Natural Ingredients of Transdermal Drug Delivery Systems as Permeation Enhancers of Active Substances through the Stratum Corneum

Molecular Pharmaceutics, Journal Year: 2023, Volume and Issue: 20(7), P. 3278 - 3297

Published: June 6, 2023

In recent years, significant progress has been made in transdermal drug delivery systems, but there is still a search for enhancers that can improve the absorption of active substances through stratum corneum. Although permeation have described scientific literature, use naturally occurring this role particular interest, because they offer high level safety use, with low risk skin irritation, and efficiency. addition, these ingredients are biodegradable, easily available, widely accepted by consumers due to growing trust natural compounds. This article provides information on derived compounds systems help them penetrate skin. The work focuses components found corneum such as sterols, ceramides, oleic acid, urea. Penetration nature, mainly plants, terpenes, polysaccharides, fatty acids also described. mechanism action discussed, methods assessing their penetration efficiency provided. Our review covers original papers from 2017 2022, supplemented papers, then older publications used supplement or verify data. shown increase transport compete synthetic counterparts.

Language: Английский

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An Updated Overview of the Emerging Role of Patch and Film-Based Buccal Delivery Systems

Pharmaceutics, Journal Year: 2021, Volume and Issue: 13(8), P. 1206 - 1206

Published: Aug. 5, 2021

Buccal mucosal membrane offers an attractive drug-delivery route to enhance both systemic and local therapy. This review discusses the benefits drawbacks of buccal drug delivery, anatomical physiological aspects oral mucosa, various in vitro techniques frequently used for examining systems. The role mucoadhesive polymers, penetration enhancers, enzyme inhibitors circumvent formulation challenges particularly due salivary renovation cycle, masticatory effect, limited absorption area are summarized. Biocompatible films patches favored dosage forms administration because flexibility, comfort, lightness, acceptability, capacity withstand mechanical stress, customized size. Preparation methods, scale-up process manufacturing briefed. Ongoing completed clinical trials film formulations designed delivery tabulated. Polymeric or lipid nanocarriers incorporated resolve potential issues reviewed. Vaccine-enabled have ability produce antibodies mediated cell immunity. Advent novel 3D printing technologies with built-in flexibility would allow multiple combinations as well compartmentalization separate incompatible drugs. Exploring new functional excipients permeation enhancement large-molecular-weight hydrophilic drugs unstable proteins, oligonucleotides need hour rapid advancement exciting field delivery.

Language: Английский

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The impacts of complexation and glycated conjugation on the performance of soy protein isolate-gum Arabic composites at the o/w interface for emulsion-based delivery systems

Food Hydrocolloids, Journal Year: 2022, Volume and Issue: 135, P. 108168 - 108168

Published: Sept. 19, 2022

Language: Английский

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Protective Barriers Provided by the Epidermis

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(4), P. 3145 - 3145

Published: Feb. 5, 2023

The skin is the largest organ of body and consists an epidermis, dermis subcutaneous adipose tissue. surface area often stated to be about 1.8 2 m2 represents our interface with environment; however, when one considers that microorganisms live in hair follicles can enter sweat ducts, interacts this aspect environment becomes 25–30 m2. Although all layers skin, including tissue, participate antimicrobial defense, review will focus mainly on role factors epidermis at surface. outermost layer stratum corneum, physically tough chemically inert which protects against numerous environmental stresses. It provides a permeability barrier attributable lipids intercellular spaces between corneocytes. In addition barrier, there innate involves lipids, peptides proteins. has low pH poor certain nutrients, limits range survive there. Melanin trans-urocanic acid provide protection from UV radiation, Langerhans cells are poised monitor local trigger immune response as needed. Each these protective barriers discussed.

Language: Английский

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The expanding organelle lipidomes: current knowledge and challenges

Cellular and Molecular Life Sciences, Journal Year: 2023, Volume and Issue: 80(8)

Published: Aug. 1, 2023

Abstract Lipids in cell membranes and subcellular compartments play essential roles numerous cellular processes, such as energy production, signaling inflammation. A specific organelle lipidome is characterized by lipid synthesis metabolism, intracellular trafficking, homeostasis the organelle. Over years, considerable effort has been directed to identification of fingerprints organelles. However, these are not fully due large variety structural complexity lipids great variability abundance different species. The process becomes even more challenging when considering that differs health disease contexts. This review summarizes information available on composition mammalian organelles, particularly nucleus, mitochondrion, endoplasmic reticulum, Golgi apparatus, plasma membrane organelles endocytic pathway. compositions extracellular vesicles lamellar bodies also described. In addition, several examples dynamics under physiological pathological conditions presented. Finally, challenges mapping lipidomes discussed.

Language: Английский

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Ethosomes as Promising Transdermal Delivery Systems of Natural‐Derived Active Compounds

Advanced NanoBiomed Research, Journal Year: 2023, Volume and Issue: 3(10)

Published: Aug. 3, 2023

Ethosomes are novel lipid‐based vesicular systems that demonstrate unique improvements in drug delivery with respect to other nanoparticles, especially for transdermal applications. Their high ethanol content strongly improves flexibility and deformability, which allows squeezing through the intercellular spaces without any leakage. The ethanol, moreover, contributes increase fluidity of lipids cell membranes dermal layers, allowing an in‐depth penetration nanostructures. Moreover, ethosomes promotion encapsulation either hydrophilic or lipophilic active agents, a feature particularly useful when it deals natural extracts, family compounds characterized by huge chemical variability. As further advantage, being extracts often obtained ethanol‐based solutions, their incorporation makes not necessarily expensive time‐consuming procedures finalized at solvent removal. Following initial exploitation ethosomes, research focuses on development variants such as invasomes transethosomes, show improved capacity. This review provides state‐of‐the‐art ethosomal research, special attention delivery.

Language: Английский

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Biopolymer Drug Delivery Systems for Oromucosal Application: Recent Trends in Pharmaceutical R&D

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(10), P. 5359 - 5359

Published: May 14, 2024

Oromucosal drug delivery, both local and transmucosal (buccal), is an effective alternative to traditional oral parenteral dosage forms because it increases bioavailability reduces systemic toxicity. The mucosa has a good blood supply, which ensures that molecules enter the circulation directly, avoiding metabolism during first passage through liver. At same time, number of barriers, including mucus, epithelium, enzymes, immunocompetent cells, are designed prevent entry foreign substances into body, also complicates absorption drugs. development oromucosal delivery systems based on mucoadhesive biopolymers their derivatives (especially thiolated catecholated derivatives) promising strategy for pharmaceutical safe forms. Solid, semi-solid liquid formulations have several advantageous properties, such as prolonged residence time due high mucoadhesion, unidirectional modified release capabilities, enhanced permeability. Biopolymers non-toxic, biocompatible, biodegradable may possess intrinsic bioactivity. A rational approach design requires understanding anatomy/physiology physicochemical biopharmaceutical properties molecule/biopolymer, presented in this review. This review summarizes advances (e.g., patches, buccal tablets, hydrogel systems), nanotechnology-based biopolymer nanoparticle solid lipid particles, liposomes, polyelectrolyte hybrid nanoparticles, etc.).

Language: Английский

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Immune Tolerance in the Oral Mucosa

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(22), P. 12149 - 12149

Published: Nov. 10, 2021

The oral mucosa is a site of intense immune activity, where large variety cells meet to provide first line defense against pathogenic organisms. Interestingly, the exposed plethora antigens from food and commensal bacteria that must be tolerated. mechanisms enable this tolerance are not yet fully defined. Many works have focused on active involving dendritic regulatory T cells. However, epithelial also make major contribution by influencing both innate adaptive immunity. Therefore, tolerogenic concurring in intertwined. Here, we review them systematically, paying special attention role

Language: Английский

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Skin models for dermal exposure assessment of phthalates

Chemosphere, Journal Year: 2022, Volume and Issue: 295, P. 133909 - 133909

Published: Feb. 7, 2022

Language: Английский

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Oral Mucosa Models to Evaluate Drug Permeability

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(5), P. 1559 - 1559

Published: May 22, 2023

Due to its numerous advantages, such as excellent drug accessibility, rapid absorption, and bypass of first-pass metabolism, the route administration that involves crossing oral mucosa is highly favored. As a result, there significant interest in investigating permeability drugs through this region. The purpose review describe various ex vivo vitro models used study conveyed non-conveyed mucosa, with focus on most effective models. Currently, growing need for standardized can be developing new delivery systems. Oral Mucosa Equivalents (OMEs) may provide promising future perspective they are capable overcoming limitations present many existing

Language: Английский

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