Differences in the prevalence of allergy and asthma among US children and adolescents during and before the COVID-19 pandemic DOI Creative Commons

Yingyu Liang,

Qian Li, Man Wang

et al.

BMC Public Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: Aug. 6, 2024

The increasing prevalence of allergies and asthma has led to a growing global socioeconomic burden. Since the outbreak COVID-19 pandemic, health lifestyles children adolescents have changed dramatically. It's unclear how this shift impacted allergy asthma, with limited studies addressing question. We aim explore difference among US during before pandemic using nationally representative sample adolescents. This cross-sectional study included 31,503 participants in National Health Interview Survey (NHIS) between 2018 2021. Allergies were defined on an affirmative response questionnaire by parent or guardian. Chi-square tests used compare baseline characteristics for categorical variables. Differences estimated weighted logistic regression, adjusting demographic factors. Interaction analyses explored variations across strata. In aged 0 17, any was 26.1% (95% CI, 24.8%- 27.4%) 27.1% 25.9%- 28.2%) Thereinto, 2018, respiratory allergies, food skin 14.0% 13.1%- 15.0%), 6.5% 5.8%- 7.1%) 12.6% 11.6%- 13.5%), respectively, 2021, 18.8% 17.8%- 19.9%), 5.8% 5.2%- 6.4%) 10.7% 9.9%- 11.5%), respectively. And 11.1% 10.5%- 11.7%) 2018–2019 9.8% 9.2%- 10.4%) 2020–2021. Prevalence had statistically significant differences. differences persisted after increased both decreased compared pre-COVID-19 pandemic. Further research is required association allergic diseases particular emphasis impact lifestyle changes resulting from measures prevent infection.

Language: Английский

Carbon quantum dots in bioimaging and biomedicines DOI Creative Commons

Surya Shekhar Das,

Somnath Mondal, Dhiman Ghosh

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 11

Published: Jan. 22, 2024

Carbon quantum dots (CQDs) are gaining a lot more attention than traditional semiconductor owing to their intrinsic fluorescence property, chemical inertness, biocompatibility, non-toxicity, and simple inexpensive synthetic route of preparation. These properties allow CQDs be utilized for broad range applications in various fields scientific research including biomedical sciences, particularly bioimaging biomedicines. promising choice advanced nanomaterials biomedicines unique chemical, physical, optical properties. doped with hetero atom, or polymer composite materials extremely advantageous biochemical, biological, since they easy prepare, biocompatible, have beneficial This type CQD is highly useful phototherapy, gene therapy, medication delivery, bioimaging. review explores the biomedicine, highlighting recent advancements future possibilities increase interest numerous advantages therapeutic applications.

Language: Английский

Citations

52
Updated Insights into the T Cell-Mediated Immune Response against SARS-CoV-2: A Step towards Efficient and Reliable Vaccines DOI Creative Commons
Manish Dhawan, Ali A. Rabaan,

Mahmoud M. Al Fawarah

et al.

Vaccines, Journal Year: 2023, Volume and Issue: 11(1), P. 101 - 101

Published: Jan. 1, 2023

The emergence of novel variants SARS-CoV-2 and their abilities to evade the immune response elicited through presently available vaccination makes it essential recognize mechanisms which interacts with human response. It is not only comprehend infection mechanism but also for generation effective reliable vaccines against COVID-19. effectiveness vaccine supported by adaptive response, mainly consists B T cells, play a critical role in deciding prognosis COVID-19 disease. cells are reducing viral load containing infection. A plethora proteins can be recognized provide broad range protection, especially amid SARS-CoV-2. However, hyperactivation effector reduced number lymphocytes have been found key characteristics severe Notably, excessive cell activation may cause acute respiratory distress syndrome (ARDS) producing unwarranted amounts cytokines chemokines. Nevertheless, still unknown how T-cell-mediated responses function determining Additionally, functional perturbations lead form disease protection many other infections. Hence, an updated review has developed understand involvement mechanism, turn determines Importantly, we focused on cells’ exhaustion under certain conditions these modulated therapeutic strategies discussed that elevate cell-mediated either directly or indirectly.

Language: Английский

Citations

36
SARS-CoV2 infection induce miR-155 expression and skewed Th17/Treg balance by changing SOCS1 level: A clinical study DOI Open Access
Mohammad Sadegh Soltani‐Zangbar, Mahsa Hajivalili, Danyal Daneshdoust

et al.

Cytokine, Journal Year: 2023, Volume and Issue: 169, P. 156248 - 156248

Published: June 8, 2023

Language: Английский

Citations

15
Targeting immune checkpoints in anti-neutrophil cytoplasmic antibodies associated vasculitis: the potential therapeutic targets in the future DOI Creative Commons
Menglu Pan, Huanhuan Zhao,

Ruimin Jin

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: April 6, 2023

Anti-neutrophil cytoplasmic autoantibodies (ANCA) associated vasculitis (AAV) is a necrotizing mainly involving small blood vessels. It demonstrated that T cells are important in the pathogenesis of AAV, including regulatory (Treg) and helper (Th), especially Th2, Th17, follicular Th (Tfh). In addition, exhaustion predicted favorable prognosis AAV. The immune checkpoints (ICs) consist group co-stimulatory co-inhibitory molecules expressed on surface cells, which maintains balance between activation cells. CD28, inducible T-cell co-stimulator (ICOS), OX40, CD40L, glucocorticoid induced tumor necrosis factor receptor (GITR), CD137 common molecules, while programmed cell death 1 (PD-1), cytotoxic lymphocyte-associated molecule 4 (CTLA-4), immunoglobulin (Ig) mucin domain-containing protein 3 (TIM-3), B lymphocyte attenuator (BTLA), V-domain Ig suppressor (VISTA), T‐cell ITIM domain (TIGIT), CD200, gene (LAG-3) belong to molecules. If this was disrupted increased, autoimmune diseases (AIDs) might be induced. Even treatment malignant tumors, by checkpoint inhibitors (ICIs) may result AIDs known as rheumatic immune-related adverse events (Rh-irAEs), suggesting importance ICs AIDs. review, we summarized features AAV immunotherapy using ICIs patients with then reviewed biological characteristics different ICs. Our aim explore potential targets for future

Language: Английский

Citations

11
The Correlation Between Interleukin -6 and Dehydroepiandrosterone Sulfate in Patients with Severe COVID-19 DOI Creative Commons

Sinan B. Alrifai,

Nadia H. Mohammed, Noor Hamdi Jasem

et al.

AL-Kindy College Medical Journal, Journal Year: 2024, Volume and Issue: 20(1), P. 14 - 19

Published: April 1, 2024

Background: Numerous studies have demonstrated that interleukin-6 (IL-6) and serum dehydroepiandrosterone sulfate levels are negatively correlated. Low DHEA-S may be associated with severe disease clinically ailing patients in the context of infectious diseases. Individuals infected Coronavirus who exhibit elevated IL-6 undergo a cytokine storm, which can result manifestations dismal prognosis. Objectives: To examine relationship between Il-6 exhibiting COVID-19. Subjects Methods: A case-control investigation 79 patients, ranging age from 36 to 74 years, were admitted hospital due COVID-19 disease. control group 72 ostensibly healthy individuals was also included study. Using ELISA method, concentrations both groups determined. The statistical analyses involved application Pearson correlation coefficient T-test. None authors present any conflicts interest. Results: With (r) -0.8349, study revealed highly significant negative (P < 0.0001) mean level (64.369 pg/ml ± 2.6237) (1.2728 ng/ml 1.7005) group. An exceptionally disparity identified when compared groups. Conclusions: In severely inverse indicates deficiency play role storm formation for these patients.

Language: Английский

Citations

3
Combining nano-curcumin with catechin improves COVID-19-infected patient's inflammatory conditions DOI Open Access
Talar Ahmad Merza Mohammad

Human Immunology, Journal Year: 2023, Volume and Issue: 84(9), P. 471 - 483

Published: June 5, 2023

Language: Английский

Citations

5
The presence of ACE2 and regulatory miRNAs (miR-200c-3p and miR-421-5p) in the saliva of periodontitis patients post-COVID-19 vaccination DOI Creative Commons

Boy M. Bachtiar,

Natalina Haerani,

Yuniarti Soeroso

et al.

Frontiers in Dental Medicine, Journal Year: 2024, Volume and Issue: 5

Published: Sept. 4, 2024

The effectiveness of COVID-19 mRNA vaccines in individuals with periodontitis is crucial. This study evaluated the efficacy BNT162b2 vaccine who had been vaccinated at least 6 months earlier. Using real-time PCR, association between SARS-CoV-2 receptor angiotensin-converting enzyme 2 (ACE2) and miRNA-200c-3p miRNA-421-5p as well interleukin-6 (IL-6) was examined saliva moderate (G1, n = 10) severe (G2, subjects. Participants without were included a control group. transcription levels soluble ACE2 IL-6 higher participants than participants, but within groups, only expression G2 G1. A positive strong correlation observed group (p 0.008). miR-200c-3p not miR-421-5p individuals. Their relationship In all inverse two microRNAs ACE2. However, receiver operating characteristic (ROC) analysis showed that miR-4215p potential biomarker for vaccine, areas under ROC curve 0.92 0.80 G1 respectively. Our revealed active non-active conditions do interfere post-vaccination. suggests periodontitis, may serve preliminary indicator response.

Language: Английский

Citations

1
Potent SARS‐CoV2 ‐specific T‐cell response in asymptomatic hemodialysis patients with hidden COVID ‐19 infection history DOI Creative Commons
Jalal Etemadi,

Roza Motavalli,

Seyed Alireza Mirghaffari

et al.

Journal of Clinical Laboratory Analysis, Journal Year: 2023, Volume and Issue: 37(5)

Published: March 1, 2023

COVID-19-related immune responses in patients with end-stage renal disease (ESRD) are characterized detail by the humoral response, but their cellular immunity has not been clarified. Here, we evaluated virus-specific T cells parallel serology-related tests.In this study, 104 ESRD at hemodialysis ward of Imam Reza hospital Tabriz (Iran) were enrolled. After blood sampling, SARS-CoV2-specific and IgM/IgG ELISA peptide/MHCI-Tetramers flow cytometry, respectively.Our results showed that 14 (13.5%) 45 (43.3%) had specific SARS-CoV2 IgM IgG sera, respectively. Immunophenotyping for CD8+ lymphocytes revealed 68 (65.4%) these types cells. Among positive subjects, 13 43 individuals existence, Also, there was a relationship between (p = 0.031) < 0.0001) existence having TCD8+ studied population.Despite clinical symptoms, high rate T-cell response asymptomatic may reveal burden COVID-19 infection patients.

Language: Английский

Citations

3
Hypoxia-altered cholesterol homeostasis enhances the expression of interferon-stimulated genes upon SARS-CoV-2 infections in monocytes DOI Creative Commons
Rebekka Bauer,

Sofie Patrizia Meyer,

Rebecca Raue

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: June 12, 2023

Hypoxia contributes to numerous pathophysiological conditions including inflammation-associated diseases. We characterized the impact of hypoxia on immunometabolic cross-talk between cholesterol and interferon (IFN) responses. Specifically, reduced biosynthesis flux provoked a compensatory activation sterol regulatory element-binding protein 2 (SREBP2) in monocytes. Concomitantly, broad range interferon-stimulated genes (ISGs) increased under absence an inflammatory stimulus. While changes intermediates SREBP2 activity did not contribute hypoxic ISG induction, intracellular distribution appeared critical enhance expression chemokine ISGs. Importantly, further boosted monocytes upon infection with severe acute respiratory syndrome coronavirus type (SARS-CoV-2). Mechanistically, sensitized toll-like receptor 4 (TLR4) signaling by SARS-CoV-2 spike protein, which emerged as major hub induction following These data depict hypoxia-regulated mechanism implications for development systemic responses cases disease-2019 (COVID-19).

Language: Английский

Citations

3
The impact of Hyssop (Hyssopus officinalis) extract on activation of endosomal toll like receptors and their downstream signaling pathways DOI Creative Commons
Masoumeh Ghasempour, Maryam Hosseini, Mohammad Sadegh Soltani‐Zangbar

et al.

BMC Research Notes, Journal Year: 2022, Volume and Issue: 15(1)

Published: Dec. 12, 2022

Abstract Objectives From the ancient, medicinal benefits of Hyssop ( Hyssopus officinalis L. ) have been implicated for respiratory and digestive diseases despite effects on viral infections not mechanistically investigated. In this study, we examined whether extract activated anti-viral innate immunity, as a sentinel immune system, through activation endosomal TLRs recognizing nucleic acids their downstream signaling. The herb extracts was prepared co-cultured with healthy individual’s peripheral blood mononuclear cells (PBMCs). After viability assay, gene expression levels TLR3,7,8,9, well MyD88 NF-κB, were evaluated in treated PBMCs using Real-time PCR. Next, secretion level related cytokines quantified via ELISA. Results Post 24 h, 40 µg/ml significantly inhibited less than 50% compared to control had maximum effect cellular function. Hyssop-treated demonstrated an elevated genes, NF-κB. Moreover, release INF-α β notably enhanced cell culture supernatant, while content inflammatory remarkably diminished (P < 0.05). capable inducing antiviral responses so can be promising drug strategies.

Language: Английский

Citations

4