Published: Jan. 1, 2025
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(7), P. 6328 - 6328
Published: March 28, 2023
Neuroinflammation is a critical factor in developing and progressing numerous brain diseases, including neurodegenerative diseases. Chronic or excessive neuroinflammation can lead to neurotoxicity, causing damage contributing the onset progression of various Therefore, understanding mechanisms strategies control them crucial for treating Studies have shown that plays vital role such as Alzheimer's (AD) Parkinson's (PD), stroke. Additionally, effects PM
Language: Английский
Citations
92
Antioxidants, Journal Year: 2023, Volume and Issue: 12(3), P. 663 - 663
Published: March 7, 2023
Flavonoids are a biodiverse family of dietary compounds that have antioxidant, anti-inflammatory, antiviral, and antibacterial cell protective profiles. They received considerable attention as potential therapeutic agents in biomedicine been widely used traditional complimentary medicine for generations. Such medical herbal formulations extremely complex mixtures many pharmacologically active provide outcome through network pharmacological effects complexity. Methods emerging to determine the components their targets decipher complexities how pharmacology provides such effects. The gut microbiome has important roles play generation bioactive flavonoid metabolites retaining or exceeding antioxidative anti-inflammatory properties intact and, some cases, new antitumor antineurodegenerative bioactivities. Certain food items identified with high prebiotic profiles suggesting neutraceutical supplementation may be beneficially employed preserve healthy population bacterial symbiont species minimize establishment harmful pathogenic organisms. Gut health is an consideration effecting overall wellbeing linked organ systems. Bioconversion generates can also transported by vagus nerve systemic circulation brain populations exert beneficial effect. This particularly number neurological disorders (autism, bipolar disorder, AD, PD) characterized on moods, resulting depression anxiety, impaired motor function, long-term cognitive decline. Native flavonoids alleviation inflammation tissues, however, concerns raised levels not achieved, thus allowing them display optimal Dietary manipulation vagal stimulation both yielded responses treatment autism spectrum disorders, depression, establishing route communication gut-brain axis established disease intervention. While native known penetrate blood–brain barrier, microbiome-generated (e.g., protocatechuic acid, urolithins, γ-valerolactones), which retain antioxidant potency addition promote mitochondrial cerebrovascular microcapillary should considered biotherapeutic agents. Studies warranted experimentally examine efficacy directly, they emerge novel options.
Language: Английский
Citations
44
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(21)
Published: Feb. 12, 2024
Abstract Ischemic stroke is a dreadful vascular disorder that poses enormous threats to the public health. Due its complicated pathophysiological features, current treatment options after ischemic attack remains unsatisfactory. Insufficient drug delivery lesions impeded by blood–brain barrier (BBB) largely limits therapeutic efficacy of most anti‐stroke agents. Herein, inspired rapid BBB penetrability 4T1 tumor cells upon their brain metastasis and natural roles platelet in targeting injured vasculatures, bio‐derived nanojacket developed fusing cell membrane with membrane, which further clothes on surface paeonol polymetformin‐loaded liposome obtain biomimetic nanoplatforms (PP@PCL) for treatment. The designed PP@PCL could remarkably alleviate ischemia‐reperfusion injury efficiently lesion, preventing neuroinflammation, scavenging excess reactive oxygen species (ROS), reprogramming microglia phenotypes, promoting angiogenesis due synergistic mechanisms anchor characteristics stroke. As result, exerts desirable PC12 neuronal rat model stroke, significantly attenuates apoptosis, reduces infarct volume, recovers neurological functions, bringing new insights into exploiting promising strategies cerebral management.
Language: Английский
Citations
33
BMC Complementary Medicine and Therapies, Journal Year: 2025, Volume and Issue: 25(1)
Published: Feb. 4, 2025
Language: Английский
Citations
2
Trends in Pharmacological Sciences, Journal Year: 2023, Volume and Issue: 45(1), P. 9 - 23
Published: Dec. 7, 2023
Language: Английский
Citations
32
Phytotherapy Research, Journal Year: 2023, Volume and Issue: 37(12), P. 5700 - 5723
Published: Sept. 25, 2023
Abstract Galangin is an important flavonoid with natural activity, that abundant in galangal and propolis. Currently, various biological activities of galangin have been disclosed, including anti‐inflammation, antibacterial effect, anti‐oxidative stress aging, anti‐fibrosis, antihypertensive effect. Based on the above bioactivities, more attention has paid to role neurodegenerative diseases, rheumatoid arthritis, osteoarthritis, osteoporosis, skin cancer. In this paper, sources, pharmacokinetics, therapeutic potential against diseases were systematically reviewed by collecting summarizing relevant literature. addition, molecular mechanism new preparation treatment related are also discussed, broaden application prospect provide reference for its clinical application. Furthermore, it should be noted current toxicity studies insufficient, evidence needed support possibility as a functional food.
Language: Английский
Citations
27
Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14
Published: Oct. 18, 2023
Naturally occurring flavonoids have long been utilized as essential templates for the development of novel drugs and critical ingredients functional foods. Astragalin (AG) is a natural flavonoid that can be isolated from variety familiar edible plants, such seeds green tea, Morus alba L., Cuscuta chinensis. It noteworthy AG has wide range pharmacological activities possesses therapeutic effects against diseases, covering cancers, osteoarthritis, osteoporosis, ulcerative colitis, mastitis, obesity, diabetes mellitus, diabetic complications, ischemia/reperfusion injury, neuropathy, respiratory reproductive system diseases. This article reviewed source pharmacokinetics systematically summarized potential mechanisms in treating diverse diseases order to promote food, doing so providing references its clinical application disease therapy.
Language: Английский
Citations
27
Heliyon, Journal Year: 2024, Volume and Issue: 10(13), P. e33670 - e33670
Published: June 26, 2024
Inflammation is a complex physiological phenomenon, which the body's defensive response, but abnormal inflammation can have adverse effects, and many diseases are related to inflammatory response. AMPK, as key sensor of cellular energy status, plays crucial role in regulating homeostasis glycolipid metabolism. In recent years, anti-inflammation effect AMPK signalling cascade has begun enter everyone's field vision – not least impact on metabolic diseases. A great number studies shown that anti-inflammatory drugs work through pathways.Herein, this article summarises advances compounds show effects by activating attempts comment them.
Language: Английский
Citations
13
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(2), P. 1071 - 1071
Published: Jan. 15, 2024
As the global population ages, prevalence of Parkinson’s disease (PD) is steadily on rise. PD demonstrates chronic and progressive characteristics, many cases can transition into dementia. This increases societal economic burdens, emphasizing need to find effective treatments. Among widely recognized causes abnormal accumulation proteins, autophagy dysfunction accelerates this accumulation. The resultant Lewy bodies are also commonly found in Alzheimer’s patients, suggesting an increased potential for onset Additionally, production free radicals due mitochondrial contributes neuronal damage degeneration. activation astrocytes M1 phenotype microglia promote dopamine neurons. drugs currently used only delay clinical progression exacerbation without targeting its root cause, come with various side effects. Thus, there a demand treatments fewer effects, much offered by natural products. In study, we reviewed total 14 articles related herbal medicines products investigated their relevance possible treatment. results showed that against lysosomal disorder, dysfunction, inflammation, key mechanisms underlying PD. Therefore, reduce neurotoxicity might improve both motor non-motor symptoms associated Furthermore, these products, multi-target enhance bioavailability, inhibit antibiotic resistance, additionally eliminate making them good alternative therapies
Language: Английский
Citations
11
Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(5), P. 2411 - 2433
Published: Jan. 29, 2024
As an important signaling pathway in multicellular eukaryotes, the Wnt participates a variety of physiological processes. Recent studies have confirmed that plays role neurological disorders such as stroke, Alzheimer's disease, and Parkinson's disease. The regulation by natural compounds herbal medicines nutraceuticals has emerged potential strategy for development new drugs disorders.
Language: Английский
Citations
11