The Role of Silver Nanoparticles in the Diagnosis and Treatment of Cancer: Are There Any Perspectives for the Future?

Life, Journal Year: 2023, Volume and Issue: 13(2), P. 466 - 466

Published: Feb. 7, 2023

Cancer is a fatal disease with complex pathophysiology. Lack of specificity and cytotoxicity, as well the multidrug resistance traditional cancer chemotherapy, are most common limitations that often cause treatment failure. Thus, in recent years, significant efforts have concentrated on development modernistic field called nano-oncology, which provides possibility using nanoparticles (NPs) aim to detect, target, treat diseases. In comparison conventional anticancer strategies, NPs provide targeted approach, preventing undesirable side effects. What more, nanoparticle-based drug delivery systems shown good pharmacokinetics precise targeting, reduced resistance. It has been documented that, cells, promote reactive oxygen species (ROS) production, induce cell cycle arrest apoptosis, activate ER (endoplasmic reticulum) stress, modulate various signaling pathways, etc. Furthermore, their ability inhibit tumor growth vivo also documented. this paper, we reviewed role silver (AgNPs) nanomedicine, discussing numerous mechanisms by they render properties under both vitro conditions, potential diagnosis cancer.

Language: Английский

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Targeting the “hallmarks of aging” to slow aging and treat age-related disease: fact or fiction?

Molecular Psychiatry, Journal Year: 2022, Volume and Issue: 28(1), P. 242 - 255

Published: July 15, 2022

Aging is a major risk factor for number of chronic diseases, including neurodegenerative and cerebrovascular disorders. processes have therefore been discussed as potential targets the development novel broadly effective preventatives or therapeutics age-related those affecting brain. Mechanisms thought to contribute aging summarized under term "hallmarks aging" include loss proteostasis, mitochondrial dysfunction, altered nutrient sensing, telomere attrition, genomic instability, cellular senescence, stem cell exhaustion, epigenetic alterations intercellular communication. We here examine key claims about aging". Our analysis reveals important weaknesses that preclude strong definitive conclusions concerning possible role these in shaping organismal rate. Significant ambiguity arises from overreliance on lifespan proxy marker aging, use models with unclear relevance study designs do not allow properly estimate intervention effects also discuss future research directions should be taken clarify if what extent putative regulators fact interact aging. These multidimensional analytical frameworks well facilitate proper assessment

Language: Английский

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Cancer cell cycle heterogeneity as a critical determinant of therapeutic resistance

Genes & Diseases, Journal Year: 2023, Volume and Issue: 11(1), P. 189 - 204

Published: Jan. 14, 2023

Intra-tumor heterogeneity is now arguably one of the most-studied topics in tumor biology, as it represents a major obstacle to effective cancer treatment. Since cells are highly diverse at genetic, epigenetic, and phenotypic levels, intra-tumor can be assumed an important contributing factor nullification chemotherapeutic effects, recurrence tumor. Based on role heterogeneous subpopulations with varying cell-cycle dynamics behavior during progression treatment; herein, we aim establish comprehensive definition for adaptation neoplastic against therapy. We discuss two parallel yet distinct that play pivotal roles reducing effects chemotherapy: "resistant" "tolerant" populations. Furthermore, this review also highlights impact quiescent phase cell cycle survival mechanism cells. Beyond understanding mechanisms underlying quiescence, provides insightful perspective stem (CSCs) their dual intertwined functions based state response Moreover, CSCs, epithelial–mesenchymal transformed cells, circulating (CTCs), disseminated (DTCs), which mostly proved have multiple biological links implicated our viewpoint tumors. Overall, increasing knowledge key identifying new therapeutic solutions, emerging concept may provide us opportunities prevent dreadful recurrence.

Language: Английский

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Assessment of the electrostatic binding of ferrocenylmethyl-nitroaniline derivatives to DNA: A combined experimental and theoretical study

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1308, P. 138386 - 138386

Published: April 25, 2024

Language: Английский

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Advances in research on the anti-tumor mechanism of Astragalus polysaccharides

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: March 6, 2024

The dry root of the soybean plant Astragalus membranaceus (Fisch) Bge. var. mongholicus (Bge) Hsiao or A. Bge, Astragali Radix (AR) has a long medicinal history. polysaccharide (APS), natural macromolecule that exhibits immune regulatory, anti-inflammatory, anti-tumor, and other pharmacological activities, is an important active ingredient extracted from AR. Recently, APS been increasingly used in cancer therapy owing to its anti-tumor ability as it prevents progression prostate, liver, cervical, ovarian, non-small-cell lung by suppressing tumor cell growth invasion enhancing apoptosis. In addition, enhances sensitivity tumors antineoplastic agents improves body’s immunity. This prospects for broad application through various pathways. this article, we present latest progress research on effects underlying mechanisms, aiming provide novel theoretical support reference use therapy.

Language: Английский

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Nanoparticle-Mediated Drug Delivery Systems for Precision Targeting in Oncology

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(6), P. 677 - 677

Published: May 24, 2024

Nanotechnology has emerged as a transformative force in oncology, facilitating advancements site-specific cancer therapy and personalized oncomedicine. The development of nanomedicines explicitly targeted to cells represents pivotal breakthrough, allowing the precise interventions. These cancer-cell-targeted operate within intricate milieu tumour microenvironment, further enhancing their therapeutic efficacy. This comprehensive review provides contemporary perspective on precision medicine underscores critical role nanotechnology advancing It explores categorization nanoparticle types, distinguishing between organic inorganic variants, examines significance delivery anticancer drugs. Current insights into strategies for developing actively across various types are also provided, thus addressing relevant challenges associated with drug barriers. Promising future directions nanomedicine approaches delivered, emphasising imperative continued optimization nanocarriers medicine. discussion translational research’s need enhance patients’ outcomes by refining nanocarrier technologies nanotechnology-driven, therapy.

Language: Английский

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Green synthesis of zinc oxide nanoparticles using Rhus coriaria extract and their anticancer activity against triple-negative breast cancer cells

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: June 12, 2024

Abstract The growing interest in using plant extracts for the biogenic synthesis of zinc oxide nanoparticles (ZnO NPs) stems from their facile, eco-friendly, and biologically safe approach instead chemical routes. For first time, ZnO NPs were successfully biosynthesized Rhus coriaria fruit aqueous extract as a reducing capping agent. Characterization revealed that possessed maximum absorbance approximately 359 nm closely resembled hexagonal wurtzite crystalline structure, with an average size 16.69 nm. transmission electron microscope (TEM) showed presence spherical morphologies, grain 20.51 ± 3.90 Moreover, elemental composition synthesized was assessed via energy-dispersive X-ray spectrometry (EDX), phytocompounds on surface subsequently verified through FT-IR analysis. ζ-potential recorded at − 19.9 0.1663 mV. Regarding anti-cancer properties, found to possess potent anti-tumor effects MCF-7 MDA-MB-231 breast cancer cells. Their efficacy dose-dependent, IC 50 values ranging 35.04–44.86 μg/mL 55.54–63.71 µg/mL Mechanistic studies cells apoptosis induction, validated by DAPI staining, confocal microscopy, Annexin V/PI showing 12.59% 81.57% ½ values, respectively. Additionally, observed provoke S-phase arrest inhibit colony-forming metastatic potential modulating metastasis-related genes. This study unravels new insights into how cell death metastasis, revealing prospects nanotechnology.

Language: Английский

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Robust, anti-freezing and conductive bonding of chitosan-based double-network hydrogels for stable-performance flexible electronic

Carbohydrate Polymers, Journal Year: 2021, Volume and Issue: 276, P. 118753 - 118753

Published: Oct. 22, 2021

Language: Английский

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Potential Prognostic Biomarkers of NIMA (Never in Mitosis, Gene A)-Related Kinase (NEK) Family Members in Breast Cancer

Journal of Personalized Medicine, Journal Year: 2021, Volume and Issue: 11(11), P. 1089 - 1089

Published: Oct. 26, 2021

Breast cancer remains the most common malignant in women, with a staggering incidence of two million cases annually worldwide; therefore, it is crucial to explore novel biomarkers assess diagnosis and prognosis breast patients. NIMA-related kinase (NEK) protein contains 11 family members named NEK1-NEK11, which were discovered from Aspergillus Nidulans; however, role NEK genes for tumor development unclear requires additional study. In present study, we investigate relationships development, as well gene expression signature via bioinformatics approach. The results several integrative analyses revealed that are overexpressed cancer. Among these genes, NEK2/6/8 overexpression had poor prognostic significance distant metastasis-free survival (DMFS) Meanwhile, NEK2/6 highest level DNA methylation, functional enrichment analysis MetaCore Gene Set Enrichment Analysis (GSEA) suggested NEK2 was associated cell cycle, G2M checkpoint, repair, E2F, MYC, MTORC1, interferon-related signaling. Moreover, Tumor Immune Estimation Resource (TIMER) showed transcriptional levels positively correlated immune infiltration B cells CD4+ T Cell. Collectively, current study indicated especially involved infiltration, may serve progression.

Language: Английский

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Emerging nanotechnology-based therapeutics to combat multidrug-resistant cancer

Journal of Nanobiotechnology, Journal Year: 2022, Volume and Issue: 20(1)

Published: Sept. 24, 2022

Cancer often develops multidrug resistance (MDR) when cancer cells become resistant to numerous structurally and functionally different chemotherapeutic agents. MDR is considered one of the principal reasons for failure many forms clinical chemotherapy. Several factors are involved in development including increased expression efflux transporters, tumor microenvironment, changes molecular targets activity stem cells. Recently, researchers have designed developed a number small molecule inhibitors derivatives natural compounds overcome various mechanisms MDR. Unfortunately, most chemosensitizing approaches failed trials due non-specific interactions adverse side effects at pharmacologically effective concentrations. Nanomedicine provide an efficient drug delivery platform limitations conventional chemotherapy improve therapeutic effectiveness. Multifunctional nanomaterials been found facilitate by improving bioavailability pharmacokinetics, enhancing efficacy drugs In this review article, we discuss major contributing existing chemotherapy- nanocarrier-based systems mechanisms. We critically recent nanotechnology-based combat heterogeneity, mechanisms, DNA repair apoptotic machineries Recent successful therapies nature include liposomal nanoformulations, cRGDY-PEG-Cy5.5-Carbon dots Cds/ZnS core-shell quantum that employed treatment sub-types cell lung, head neck breast cancers.

Language: Английский

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