Aging and Disease,
Journal Year:
2022,
Volume and Issue:
13(6), P. 1591 - 1591
Published: Jan. 1, 2022
Diabetes
mellitus
(DM)
and
Parkinson's
disease
(PD)
are
both
age-related
diseases
of
global
concern
being
among
the
most
common
chronic
metabolic
neurodegenerative
diseases,
respectively.
While
can
be
genetically
inherited,
environmental
factors
play
a
vital
role
in
their
pathogenesis.
Moreover,
DM
PD
have
underlying
molecular
mechanisms,
such
as
misfolded
protein
aggregation,
mitochondrial
dysfunction,
oxidative
stress,
inflammation,
microbial
dysbiosis.
Recently,
epidemiological
experimental
studies
reported
that
affects
incidence
progression
PD.
certain
antidiabetic
drugs
been
proven
to
decrease
risk
delay
its
progression.
In
this
review,
we
elucidate
pathophysiological
association
between
summarize
used
animal
models
clinical
trials
PD,
which
may
provide
reference
for
translation
treatment.
Microbial Cell,
Journal Year:
2023,
Volume and Issue:
10(3), P. 49 - 62
Published: Feb. 24, 2023
Lactic
acid
bacteria
(LAB)
are
ubiquitous
microorganisms
that
can
colonize
the
intestine
and
participate
in
physiological
metabolism
of
host.
LAB
produce
a
variety
metabolites,
including
organic
acids,
bacteriocin,
amino
exopolysaccharides
vitamins.
These
metabolites
basis
function
have
profound
impact
on
host
health.
The
is
colonized
by
large
number
gut
with
high
species
diversity.
Metabolites
keep
balance
stability
microbiota
through
aiding
maintenance
intestinal
epithelial
barrier,
resisting
to
pathogens
regulating
immune
responses,
which
further
influence
nutrition,
behavior
In
this
review,
we
summarize
their
intestine.
We
also
discuss
underlying
regulatory
mechanisms
emphasize
link
between
human
from
perspective
health
promotion.
Microbiology Insights,
Journal Year:
2023,
Volume and Issue:
16
Published: Jan. 1, 2023
Evidence
indicates
that
short-chain
fatty
acids
(SCFAs)
generated
from
the
gut
microbiota
play
crucial
roles
in
host
metabolism.
They
contribute
to
metabolic
regulation
and
energy
acquisition
of
by
influencing
development
disorders.
This
review
aims
synthesize
recent
advances
literature
investigate
implication
SCFAs
modulation
obesity
diabetes
pathologies.
For
a
better
understanding
relationships
between
metabolism,
we
need
answer
some
questions:
What
is
biochemistry
SCFAs,
how
they
are
microbiota?
bacteria
producing
which
routes?
How
absorbed
transported
different
mechanisms
receptors?
involved
pathologies?
Journal of Translational Medicine,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Jan. 28, 2024
Abstract
The
study
of
microbial
communities
has
undergone
significant
advancements,
starting
from
the
initial
use
16S
rRNA
sequencing
to
adoption
shotgun
metagenomics.
However,
a
new
era
emerged
with
advent
long-read
(LRS),
which
offers
substantial
improvements
over
its
predecessor,
short-read
(SRS).
LRS
produces
reads
that
are
several
kilobases
long,
enabling
researchers
obtain
more
complete
and
contiguous
genomic
information,
characterize
structural
variations,
epigenetic
modifications.
current
leaders
in
technologies
Pacific
Biotechnologies
(PacBio)
Oxford
Nanopore
Technologies
(ONT),
each
offering
distinct
set
advantages.
This
review
covers
workflow
metagenomics
sequencing,
including
sample
preparation
(sample
collection,
extraction,
library
preparation),
processing
(quality
control,
assembly,
binning),
analysis
(taxonomic
annotation
functional
annotation).
Each
section
provides
concise
outline
key
concept
methodology,
presenting
original
as
well
how
it
is
challenged
or
modified
context
LRS.
Additionally,
introduces
range
tools
compatible
can
be
utilized
execute
process.
aims
present
metagenomics,
highlight
transformative
impact
LRS,
provide
selection
suitable
for
this
task.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(6), P. 3086 - 3086
Published: March 7, 2024
Diabetic
kidney
disease
(DKD)
is
a
major
cause
of
chronic
(CKD),
and
it
heightens
the
risk
cardiovascular
incidents.
The
pathogenesis
DKD
thought
to
involve
hemodynamic,
inflammatory,
metabolic
factors
that
converge
on
fibrotic
pathway.
Genetic
predisposition
unhealthy
lifestyle
practices
both
play
significant
role
in
development
progression
DKD.
In
spite
recent
emergence
angiotensin
receptors
blockers
(ARBs)/angiotensin
converting
enzyme
inhibitor
(ACEI),
sodium-glucose
cotransporter
2
(SGLT2)
inhibitors,
nonsteroidal
mineralocorticoid
antagonists
(NS-MRAs),
current
therapies
still
fail
effectively
arrest
Glucagon-like
peptide
1
receptor
agonists
(GLP-1RAs),
promising
class
agents,
possess
potential
act
as
renal
protectors,
slowing
Other
including
pentoxifylline
(PTF),
selonsertib,
baricitinib
hold
great
promise
for
due
their
anti-inflammatory
antifibrotic
properties.
Multidisciplinary
treatment,
encompassing
modifications
drug
therapy,
can
decelerate
Based
treatment
heart
failure,
recommended
use
multiple
drugs
combination
rather
than
single-use
Unearthing
mechanisms
underlying
urgent
optimize
management
Inflammatory
(including
IL-1,
MCP-1,
MMP-9,
CTGF,
TNF-a
TGF-β1),
along
with
lncRNAs,
not
only
serve
diagnostic
biomarkers,
but
also
therapeutic
targets.
this
review,
we
delve
into
We
explore
additional
value
combing
these
develop
novel
strategies.
Drawing
from
understanding
pathogenesis,
propose
HIF
AGE
epigenetic
targets
future.
PLoS ONE,
Journal Year:
2025,
Volume and Issue:
20(1), P. e0314029 - e0314029
Published: Jan. 9, 2025
Increasing
evidence
suggests
that
dysbiosis
of
gut
microbiota
exacerbates
chronic
kidney
disease
(CKD)
progression.
Curcumin
(CUR)
has
been
reported
to
alleviate
renal
fibrosis
in
animal
models
CKD.
However,
the
relationship
between
CUR
and
microbiome
CKD
remains
unclear.
This
study
aims
investigate
potential
anti-renal
effects
from
perspective.
A
5/6
nephrectomy
(5/6Nx)
rat
model
was
used
explore
therapeutic
effect
on
fibrosis.
Tight
junction
protein
expression
levels
were
measured
assess
intestinal
barrier
function.
16S
rRNA
sequencing
employed
evaluate
changes
composition,
metabolomics
utilized
detect
alterations
plasma
metabolites.
The
administration
significantly
ameliorated
inhibited
inflammation
5/6Nx
rats.
Additionally,
markedly
improved
tight
proteins
local
colon
inflammation.
also
positively
reconstructed
microbiota,
increasing
abundance
beneficial
bacteria,
such
as
Lachnospiraceae_NK4A136_group
,
Eubacterium_siraeum_group
Muribaculaceae
increased.
Metabolomics
revealed
reduced
uremic
retention
solutes
elevated
Vitamin
D
short-chain
fatty
acids
(SCFAs).
Spearman
correlation
analysis
indicated
genera
enriched
by
correlated
with
SCFA
negatively
injury
biomarkers.
Mechanistically,
we
found
inhibition
LPS/TLR4/NF-κB
TGF-β1/Smads
pathway
CUR-treated
Our
indicates
modulate
this
modulation
may
contribute
anti-fibrosis
CUR.
Frontiers in Nutrition,
Journal Year:
2022,
Volume and Issue:
9
Published: June 24, 2022
Obesity
is
the
epidemic
of
our
era
and
its
incidence
supposed
to
increase
by
more
than
30%
2030.
It
commonly
defined
as
a
chronic
metabolic
disease
with
an
excessive
accumulation
body
fat
in
relation
fat-free
mass,
both
terms
quantity
distribution
at
specific
points
on
body.
The
effects
obesity
have
important
impact
different
clinical
areas,
particularly
endocrinology,
cardiology,
nephrology.
Indeed,
increased
rates
been
associated
risk
cardiovascular
(CVD),
cancer,
type
2
diabetes
(T2D),
dyslipidemia,
hypertension,
renal
diseases,
neurocognitive
impairment.
Obesity-related
kidney
(CKD)
has
ascribed
intrarenal
along
proximal
tubule,
glomeruli,
sinus,
around
capsule,
hemodynamic
changes
hyperfiltration,
albuminuria,
impaired
glomerular
filtration
rate.
In
addition,
diabetes,
which
arise
consequence
overweight,
contribute
amplifying
dysfunction
native
transplanted
kidney.
Overall,
several
mechanisms
are
closely
related
onset
progression
CKD
general
population,
including
hemodynamics,
neurohumoral
pathways,
adiposity,
local
systemic
inflammation,
dysbiosis
microbiota,
insulin
resistance,
fibrotic
process.
Unfortunately,
there
no
practice
guidelines
for
management
patients
obesity-related
CKD.
Therefore,
dietary
based
nutritional
care
adults
CKD,
developed
published
National
Kidney
Foundation,
Disease
Outcome
Quality
Initiative
common
recommendations
healthy
population.
Optimal
these
should
follow
Mediterranean
diet,
known
be
lower
CVD
beneficial
diseases
such
obesity,
cognitive
health.
Mediterranean-style
diets
often
unsuccessful
promoting
efficient
weight
loss,
especially
altered
glucose
metabolism.
For
this
purpose,
review
also
discusses
use
non-classical
loss
approaches
intermittent
fasting
ketogenic
diet
contrast
The American Journal of Chinese Medicine,
Journal Year:
2022,
Volume and Issue:
50(07), P. 1739 - 1779
Published: Jan. 1, 2022
Diabetic
nephropathy
(DN)
is
a
common
microvascular
complication
of
diabetes
mellitus
(DM),
which
can
lead
to
renal
failure
in
diabetic
patients.
At
present,
the
first-line
drugs
for
DN
are
mainly
renin–angiotensin
system
(RAS)
inhibitors
or
angiotensin
receptor
blockers,
and
latest
approved
aldosterone
antagonist
finerenone,
delay
progression
end-stage
disease
(ESRD),
but
therapeutic
effect
still
not
ideal.
With
history
thousands
years,
traditional
Chinese
medicine
(TCM)
has
rich
experience
treatment
DN.
Based
on
theory
TCM,
clinical
focuses
generating
fluid
nourishing
blood,
Qi
Yin,
detoxifying
detumescent.
In
recently
effects
mechanisms
TCM
prescription,
herbal
medicine,
its
active
components
have
received
extensive
attention
new
drug
development.
This
paper
reviews
research
progress
mechanism
Nature Communications,
Journal Year:
2023,
Volume and Issue:
14(1)
Published: Sept. 4, 2023
Diabetes
and
associated
comorbidities
are
a
global
health
threat
on
the
rise.
We
conducted
six-month
dietary
intervention
in
pre-diabetic
individuals
(NCT03222791),
to
mitigate
hyperglycemia
enhance
metabolic
health.
The
current
work
explores
early
diabetes
markers
200
who
completed
trial.
find
166
of
2,803
measured
features,
including
oral
gut
microbial
species
pathways,
serum
metabolites
cytokines,
show
significant
change
response
personalized
postprandial
glucose-targeting
diet
or
standard
care
Mediterranean
diet.
These
changes
include
established
as
well
novel
features
that
can
now
be
investigated
potential
therapeutic
targets.
Our
results
indicate
microbiome
mediates
effect
glycemic,
immune
measurements,
with
compositional
explaining
12.25%
variance.
Although
displays
greater
compared
microbiome,
demonstrates
more
at
genetic
level,
trends
dependent
environmental
richness
prevalence
population.
In
conclusion,
our
study
shows
interventions
affect
cardiometabolic
profile
host,
these
factors
each
other,
harnessed
for
new
modalities.
