Serum lipids mediate the association of per- and polyfluoroalkyl substances exposure and age-related macular degeneration DOI Creative Commons

Xiaodong Chen,

Jiaqi Li, Ningda Xu

et al.

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(1), P. e0317678 - e0317678

Published: Jan. 31, 2025

This study aims to investigate the connection between serum lipids, per- and polyfluoroalkyl substances (PFAS), age-related macular degeneration (AMD) risk assess whether lipids mediate association PFAS AMD. 1605 participants were enrolled from NHANES 2005-2008. Four levels with high detective rates, including perfluorononanoic acid (PFNA), perfluorooctanoic (PFOA), perfluorooctane sulfonic (PFOS), perfluorohexane (PFHxS) examined. Restricted cubic spline analysis (RCS) weighted quantile sum (WQS) employed detect nonlinear mixed exposure effects. PFOS level was associated any AMD (OR, 1.54; 95% CI, 1.12 2.11; P = 0.011), early 1.43; 1.06 1.95; 0.024), late 3.35; 1.55 7.23; 0.004) risk. PFHxS 1.72; 1.01 2.93; 0.045) PFOA 2.10; 1.21 3.63; 0.011) The RCS showed a (P 0.006). WQS indicated positive relationship 1.34; 1.03 1.75; 0.030). Serum total cholesterol (TC) high-density lipoprotein (HDL) (ORTC, 1.005; 1.001 1.009; 0.026. ORHDL, 1.028; 1.014 1.042; P<0.001), mediated of risk, mediation proportions 5.73% 0.020) 7.27% 0.032), respectively. connected TC HDL this relationship.

Language: Английский

The Antisenescence Effect of Exosomes from Human Adipose-Derived Stem Cells on Skin Fibroblasts DOI Creative Commons
Jian Guo, Pijun Yu, Dong-Qin Yang

et al.

BioMed Research International, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 12

Published: June 29, 2022

Human adipose-derived stem cells (ADSCs) have become a promising therapeutic approach against skin aging. Recent studies confirm that exosomes partially mediate the effect of cells. This study successfully isolated from ADSC culture medium and discovered ADSC-derived (ADSC-Exos) could alleviate human dermal fibroblast (HDF) senescence stimulate HDF migration. Moreover, ADSC-Exos increased type I collagen expression level reduced reactive oxygen species (ROS) senescence-associated β-galactosidase (SA-β-Gal) activity in HDFs. In addition, we demonstrated significantly inhibited senescence-related protein levels p53, p21, p16. conclusion, our results revealed antisenescence effects on HDFs may be novel cell-free tool for antiaging.

Language: Английский

Citations

20
Photobiology of lipofuscin granules in the retinal pigment epithelium cells of the eye: norm, pathology, age DOI
T. B. Feldman, А. Е. Донцов, M. A. Yakovleva

et al.

Biophysical Reviews, Journal Year: 2022, Volume and Issue: 14(4), P. 1051 - 1065

Published: Aug. 1, 2022

Language: Английский

Citations

20
Methods to measure blood flow and vascular reactivity in the retina DOI Creative Commons
Elsa Wilma Böhm, Norbert Pfeiffer, Felix Mathias Wagner

et al.

Frontiers in Medicine, Journal Year: 2023, Volume and Issue: 9

Published: Jan. 12, 2023

Disturbances of retinal perfusion are involved in the onset and maintenance several ocular diseases, including diabetic retinopathy, glaucoma, vascular occlusion. Hence, knowledge on anatomy function is highly relevant for basic research studies clinical judgment treatment. The vasculature composed superficial, intermediate, deep layer. Detection changes blood flow diameter especially smaller vessels essential to understand analyze diseases. Several methods evaluate regulation retina have been described so far, but no gold standard has established. For reliable assessment flow, exact determination vessel necessary. measurement already reported humans. But further analysis laboratory animals, genetically modified mice, important. As small size challenging requiring devices with high optic resolution. In this review, we recapitulate different measurement. Moreover, humans experimental animals described.

Language: Английский

Citations

11
Cord blood platelet-rich plasma: proteomics analysis for ophthalmic applications DOI Creative Commons
Maria Cristina Savastano, Federico Giannuzzi, Alfonso Savastano

et al.

Clinical Proteomics, Journal Year: 2025, Volume and Issue: 22(1)

Published: Jan. 3, 2025

Our objective is to determine the protein and complements constituents of Cord blood Platelet-rich plasma (CB-PRP), based on hypothesis that it contains beneficial components capable arresting or potentially decelerating advancement atrophic age-related macular degeneration (dry-AMD), with support radiomics. Two distinct pools CB-PRP were assessed, each pool obtained from a total 15 umbilical cord-blood donors. One aliquot respectively was subjected proteomic analysis in order enhance significance our findings, by identifying proteins are shared between two sample gaining insights into pathways they associated with. The bioinformatics developed using Reactome software. Three-hundred-seven (307) found. hundred fifteen (215) elements mentioned above both pools. Seventy (70) exclusive S1, while S2 22. We detected 109 representative statistically significant out 549. found related immune system, signal transduction, vesicle-mediated transport, cell–cell communication, hemostasis, cellular responses stimuli, cell cycle, developmental biology. showed presence P15692-12, representing VEGF factor A, long form. With over 200 proteins, can increase response, including BCR, CD-22, FCGR, phospholipids, IL-10, FCGR-3A, others. Discovering crucial trophic complement-regulating variables highly for potential applications dry AMD. future research will examine effects intravitreal dry-AMD eyes.

Language: Английский

Citations

0
Serum lipids mediate the association of per- and polyfluoroalkyl substances exposure and age-related macular degeneration DOI Creative Commons

Xiaodong Chen,

Jiaqi Li, Ningda Xu

et al.

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(1), P. e0317678 - e0317678

Published: Jan. 31, 2025

This study aims to investigate the connection between serum lipids, per- and polyfluoroalkyl substances (PFAS), age-related macular degeneration (AMD) risk assess whether lipids mediate association PFAS AMD. 1605 participants were enrolled from NHANES 2005-2008. Four levels with high detective rates, including perfluorononanoic acid (PFNA), perfluorooctanoic (PFOA), perfluorooctane sulfonic (PFOS), perfluorohexane (PFHxS) examined. Restricted cubic spline analysis (RCS) weighted quantile sum (WQS) employed detect nonlinear mixed exposure effects. PFOS level was associated any AMD (OR, 1.54; 95% CI, 1.12 2.11; P = 0.011), early 1.43; 1.06 1.95; 0.024), late 3.35; 1.55 7.23; 0.004) risk. PFHxS 1.72; 1.01 2.93; 0.045) PFOA 2.10; 1.21 3.63; 0.011) The RCS showed a (P 0.006). WQS indicated positive relationship 1.34; 1.03 1.75; 0.030). Serum total cholesterol (TC) high-density lipoprotein (HDL) (ORTC, 1.005; 1.001 1.009; 0.026. ORHDL, 1.028; 1.014 1.042; P<0.001), mediated of risk, mediation proportions 5.73% 0.020) 7.27% 0.032), respectively. connected TC HDL this relationship.

Language: Английский

Citations

0