Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2023, Volume and Issue: 1878(6), P. 188993 - 188993
Published: Oct. 7, 2023
Language: Английский
Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 260, P. 155424 - 155424
Published: June 20, 2024
Language: Английский
Citations
10
Antioxidants, Journal Year: 2024, Volume and Issue: 13(9), P. 1060 - 1060
Published: Aug. 30, 2024
Carotenoids, known for their antioxidant properties, have garnered significant attention potential antitumour activities. This comprehensive review aims to elucidate the diverse mechanisms by which carotenoids exert effects, focusing on both well-established and novel findings. We explore role in inducing apoptosis, inhibiting cell cycle progression preventing metastasis affecting oncogenic tumour suppressor proteins. The also explores pro-oxidant function of within cancer cells. In fact, although overall contribution cellular defences is well significant, some can exhibit effects under certain conditions are able elevate reactive oxygen species (ROS) levels tumoural cells, triggering mitochondrial pathways that would lead death. final balance between activities depends several factors, including specific carotenoid, its concentration redox environment cell. Clinical trials discussed, highlighting conflicting results treatment importance personalized approaches. Emerging research rare like bacterioruberin showcases superior capacity selective cytotoxicity against aggressive subtypes, such as triple-negative breast cancer. Future directions include innovative delivery systems, combinations treatments, aiming enhance therapeutic carotenoids. highlights promising yet complex landscape carotenoid-based therapies, calling continued clinical exploration.
Language: Английский
Citations
10
TrAC Trends in Analytical Chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 117978 - 117978
Published: Sept. 1, 2024
Language: Английский
Citations
9
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 936 - 936
Published: Jan. 23, 2025
Hypoxia is a well-known characteristic of the tumor microenvironment which significantly influences cancer development and closely linked to unfavorable outcomes. Long noncoding RNAs (lncRNAs), are part genome, have garnered increasing attention because their varied functions in metastasis. (lncRNAs) defined as longer than 200 nucleotides, they regulate diverse cellular processes by modulating gene expression at transcriptional, post-transcriptional epigenetic levels. well-established environmental factor enhances metastasis solid tumors. Epithelial-mesenchymal transition (EMT) represents one key mechanisms triggered hypoxia contributes Numerous lncRNAs been identified being upregulated hypoxia. These contribute toward cell migration, invasion Recent studies crucial role for these hypoxia-induced chemotherapy resistance. hypoxia-related can be plausible therapeutic targets devising effective therapies.
Language: Английский
Citations
1
Biomolecules, Journal Year: 2025, Volume and Issue: 15(3), P. 326 - 326
Published: Feb. 24, 2025
Colorectal cancer (CRC) is one of the deadliest neoplasia. Intrinsic or acquired resistance main cause failure therapy regimens that leads to relapse and death in CRC patients. The widely used chemotherapeutic agent 5-fluorouracil (5-FU) remains mainstay for therapeutic combinations. Unfortunately, side effects are frequent events compromise success these therapies; dysregulation enzymes regulate 5-FU metabolism increases expression activity efflux pumps. Additional tumor cell adaptations such as epithelial–mesenchymal transition (EMT), autophagy shaping microenvironment, inflammation contribute chemoresistance. Finding new strategies alternatives enhance conventional chemotherapies has become necessary. Recently, study natural compounds been gaining strength an alternative chemotherapeutics different cancers. Curcumin, trimethylglycine, resveratrol, artemisinin, some helminth-derived molecules, among others, studied context CRC. This review discusses benefits, mechanisms, advances, dark currently evaluated treatment. We also analyzed landscape non-conventional their underlying mechanisms action, which could, short term, provide fundamental knowledge harness anti-tumor allow them be adjuvant therapies.
Language: Английский
Citations
1
Cancer and Metastasis Reviews, Journal Year: 2025, Volume and Issue: 44(1)
Published: March 1, 2025
Language: Английский
Citations
1
Science China Life Sciences, Journal Year: 2023, Volume and Issue: 67(4), P. 653 - 662
Published: Dec. 29, 2023
Language: Английский
Citations
17
Heliyon, Journal Year: 2024, Volume and Issue: 10(5), P. e27207 - e27207
Published: March 1, 2024
Cancer drug resistance stands as a formidable obstacle in the relentless fight against top five prevalent cancers: breast, lung, colorectal, prostate, and gastric cancers. These malignancies collectively account for significant portion of cancer-related deaths worldwide. In recent years, long non-coding RNAs (lncRNAs) have emerged pivotal players intricate landscape cancer biology, their roles driving are steadily coming to light. This comprehensive review seeks underscore paramount significance lncRNAs orchestrating across spectrum different drugs, including platinum drugs (DDP), tamoxifen, trastuzumab, 5-fluorouracil (5-FU), paclitaxel (PTX), Androgen Deprivation Therapy (ADT) most types cancer. It delves into multifaceted mechanisms through which exert influence on resistance, shedding light regulatory various facets biology. A understanding these lncRNA-mediated may pave way more effective personalized treatment strategies, ultimately improving patient outcomes challenging malignancies.
Language: Английский
Citations
8
Cancer Communications, Journal Year: 2024, Volume and Issue: 44(10), P. 1130 - 1167
Published: Aug. 1, 2024
The intratumoral microbiome (TM) refers to the microorganisms in tumor tissues, including bacteria, fungi, viruses, and so on, is distinct from gut circulating microbiota. TM strongly associated with tumorigenesis, progression, metastasis, response therapy. This paper highlights current status of TM. Tract sources, adjacent normal tissue, circulatory system, concomitant co-metastasis are main origin advanced techniques analysis comprehensively summarized. Besides, involved progression through several mechanisms, DNA damage, activation oncogenic signaling pathways (phosphoinositide 3-kinase [PI3K], signal transducer activator transcription [STAT], WNT/β-catenin, extracellular regulated protein kinases [ERK]), influence cytokines induce inflammatory responses, interaction microenvironment (anti-tumor immunity, pro-tumor microbial-derived metabolites). Moreover, promising directions therapy include immunotherapy, chemotherapy, radiotherapy, application probiotics/prebiotics/synbiotics, fecal transplantation, engineered microbiota, phage therapy, oncolytic virus inherent challenges clinical also review provides a comprehensive landscape for analyzing TM, especially TM-related mechanisms TM-based treatment cancer.
Language: Английский
Citations
8
Cellular Signalling, Journal Year: 2024, Volume and Issue: 122, P. 111329 - 111329
Published: Aug. 5, 2024
Language: Английский
Citations
8