Crosstalk between COVID-19 Infection and Kidney Diseases: A Review on the Metabolomic Approaches DOI Creative Commons

Reshma Murali,

Uddesh Ramesh Wanjari, Anirban Goutam Mukherjee

et al.

Vaccines, Journal Year: 2023, Volume and Issue: 11(2), P. 489 - 489

Published: Feb. 20, 2023

The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19, a disorder. Various organ injuries have been reported in response to this virus, including kidney injury and, particular, tubular injury. It has discovered that infection with the virus does not only cause new disease but also increases treatment difficulty and mortality rates people diseases. In individuals hospitalized urinary metabolites from several metabolic pathways are used distinguish between patients (AKI) those without. This review summarizes pathogenesis, pathophysiology, strategies, role of metabolomics relation AKI COVID-19 patients. Metabolomics is likely play greater predicting outcomes for varying levels severity near future as data on profiles expand rapidly. Here, we discuss correlation diseases available approaches.

Language: Английский

Molecular pathways involved in COVID-19 and potential pathway-based therapeutic targets DOI Open Access
Masoumeh Farahani, Zahra Niknam, Leila Mohammadi Amirabad

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2021, Volume and Issue: 145, P. 112420 - 112420

Published: Nov. 12, 2021

Deciphering the molecular downstream consequences of severe acute respiratory syndrome coronavirus (SARS-CoV)- 2 infection is important for a greater understanding disease and treatment planning. Furthermore, underlying mechanisms diagnostic therapeutic strategies can help in development vaccines drugs against COVID-19. At present, SARS-CoV-2 host cells are not sufficiently comprehended. Some proposed considering existing similarities between other members β-CoVs, others explained based on studies advanced structure function SARS-CoV-2. In this review, we endeavored to map possible response following surveyed current research conducted by vitro, vivo human observations, as well suggestions. We addressed specific signaling events that cause cytokine storm demonstrated three forms cell death virus infection, including apoptosis, pyroptosis, necroptosis. Given elicited pathways, introduced pathway-based targets; ADAM17 was especially highlighted one most elements several pathways involved immunopathogenesis also provided drug candidates these targets. Moreover, cytokine-cytokine receptor interaction pathway found cross-talk through pathway-pathway analysis infection.

Language: Английский

Citations

103
The association of COVID-19 severity and susceptibility and genetic risk factors: A systematic review of the literature DOI Open Access
Angela Ishak, Meghana Mehendale, Mousa M. AlRawashdeh

et al.

Gene, Journal Year: 2022, Volume and Issue: 836, P. 146674 - 146674

Published: June 14, 2022

Language: Английский

Citations

41
Is Covid-19 Severity Associated With ACE2 Degradation? DOI Creative Commons
Ugo Bastolla, Patrick Chambers, David Abia

et al.

Frontiers in Drug Discovery, Journal Year: 2022, Volume and Issue: 1

Published: Jan. 25, 2022

Covid-19 is particularly mild with children, and its severity escalates age. Several theories have been proposed to explain these facts. In particular, it was that the lower expression of viral receptor ACE2 in children protects them from severe Covid-19. However, other works suggested an inverse relationship between disease severity. Here we review seemingly contradicting observations on at levels mRNA, membrane protein serum humans rodents try reconcile light Renin-Angiotensin system (RAS) bradykinin system, which constitute integrated inflammatory connected by common peptidases interacting receptors. We find level not monotonically related age but reaches a maximum young depends cell type then decreases, consistently almost all existing data. The increase protease Tumor necrosis factor alpha (TNF- α ) converting enzyme (TACE), also known as ADAM17 (a disintegrin metalloproteinase 17) sheds predicts decrease occurs before steeper for than mRNA. This negative relation old paradoxical consistent mathematical model higher does necessarily favour virus propagation can even slow down. More importantly, angiotensin-bradykinin characterized powerful positive feedback loop enhances inflammation through Angiotensin Bradykinin receptors upregulate ADAM17, turn downregulates upregulates TNF- pro-inflammatory cytokine interleukin 6 (IL6). propose contributes essentially reverse this state downregulating peptides failure do this, possibly induced degradation SARS-COV-2, may underlie both CoViD-19 infection many post-infection manifestations, including multi-inflammatory syndrome (MIS-C). Within view, despite be their alternative angiotensin II ATR2 general anti-inflammatory arm RAS

Language: Английский

Citations

39
Innate and Adaptive Immunity during SARS-CoV-2 Infection: Biomolecular Cellular Markers and Mechanisms DOI Creative Commons
Brent Brown,

Vanshika Ojha,

Ingo Fricke

et al.

Vaccines, Journal Year: 2023, Volume and Issue: 11(2), P. 408 - 408

Published: Feb. 10, 2023

The coronavirus 2019 (COVID-19) pandemic was caused by a positive sense single-stranded RNA (ssRNA) severe acute respiratory syndrome 2 (SARS-CoV-2). However, other human coronaviruses (hCoVs) exist. Historical pandemics include smallpox and influenza, with efficacious therapeutics utilized to reduce overall disease burden through effectively targeting competent host immune system response. is composed of primary/secondary lymphoid structures initially eight types cell types, many subtypes, traversing membranes utilizing signaling cascades that contribute towards clearance pathogenic proteins. Other proteins discussed cluster differentiation (CD) markers, major histocompatibility complexes (MHC), pleiotropic interleukins (IL), chemokines (CXC). historical concepts immunity are the innate adaptive systems. represented T cells, B antibodies. macrophages, neutrophils, dendritic complement system. viruses can affect regulate cycle progression for example, in cancers papillomavirus (HPV: cervical carcinoma), Epstein-Barr virus (EBV: lymphoma), Hepatitis C (HB/HC: hepatocellular carcinoma) Leukemia Virus-1 (T leukemia). Bacterial infections also increase risk developing cancer (e.g.,

Language: Английский

Citations

37
Differential Co-Expression Network Analysis Reveals Key Hub-High Traffic Genes as Potential Therapeutic Targets for COVID-19 Pandemic DOI Creative Commons
Aliakbar Hasankhani, Abolfazl Bahrami, Negin Sheybani

et al.

Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 12

Published: Dec. 15, 2021

The recent emergence of COVID-19, rapid worldwide spread, and incomplete knowledge molecular mechanisms underlying SARS-CoV-2 infection have limited development therapeutic strategies. Our objective was to systematically investigate regulatory using a combination high throughput RNA-sequencing-based transcriptomics systems biology approaches.

Language: Английский

Citations

52
COVID-19 patients with high TNF/IFN-γ levels show hallmarks of PANoptosis, an inflammatory cell death DOI Creative Commons
Yadira Palacios, Lucero A. Ramón‐Luing, Andy Ruíz

et al.

Microbes and Infection, Journal Year: 2023, Volume and Issue: 25(8), P. 105179 - 105179

Published: July 1, 2023

TNF and IFN-γ trigger cell damage during SARS CoV-2 infection; these cytokines can induce senescence a death process called PANoptosis. This study included 138 vaccine-naïve COVID-19 patients, who were divided into four groups (Gp) according to the plasma level of (High [

Language: Английский

Citations

18
S Protein, ACE2 and Host Cell Proteases in SARS-CoV-2 Cell Entry and Infectivity; Is Soluble ACE2 a Two Blade Sword? A Narrative Review DOI Creative Commons
Reza Nejat,

Maziar Fayaz Torshizi,

David J. Najafi

et al.

Vaccines, Journal Year: 2023, Volume and Issue: 11(2), P. 204 - 204

Published: Jan. 17, 2023

Since the spread of deadly virus SARS-CoV-2 in late 2019, researchers have restlessly sought to unravel how enters host cells. Some proteins on each side interaction between and cells are involved as major contributors this process: (1) nano-machine spike protein behalf virus, (2) angiotensin converting enzyme II, mono-carboxypeptidase key component renin system cell, (3) some proteases exploited by SARS-CoV-2. In review, complex process entrance into with contribution well sequential conformational changes tending increase probability complexification latter receptor cells, discussed. Moreover, release catalytic ectodomain II its soluble form extracellular space positive or negative impact infectivity considered.

Language: Английский

Citations

17
Factors Modulating COVID-19: A Mechanistic Understanding Based on the Adverse Outcome Pathway Framework DOI Open Access
Laure‐Alix Clerbaux, Maria Cristina Albertini, Núria Amigó

et al.

Journal of Clinical Medicine, Journal Year: 2022, Volume and Issue: 11(15), P. 4464 - 4464

Published: July 31, 2022

Addressing factors modulating COVID-19 is crucial since abundant clinical evidence shows that outcomes are markedly heterogeneous between patients. This requires identifying the and understanding how they mechanistically influence COVID-19. Here, we describe eleven selected (age, sex, genetic factors, lipid disorders, heart failure, gut dysbiosis, diet, vitamin D deficiency, air pollution exposure to chemicals) by applying Adverse Outcome Pathway (AOP), which well-established in regulatory toxicology. framework aims model sequence of events leading an adverse health outcome. Several linear AOPs depicting pathways from binding virus ACE2 up observed have been developed integrated into a network offering unique overview mechanisms underlying disease. As SARS-CoV-2 infectibility activity major starting points inflammatory response central development COVID-19, evaluated those intrinsic extrinsic modulate processes impacting outcomes. Applying this AOP-aligned approach enables identification current knowledge gaps orientating for further research allows propose biomarkers identify high-risk also facilitates expertise synergy different disciplines address public issues.

Language: Английский

Citations

23
Coagulopathy and Fibrinolytic Pathophysiology in COVID-19 and SARS-CoV-2 Vaccination DOI Open Access
Shinya Yamada, Hidesaku Asakura

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(6), P. 3338 - 3338

Published: March 19, 2022

Coronavirus Disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and frequently complicated thrombosis. In some cases of COVID-19, fibrinolysis may be markedly enhanced within a few days, resulting in fatal bleeding. the treatment attention should paid to both coagulation activation fibrinolytic activation. Various thromboses are known occur after vaccination with SARS-CoV-2 vaccines. Vaccine-induced immune thrombotic thrombocytopenia (VITT) can adenovirus-vectored vaccination, characterized detection anti-platelet factor 4 antibodies enzyme-linked immunosorbent assay thrombosis unusual locations such as cerebral venous sinuses visceral veins. Treatment comprises high-dose immunoglobulin, argatroban, fondaparinux. Some VITT show marked decreases fibrinogen platelets increases D-dimer, suggesting presence enhanced-fibrinolytic-type disseminated intravascular high risk VITT, evaluation important, adjusting treatments accordingly improve outcomes.

Language: Английский

Citations

21
Immune system-related soluble mediators and COVID-19: basic mechanisms and clinical perspectives DOI Creative Commons
Mohammad Sadegh Soltani‐Zangbar, Forough Parhizkar,

Mojtaba Abdollahi

et al.

Cell Communication and Signaling, Journal Year: 2022, Volume and Issue: 20(1)

Published: Aug. 29, 2022

Abstract During SARS-CoV-2 infection, an effective immune response provides the first line of defense; however, excessive inflammatory innate immunity and impaired adaptive may harm tissues. Soluble mediators are involved in dynamic interaction ligands with membrane-bound receptors to maintain restore health after pathological events. In some cases, dysregulation their expression can lead disease pathology. this literature review, we described current knowledge basic features soluble during infections highlighted contribution severity mortality.

Language: Английский

Citations

21