Exploring miRNA Biomarkers in Major Depressive Disorder: A Molecular Medicine Perspective DOI Creative Commons
Cătălin Prodan-Bărbulescu, Laura Andreea Ghenciu,

Edward Paul Şeclăman

et al.

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(10), P. 10846 - 10853

Published: Sept. 27, 2024

Major depressive disorder (MDD) is a complex mental health condition with multifaceted and incompletely elucidated pathophysiology. MicroRNAs (miRNAs) have emerged as potential biomarkers due to their role in gene regulation the observed dysregulation MDD. The aim of this study detect presence specific molecular diagnostic major disorder. This cross-sectional analyzed plasma miRNA expression ten MDD patients eight healthy controls using real-time PCR. Differentially expressed miRNAs were identified independent t-tests, was assessed ROC curve analysis. Fifteen exhibited significant patients. Notably, hsa-miR-29c-3p, hsa-miR-376a-3p, hsa-miR-532-5p, hsa-miR-339-5p showed excellent discriminatory power (AUC > 0.8). identifies differentially MDD, suggesting for improved diagnosis personalized treatment. However, further validation larger cohorts investigation into functional roles are warranted.

Language: Английский

Phytanic Acid Intake and Lifestyle Modifications on Quality of Life in Individuals with Adult Refsum Disease: A Retrospective Survey Analysis DOI Creative Commons

Jeffrey J. Li,

Jane J. Kim, Fauzia Nausheen

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(11), P. 2551 - 2551

Published: May 30, 2023

Adult Refsum disease (ARD) is a rare peroxisomal biogenesis disorder inherited in an autosomal recessive fashion and often characterized by retinitis pigmentosa, cerebellar ataxia, polyneuropathy. Many patients with ARD require diet modification, psychosocial support, various specialist visits to manage their symptoms. In this study, we explored the quality of life individuals analyzing retrospective survey data collected Coordination Rare Diseases at Sanford (CoRDS) Registry Global Defeat Everywhere (DARE) Foundation. Statistical tests used were frequencies, mean, median. There 32 respondents, ranging between 11 responses for each question. The mean age diagnosis was 35.5 ± 14.5 years (range 6-64) 36.4% male 63.6% female respondents. average pigmentosa 22.8 15.7 2-61). Dieticians most frequently seen (41.7%) management low-phytanic-acid diets. Most participants exercise least once per week (92.5%). Depression symptoms reported 86.2% participants. Early important managing preventing progression visual impairment due phytanic acid buildup. Interdisciplinary approach should be address physical impairments ARD.

Language: Английский

Citations

6
piRNA and miRNA Can Suppress the Expression of Multiple Sclerosis Candidate Genes DOI Creative Commons
Saltanat Kamenova,

Aksholpan Sharapkhanova,

Aigul Akimniyazova

et al.

Nanomaterials, Journal Year: 2022, Volume and Issue: 13(1), P. 22 - 22

Published: Dec. 21, 2022

Multiple sclerosis (MS) is a common inflammatory demyelinating disease with high mortality rate. MS caused by many candidate genes whose specific involvement has yet to be established. The aim of our study was identify endogenous miRNAs and piRNAs involved in the regulation gene expression using bioinformatic methods. A program used quantify interaction miRNA piRNA nucleotides mRNA target genes. We 7310 from three databases 40,000 piRNAs. mRNAs revealed binding sites (BSs), which were located separately or formed clusters BSs overlapping nucleotide sequences. studied generally bound different combinations, but only one database some For first time, direct between complete sequence their shown. One several identified ADAM17, AHI1, CD226, EOMES, EVI5, IL12B, IL2RA, KIF21B, MGAT5, MLANA, SOX8, TNFRSF1A, ZBTB46 These form system coordinate synthesis proteins. Based on these findings, associations miRNAs, piRNAs, for diagnosis are recommended.

Language: Английский

Citations

10
Spinal Cord Injury: From MicroRNAs to Exosomal MicroRNAs DOI
Xiangyang Xu, Ruyin Liu, Yunpeng Li

et al.

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: 61(8), P. 5974 - 5991

Published: Jan. 23, 2024

Language: Английский

Citations

1
The modulation effect of green tea and pumpkin oils on hyperlipidemia, oxidative stress, and hematological abnormalities in an experimental multiple sclerosis rat model DOI Creative Commons
Nahed S. Lamloum,

Hanan A. Soliman,

Rasha R. Ahmed

et al.

Clinical Phytoscience, Journal Year: 2024, Volume and Issue: 10(1)

Published: March 4, 2024

Abstract Background Multiple sclerosis (MS) is a chronic inflammatory condition that can impair the body’s physiological functions. Although many diseases have been successfully treated with herbal treatments for long time, majority of herbs utilized unclear mechanisms. Therefore, this study aimed to examine modulation effects green tea oil (GTO) and pumpkin (PO) on hyperlipidemia, oxidative stress, hematological abnormalities in an experimental multiple rat model. Methods Forty albino male Wistar rats (weighing 120–140 g) were divided into four groups six each: group 1, control group; 2, myelin oligodendrocyte glycoprotein (MOG)-injected 3 4, MOG-injected GTO PO at 5 mg/kg b.w., respectively. At end experiments, animals anesthetized diethyl ether inhalation, blood samples collected from jugular vein. A Beckman Coulter was then used determine differential complete counts. The obtained serum rapidly stored 20 °C assess lipid profile stress antioxidant biomarkers. Results Our findings showed treatment produced significant reduction total cholesterol (TC), triglycerides (TG), high-density lipoprotein-cholesterol (HDL-C), low-density (LDL-C), very (VLDL-C) levels. Furthermore, alleviated elevated cardiovascular risk indices 1 2. Thiobarbituric acid reactive substance (TBARS) concentration significantly decreased glutathione (GSH), superoxide dismutase (SOD), peroxidase (GPx) levels increased injected MOG PO. after treatment, reduced red cells (RBCs) count, hemoglobin content (Hb%), lymphocyte percentage, hematocrit (HCT) increased, while white (WBCs), platelet, neutrophil percentage substantially declined. Conclusion Collectively, our research revealed may be capable modulating MS

Language: Английский

Citations

1
Molekulare Biomarker bei neuroinflammatorischen Erkrankungen DOI
Louisa Müller‐Miny, Jan D. Lünemann

Neurologie up2date, Journal Year: 2024, Volume and Issue: 07(01), P. 29 - 44

Published: March 1, 2024

Biomarker gelten als Schlüsselelement für die Umsetzung von Präzisionsmedizin. Technische Fortschritte in der Quantifizierbarkeit ZNS-Molekülen im peripheren Blut und Design klinischen Studien zur Identifizierung Validierung Biomarkern haben den letzten Jahren zu einer starken Dynamik Biomarkerentwicklung sowohl bei entzündlichen auch degenerativen Erkrankungen des Nervensystems geführt. Die vorliegende Übersicht fasst aktuellen Stand Entwicklungslinien molekularen neurologischen zusammen.

Citations

1
Psychological stress disturbs bone metabolism via miR-335-3p/Fos signaling in osteoclast DOI Creative Commons
Jiayao Zhang, Juan Li,

Jiehong Huang

et al.

eLife, Journal Year: 2024, Volume and Issue: 13

Published: April 29, 2024

It has been well validated that chronic psychological stress leads to bone loss, but the underlying mechanism remains unclarified. In this study, we established and analyzed unpredictable mild (CUMS) mice investigate miRNA-related pathogenic involved in stress-induced osteoporosis. Our result found these CUMS exhibited osteoporosis phenotype is mainly attributed abnormal activities of osteoclasts. Subsequently, miRNA sequencing other analysis showed miR-335-3p, which normally highly expressed brain, was significantly downregulated nucleus ambiguous, serum, mice. Additionally, vitro studies detected miR-335-3p important for osteoclast differentiation, with its direct targeting site Fos . Further demonstrated FOS upregulated osteoclast, inhibition suppressed accelerated osteoclastic as expression genes, such Nfatc1, Acp5, Mmp9 , miR-335-3p-restrained conclusion, work indicated may downregulate expression, resulted accumulation upregulation NFACT1 signaling pathway osteoclasts, leading differentiation activity. These results decipher a previously unrecognized paradigm can act link between metabolism.

Language: Английский

Citations

1
The effects of venlafaxine on depressive-like behaviors and gut microbiome in cuprizone-treated mice DOI Creative Commons

Chunhai Du,

Tian Zhang,

Chong Feng

et al.

Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15

Published: June 3, 2024

Background Cuprizone (CPZ)-treated mice show significant demyelination, altered gut microbiome, and depressive-like behaviors. However, the effects of venlafaxine (Ven) on microbiome behavior CPZ-treated are largely unclear. Methods Male C57BL/6J were fed a chow containing 0.2% cuprizone (w/w) for 5 weeks to induce model demyelination. Meanwhile, microbiota behaviors assessed after with Ven (20 mg/kg/day) or equal volumes distilled water 2 by oral gavage from third week onward during CPZ treatment. Results treatment decreased sucrose preference rate in test increased immobility time tail-suspension test, it also induced an abnormality β-diversity changes microbial composition. alleviated regulated composition microbiota, such as increase Lactobacillus Bifidobacterium mice. Conclusion The anti-depressant might be related regulation

Language: Английский

Citations

1
The Impacts of the Clinical and Genetic Factors on Chronic Damage in Caucasian Systemic Lupus Erythematosus Patients DOI Open Access
Fulvia Ceccarelli, G. Olivieri, Carmelo Pirone

et al.

Journal of Clinical Medicine, Journal Year: 2022, Volume and Issue: 11(12), P. 3368 - 3368

Published: June 12, 2022

Objective: The purpose of this study was to determine the distribution organ damage in a cohort systemic lupus erythematosus (SLE) patients and evaluate roles clinical genetic factors determining development chronic damage. Methods: Organ assessed by SLICC Damage Index (SDI). We analyzed panel 17 single-nucleotide polymorphism (SNPs) genes already associated with SLE, we performed phenotype–genotype correlation analysis evaluating specific domains SDI. Results: Among 175 Caucasian SLE patients, 105 (60%) exhibited (SDI ≥1), median value 1.0 (IQR 3.0). musculoskeletal (26.2%), neuropsychiatric (24.6%) ocular (20.6%) were involved most frequently. presence higher age, longer disease duration, (NP) manifestations, anti-phospholipid syndrome positivity anti-dsDNA. Concerning therapies, cyclophosphamide, mycophenolate mofetil glucocorticoids genotype–phenotype showed an association between renal damage, identified 6.9% rs2205960 TNFSF4 (p = 0.001; OR 17.0). This SNP significantly end-stage 0.018, 9.68) estimated GFR < 50% 0.025, 1.06). rs1463335 MIR1279 gene NP 0.029; 2.783). multivariate logistic regression confirmed associations 0.027, B 2.47) 0.014, 1.29). Conclusions: Our could provide new insights into role background

Language: Английский

Citations

5
Relationship Between Fatigue, Cognitive Functions, Depression, and Disability in Multiple Sclerosis Patients DOI Creative Commons
Gökçe Zeytin Demiral

Acta Medica Alanya, Journal Year: 2023, Volume and Issue: 7(2), P. 184 - 189

Published: Oct. 14, 2023

Aim : Multiple Sclerosis (MS) is a chronic, progressive, and neurodegenerative disorder of the central nervous system. It frequently leads to symptoms such as disability, cognitive impairment, fatigue, depression. This study aims examine relationship between functions, depression, disability among individuals with MS. Methods: Seventy-four MS patients were evaluated by using Cognitive Failure Questionnaire (CFQ) battery. The Expanded Disability Status Scale (EDSS) was used in determining level whereas Fatigue Severity (FSS) Beck Depression Inventory (BDI) utilized measuring levels fatigue respectively. Results :Moderate positive correlations found EDSS BDI (r1=0.342; p&lt;0.001), FSS (r1=0.392; CFQ (r1=0.451; (r1=0.425; (r1=0.424; p&lt;0.001). Conclusion :The results achieved this indicate that depression increase increases impairment associated both fatigue.

Language: Английский

Citations

2
Epigenetics: Implication on Multiple Sclerosis DOI

Rawdah Elbahrawi,

Sara Aljoudi,

Nadia Rabeh

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

0