Nutrition and Diabetes,
Journal Year:
2023,
Volume and Issue:
13(1)
Published: Feb. 28, 2023
Abstract
Aim
Adiponectin,
a
major
adipokine
secreted
by
adipose
tissue,
has
been
shown
to
improve
insulin
sensitivity.
Myo-inositol
hexaphosphate
(phytate;
InsP6)
is
natural
compound
that
abundant
in
cereals,
legumes,
and
nuts
demonstrated
have
different
beneficial
properties
patients
with
diabetes
type
2.
Methods
We
performed
randomized
crossover
trial
investigate
the
impact
of
daily
consumption
InsP6
on
serum
levels
adiponectin,
TNF-alpha,
IL-6,
IL-1beta
2
mellitus
(T2DM;
n
=
39).
Thus,
we
measure
these
inflammatory
markers,
classic
vascular
risk
factors,
urinary
at
baseline
end
intervention
period.
Results
Patients
who
consumed
supplements
for
3
months
had
higher
adiponectin
lower
HbA1c
than
those
did
not
consume
InsP6.
No
differences
were
found
IL-1beta.
Conclusion
This
first
report
show
increases
plasma
concentration
T2DM.
Consequently,
our
findings
indicate
following
phytate-rich
diet
effects
concentrations
it
could
help
prevent
or
minimize
diabetic-related
complications.
Heliyon,
Journal Year:
2024,
Volume and Issue:
10(4), P. e25911 - e25911
Published: Feb. 1, 2024
In
the
development
of
novel
antidiabetic
agents,
a
series
isoxazolidine-isatin
hybrids
were
designed,
synthesized,
and
evaluated
as
dual
α-amylase
α-glucosidase
inhibitors.
The
precise
structures
synthesized
scaffolds
characterized
using
different
spectroscopic
techniques
elemental
analysis.
obtained
results
compared
to
those
reference
drug,
acarbose
(IC
Molecules,
Journal Year:
2024,
Volume and Issue:
29(4), P. 896 - 896
Published: Feb. 18, 2024
Non-communicable
diseases
(NCDs)
are
described
as
a
collection
of
chronic
that
do
not
typically
develop
from
an
acute
infection,
have
long-term
health
effects,
and
frequently
require
ongoing
care
therapy.
These
include
heart
disease,
stroke,
cancer,
lung
neurological
diseases,
osteoporosis,
mental
disorders,
etc.
Known
synthetic
drugs
for
the
treatment
or
prevention
NCDs
become
increasingly
dangerous
over
time
pose
high
risks
due
to
side
effects
such
hallucination,
attack,
liver
failure,
As
result,
scientists
had
look
other
alternatives
natural
products
known
be
less
detrimental
contain
useful
bioactive
compounds.
The
increasing
understanding
biological
pharmacological
significance
carbohydrates
has
helped
raise
awareness
their
importance
in
living
systems
medicine,
given
they
play
numerous
roles.
For
example,
pectin
been
identified
class
secondary
metabolites
found
medicinal
plants
may
significant
role
management
variety
NCDs.
Pectin
is
mainly
made
homogalacturonan,
which
linear
polymer
composed
primarily
D-galacturonic
acid
units
(at
least
65%)
linked
chain
by
α-(1,4)-glycosidic
linkages.
There
also
modified
pectins
derivatives
improve
pectin’s
bioavailability.
cell
walls
higher
(pteridophytes,
angiosperms,
gymnosperms),
particularly
middle
lamella
plant
material.
Citrus
used
various
industries.
This
article
compiles
information
available
years
about
therapeutic
different
modes
extraction,
chemistry
pectin,
potency
its
derivatives.
Biomedicine & Pharmacotherapy,
Journal Year:
2022,
Volume and Issue:
150, P. 112946 - 112946
Published: April 9, 2022
Betaine
(N,
N,
N-trimethylglycine)
is
an
amino-acid
derivative
exerting
numerous
beneficial
effects
on
the
organism.
This
compound
found
in
human
and
animal
diets
but
also
endogenously
generated.
However,
its
synthesis
may
be
insufficient
to
maintain
or
improve
health.
Moreover,
tissue
content
of
betaine
reduces
under
some
pathological
conditions,
such
as
type
2
diabetes.
decrease
be,
however,
easily
alleviated
by
dietary
supplementation.
Rodent
studies
provided
evidence
that
effectively
limits
many
diabetes-related
disturbances.
therapy
improves
glucose
tolerance
insulin
action,
which
strongly
associated
with
changes
insulin-sensitive
tissues,
skeletal
muscle,
adipose
tissue,
liver.
supplementation
positively
affects
multiple
genes,
expression
dysregulated
AMP-activated
protein
kinase
thought
play
a
central
role
mechanism
underlying
anti-diabetic
action.
models
diabetes
have
shown
exerts
anti-inflammatory
anti-oxidant
effects,
alleviates
endoplasmic
reticulum
stress.
These
contribute
improved
sensitivity
better
blood
clearance.
The
results
encourage
exploration
therapeutic
efficacy
humans
Nutrition and Diabetes,
Journal Year:
2023,
Volume and Issue:
13(1)
Published: Feb. 28, 2023
Abstract
Aim
Adiponectin,
a
major
adipokine
secreted
by
adipose
tissue,
has
been
shown
to
improve
insulin
sensitivity.
Myo-inositol
hexaphosphate
(phytate;
InsP6)
is
natural
compound
that
abundant
in
cereals,
legumes,
and
nuts
demonstrated
have
different
beneficial
properties
patients
with
diabetes
type
2.
Methods
We
performed
randomized
crossover
trial
investigate
the
impact
of
daily
consumption
InsP6
on
serum
levels
adiponectin,
TNF-alpha,
IL-6,
IL-1beta
2
mellitus
(T2DM;
n
=
39).
Thus,
we
measure
these
inflammatory
markers,
classic
vascular
risk
factors,
urinary
at
baseline
end
intervention
period.
Results
Patients
who
consumed
supplements
for
3
months
had
higher
adiponectin
lower
HbA1c
than
those
did
not
consume
InsP6.
No
differences
were
found
IL-1beta.
Conclusion
This
first
report
show
increases
plasma
concentration
T2DM.
Consequently,
our
findings
indicate
following
phytate-rich
diet
effects
concentrations
it
could
help
prevent
or
minimize
diabetic-related
complications.
