Comparison of antibody and T cell responses elicited by BBIBP-CorV (Sinopharm) and BNT162b2 (Pfizer-BioNTech) vaccines against SARS-CoV-2 in healthy adult humans

GeroScience, Journal Year: 2021, Volume and Issue: 43(5), P. 2321 - 2331

Published: Oct. 1, 2021

Abstract In the present study, humoral and T cell-mediated immune responses elicited by BBIBP-CorV (inactivated virus) BNT162b2 (mRNA-based) vaccines against SARS-CoV-2 virus were compared. Convalescent volunteers also investigated to evaluate adaptive immunity induced live virus. Although both antibody- responses, our analysis revealed significant quantitative qualitative differences between two types of challenges. The vaccine antireceptor-binding domain (RBD) IgG, as well anti-spike protein (S) IgG IgA antibodies in healthy individuals, levels which much lower than after vaccination but still higher convalescent patients. cumulative IFNγ-positive cell response, however, was only twofold participants injected with compared those who primed boosted vaccine. Moreover, inactivated response that targets not S nucleocapsid (N) membrane (M) proteins, whereas mRNA able elicit a narrower epitopes only. Thus, pattern BBIBP-CorV-induced virus-naive similar anti-SARS-CoV-2 observed Based on these data, we can conclude is immunologically effective. However, duration integrated, antibody, cell-mediated, needs further investigation.

Language: Английский

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Modeling SARS-CoV-2: Comparative Pathology in Rhesus Macaque and Golden Syrian Hamster Models

Toxicologic Pathology, Journal Year: 2022, Volume and Issue: 50(3), P. 280 - 293

Published: Feb. 5, 2022

Coronavirus disease 2019 (COVID-19) in humans has a wide range of presentations, ranging from asymptomatic or mild symptoms to severe illness. Suitable animal models mimicking varying degrees clinical manifestations could expedite development therapeutics and vaccines for COVID-19. Here we demonstrate that acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection resulted subclinical rhesus macaques with pneumonia Syrian hamsters pneumonia. SARS-CoV-2 was confirmed by formalin-fixed, paraffin-embedded (FFPE) polymerase chain reaction (PCR), immunohistochemistry, situ hybridization. Replicating virus the lungs identified using hybridization plaque forming assays. Viral encephalitis, reported some COVID-19 patients, one macaque immunohistochemistry. There no evidence encephalitis hamsters. Severity distribution lung inflammation were substantially more compared exhibited vascular changes virus-induced cytopathic as seen patients. Neither hamster nor demonstrated multisystemic inflammatory (MIS). Data presented here may be appropriate mechanistic studies COVID-19-associated whereas suited study

Language: Английский

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An immunologist’s guide to immunosenescence and its treatment

Expert Review of Clinical Immunology, Journal Year: 2022, Volume and Issue: 18(9), P. 961 - 981

Published: July 25, 2022

Introduction Aging causes several changes in the immune system, although aging is strongly influenced by individual immunological history, as well genetic and environmental factors leading to inter-individual variability.Areas covered We focused on biological clinical meaning of immunosenescence. SARS-CoV-2 Yellow Fever vaccine have demonstrated relevance immunosenescence, while inconsistent results, obtained from longitudinal studies aimed at looking for risk phenotypes, revealed that immunosenescence highly context-dependent. Large projects allowed delineation drivers system variance, including factors, sex, smoking, co-habitation. Therefore, it difficult identify interventions can be envisaged maintain or improve function older people. That suggests drug treatment should require personalized intervention. Regarding this, we discussed role lifestyle a potential therapeutic approach.Expert opinion Our review points out age only part problem Everyone ages differently because unique genetics experience life this applies even more (immunobiography). Finally, shows how appreciable results modification biomarkers achieved with modification.

Language: Английский

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Sex and gender affect immune aging

Frontiers in Aging, Journal Year: 2023, Volume and Issue: 4

Published: Nov. 28, 2023

The proposed review aims to elucidate the intricate interplay between biological factors (sex differences) and socially constructed (gender in context of immune aging. While influence differences men women on various aspects responses has long been recognized, it is crucial acknowledge that gender, encompassing social cultural roles expectations associated with being male or female, also significantly shapes these processes. Gender can either accelerate aging promote longevity. By recognizing impact both factors, this work seeks offer a comprehensive understanding why may experience divergent trajectories varying outcomes terms Discrepancies perceived sexes, within families at work, contribute differing patterns antigen exposure. Additionally, variations micronutrient intake access preventive healthcare facilities exist. Health promotion knowledge often correlates educational attainment, which unequally represented males females many cultures across generations Western world. In countries without universal system, relies family prioritization strategies cope economic constraints, potentially limiting specific treatments affecting negatively. As result, behavioral gender disparities responses, susceptibility infections, autoimmune diseases, vaccine among older individuals. However, as demonstrated by COVID-19 pandemic, exhibit greater resilience infections than males. Given role system achieving longevity, not surprising live longer men, number female centenarians surpasses centenarians.

Language: Английский

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Role of Sex and Age in Fatal Outcomes of COVID-19: Women and Older Centenarians Are More Resilient

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(3), P. 2638 - 2638

Published: Jan. 30, 2023

In the present paper, we have analysed role of age and sex in fatal outcome COVID-19, as there are conflicting results literature. As such, answered three controversial questions regarding this aspect COVID-19 pandemic: (1) Have women been more resilient than men? (2) Did centenarians die less remaining older people? (3) Were resistant to SARS-CoV-2 younger centenarians? The literature review demonstrated that: it is who resilient, agreement with data showing that live longer men even during severe famines epidemics; however, centenarian men; overall did not people, likely linked their frailty; first pandemic wave 2020, > 101 years old (i.e., born before 1919), but "younger centenarians", may be related 1918 Spanish flu epidemic, although unclear what mechanisms might involved.

Language: Английский

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HLA‐A*11:01 and HLA‐C*04:01 are associated with severe COVID‐19

HLA, Journal Year: 2023, Volume and Issue: 102(6), P. 731 - 739

Published: Aug. 1, 2023

We analyzed the association between HLA polymorphisms and susceptibility to SARS‐CoV‐2 infection disease severity. Genotyping data from a total of 9373 COVID‐19‐positive cases Spanish Coalition Unlock Research on Host Genetics COVID‐19 (SCOURGE) consortium 5943 population controls were included in study. found an alleles HLA‐B*14:02 HLA‐C*08:02 with lower risk ( p = 0.006, OR 0.84, 95% CI [0.75–0.95], 0.024, 0.86, [0.78–0.95], respectively). also HLA‐A*11:01 HLA‐C*04:01 associated severity 0.033, 1.16, [1.04–1.31], 0.045, 1.14, [1.05–1.25], These results suggest that effective presentation viral peptides by class I involve faster clearance, decreasing COVID‐19.

Language: Английский

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Immunopathogenesis and Immunogenetic Variants in COVID-19

Current Pharmaceutical Design, Journal Year: 2022, Volume and Issue: 28(22), P. 1780 - 1797

Published: May 22, 2022

Coronavirus disease 2019 (COVID-19) continues to spread globally despite the discovery of vaccines. Many people die due COVID-19 as a result catastrophic consequences, such acute respiratory distress syndrome, pulmonary embolism, and disseminated intravascular coagulation caused by cytokine storm. Immunopathology immunogenetic research may assist in diagnosing, predicting, treating severe storm associated with COVID-19. This paper reviews immunopathogenesis variants that play role Although various immune-related genetic have been investigated relation COVID-19, NOD-like receptor protein 3 (NLRP3) interleukin 18 (IL-18) not assessed for their potential significance clinical outcome. Here, we a) summarize current understanding etiology pathophysiology storm; b) construct analyze protein-protein interaction (PPI) networks (using enrichment annotation analysis) based on NLRP3 IL18 all genes, which were established Our PPI network analyses predict useful drug targets prevent onset including key antiviral pathways Toll-Like-Receptor cascades, signaling, RIG-induction interferon (IFN) α/β, (IL)-1, IL-6, IL-12, IL-18, tumor necrosis factor signaling; SARS-CoV-2 innate immune evasion participation MYD88 MAVS The be used more outcomes, thereby opening door targeted preventive treatments.

Language: Английский

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Centenarians born before 1919 are resistant to COVID-19

Aging Clinical and Experimental Research, Journal Year: 2022, Volume and Issue: 35(1), P. 217 - 220

Published: Nov. 1, 2022

Language: Английский

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Spotlight on contributory role of host immunogenetic profiling in SARS-CoV-2 infection: Susceptibility, severity, mortality, and vaccine effectiveness

Life Sciences, Journal Year: 2023, Volume and Issue: 328, P. 121907 - 121907

Published: June 30, 2023

Language: Английский

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Immunopathology and Immunosenescence, the Immunological Key Words of Severe COVID-19. Is There a Role for Stem Cell Transplantation?

Frontiers in Cell and Developmental Biology, Journal Year: 2021, Volume and Issue: 9

Published: Sept. 14, 2021

The outcomes of Coronavirus disease-2019 (COVID-19) vary depending on the age, health status and sex an individual, ranging from asymptomatic to lethal. From immunologic viewpoint, final severe lung damage observed in COVID-19 should be caused by cytokine storm, driven mainly interleukin-6 other pro-inflammatory cytokines. However, which immunopathogenic precedes this “cytokine storm” why male older population is more severely affected, are currently unanswered questions. aging immune system, i.e., immunosenescence, closely associated with a low-grade inflammatory called “inflammageing,” play key role. remodeling both innate adaptive response can partly explain age gradient severity mortality COVID-19. This review discusses how impacts virus, focusing possible strategies rejuvenate system stem cell-based therapies. Indeed, due immunomodulatory anti-inflammatory properties, multipotent mesenchymal cells (MSCs) worth-considering option against adverse outcomes.

Language: Английский

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