Exploring miRNA Biomarkers in Major Depressive Disorder: A Molecular Medicine Perspective DOI Creative Commons
Cătălin Prodan-Bărbulescu, Laura Andreea Ghenciu,

Edward Paul Şeclăman

et al.

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(10), P. 10846 - 10853

Published: Sept. 27, 2024

Major depressive disorder (MDD) is a complex mental health condition with multifaceted and incompletely elucidated pathophysiology. MicroRNAs (miRNAs) have emerged as potential biomarkers due to their role in gene regulation the observed dysregulation MDD. The aim of this study detect presence specific molecular diagnostic major disorder. This cross-sectional analyzed plasma miRNA expression ten MDD patients eight healthy controls using real-time PCR. Differentially expressed miRNAs were identified independent t-tests, was assessed ROC curve analysis. Fifteen exhibited significant patients. Notably, hsa-miR-29c-3p, hsa-miR-376a-3p, hsa-miR-532-5p, hsa-miR-339-5p showed excellent discriminatory power (AUC > 0.8). identifies differentially MDD, suggesting for improved diagnosis personalized treatment. However, further validation larger cohorts investigation into functional roles are warranted.

Language: Английский

miRNAs in neurodegenerative diseases: from target screening to precision therapy DOI
Dongyi Liao, Yujie Zhang, Shuangyang Li

et al.

Neurological Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Language: Английский

Citations

2
(R)-ketamine as prophylactic and therapeutic drug for neurological disorders: Beyond depression DOI Creative Commons

Xingming Wang,

Jianjun Yang, Kenji Hashimoto

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2022, Volume and Issue: 139, P. 104762 - 104762

Published: June 30, 2022

Neurological disorders are the leading cause of disability and second death worldwide. The increasing social economic burdens neurological driven by global population growth aging. Depression is a common psychiatric symptom in numerous disorders. It also risk factor for Alzheimer's disease (AD) other dementias, Parkinson's (PD), stroke. rapid-acting sustained antidepressant actions (R,S)-ketamine severe depression was accidentally discovered. Interestingly, (R)-ketamine has greater potency longer-lasting antidepressant-like effects than (S)-ketamine rodents. Importantly, its side rodents humans lower those (S)-ketamine. Furthermore, could elicit beneficial various rodent models disorders, including PD, multiple sclerosis (MS), In this article, we review potential as prophylactic or therapeutic drug AD MS,

Language: Английский

Citations

41
Emerging imaging and liquid biomarkers in multiple sclerosis DOI Open Access
Alexander J. Gill, Emily Schorr, Sachin P. Gadani

et al.

European Journal of Immunology, Journal Year: 2023, Volume and Issue: 53(8)

Published: May 17, 2023

Abstract The advent of highly effective disease modifying therapy has transformed the landscape multiple sclerosis (MS) care over last two decades. However, there remains a critical, unmet need for sensitive and specific biomarkers to aid in diagnosis, prognosis, treatment monitoring, development new interventions, particularly people with progressive disease. This review evaluates current data several emerging imaging liquid MS. MRI findings such as central vein sign paramagnetic rim lesions may improve MS diagnostic accuracy evaluation efficacy Serum cerebrospinal fluid levels neuroglial proteins, neurofilament light chain glial fibrillary acidic protein, show potential be pathologic processes neuro‐axonal injury or glial‐inflammation. Additional promising biomarkers, including optical coherence tomography, cytokines chemokines, microRNAs, extracellular vesicles/exosomes, are also reviewed, among others. Beyond their integration into clinical interventional trials, these informative pathogenesis help elucidate novel targets strategies.

Language: Английский

Citations

24
A Review of Nanotechnology in microRNA Detection and Drug Delivery DOI Creative Commons
Hsiuying Wang

Cells, Journal Year: 2024, Volume and Issue: 13(15), P. 1277 - 1277

Published: July 30, 2024

MicroRNAs (miRNAs) are small, non-coding RNAs that play a crucial role in regulating gene expression. Dysfunction miRNAs can lead to various diseases, including cancers, neurological disorders, and cardiovascular conditions. To date, approximately 2000 have been identified humans. These small molecules shown promise as disease biomarkers potential therapeutic targets. Therefore, identifying miRNA for diseases developing effective drug delivery systems essential. Nanotechnology offers promising new approaches addressing scientific medical challenges. Traditional detection methods include next-generation sequencing, microarrays, Northern blotting, reverse transcription-quantitative polymerase chain reaction (RT-qPCR). serve an alternative blotting RT-qPCR detection. Moreover, nanomaterials exhibit unique properties differ from larger counterparts, enabling therapeutics more effectively enter target cells, reduce degradation the bloodstream, be released specific tissues or cells. This paper reviews application of nanotechnology systems. Given still stages, holds great accelerating development.

Language: Английский

Citations

10
The role of miRNAs in multiple sclerosis pathogenesis, diagnosis, and therapeutic resistance DOI
Ahmed S. Doghish, Ola Elazazy, Hend H. Mohamed

et al.

Pathology - Research and Practice, Journal Year: 2023, Volume and Issue: 251, P. 154880 - 154880

Published: Oct. 11, 2023

Language: Английский

Citations

16
MicroRNAs in spinal cord injury: A narrative review DOI Creative Commons

Chunjia Zhang,

Zuliyaer Talifu,

Xin Xu

et al.

Frontiers in Molecular Neuroscience, Journal Year: 2023, Volume and Issue: 16

Published: Feb. 2, 2023

Spinal cord injury (SCI) is a global medical problem with high disability and mortality rates. At present, the diagnosis treatment of SCI are still lacking. has complex etiology, lack diagnostic methods, poor effect other problems, which lead to difficulty spinal regeneration repair, functional recovery. Recent studies have shown that gene expression plays an important role in regulation repair. MicroRNAs (miRNAs) non-coding RNA molecules target mRNA order silence, translate, or interfere protein synthesis. Secondary damage, such as oxidative stress, apoptosis, autophagy, inflammation, occurs after SCI, differentially expressed miRNAs contribute these events. This article reviews pathophysiological mechanism secondary focusing on neuroinflammation so provide new ideas basis for clinical SCI. The mechanisms neurological diseases may also make them potential biomarkers therapeutic targets injuries.

Language: Английский

Citations

14
Depression and anxiety in multiple sclerosis. Review of a fatal combination DOI
K. A. Jellinger

Journal of Neural Transmission, Journal Year: 2024, Volume and Issue: 131(8), P. 847 - 869

Published: June 13, 2024

Language: Английский

Citations

4
Psychological stress disturbs bone metabolism via miR-335-3p/Fos signaling in osteoclast DOI Creative Commons
Jiayao Zhang, Juan Li,

Jiehong Huang

et al.

eLife, Journal Year: 2025, Volume and Issue: 13

Published: Jan. 8, 2025

It has been well validated that chronic psychological stress leads to bone loss, but the underlying mechanism remains unclarified. In this study, we established and analyzed unpredictable mild (CUMS) mice investigate miRNA-related pathogenic involved in stress-induced osteoporosis. Our result found these CUMS exhibited osteoporosis phenotype is mainly attributed abnormal activities of osteoclasts. Subsequently, miRNA sequencing other analysis showed miR-335-3p, which normally highly expressed brain, was significantly downregulated nucleus ambiguous, serum, mice. Additionally, vitro studies detected miR-335-3p important for osteoclast differentiation, with its direct targeting site Fos . Further demonstrated FOS upregulated osteoclast, inhibition suppressed accelerated osteoclastic as expression genes, such Nfatc1, Acp5, Mmp9 , miR-335-3p-restrained conclusion, work indicated may downregulate expression, resulted accumulation upregulation NFACT1 signaling pathway osteoclasts, leading differentiation activity. These results decipher a previously unrecognized paradigm can act link between metabolism.

Language: Английский

Citations

0
(R)-ketamine ameliorates the progression of experimental autoimmune encephalomyelitis in mice DOI Creative Commons

Xingming Wang,

Lijia Chang, Yunfei Tan

et al.

Brain Research Bulletin, Journal Year: 2021, Volume and Issue: 177, P. 316 - 323

Published: Oct. 22, 2021

Language: Английский

Citations

18
Beyond monoamines: I. Novel targets and radiotracers for Positron emission tomography imaging in psychiatric disorders DOI
Brian J. Lopresti, Sarah K. Royse, Chester A. Mathis

et al.

Journal of Neurochemistry, Journal Year: 2022, Volume and Issue: 164(3), P. 364 - 400

Published: May 10, 2022

With the emergence of positron emission tomography (PET) in late 1970s, psychiatry had access to a tool capable non-invasive assessment human brain function. Early applications focused on identifying characteristic blood flow and metabolic derangements using radiotracers such as [15 O]H2 O [18 F]FDG. Despite success these techniques, it became apparent that more specific probes were needed understand neurochemical bases psychiatric disorders. The first PET imaging targeted sites action neuroleptic (dopamine D2 receptors) psychoactive (serotonin drugs. Based centrality monoamine dysfunction disorders measured monoamine-enhancing drugs treating them, next 30 years witnessed development an armamentarium radiopharmaceuticals methodologies for studying monoamines. Continued over this time however was less successful, realizing only modest gains efficacy tolerability. As patent protection many widely prescribed profitable lapsed, drug pipelines shifted away from monoamines search novel targets with promises improved efficacy, or abandoned altogether. Over period, radiopharmaceutical activities closely paralleled priorities resulting new agents non-monoamine targets. Part one review will briefly survey relevance field psychiatry, which include metabotropic glutamate receptor type 5 (mGluR5), purinergic P2 X7 receptor, 1 cannabinoid (CB1 ), phosphodiesterase 10A (PDE10A), describe developed other have matured subject investigations. Current limitations techniques also be discussed.

Language: Английский

Citations

12