Integrated transcriptomics and metabolomics reveal the mechanism of intestinal damage upon acute patulin exposure in mice DOI Creative Commons
Ting Zhang, Min Yan,

Min Chang

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 276, P. 116270 - 116270

Published: April 3, 2024

Mycotoxin contamination has become a major food safety issue and greatly threatens human animal health. Patulin (PAT), common mycotoxin in the environment, is exposed through chain damages gastrointestinal tract. However, its mechanism of enterotoxicity at genetic metabolic levels remains to be elucidated. Herein, intestinal histopathological biochemical indices, transcriptome, metabolome C57BL/6 J mice different doses PAT were successively assessed, as well toxicokinetics vivo. The results showed that acute exposure induced damaged villi crypts, reduced mucus secretion, decreased SOD GSH-Px activities, enhanced MPO activity small intestine mild damage colon. At transcriptional level, genes affected by dose-dependently altered fluctuated primarily inflammation-related signaling pathways oxidative phosphorylation immune responses amino acids decreased, extensive lipids accumulated Seven jointly two sites. Moreover, changes products GST detected tissue but not colonic tissue, explaining degrees Finally, integrated collectively explained toxicological PAT, which directly colon indirectly. These paint clear panorama after provide valuable information on risk toxic PAT.

Language: Английский

The Role of Serotonin Neurotransmission in Gastrointestinal Tract and Pharmacotherapy DOI Creative Commons
Tomasz Guzel, Dagmara Mirowska‐Guzel

Molecules, Journal Year: 2022, Volume and Issue: 27(5), P. 1680 - 1680

Published: March 3, 2022

5-Hydroxytryptamine (5-HT, serotonin) is a neurotransmitter in both the central nervous system and peripheral structures, acting also as hormone platelets. Although its concentration gut covers >90% of all organism resources, serotonin mainly known that takes part pathology mental diseases. Serotonin modulates not only CNS neurons, but pain transmission platelet aggregation. In periphery, 5-HT influences muscle motility gut, bronchi, uterus, vessels directly through neurons. synthesis starts from hydroxylation orally delivered tryptophan, followed by decarboxylation. acts via numerous types receptors clinically plays role several neural, mental, other chronic disorders, such migraine, carcinoid syndrome, some dysfunctions alimentary system. paracrine growth factor. brain are targets for drugs modifying neurotransmission. The aim present article to review gastrointestinal (GI) tract determine GI physiology pathology, including diseases pharmacotherapy.

Language: Английский

Citations

98
Gut liver brain axis in diseases: the implications for therapeutic interventions DOI Creative Commons

Mengyao Yan,

Shuli Man,

Benyue Sun

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Dec. 6, 2023

Gut-liver-brain axis is a three-way highway of information interaction system among the gastrointestinal tract, liver, and nervous systems. In past few decades, breakthrough progress has been made in gut liver brain axis, mainly through understanding its formation mechanism increasing treatment strategies. this review, we discuss various complex networks including barrier permeability, hormones, microbial metabolites, vagus nerve, neurotransmitters, immunity, toxic β-amyloid (Aβ) metabolism, epigenetic regulation gut-liver-brain axis. Some therapies containing antibiotics, probiotics, prebiotics, synbiotics, fecal microbiota transplantation (FMT), polyphenols, low FODMAP diet nanotechnology application regulate Besides, some special treatments targeting gut-liver include farnesoid X receptor (FXR) agonists, takeda G protein-coupled 5 (TGR5) glucagon-like peptide-1 (GLP-1) antagonists fibroblast growth factor 19 (FGF19) analogs. Targeting gut-brain embraces cognitive behavioral therapy (CBT), antidepressants tryptophan metabolism-related therapies. liver-brain contains Aβ future, better interactions will promote development novel preventative strategies discovery precise therapeutic targets multiple diseases.

Language: Английский

Citations

86
The interplay between sleep and gut microbiota DOI
Mengqi Han, Shiying Yuan, Jiancheng Zhang

et al.

Brain Research Bulletin, Journal Year: 2022, Volume and Issue: 180, P. 131 - 146

Published: Jan. 13, 2022

Language: Английский

Citations

80
Insights from antibiotic-induced gut microbiota dysbiosis and metabolic changes in the gut and hypothalamus into the microbiota–gut–brain axis in large yellow croaker (Larimichthys crocea) DOI
Jingan Wang, Mingtao Lei, Yu Liu

et al.

Aquaculture, Journal Year: 2025, Volume and Issue: unknown, P. 742157 - 742157

Published: Jan. 1, 2025

Language: Английский

Citations

2
Neurotransmitter and Intestinal Interactions: Focus on the Microbiota-Gut-Brain Axis in Irritable Bowel Syndrome DOI Creative Commons
Minjia Chen, Guangcong Ruan, Lu Chen

et al.

Frontiers in Endocrinology, Journal Year: 2022, Volume and Issue: 13

Published: Feb. 16, 2022

Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder of unknown etiology. IBS caused by disruption in the gut-brain axis. Given importance gut microbiota maintaining local and systemic homeostasis immunity, endocrine, other physiological processes, microbiota-gut-brain axis has been proposed as key regulator IBS. Neurotransmitters have shown to affect blood flow regulation, intestinal motility, nutrient absorption, immune system, recent studies. It potential role play function pathophysiology neurological systems. Transmitters their receptors, including 5-hydroxytryptamine, dopamine, γ-aminobutyric acid, histamine, an important IBS, especially visceral sensitivity motility. Studies this field shed light on revealing mechanism which neurotransmitters act pathogenesis discovering new therapeutic strategies based traditional pharmacological approaches that target nervous system or novel therapies microbiota.

Language: Английский

Citations

69
Interactions between Tryptophan Metabolism, the Gut Microbiome and the Immune System as Potential Drivers of Non-Alcoholic Fatty Liver Disease (NAFLD) and Metabolic Diseases DOI Creative Commons

Charlotte Teunis,

Max Nieuwdorp, Nordin M.J. Hanssen

et al.

Metabolites, Journal Year: 2022, Volume and Issue: 12(6), P. 514 - 514

Published: June 2, 2022

The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing and therefore its burden as NALFD a risk factor for cirrhosis associated with other metabolic conditions such type II diabetes, obesity, dyslipidaemia atherosclerosis. Linking these cardiometabolic diseases state low-grade inflammation, higher cytokines c-reactive protein levels found in individuals NAFLD, obesity diabetes. A possible therapeutic target to decrease this inflammation the metabolism essential amino-acid tryptophan. Its three main pathways (kynurenine pathway, indole pathway serotonin/melatonin pathway) result metabolites kynurenic acid, xanturenic indole-3-propionic acid serotonin/melatonin. kynurenine regulated by indoleamine 2,3-dioxygenase (IDO), an enzyme that upregulated pro-inflammatory molecules INF, IL-6 LPS. Higher activity IDO increased fibrosis well glucose levels, On hand, concentrations metabolites, gut microbiome, seem more favorable outcomes. This narrative review summarizes interactions between tryptophan metabolism, microbiome immune system potential drivers NAFLD.

Language: Английский

Citations

69
Cardiac Roles of Serotonin (5-HT) and 5-HT-Receptors in Health and Disease DOI Open Access
Joachim Neumann, Britt Hofmann, Stefan Dhein

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(5), P. 4765 - 4765

Published: March 1, 2023

Serotonin acts solely via 5-HT4-receptors to control human cardiac contractile function. The effects of serotonin lead positive inotropic and chronotropic effects, as well arrhythmias, in the heart. In addition, may play a role sepsis, ischaemia, reperfusion. These presumptive are focus present review. We also discuss formation inactivation body, namely, identify cardiovascular diseases where might causative or additional role. address mechanisms which can use for signal transduction their possible roles diseases. define areas further research this regard should be directed future, animal models that generated end. Finally, we what 5-HT4-receptor agonists antagonists useful drugs could enter clinical practice. has been target many studies decades; thus, found it timely summarise our current knowledge here.

Language: Английский

Citations

41
Exploring the serotonin‐probiotics‐gut health axis: A review of current evidence and potential mechanisms DOI Creative Commons
Noor Akram, Zargham Faisal, Rushba Irfan

et al.

Food Science & Nutrition, Journal Year: 2023, Volume and Issue: 12(2), P. 694 - 706

Published: Dec. 7, 2023

Modulatory effects of serotonin (5-Hydroxytryptamine [5-HT]) have been seen in hepatic, neurological/psychiatric, and gastrointestinal (GI) disorders. Probiotics are live microorganisms that confer health benefits to their host. Recent research has suggested probiotics can promote signaling, a crucial pathway the regulation mood, cognition, other physiological processes. Reviewing literature, we find peripheral increases nutrient uptake storage, regulates composition gut microbiota, is involved mediating neuronal This review explores mechanisms underlying probiotic-mediated increase highlighting role microbiota production modulation neurotransmitter receptors. Additionally, this discusses potential clinical implications as therapeutic strategy for disorders associated with altered such GI neurological Overall, demonstrates promising avenue treatment serotonin-related signaling serotonin.

Language: Английский

Citations

38
Neuroinflammation through the vagus nerve-dependent gut–microbiota–brain axis in treatment-resistant depression DOI
Kenji Hashimoto

Progress in brain research, Journal Year: 2023, Volume and Issue: unknown, P. 61 - 77

Published: Jan. 1, 2023

Language: Английский

Citations

31
Bifidobacterium longum promotes postoperative liver function recovery in patients with hepatocellular carcinoma DOI Creative Commons
Jingjing Yu, Peng Zhu,

Linlin Shi

et al.

Cell Host & Microbe, Journal Year: 2023, Volume and Issue: 32(1), P. 131 - 144.e6

Published: Dec. 12, 2023

Timely liver function recovery (LFR) is crucial for postoperative hepatocellular carcinoma (HCC) patients. Here, we established the significance of LFR on patient long-term survival through retrospective and prospective cohorts identified a key gut microbe, Bifidobacterium longum, depleted in patients with delayed recovery. Fecal microbiota transfer from HCC to mice similarly impacted time post hepatectomy. However, oral gavage B. longum improved repair these mice. In clinical trial patients, orally administering probiotic bacteria cocktail containing reduced rates recovery, shortened hospital stays, overall 1-year survival. These benefits, attributed diminished inflammation, fibrosis, hepatocyte proliferation, were associated changes metabolic pathways, including 5-hydroxytryptamine, secondary bile acids, short-chain fatty acids. Our findings propose that modulation can enhance LFR, thereby improving outcomes

Language: Английский

Citations

29