessary fully understand role establish them advanced targets age-related neuroinflammatory conditions.

Language: Английский

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Antioxidant, Anti-Inflammatory, Anti-Diabetic, and Pro-Osteogenic Activities of Polyphenols for the Treatment of Two Different Chronic Diseases: Type 2 Diabetes Mellitus and Osteoporosis

Biomolecules, Journal Year: 2024, Volume and Issue: 14(7), P. 836 - 836

Published: July 11, 2024

Polyphenols are natural bioactives occurring in medicinal and aromatic plants food beverages of plant origin. Compared with conventional therapies, plant-derived phytochemicals more affordable accessible have no toxic side effects. Thus, pharmaceutical research is increasingly inclined to discover study new innovative molecules for the treatment several chronic human diseases, like type 2 diabetes mellitus (T2DM) osteoporosis. These pathological conditions characterized by a inflammatory state persistent oxidative stress, which interconnected lead development worsening these two health disorders. Oral nano delivery strategies been used improve bioavailability polyphenols allow exert their antioxidant, anti-inflammatory, anti-diabetic, pro-osteogenic biological activities vivo experimental models patients. commonly formulations nutraceuticals, can counteract detrimental effects T2DM osteoporosis pathologies. This review describes that protective against through modulation specific molecular markers pathways. could be as adjuvants, combination synthetic drugs, future develop therapeutic

Language: Английский

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Quercetin in the Prevention of Induced Periodontal Disease in Animal Models: A Systematic Review and Meta-Analysis

Nutrients, Journal Year: 2024, Volume and Issue: 16(5), P. 735 - 735

Published: March 4, 2024

Background: Periodontitis is an inflammatory condition initiated by oral bacteria and associated with several systemic diseases. Quercetin anti-inflammatory anti-bacterial poly-phenol present in various foods. The aim of this meta-analysis was the evaluation effects quercetin administration animal models experimental periodontitis. Methods: A systematic search performed electronic databases using following terms: “periodontitis” or “periodontal disease” “gingivitis” “quercetin” “cyanidanol” “sophoretin” “pentahydroxyflavone”. In vivo preclinical periodontal disease a measurement alveolar bone loss were included analysis. risk bias studies assessed SYRCLE tool. Results: yielded 335 results. Five included, four them qualified for meta-analysis. showed that decreased (τ2 = 0.31, 1.88 mm 95%CI: 1.09, 2.67) models. However, assessment indicated domains had high bias. Conclusions: diminishes prevents progression disease. might facilitate tissue hemostasis reducing senescent cells, decreasing oxidative stress via SIRT1-induced autophagy, limiting inflammation, fostering bacterial microenvironment symbiotic microbiota health. Future research will show whether how promising results can be translated into clinical treatment

Language: Английский

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Apigenin-mediated MARK4 inhibition: a novel approach in advancing Alzheimer’s disease therapeutics

Molecular Diversity, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Language: Английский

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Nutrition: A non‐negligible factor in the pathogenesis and treatment of Alzheimer's disease

Alzheimer s & Dementia, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

Abstract Alzheimer's disease (AD) is a degenerative characterized by progressive cognitive dysfunction. The strong link between nutrition and the occurrence progression of AD pathology has been well documented. Poor nutritional status accelerates progress potentially aggravating amyloid beta (Aβ) tau deposition, exacerbating oxidative stress response, modulating microbiota–gut–brain axis, disrupting blood–brain barrier function. advanced stage tends to lead malnutrition due impairments, sensory dysfunctions, brain atrophy, behavioral psychological symptoms dementia (BPSD). This, in turn, produces vicious cycle AD. This review discusses how factors deteriorate each other from early terminal stages AD, focusing on potential different levels factors, ranging micronutrients diet patterns. provides novel insights into reducing risk delaying its progression, improving prognosis. Highlights Two‐fifths cases worldwide have attributed modifiable factors. Up ≈26% community‐dwelling patients with are malnourished, compared 7%∼76% institutionalized patients. Undernutrition effects onset, prognosis through multiple mechanisms. Various supports were confirmed be protective for via specific

Language: Английский

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Antineoplastics for treating Alzheimer's disease and dementia: Evidence from preclinical and observational studies

Medicinal Research Reviews, Journal Year: 2024, Volume and Issue: 44(5), P. 2078 - 2111

Published: March 26, 2024

Abstract As the world population ages, there will be an increasing need for effective therapies aging‐associated neurodegenerative disorders, which remain untreatable. Dementia due to Alzheimer's disease (AD) is one of leading neurological diseases in aging population. Current therapeutic approaches treat this disorder are solely symptomatic, making new molecular entities acting on causes extremely urgent. One potential solutions use compounds that already market. The structures have known pharmacokinetics, pharmacodynamics, toxicity profiles, and patient data available several countries. Several drugs been used successfully different from their original purposes, such as autoimmunity peripheral inflammation. Herein, we divulge repurposing area diseases, focusing antineoplastics dementia AD dementia. We briefly touch upon shared pathological mechanism between cancer drug strategies, with a focus artificial intelligence. Next, bring out current status research development drugs, provide supporting evidence retrospective, clinical, preclinical studies antineoplastic use, areas, prion‐like spreading pathologies treating AD.

Language: Английский

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Dopamine synthesis and transport: current and novel therapeutics for parkinsonisms

Biochemical Society Transactions, Journal Year: 2024, Volume and Issue: 52(3), P. 1275 - 1291

Published: May 30, 2024

Parkinsonism is the primary type of movement disorder in adults, encompassing a set clinical symptoms, including rigidity, tremors, dystonia, bradykinesia, and postural instability. These symptoms are primarily caused by deficiency dopamine (DA), an essential neurotransmitter brain. Currently, DA precursor levodopa (synthetic L-DOPA) standard medication to treat deficiency, but it only addresses rather than provides cure. In this review, we provide overview disorders associated with dysregulation particularly Parkinson's disease rare inherited leading predominantly dystonia and/or parkinsonism, even childhood. Although relatively effective for management motor dysfunctions, less severe forms parkinsonism also side effects loss efficacy over time. We present ongoing efforts reinforce effect develop innovative therapies that target underlying pathogenic mechanisms affecting synthesis transport, increasing neurotransmission through disease-modifying approaches, such as cell-based therapies, nucleic acid- protein-based biologics, small molecules.

Language: Английский

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The role of polyphenols in modulating mitophagy: Implications for therapeutic interventions

Pharmacological Research, Journal Year: 2024, Volume and Issue: 207, P. 107324 - 107324

Published: July 24, 2024

This review rigorously assesses the burgeoning research into role of polyphenols in modulating mitophagy, an essential cellular mechanism for targeted removal impaired mitochondria. These natural compounds, known their low toxicity, are underscored potential therapeutic strategies against a diverse array diseases, such as neurodegenerative, cardiovascular, and musculoskeletal disorders. The analysis penetrates deeply molecular mechanisms whereby promote particularly by influencing crucial signaling pathways transcriptional regulators, including phosphatase tensin homolog (PTEN) induced putative kinase 1 (PINK1)/parkin forkhead box O3 (FOXO3a) pathways. Noteworthy discoveries include neuroprotective properties resveratrol curcumin, which affect both autophagic mitochondrial dynamics, pioneering integration with other substances to amplify effectiveness. Furthermore, confronts issue polyphenol bioavailability emphasizes imperative clinical trials corroborate viability. By delivering exhaustive synthesis contemporary insights recent advancements mitophagy research, this endeavors catalyze additional foster creation innovative modalities that exploit distinctive attributes manage prevent disease.

Language: Английский

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Date palm: a potential nutraceutical and phytomedicine in most frequent aging associated diseases

Journal of Umm Al-Qura University for Applied Sciences, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 18, 2024

Abstract Senescence, often known as ageing, is a condition of decline that shows itself decrease in fertility and survival at older ages. Ageing theory suggests ageing evolves function life history optimization or because mutation pressure, depending on the degree externally imposed mortality shocks to fertility. An important key factor many aging-related disorders (ARDs), such hypertension, myocardial infarction, atherosclerosis, osteoporosis, cancer, neurodegenerative diseases like Alzheimer’s Parkinson’s disease, process influenced by countless biological genetic pathways. While there have been significant advancements therapeutics for age-related disorders, nutritional therapy, encasing various products from natural sources recommended durable fruitful treatment. Numerous health advantages date palm, Phoenix dactylifera , well-documented. These include antioxidant, anti-inflammatory, cardioprotective, neuroprotective activity. Phytochemical analysis palm demonstrates lot beneficial nutraceuticals can ameliorate ARDs polyphenols, phytosterols, carotenoids, flavonoids, terpenoids, fatty acids, carbohydrates, vitamins, amino acids etc. The major signaling molecular pathways which these phytoconstituents exert their anti-ageing effects terminating inflammation blocking release IL-6, TNF-α clearance Aβ plaques diseases; ACE-II HMG-CoA cardio-protection; regulating RANK, p38MAPK-Runx2 pathways, insulin-growth factor-1 (IGF-1) osteoporosis. However, research benefits still lacking. purpose this review shed light activities explore its remedial mechanisms.

Language: Английский

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