Critical Review of the Cross-Links Between Dietary Components, the Gut Microbiome, and Depression

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 614 - 614

Published: Jan. 13, 2025

The complex relationship between diet, the gut microbiota, and mental health, particularly depression, has become a focal point of contemporary research. This critical review examines how specific dietary components, such as fiber, proteins, fats, vitamins, minerals, bioactive compounds, shape microbiome influence microbial metabolism in order to regulate depressive outcomes. These dietary-induced changes microbiota can modulate production metabolites, which play vital roles gut–brain communication. axis facilitates this communication through neural, immune, endocrine pathways. Alterations metabolites central nervous system (CNS) functions by impacting neuroplasticity, inflammatory responses, neurotransmitter levels—all are linked onset course depression. highlights recent findings linking components with beneficial composition reduced symptoms. We also explore challenges individual variability responses interventions long-term sustainability these strategies. underscores necessity for further longitudinal mechanistic studies elucidate precise mechanisms diet interactions be leveraged mitigate paving way personalized nutritional therapies.

Language: Английский

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Modulation of the Neuro–Cancer Connection by Metabolites of Gut Microbiota

Biomolecules, Journal Year: 2025, Volume and Issue: 15(2), P. 270 - 270

Published: Feb. 12, 2025

The gut-brain-cancer axis represents a novel and intricate connection between the gut microbiota, neurobiology, cancer progression. Recent advances have accentuated significant role of microbiota metabolites in modulating systemic processes that influence both brain health tumorigenesis. This paper explores emerging concept metabolite-mediated modulation within connection, focusing on key such as short-chain fatty acids (SCFAs), tryptophan derivatives, secondary bile acids, lipopolysaccharides (LPS). While microbiota's impact immune regulation, neuroinflammation, tumor development is well established, gaps remain grasping how specific contribute to neuro-cancer interactions. We discuss with potential implications for neurobiology cancer, indoles polyamines, which yet be extensively studied. Furthermore, we review preclinical clinical evidence linking dysbiosis, altered metabolite profiles, tumors, showcasing limitations research gaps, particularly human longitudinal studies. Case studies investigating microbiota-based interventions, including dietary changes, fecal transplantation, probiotics, demonstrate promise but also indicate hurdles translating these findings therapies. concludes call standardized multi-omics approaches bi-directional frameworks integrating microbiome, neuroscience, oncology develop personalized therapeutic strategies patients.

Language: Английский

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Interkingdom signaling between gastrointestinal hormones and the gut microbiome

Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 24, 2025

The interplay between the gut microbiota and gastrointestinal hormones plays a pivotal role in health of host development diseases. As vital component intestinal microecosystem, influences synthesis release many through mechanisms such as modulating environment, producing metabolites, impacting mucosal barriers, generating immune inflammatory responses, releasing neurotransmitters. Conversely, exert feedback regulation on by nutrient absorption utilization, bacterial biological behavior composition. distributions are anatomically intertwined, close interactions crucial for maintaining homeostasis. Interventions leveraging have been employed clinical management metabolic diseases bowel diseases, bariatric surgery fecal transplantation, offering promising targets treatment dysbiosis-related

Language: Английский

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Role of Probiotics in Depression: Connecting Dots of Gut-Brain-Axis Through Hypothalamic-Pituitary Adrenal Axis and Tryptophan/Kynurenic Pathway involving Indoleamine-2,3-dioxygenase

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Language: Английский

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Interactions between Tryptophan Metabolism, the Gut Microbiome and the Immune System as Potential Drivers of Non-Alcoholic Fatty Liver Disease (NAFLD) and Metabolic Diseases

Metabolites, Journal Year: 2022, Volume and Issue: 12(6), P. 514 - 514

Published: June 2, 2022

The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing and therefore its burden as NALFD a risk factor for cirrhosis associated with other metabolic conditions such type II diabetes, obesity, dyslipidaemia atherosclerosis. Linking these cardiometabolic diseases state low-grade inflammation, higher cytokines c-reactive protein levels found in individuals NAFLD, obesity diabetes. A possible therapeutic target to decrease this inflammation the metabolism essential amino-acid tryptophan. Its three main pathways (kynurenine pathway, indole pathway serotonin/melatonin pathway) result metabolites kynurenic acid, xanturenic indole-3-propionic acid serotonin/melatonin. kynurenine regulated by indoleamine 2,3-dioxygenase (IDO), an enzyme that upregulated pro-inflammatory molecules INF, IL-6 LPS. Higher activity IDO increased fibrosis well glucose levels, On hand, concentrations metabolites, gut microbiome, seem more favorable outcomes. This narrative review summarizes interactions between tryptophan metabolism, microbiome immune system potential drivers NAFLD.

Language: Английский

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Synthesis, Molecular Docking, and Biological Evaluation of Novel Anthranilic Acid Hybrid and Its Diamides as Antispasmodics

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(18), P. 13855 - 13855

Published: Sept. 8, 2023

The present article focuses on the synthesis and biological evaluation of a novel anthranilic acid hybrid its diamides as antispasmodics. Methods: Due to predicted in silico methods spasmolytic activity, we synthesized molecule 2-(3-chlorophenyl)ethylamine. obtained was then applied acylation with different acyl chlorides. Using analysis, pharmacodynamic profiles compounds were predicted. A thorough conducted assessing their vitro antimicrobial, cytotoxic, anti-inflammatory ex vivo activity. Density functional theory (DFT) calculation, including geometry optimization, molecular electrostatic potential (MEP) surface, HOMO-LUMO analysis for using B3LYP/6-311G(d,p) method explore electronic behavior, reactive regions, stability chemical reactivity compounds. Furthermore, docking simulation along viscosity measurement indicated that newly interact DNA via groove binding mode. results from all experiments demonstrate inherit spasmolytic, capabilities, making them excellent candidates future medications.

Language: Английский

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Exploring the serotonin‐probiotics‐gut health axis: A review of current evidence and potential mechanisms

Food Science & Nutrition, Journal Year: 2023, Volume and Issue: 12(2), P. 694 - 706

Published: Dec. 7, 2023

Modulatory effects of serotonin (5-Hydroxytryptamine [5-HT]) have been seen in hepatic, neurological/psychiatric, and gastrointestinal (GI) disorders. Probiotics are live microorganisms that confer health benefits to their host. Recent research has suggested probiotics can promote signaling, a crucial pathway the regulation mood, cognition, other physiological processes. Reviewing literature, we find peripheral increases nutrient uptake storage, regulates composition gut microbiota, is involved mediating neuronal This review explores mechanisms underlying probiotic-mediated increase highlighting role microbiota production modulation neurotransmitter receptors. Additionally, this discusses potential clinical implications as therapeutic strategy for disorders associated with altered such GI neurological Overall, demonstrates promising avenue treatment serotonin-related signaling serotonin.

Language: Английский

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Podophyllotoxin-mediated neurotoxicity via the microbiota-gut-brain axis in SD rats based on the toxicological evidence chain (TEC) concept

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 907, P. 168106 - 168106

Published: Oct. 24, 2023

Language: Английский

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Latest updates on the serotonergic system in depression and anxiety

Frontiers in Synaptic Neuroscience, Journal Year: 2023, Volume and Issue: 15

Published: May 9, 2023

Psychiatric disorders are among the leading causes of global health burden, with depression and anxiety being most disabling subtypes. The two common disorders, anxiety, usually coexist pathologically polygenic complicated etiologies. Current drug-based therapies include selective serotonin reuptake inhibitors, norepinephrine 5-hydroxytryptamine partial agonists. However, these modalities share limitations, such as slow onset low efficacy, which is why potential mechanistic insights for new drug targets needed. In this review, we summarize recent advances in brain localization, pathology, therapeutic mechanisms serotonergic system anxiety.

Language: Английский

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Shared genetic architecture between irritable bowel syndrome and psychiatric disorders reveals molecular pathways of the gut-brain axis

Genome Medicine, Journal Year: 2023, Volume and Issue: 15(1)

Published: Aug. 1, 2023

Abstract Background Irritable bowel syndrome (IBS) often co-occurs with psychiatric and gastrointestinal disorders. A recent genome-wide association study (GWAS) identified several genetic risk variants for IBS. However, most of the heritability remains unidentified, overlap somatic disorders is not quantified beyond correlations. Here, we characterize architecture IBS, further, investigate its phenotypes, identify novel genomic loci. Methods Using GWAS summary statistics IBS (53,400 cases 433,201 controls), performed bivariate casual mixture model analysis to between these phenotypes. We leveraged boost discovery loci associated specific shared both using conditional/conjunctional false rate (condFDR/conjFDR) framework. used functional mapping gene annotation (FUMA) analyses. Results was highly polygenic 12k trait-influencing variants. found extensive a lesser extent diseases. 132 independent IBS-associated (condFDR < 0.05) by conditioning on ( n = 127) diseases 24). conjFDR, 70 unique were Functional analyses revealed enrichment biological pathways nervous immune systems. Genetic correlations subtypes different. Conclusions phenotypes what Leveraging overlap, discovered which implicate wide range gut-brain axis. differences may underlie clinical subtype These results increase our understanding pathophysiology form basis development individualized interventions.

Language: Английский

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