Neurochemical Research, Journal Year: 2024, Volume and Issue: 49(10), P. 2871 - 2887
Published: July 18, 2024
Language: Английский
Translational Stroke Research, Journal Year: 2023, Volume and Issue: unknown
Published: Oct. 3, 2023
Language: Английский
Citations
13
Cell Biochemistry and Function, Journal Year: 2024, Volume and Issue: 42(2)
Published: March 1, 2024
Abstract Cerebral ischemic damage is prevalent and the second highest cause of death globally across patient populations; it as a substantial reason morbidity mortality. Mesenchymal stromal cells (MSCs) have garnered significant interest potential treatment for cerebral damage, shown in stroke, because their potent intrinsic features, which include self‐regeneration, immunomodulation, multi‐potency. Additionally, MSCs are easily obtained, isolated, cultured. Despite this, there number obstacles that hinder effectiveness MSC‐based treatment, such adverse microenvironmental conditions both vivo vitro. To overcome these obstacles, naïve MSC has undergone modification processes to enhance its innate therapeutic qualities. Genetic preconditioning (with medications, growth factors, other substances) two main categories into techniques can be separated. This field advanced significantly still attracting attention innovation. We examine cutting‐edge methods preserving even improving natural biological functions relation adhesion, migration, homing target site, survival, delayed premature senescence. address use genetically altered stroke‐induced damage. Future strategies result addressing difficulties associated with also discussed.
Language: Английский
Citations
5
Frontiers in Cellular Neuroscience, Journal Year: 2025, Volume and Issue: 19
Published: April 7, 2025
Stroke is characterized with high morbidity, mortality and disability all over the world, one of its core pathologies blood-brain barrier (BBB) dysfunction. BBB plays a crucial physiological role in protecting brain tissues maintaining homeostasis central nervous system (CNS). dysfunction serves as key factor development cerebral edema, inflammation, further neurological damage stroke patients. Currently, stem cells their derived exosomes have shown remarkable potential repairing damaged improving function after stroke. Stem repair integrity through anti-inflammatory, antioxidant, angiogenesis regulation intercellular signaling mechanisms, while cell-derived exosomes, natural nanocarriers, enhance therapeutic effect by carrying active substances such proteins, RNAs miRNAs. This review will present latest research advances treatment, well challenges cell source, transplantation timing, dosage, route administration clinical application, aiming to discuss mechanisms for proposes future directions. are expected provide new strategies early diagnosis precise treatment stroke, promote breakthroughs field
Language: Английский
Citations
0
Neural Regeneration Research, Journal Year: 2023, Volume and Issue: 19(7), P. 1584 - 1592
Published: Nov. 8, 2023
Abstract Parkinson's disease is characterized by the loss of dopaminergic neurons in substantia nigra pars compacta, and although restoring striatal dopamine levels may improve symptoms, no treatment can cure or reverse itself. Stem cell therapy has a regenerative effect being actively studied as candidate for disease. Mesenchymal stem cells are considered promising option due to fewer ethical concerns, lower risk immune rejection, teratogenicity. We performed meta-analysis evaluate therapeutic effects mesenchymal their derivatives on motor function, memory, preservation animal model. searched bibliographic databases (PubMed/MEDLINE, Embase, CENTRAL, Scopus, Web Science) identify articles included only peer-reviewed vivo interventional studies published any language through June 28, 2023. The study utilized random-effect model estimate 95% confidence intervals (CI) standard mean differences (SMD) between control groups. use systematic review center laboratory experimentation's bias tool collaborative approach checklist quality assessment. A total 33 with data from 840 animals were meta-analysis. Treatment significantly improved function assessed amphetamine-induced rotational test. Among types, bone marrow MSCs neurotrophic factor group showed largest size (SMD [95% CI] = –6.21 [–9.50 –2.93], P 0.0001, I 2 0.0 %). had more tyrosine hydroxylase positive striatum ([95% 1.04 [0.59 1.49], 65.1 %) 1.38 [0.89 1.87], 75.3 %), indicating protective neurons. Subgroup analysis rotation test significant reduction intracranial-striatum route –2.59 [–3.25 –1.94], 74.4 memory improvement intravenous 4.80 [1.84 7.76], 0.027, 79.6 have been shown positively impact protect preclinical models Further research required determine optimal modifications, transplanted numbers, delivery methods these protocols.
Language: Английский
Citations
10
Frontiers in Cellular Neuroscience, Journal Year: 2025, Volume and Issue: 19
Published: Feb. 7, 2025
Ischemic stroke is a leading cause of mortality and long-term disability globally. One its aspects the breakdown blood-brain barrier (BBB). The disruption BBB's integrity during exacerbates neurological damage hampers therapeutic intervention. Recent advances in regenerative medicine suggest that mesenchymal stem cells (MSCs) derived extracellular vesicles (EVs) show promise for restoring BBB integrity. This review explores potential MSC-derived EVs mediating neuroprotective reparative effects on after ischemic stroke. We highlight molecular cargo EVs, including miRNAs, their role enhancing angiogenesis, promoting neural repair, mitigating apoptosis. Furthermore, we discuss challenges associated with clinical translation EV therapies possibilities further EVs' innate protective qualities. Our findings underscore need research to optimize establish efficacy safety settings.
Language: Английский
Citations
0
Neuroprotection/Neuroprotection (Chichester, England. Print), Journal Year: 2023, Volume and Issue: 1(2), P. 99 - 116
Published: Dec. 1, 2023
Abstract Exosome‐based treatments are gaining traction as a viable approach to addressing the various issues faced by an ischemic stroke. These extracellular vesicles, mainly produced mesenchymal stem cells, exhibit many properties with substantial therapeutic potential. Exosomes particularly appealing for stroke therapy because of their low immunogenicity, effective cargo transport, and ability cross blood–brain barrier. Their diverse effects include neuroprotection, angiogenesis stimulation, inflammatory response modulation, cell death pathway attenuation, synergistically promoting neuronal survival, tissue regeneration, functional recovery. also show potential diagnostic indicators early identification customized treatment options. Despite these promising qualities, current exosome‐based therapeutics have some limitations. The heterogeneity exosome release among types, difficulty in standardization isolation techniques, complications linked dosage targeted administration necessitates extensive investigation. It is critical thoroughly understand exosomal processes complicated interactions within cellular milieu. To improve practicality efficacy medicines, research efforts must focus on improving production processes, developing robust evaluation criteria, large‐scale techniques. Altogether, exosomes’ multifunctional offer new route transforming significantly patient outcomes.
Language: Английский
Citations
9
Cells, Journal Year: 2021, Volume and Issue: 10(11), P. 2997 - 2997
Published: Nov. 3, 2021
Animal model studies and first clinical trials have demonstrated the safety efficacy of mesenchymal stem cells' (MSCs) transplantation in stroke. Intra-arterial (IA) administration looks especially promising, since it provides targeted cell delivery to ischemic brain, is highly effective, can be safe as long infusion conducted appropriately. However, wider application IA MSCs will only possible after a better understanding mechanism their therapeutic action achieved. On way achieve this goal, study transplanted fate interactions with blood-brain barrier (BBB) structures could one key factors. In review, we analyze available data concerning most important aspects MSCs' action-the ability cells cross vitro vivo into animals experimental The collected show that some temporarily attach walls cerebral vessels then return bloodstream or penetrate BBB either undergo homing perivascular space deeper parenchyma. Transmigration across not necessary for induction effects, which incited through paracrine even by located inside blood vessels.
Language: Английский
Citations
18
Cells, Journal Year: 2024, Volume and Issue: 13(7), P. 617 - 617
Published: April 2, 2024
Glioblastoma is the most aggressive, malignant, and lethal brain tumor of central nervous system. Its poor prognosis lies in its inefficient response to currently available treatments that consist surgical resection, radiotherapy, chemotherapy. Recently, use mesenchymal stem cells (MSCs) as a possible kind cell therapy against glioblastoma gaining great interest due their immunomodulatory properties, tropism, differentiation into other types. However, MSCs seem present both antitumor pro-tumor properties depending on tissue from which they come. In this work, possibility using deliver therapeutic genes, oncolytic viruses, miRNA presented, well strategies can improve efficacy glioblastoma, such CAR-T cells, nanoparticles, exosomes.
Language: Английский
Citations
2
Molecular and Cellular Biochemistry, Journal Year: 2024, Volume and Issue: 479(7), P. 1643 - 1671
Published: July 1, 2024
Language: Английский
Citations
2
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(6), P. 5640 - 5640
Published: March 15, 2023
Aquaporin-4 (AQP4) plays a crucial role in brain water circulation and is considered therapeutic target hydrocephalus. Congenital hydrocephalus associated with reaction of astrocytes the periventricular white matter both experimental models human cases. A previous report showed that bone marrow-derived mesenchymal stem cells (BM-MSCs) transplanted into lateral ventricles hyh mice exhibiting severe congenital are attracted by astrocyte reaction, cerebral tissue displays recovery. The present investigation aimed to test effect BM-MSC treatment on formation. BM-MSCs were injected four-day-old mice, was detected two weeks later. protein expression analysis differentiated BM-MSC-treated from controls revealed effects neural development. In vivo vitro experiments, stimulated generation reactive overexpressing AQP4 its regulatory kinase D-interacting substrate 220 kDa (Kidins220). tissue, mRNA overexpression nerve growth factor (NGF), vascular endothelial (VEGF), hypoxia-inducible factor-1 (HIF1α), transforming beta 1 (TGFβ1) could be related regulation expression. conclusion, can stimulate key developmental process such as where implicated
Language: Английский
Citations
6