Current Issues in Molecular Biology,
Год журнала:
2024,
Номер
46(10), С. 10846 - 10853
Опубликована: Сен. 27, 2024
Major
depressive
disorder
(MDD)
is
a
complex
mental
health
condition
with
multifaceted
and
incompletely
elucidated
pathophysiology.
MicroRNAs
(miRNAs)
have
emerged
as
potential
biomarkers
due
to
their
role
in
gene
regulation
the
observed
dysregulation
MDD.
The
aim
of
this
study
detect
presence
specific
molecular
diagnostic
major
disorder.
This
cross-sectional
analyzed
plasma
miRNA
expression
ten
MDD
patients
eight
healthy
controls
using
real-time
PCR.
Differentially
expressed
miRNAs
were
identified
independent
t-tests,
was
assessed
ROC
curve
analysis.
Fifteen
exhibited
significant
patients.
Notably,
hsa-miR-29c-3p,
hsa-miR-376a-3p,
hsa-miR-532-5p,
hsa-miR-339-5p
showed
excellent
discriminatory
power
(AUC
>
0.8).
identifies
differentially
MDD,
suggesting
for
improved
diagnosis
personalized
treatment.
However,
further
validation
larger
cohorts
investigation
into
functional
roles
are
warranted.
Neuroscience & Biobehavioral Reviews,
Год журнала:
2022,
Номер
139, С. 104762 - 104762
Опубликована: Июнь 30, 2022
Neurological
disorders
are
the
leading
cause
of
disability
and
second
death
worldwide.
The
increasing
social
economic
burdens
neurological
driven
by
global
population
growth
aging.
Depression
is
a
common
psychiatric
symptom
in
numerous
disorders.
It
also
risk
factor
for
Alzheimer's
disease
(AD)
other
dementias,
Parkinson's
(PD),
stroke.
rapid-acting
sustained
antidepressant
actions
(R,S)-ketamine
severe
depression
was
accidentally
discovered.
Interestingly,
(R)-ketamine
has
greater
potency
longer-lasting
antidepressant-like
effects
than
(S)-ketamine
rodents.
Importantly,
its
side
rodents
humans
lower
those
(S)-ketamine.
Furthermore,
could
elicit
beneficial
various
rodent
models
disorders,
including
PD,
multiple
sclerosis
(MS),
In
this
article,
we
review
potential
as
prophylactic
or
therapeutic
drug
AD
MS,
European Journal of Immunology,
Год журнала:
2023,
Номер
53(8)
Опубликована: Май 17, 2023
Abstract
The
advent
of
highly
effective
disease
modifying
therapy
has
transformed
the
landscape
multiple
sclerosis
(MS)
care
over
last
two
decades.
However,
there
remains
a
critical,
unmet
need
for
sensitive
and
specific
biomarkers
to
aid
in
diagnosis,
prognosis,
treatment
monitoring,
development
new
interventions,
particularly
people
with
progressive
disease.
This
review
evaluates
current
data
several
emerging
imaging
liquid
MS.
MRI
findings
such
as
central
vein
sign
paramagnetic
rim
lesions
may
improve
MS
diagnostic
accuracy
evaluation
efficacy
Serum
cerebrospinal
fluid
levels
neuroglial
proteins,
neurofilament
light
chain
glial
fibrillary
acidic
protein,
show
potential
be
pathologic
processes
neuro‐axonal
injury
or
glial‐inflammation.
Additional
promising
biomarkers,
including
optical
coherence
tomography,
cytokines
chemokines,
microRNAs,
extracellular
vesicles/exosomes,
are
also
reviewed,
among
others.
Beyond
their
integration
into
clinical
interventional
trials,
these
informative
pathogenesis
help
elucidate
novel
targets
strategies.
Cells,
Год журнала:
2024,
Номер
13(15), С. 1277 - 1277
Опубликована: Июль 30, 2024
MicroRNAs
(miRNAs)
are
small,
non-coding
RNAs
that
play
a
crucial
role
in
regulating
gene
expression.
Dysfunction
miRNAs
can
lead
to
various
diseases,
including
cancers,
neurological
disorders,
and
cardiovascular
conditions.
To
date,
approximately
2000
have
been
identified
humans.
These
small
molecules
shown
promise
as
disease
biomarkers
potential
therapeutic
targets.
Therefore,
identifying
miRNA
for
diseases
developing
effective
drug
delivery
systems
essential.
Nanotechnology
offers
promising
new
approaches
addressing
scientific
medical
challenges.
Traditional
detection
methods
include
next-generation
sequencing,
microarrays,
Northern
blotting,
reverse
transcription-quantitative
polymerase
chain
reaction
(RT-qPCR).
serve
an
alternative
blotting
RT-qPCR
detection.
Moreover,
nanomaterials
exhibit
unique
properties
differ
from
larger
counterparts,
enabling
therapeutics
more
effectively
enter
target
cells,
reduce
degradation
the
bloodstream,
be
released
specific
tissues
or
cells.
This
paper
reviews
application
of
nanotechnology
systems.
Given
still
stages,
holds
great
accelerating
development.
Frontiers in Molecular Neuroscience,
Год журнала:
2023,
Номер
16
Опубликована: Фев. 2, 2023
Spinal
cord
injury
(SCI)
is
a
global
medical
problem
with
high
disability
and
mortality
rates.
At
present,
the
diagnosis
treatment
of
SCI
are
still
lacking.
has
complex
etiology,
lack
diagnostic
methods,
poor
effect
other
problems,
which
lead
to
difficulty
spinal
regeneration
repair,
functional
recovery.
Recent
studies
have
shown
that
gene
expression
plays
an
important
role
in
regulation
repair.
MicroRNAs
(miRNAs)
non-coding
RNA
molecules
target
mRNA
order
silence,
translate,
or
interfere
protein
synthesis.
Secondary
damage,
such
as
oxidative
stress,
apoptosis,
autophagy,
inflammation,
occurs
after
SCI,
differentially
expressed
miRNAs
contribute
these
events.
This
article
reviews
pathophysiological
mechanism
secondary
focusing
on
neuroinflammation
so
provide
new
ideas
basis
for
clinical
SCI.
The
mechanisms
neurological
diseases
may
also
make
them
potential
biomarkers
therapeutic
targets
injuries.
It
has
been
well
validated
that
chronic
psychological
stress
leads
to
bone
loss,
but
the
underlying
mechanism
remains
unclarified.
In
this
study,
we
established
and
analyzed
unpredictable
mild
(CUMS)
mice
investigate
miRNA-related
pathogenic
involved
in
stress-induced
osteoporosis.
Our
result
found
these
CUMS
exhibited
osteoporosis
phenotype
is
mainly
attributed
abnormal
activities
of
osteoclasts.
Subsequently,
miRNA
sequencing
other
analysis
showed
miR-335-3p,
which
normally
highly
expressed
brain,
was
significantly
downregulated
nucleus
ambiguous,
serum,
mice.
Additionally,
vitro
studies
detected
miR-335-3p
important
for
osteoclast
differentiation,
with
its
direct
targeting
site
Fos
.
Further
demonstrated
FOS
upregulated
osteoclast,
inhibition
suppressed
accelerated
osteoclastic
as
expression
genes,
such
Nfatc1,
Acp5,
Mmp9
,
miR-335-3p-restrained
conclusion,
work
indicated
may
downregulate
expression,
resulted
accumulation
upregulation
NFACT1
signaling
pathway
osteoclasts,
leading
differentiation
activity.
These
results
decipher
a
previously
unrecognized
paradigm
can
act
link
between
metabolism.
Journal of Neurochemistry,
Год журнала:
2022,
Номер
164(3), С. 364 - 400
Опубликована: Май 10, 2022
With
the
emergence
of
positron
emission
tomography
(PET)
in
late
1970s,
psychiatry
had
access
to
a
tool
capable
non-invasive
assessment
human
brain
function.
Early
applications
focused
on
identifying
characteristic
blood
flow
and
metabolic
derangements
using
radiotracers
such
as
[15
O]H2
O
[18
F]FDG.
Despite
success
these
techniques,
it
became
apparent
that
more
specific
probes
were
needed
understand
neurochemical
bases
psychiatric
disorders.
The
first
PET
imaging
targeted
sites
action
neuroleptic
(dopamine
D2
receptors)
psychoactive
(serotonin
drugs.
Based
centrality
monoamine
dysfunction
disorders
measured
monoamine-enhancing
drugs
treating
them,
next
30
years
witnessed
development
an
armamentarium
radiopharmaceuticals
methodologies
for
studying
monoamines.
Continued
over
this
time
however
was
less
successful,
realizing
only
modest
gains
efficacy
tolerability.
As
patent
protection
many
widely
prescribed
profitable
lapsed,
drug
pipelines
shifted
away
from
monoamines
search
novel
targets
with
promises
improved
efficacy,
or
abandoned
altogether.
Over
period,
radiopharmaceutical
activities
closely
paralleled
priorities
resulting
new
agents
non-monoamine
targets.
Part
one
review
will
briefly
survey
relevance
field
psychiatry,
which
include
metabotropic
glutamate
receptor
type
5
(mGluR5),
purinergic
P2
X7
receptor,
1
cannabinoid
(CB1
),
phosphodiesterase
10A
(PDE10A),
describe
developed
other
have
matured
subject
investigations.
Current
limitations
techniques
also
be
discussed.
