Pharmaceuticals,
Journal Year:
2024,
Volume and Issue:
17(5), P. 636 - 636
Published: May 15, 2024
Astragalus
polysaccharide
(APS)
derived
from
A.
membranaceus
plays
a
crucial
role
in
traditional
Chinese
medicine.
These
polysaccharides
have
shown
antitumor
effects
and
are
considered
safe.
Thus,
they
become
increasingly
important
cancer
immunotherapy.
APS
can
limit
the
spread
of
by
influencing
immune
cells,
promoting
cell
death,
triggering
autophagy,
impacting
tumor
microenvironment.
When
used
combination
with
other
therapies,
enhance
treatment
outcomes
reduce
toxicity
side
effects.
combined
checkpoint
inhibitors,
relay
cellular
immunotherapy,
vaccines
broadened
application
immunotherapy
enhanced
effectiveness.
By
summarizing
research
on
over
past
two
decades,
this
review
elaborates
anticancer
mechanism
its
use
clinical
trials.
Considering
multiple
roles
APS,
emphasizes
importance
using
as
an
adjunct
to
compares
APS.
This
discussion
provides
insights
into
specific
action
reveals
molecular
targets
for
developing
effective
strategies,
highlights
wide
therapy
future.
Biomedical Journal,
Journal Year:
2024,
Volume and Issue:
unknown, P. 100741 - 100741
Published: April 1, 2024
The
impact
and
underlying
mechanisms
of
astragalus
polysaccharide
(APS)
on
prostate
cancer,
particularly
its
role
in
immunomodulation,
remain
inadequately
elucidated.
This
study
employed
the
XTT
assay
for
assessing
proliferation
cancer
cells
macrophages.
T
cell
was
determined
using
Carboxyfluorescein
diacetate
succinimidyl
ester
labeling
assay.
APS's
effect
macrophages
scrutinized
via
flow
cytometry,
Western
blot
analysis,
ELISA,
quantitative
PCR
cytokine
membrane
arrays.
APS
interaction
between
PD-L1
PD-1
investigated
by
PD-L1/PD-1
homogeneous
Additionally,
conditioned
medium
from
PC-3
migration
explored
through
assays.
It
observed
that
at
concentrations
1
5
mg/mL
enhanced
CD8+
cells.
At
a
concentration
mg/mL,
activated
both
CD4+
cells,
attenuated
expression
stimulated
with
interferon
gamma
(IFN-γ)
or
oxaliplatin,
moderately
decreased
population
PD-1+
Furthermore,
this
impeded
PD-1,
inhibited
promotion
mediated
RAW
264.7
THP-1
initiated
apoptosis
treated
(5
mg/mL)-treated
findings
indicate
potential
modulating
PD-1/PD-L1
pathway
influencing
immune
response,
encompassing
Consequently,
further
vivo
research
is
recommended
to
assess
efficacy
APS.
Pharmacognosy Magazine,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 13, 2025
Background
Epithelial-mesenchymal
transition
(EMT)
is
crucial
in
liver
cancer
progression.
Developing
novel
medicines
to
disrupt
the
progression
of
EMT
might
be
a
approach
managing
cancer.
Purpose
This
study
investigates
protective
role
Astragalus
polysaccharide
(APS),
bioactive
compound
derived
from
membranaceus,
modulating
HepG2
cells.
Methods
The
effects
APS
on
were
evaluated
by
assessing
cell
viability,
proliferation,
invasion,
migration,
cycle,
and
apoptosis
Furthermore,
involvement
NOD-like
receptor
protein
3
(NLRP3)
inflammasome
this
process
was
explored.
Results
Results:
treatment
significantly
inhibited
migration
cells
while
promoting
cycle
arrest
apoptosis.
Notably,
reduced
expression
NLRP3
components,
including
NLRP3,
apoptosis-associated
speck-like
protein,
caspase-1,
decreasing
levels
inflammatory
cytokines.
In
addition,
activator
Nigericin
dampened
effect
partially
rescuing
activity
NLRP3.
Specifically,
promoted
development
exacerbated
malignant
transformation
improved
APS.
Conclusion
Our
findings
demonstrated
function
which
inhibits
activation
protect
results
showed
that
targeting
application
appears
viable
tactic
for
preventing
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
16
Published: Feb. 18, 2025
Owing
to
its
high
mortality
rate,
lung
cancer
(LC)
remains
the
most
common
worldwide,
with
highest
malignancy
diagnosis
rate.
The
phosphatidylinositol-3-kinase
(PI3K)/protein
kinase
B
(AKT)/mammalian
target
of
rapamycin
(mTOR)
signaling
(PAM)
pathway
is
a
critical
intracellular
involved
in
various
cellular
functions
and
regulates
numerous
processes,
including
growth,
survival,
proliferation,
metabolism,
apoptosis,
invasion,
angiogenesis.
This
review
aims
highlight
preclinical
clinical
studies
focusing
on
PAM
LC
underscore
potential
natural
products
targeting
it.
Additionally,
this
synthesizes
existing
literature
discusses
combination
therapy
future
directions
for
treatment
while
acknowledging
ongoing
challenges
field.
Continuous
development
novel
therapeutic
agents,
technologies,
precision
medicine
offers
an
increasingly
optimistic
outlook
LC.
