Immunopharmacological Activities of Luteolin in Chronic Diseases

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(3), P. 2136 - 2136

Published: Jan. 21, 2023

Flavonoids have been shown to anti-oxidative effects, as well other health benefits (e.g., anti-inflammatory and anti-tumor functions). Luteolin (3′, 4′, 5,7-tetrahydroxyflavone) is a flavonoid found in vegetables, fruits, flowers, herbs, including celery, broccoli, green pepper, navel oranges, dandelion, peppermint, rosemary. has multiple useful especially regulating inflammation-related symptoms diseases. In this paper, we summarize the studies about immunopharmacological activity of luteolin on anti-inflammatory, anti-cardiovascular, anti-cancerous, anti-neurodegenerative diseases published since 2018 available PubMed or Google Scholar. review, also introduce some additional formulations improve its solubility bioavailability.

Language: Английский

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Luteolin: A promising multifunctional natural flavonoid for human diseases

Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(7), P. 3417 - 3443

Published: April 26, 2024

Abstract Natural products are closely associated with human health. Luteolin (LUT), a flavonoid polyphenolic compound, is widely found in fruits, vegetables, flowers, and herbs. It noteworthy that LUT exhibits variety of beneficial pharmacological properties holds significant potential for clinical applications, particularly antitumor, anti‐convulsion, diabetes control, anti‐inflammatory, neuroprotection, anti‐oxidation, anti‐cardiovascular, other aspects. The mechanism action has been partially elucidated, including the mediation NF‐κB, toll‐like receptor, MAPK, Wnt/β‐catenin, PI3K/Akt, AMPK/mTOR, Nrf‐2, among others. review aimed to comprehensively consolidate essential information on natural sources, effects, therapeutic preventive potential, as well mechanisms LUT. objective establish theoretical basis continued development application

Language: Английский

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Luteolin for neurodegenerative diseases: a review

Pharmacological Reports, Journal Year: 2024, Volume and Issue: 76(4), P. 644 - 664

Published: June 21, 2024

Neurodegenerative diseases such as Parkinson's disease, Alzheimer's Huntington's and multiple sclerosis affect millions of people around the world. In addition to age, which is a key factor contributing development all neurodegenerative diseases, genetic environmental components are also important risk factors. Current methods treating mostly symptomatic do not eliminate cause disease. Many studies focus on searching for natural substances with neuroprotective properties that could be used an adjuvant therapy in inhibition neurodegeneration process. These compounds include flavonoids, luteolin, showing significant anti-inflammatory, antioxidant, activity. Increasing evidence suggests luteolin may confer protection against neurodegeneration. this review, we summarize scientific reports from preclinical vitro vivo regarding beneficial effects diseases. Luteolin was studied most extensively various models disease but there several its Though very limited, possible protective discussed here. Overall, although show potential benefits disorders, clinical therapeutic efficacy still deficient.

Language: Английский

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Polyphenols, Alkaloids, and Terpenoids Against Neurodegeneration: Evaluating the Neuroprotective Effects of Phytocompounds Through a Comprehensive Review of the Current Evidence

Metabolites, Journal Year: 2025, Volume and Issue: 15(2), P. 124 - 124

Published: Feb. 13, 2025

Neurodegenerative diseases comprise a group of chronic, usually age-related, disorders characterized by progressive neuronal loss, deformation structure, or loss function, leading to substantially reduced quality life. They remain significant focus scientific and clinical interest due their increasing medical social importance. Most neurodegenerative present intracellular protein aggregation extracellular deposition (plaques), such as α-synuclein in Parkinson's disease amyloid beta (Aβ)/tau aggregates Alzheimer's. Conventional treatments for conditions incur high costs are related the development several adverse effects. In addition, many patients irresponsive them. For these reasons, there is growing tendency find new therapeutic approaches help patients. This review intends investigate some phytocompounds' effects on diseases. These generally increased oxidative stress inflammation, so phytocompounds can prevent treat To achieve our aim provide critical assessment current literature about phytochemicals targeting neurodegeneration, we reviewed reputable databases, including PubMed, EMBASE, COCHRANE, seeking trials that utilized against conditions. A few investigated humans, after screening, 13 were ultimately included following PRISMA guidelines. compounds include polyphenols (flavonoids luteolin quercetin, phenolic acids rosmarinic acid, ferulic caffeic other like resveratrol), alkaloids (such berberine, huperzine A, caffeine), terpenoids ginkgolides limonene). The gathered evidence underscores caffeine, ginkgolides, primarily anti-inflammatory, antioxidant, neuroprotective, counteracting neuroinflammation, oxidation, synaptic dysfunctions, which crucial aspects intervention various conditions, Alzheimer's dementias, depression, neuropsychiatric disorders. summary, they show use improvements cognition, memory, disinhibition, irritability/lability, aberrant behavior, hallucinations, mood

Language: Английский

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Biological Functions and Health Benefits of Flavonoids in Fruits and Vegetables: A Contemporary Review

Foods, Journal Year: 2025, Volume and Issue: 14(2), P. 155 - 155

Published: Jan. 7, 2025

Flavonoids, being prevalent in fruits and vegetables, are essential to the diverse stages of plant growth, development, storage. Furthermore, flavonoids have been shown exert substantial beneficial effects on human health, prompting heightened scientific interest their potential advantages. This review elucidates functions confirming position as natural sources these compounds, despite differences type concentration among various species. significance growth development highlighting roles enhancing pigmentation providing protection against both biotic abiotic stresses. In relation recognized for ability combat aging, mitigate inflammation, safeguard nervous system, promote overall well-being. Additionally, this proposes avenues future research domain flavonoids, underscoring necessity ongoing exploration applications benefits.

Language: Английский

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Beneficial effects of natural flavonoids on neuroinflammation

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Oct. 24, 2022

Neuroinflammation is the fundamental immune response against multiple factors in central nervous system and characterized by production of inflammatory mediators, activated microglia astrocytes, recruitment innate adaptive cells to sites, that contributes pathological process related brain diseases, such as Alzheimer’s disease, Parkinson’s depression, stroke. Flavonoids, a species important natural compounds, have been widely revealed alleviate neuroinflammation inhibiting pro-inflammatory elevating secretion anti-inflammatory factors, modulating polarization astrocyte, mainly via suppressing activation NLRP3 inflammasome, well NF-κB, MAPK, JAK/STAT pathways, promoting Nrf2, AMPK, BDNF/CREB, Wnt/β-Catenin, PI3k/Akt signals SIRT1-mediated HMGB1 deacetylation. This review will provide latest comprehensive knowledge on therapeutic benefits mechanisms flavonoids neuroinflammation, might be developed into food supplements or lead compounds for neuroinflammation-associated disorders.

Language: Английский

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Flavonoids in vegetables: improvement of dietary flavonoids by metabolic engineering to promote health

Critical Reviews in Food Science and Nutrition, Journal Year: 2022, Volume and Issue: 64(11), P. 3220 - 3234

Published: Oct. 11, 2022

Flavonoids are the most abundant polyphenols in plants, and have antioxidant effects as well other bioactivities (e.g., anti-inflammatory, anti-cancer, anti-allergic, neuroprotective effects). Vegetables rich flavonoids indispensable our daily diet. Moreover, vegetables chassis for producing natural products would emerge a promising means cost-effective sustainable production of flavonoids. Understanding metabolic engineering allows us to improve their nutrient composition. In this review, comprehensive overview vegetables, including characterized types distribution, health-promoting effects, associated pathways, applied provided. We also introduce breakthroughs multi-omics approaches that pertain elucidation metabolism prospective potential genome-editing technologies. Based on varied composition content among dietary suggestions further provided human health.

Language: Английский

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Establishing Co-Culture Blood–Brain Barrier Models for Different Neurodegeneration Conditions to Understand Its Effect on BBB Integrity

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(6), P. 5283 - 5283

Published: March 9, 2023

The blood-brain barrier (BBB) is a functional interface that provides selective permeability, protection from toxic substances, transport of nutrients, and clearance brain metabolites. Additionally, BBB disruption has been shown to play role in many neurodegenerative conditions diseases. Therefore, the aim this study was establish functional, convenient, efficient vitro co-cultured model can be used for several physiological related disruption. Mouse brain-derived endothelial (bEnd.3) astrocyte (C8-D1A) cells were on transwell membranes an intact model. its effects different neurological diseases stress conditions, including Alzheimer's disease (AD), neuroinflammation, obesity, have examined by transendothelial electrical resistance (TEER), fluorescein isothiocyanate (FITC) dextran, tight junction protein analyses. Scanning electron microscope images showed evidence end-feet processes passing through membrane transwell. Moreover, effective properties TEER, FITC, solvent persistence leakage tests when compared mono-cultured immunoblot results expression proteins such as zonula occludens-1 (ZO-1), claudin-5, occludin-1 enhanced co-culture. Lastly, under structural integrity decreased. present demonstrated mimicked BBB's and, similar damages. convenient experimental tool investigate wide range BBB-related pathological studies.

Language: Английский

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The role of natural flavonoids on neuroinflammation as a therapeutic target for Alzheimer’s disease: a narrative review

Neural Regeneration Research, Journal Year: 2023, Volume and Issue: 18(12), P. 2582 - 2591

Published: April 13, 2023

Alzheimer's disease is a neurodegenerative that affects large proportion of older adult people and characterized by memory loss, progressive cognitive impairment, various behavioral disturbances. Although the pathological mechanisms underlying are complex remain unclear, previous research has identified two widely accepted characteristics: extracellular neuritic plaques containing amyloid beta peptide, intracellular neurofibrillary tangles tau. Furthermore, revealed significant role played neuroinflammation over recent years. The inflammatory microenvironment mainly consists microglia, astrocytes, complement system, chemokines, cytokines, reactive oxygen intermediates; collectively, these factors can promote process aggravate severity disease. Therefore, development new drugs target will be step forward for treatment Flavonoids plant-derived secondary metabolites possess bioactivities. Previous found multiple natural flavonoids could exert satisfactory effects on associated with In this review, we describe pathogenesis neuroinflammatory processes disease, summarize 13 (apigenin, luteolin, naringenin, quercetin, morin, kaempferol, fisetin, isoquercitrin, astragalin, rutin, icariin, mangiferin, anthocyanin) derived from plants or medicinal herbs in As an important resource novel compounds critical diseases, it essential focus exploitation products. particular, vital investigate greater detail.

Language: Английский

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Caffeic Acid, a Polyphenolic Micronutrient Rescues Mice Brains against Aβ-Induced Neurodegeneration and Memory Impairment

Antioxidants, Journal Year: 2023, Volume and Issue: 12(6), P. 1284 - 1284

Published: June 15, 2023

Oxidative stress plays an important role in cognitive dysfunctions and is seen neurodegeneration Alzheimer's disease (AD). It has been reported that the polyphenolic compound caffeic acid possesses strong neuroprotective antioxidant effects. The current study was conducted to investigate therapeutic potential of against amyloid beta (Aβ1-42)-induced oxidative memory impairments. Aβ1-42 (5 μL/5 min/mouse) administered intracerebroventricularly (ICV) into wild-type adult mice induce AD-like pathological changes. Caffeic orally at 50 mg/kg/day for two weeks AD mice. Y-maze Morris water maze (MWM) behavior tests were assess abilities. Western blot immunofluorescence analyses used biochemical analyses. behavioral results indicated administration improved spatial learning, memory, abilities Reactive oxygen species (ROS) lipid peroxidation (LPO) assays performed showed levels ROS LPO markedly reduced acid-treated mice, as compared Aβ-induced brains. Moreover, expression nuclear factor erythroid 2-related 2 (Nrf2) heme oxygenase-1 (HO-1) regulated with acid, Aβ-injected Next, we checked ionized calcium-binding adaptor molecule 1 (Iba-1), glial fibrillary acidic proteins (GFAP), other inflammatory markers experimental which suggested enhanced these brains, treatment. Furthermore, synaptic model. Additionally, treatment also decreased Aβ BACE-1

Language: Английский

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