Green Synthesis of Gold Nanoparticles Using Plant Extracts as Beneficial Prospect for Cancer Theranostics

Molecules, Journal Year: 2021, Volume and Issue: 26(21), P. 6389 - 6389

Published: Oct. 22, 2021

Gold nanoparticles (AuNPs) have been widely explored and are well-known for their medical applications. Chemical physical synthesis methods a way to make AuNPs. In any case, the hunt other more ecologically friendly cost-effective large-scale technologies, such as environmentally biological processes known green synthesis, has gaining interest by worldwide researchers. The international focus on nanotechnology research resulted in various nanomaterials being used physiologically acceptable Several advantages over conventional chemical (simple, one-step approach synthesize, cost-effectiveness, energy efficiency, biocompatibility) drawn scientists’ attention exploring of AuNPs exploiting plants’ secondary metabolites. Biogenic approaches, mainly plant-based metal nanoparticles, chosen ideal strategy due environmental vivo safety, well ease synthesis. this review, we reviewed use synthesized treatment cancer utilizing phytochemicals found plant extracts. This article reviews producing AuNPs, characterization discusses physiochemical properties. study also recent breakthroughs achievements using different mechanisms action, reactive oxygen species (ROS), mediated mitochondrial dysfunction caspase activation, leading apoptosis, etc., anticancer cytotoxic effects. Understanding underlying therapeutic efficacy will aid developing personalized medicines treatments potential strategy.

Language: Английский

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Magnetic Nanoparticles: A Review on Synthesis, Characterization, Functionalization, and Biomedical Applications

Small, Journal Year: 2023, Volume and Issue: 20(5)

Published: Sept. 21, 2023

Abstract Nowadays, magnetic nanoparticles (MNPs) are applied in numerous fields, especially biomedical applications. Since biofluidic samples and biological tissues nonmagnetic, negligible background signals can interfere with the from MNPs biosensing imaging In addition, be remotely controlled by which make it possible for separation targeted drug delivery. Furthermore, due to unique dynamic magnetizations of when subjected alternating also proposed as a key tool cancer treatment, an example is hyperthermia therapy. Due their distinct surface chemistry, good biocompatibility, inducible moments, material morphological structure design has attracted enormous interest variety scientific domains. Herein, thorough review chemical synthesis strategies MNPs, methodologies modify better physicochemical characterization techniques well some representative applications disease diagnosis treatment provided. Further portions go into diagnostic therapeutic uses composite core/shell structures deeper analysis MNP properties learn about potential

Language: Английский

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Transmission Electron Microscopy as a Powerful Tool to Investigate the Interaction of Nanoparticles with Subcellular Structures

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(23), P. 12789 - 12789

Published: Nov. 26, 2021

Nanomedical research necessarily involves the study of interactions between nanoparticulates and biological environment. Transmission electron microscopy has proven to be a powerful tool in providing information about nanoparticle uptake, biodistribution relationships with cell tissue components, thanks its high resolution. This article aims overview transmission techniques used explore impact nanoconstructs on systems, highlighting functional value ultrastructural morphology, histochemistry microanalysis as well their fundamental contribution advancement nanomedicine.

Language: Английский

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Fluorescence image-guided tumour surgery

Nature Reviews Bioengineering, Journal Year: 2023, Volume and Issue: 1(3), P. 161 - 179

Published: Feb. 3, 2023

Language: Английский

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Iron Oxide Nanoparticles in Regenerative Medicine and Tissue Engineering

Nanomaterials, Journal Year: 2021, Volume and Issue: 11(9), P. 2337 - 2337

Published: Sept. 8, 2021

In recent years, many promising nanotechnological approaches to biomedical research have been developed in order increase implementation of regenerative medicine and tissue engineering clinical practice. the meantime, use nanomaterials for regeneration diseased or injured tissues is considered advantageous most areas medicine. particular, treatment cardiovascular, osteochondral neurological defects, but also recovery functions other organs such as kidney, liver, pancreas, bladder, urethra wound healing, are increasingly being that serve scaffolds, mimic extracellular matrix promote adhesion differentiation cells. This review focuses on latest developments medicine, which iron oxide nanoparticles (IONPs) play a crucial role cell therapy. IONPs not only enabling non-invasive observation methods monitor therapy, can accelerate enhance regeneration, either thanks their inherent magnetic properties by functionalization with bioactive therapeutic compounds, drugs, enzymes growth factors. addition, presence fields direct IONP-labeled cells specifically site action induce into specific type through mechanotransduction.

Language: Английский

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Magnetic Nanoparticles: Current Advances in Nanomedicine, Drug Delivery and MRI

Chemistry, Journal Year: 2022, Volume and Issue: 4(3), P. 872 - 930

Published: Aug. 27, 2022

Magnetic nanoparticles (MNPs) have evolved tremendously during recent years, in part due to the rapid expansion of nanotechnology and their active magnetic core with a high surface-to-volume ratio, while surface functionalization opened door plethora drug, gene bioactive molecule immobilization. Taming reactivity was achieved by various techniques, producing MNPs tailored for diagnosis treatment cardiovascular or neurological disease, tumors cancer. Superparamagnetic iron oxide (SPIONs) are established at drug-delivery systems could act as efficient agents MFH (magnetic fluid hyperthermia). Depending on intrinsic morphological features, now cover broad scope which current review aims overview. Considering exponential field, will be limited roughly past three years.

Language: Английский

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Deep Penetrating and Sensitive Targeted Magnetic Particle Imaging and Photothermal Therapy of Early‐Stage Glioblastoma Based on a Biomimetic Nanoplatform

Advanced Science, Journal Year: 2023, Volume and Issue: 10(19)

Published: May 7, 2023

Abstract Early diagnosis can effectively improve the survival of glioblastoma multiforme (GBM). A specific imaging technique that is simultaneously deep penetrating and sensitive to small tissue changes desired identify GBM. Due its excellent features in signal contrast, detection sensitivity, none or little attenuation tissue, magnetic particle (MPI) possesses great potential cancer diagnosis, especially when modality equipped with specifically targeted nanoprobes. However, gliomas are small, blood–brain barrier (BBB) complete prevents nanoprobes from entering brain, which negates theranostic effect. This study proposes a biomimetic nanoplatform assist MPI tracers breaking through BBB then demonstrate Afterward, photothermal therapy immune regulation show an therapeutic effect on It experimentally confirmed does not decay depth shows sensitivity for thousands‐cells. Only animals conducted this due limitations current commercial scanner, however, research theoretically enables large animal human studies, encourages promising pathway toward noninvasive early‐stage GBM clinics.

Language: Английский

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Recent advances in magnetic nanoparticles: Key applications, environmental insights, and future strategies

Sustainable materials and technologies, Journal Year: 2024, Volume and Issue: 40, P. e00985 - e00985

Published: May 20, 2024

Language: Английский

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System characterization of a human-sized 3D real-time magnetic particle imaging scanner for cerebral applications

Communications Engineering, Journal Year: 2024, Volume and Issue: 3(1)

Published: March 14, 2024

Abstract Since the initial patent in 2001, Magnetic Particle Imaging community has endeavored to develop a human-applicable scanner, incorporating contributions from various research fields. Here we present an improved head-sized scanner with low power consumption, operated by open-source software and characterize it emphasis on human safety. The focus is evaluation of technical components phantom experiments for brain perfusion. We achieved 3D single- multi-contrast imaging at 4 Hz frame rate. system characterization includes sensitivity, resolution, perfusion as well field measurements sequence analysis. Images were acquired clinically approved tracer within peripheral nerve stimulation thresholds. This advanced holds potential tomographic imager diagnosing conditions such ischemic stroke (different stages) or intracranial hemorrhage environments lacking electromagnetic shielding, intensive care unit.

Language: Английский

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Advancements in magnetic nanoparticle-based biosensors for point-of-care testing

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: April 25, 2024

The significance of point-of-care testing (POCT) in early clinical diagnosis and personalized patient care is increasingly recognized as a crucial tool reducing disease outbreaks improving survival rates. Within the realm POCT, biosensors utilizing magnetic nanoparticles (MNPs) have emerged subject substantial interest. This review aims to provide comprehensive evaluation current landscape emphasizing its growing within practice. Subsequently, status combination MNPs Biological detection has been presented. Furthermore, it delves into specific domain MNP-based biosensors, assessing their potential impact on POCT. By combining existing research spotlighting pivotal discoveries, this enhances our comprehension advancements promising prospects offered by context It seeks facilitate informed decision-making among healthcare professionals researchers while also promoting further exploration field study.

Language: Английский

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