Phytoestrogens and Health Effects

Nutrients, Journal Year: 2023, Volume and Issue: 15(2), P. 317 - 317

Published: Jan. 9, 2023

Phytoestrogens are literally estrogenic substances of plant origin. Although these useful for plants in many aspects, their properties essentially relevant to predators. As such, phytoestrogens can be considered potentially dedicated plant–predator interaction. Therefore, it is not surprising note that the word phytoestrogen comes from early discovery effects grazing animals and humans. Here, several compounds whose activities have been discovered at nutritional concentrations humans examined. The analyzed belong chemical families, i.e., flavanones, coumestans, resorcylic acid lactones, isoflavones, enterolignans. Following definition evocation role plants, metabolic transformations bioavailabilities discussed. A point then made regarding health effects, which either beneficial or adverse depending on subject studied, sex, age, physiological status. Toxicological information given based official data. first presented Animal models evoked when no data available with a constant reference doses plausible exposure.

Language: Английский

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Antibacterial activity and action mechanism of flavonoids against phytopathogenic bacteria

Pesticide Biochemistry and Physiology, Journal Year: 2022, Volume and Issue: 188, P. 105221 - 105221

Published: Sept. 3, 2022

Language: Английский

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Antifungal activity, mycotoxin inhibitory efficacy, and mode of action of hop essential oil nanoemulsion against Fusarium graminearum

Food Chemistry, Journal Year: 2022, Volume and Issue: 400, P. 134016 - 134016

Published: Aug. 28, 2022

Language: Английский

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An Updated Review of the Genus Humulus: A Valuable Source of Bioactive Compounds for Health and Disease Prevention

Plants, Journal Year: 2022, Volume and Issue: 11(24), P. 3434 - 3434

Published: Dec. 8, 2022

The medicinal potential of hop (Humulus lupulus L.) is widely cited in ancient literature and also allowed several official pharmacopoeias for the treatment a variety ailments, mainly related to anxiety states. This due plethora phytoconstituents (e.g., bitter acids, polyphenols, prenyl flavonoids) present female inflorescences, commonly known as cones or strobili, endowed with anti-inflammatory, antioxidant, antimicrobial, phytoestrogen activities. Hop has recently attracted interest scientific community presence xanthohumol, whose strong anti-cancer activity against various types cancer cells been well documented, 8-prenyl naringenin, most potent phytoestrogen. Studies have shown that compounds can hinder numerous signalling pathways, including ERK1/2 phosphorylation, regulation AP-1 activity, PI3K-Akt, nuclear factor NF-κB, which are main targets antiproliferative action acids prenylflavonoids. In light these considerations, aim this review was provide an up-to-date overview biologically active found hops, their vitro vivo applications human health disease prevention. To end, quantitative analysis approach used, using VOSviewer software extract process Scopus bibliometric data. addition, data on pharmacokinetics bioactive clinical studies were analysed. make information more complete, beneficial properties other two species belonging genus Humulus, H. japonicus yunnanensis, reviewed first time.

Language: Английский

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The potential application of isoxanthohumol in inhibiting Clostridium perfringens infection by targeting the type IV pili

Microbial Cell Factories, Journal Year: 2025, Volume and Issue: 24(1)

Published: Feb. 21, 2025

Clostridium perfringens (C. perfringens) is an important zoonotic pathogen. The diseases such as necrotic enteritis (NE), enterotoxemia, gas gangrene and food poisoning caused by its infection seriously threaten the lives of both humans animals. However, under severe situation antibiotic resistance, development new antibacterial strategies or drugs deserves great attention. In this study, we selected virulence factor Type IV pili (TFP) C. target for drug screening. gliding motility, biofilm formation, cell adhesion activity natural compound isoxanthohumol (IXN) against were determined. Transmission electron microscopy (TEM), TFP gene transcription analysis Western blot used to detect expression PilA pilin. therapeutic effect IXN on was demonstrated through a mouse model. It confirmed that inhibits function down-regulating TFP-encoding genes two-component regulatory genes. conclusion, our study shows has potential inhibit in anti-infection applications.

Language: Английский

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Strategy for identification of characteristic components from multiphase of Sanwu Huangqin Decoction via UHPLC‒Q-TOF‒MS and UHPLC-QQQ-MS combined with multivariate statistical analysis

Journal of Chromatography A, Journal Year: 2025, Volume and Issue: 1747, P. 465809 - 465809

Published: Feb. 21, 2025

Language: Английский

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Revealing TCA Cycle Flow Dynamics in Fungicide-Adapted Botrytis cinerea through Anionic Chromatographic Simultaneous Separation

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: May 20, 2025

The exploration of new strategies to monitor Botrytis cinerea populations is critical for disease management. This study achieved efficient and simultaneous separation all TCA cycle intermediates in mycelia treated with pyraclostrobin (PYR), tebuconazole (TEB), carbendazim (CAR) using anionic chromatography. Resolutions nine organic acids six inorganic anions, including intermediates, exceeded 1.5. fungicides inhibited mycelial growth concentration-dependently, but prolonged exposure reduced the level inhibition. TEB decreased fumarate malate levels at 48 h, increased citrate, isocitrate, oxalate α-ketoglutarate 96 h. PYR showed biphasic effects, elevating fumarate, malate, succinate both time points reducing citrate CAR attenuated flow, isocitrate declining continuously. Moreover, promoted accumulation, had no effect, suppressed it. These findings enable precise assessment fungicide adaption B. cinerea, aiding

Language: Английский

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Metschnikowia Pulcherrima yeast T-2 VOCs Enhances Postharvest Blueberry Fruit Resistance to Botrytis cinerea by Activating Flavonoid Metabolic Pathways

LWT, Journal Year: 2024, Volume and Issue: 201, P. 116112 - 116112

Published: April 20, 2024

The postharvest rot of blueberry fruits caused by Botrytis cinerea led to economic losses. Here, we found that volatile organic compounds (VOCs) emitted Metschnikowia Pulcherrima T-2 reduced fruit rot. Nevertheless, the mechanism VOCs induced resistance remains unclear. total flavonoids content in were significantly higher treatment. Metabolomic analysis unraveled contents quercetin, kaempferol and myricetin with also inhibited growth B. vitro. According transcriptome analysis, expression level VcNAC83 was highly increased after Furthermore, correlated rate content, RT-qPCR verified up-regulated. Transient overexpression enhanced cinerea, lesion diameter rate. levels flavonoid-related genes such as PAL, F3H, F3'H, DFR F3'5'H overexpressed fruits. These results support a critical role for immune response provide new method storage.

Language: Английский

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Antimicrobial activity of compounds from hop (Humulus lupulus L.) following supercritical fluid extraction: An overview

Chilean journal of agricultural research, Journal Year: 2023, Volume and Issue: 83(4), P. 499 - 509

Published: Aug. 1, 2023

Although the female inflorescences of hop (Humulus lupulus L.) are mainly used in brewing industry, they were first as a medicinal plant. The antimicrobial potential secondary metabolites, biosynthesized phenolic compounds, and derivatives such α- β-acids have been increasingly researched along with cleaner more efficient extraction practices. Extraction is one methodologies to isolate components from plant-based materials. Supercritical fluid has become most commonly method for removing natural chemical because it environmentally friendly, readily available, non-hazardous. There interest among researchers extract bioactive compounds hops benefits human health. This review describes extracted hops. Their composition, antibacterial antifungal properties explained. effect methods on discussed. Finally, supercritical CO2 reported.

Language: Английский

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The Antimicrobial Activity and Characterization of Bioactive Compounds in Peganum harmala L. Based on HPLC and HS-SPME-GC-MS

Frontiers in Microbiology, Journal Year: 2022, Volume and Issue: 13

Published: July 19, 2022

Peganum harmala L. is a perennial herb of the Tribulus family and its aerial parts seeds can be used as medicine in traditional China. However, differences chemical components antibacterial activity between different have not been reported. In this study, composition P. was characterized by high-performance liquid chromatography (HPLC) headspace-solid phase microextraction-gas chromatography-mass spectrometry (HS-SPME-GC-MS). The antimicrobial activities some isolated were also carried out on 12 bacterial strains phytopathogenic fungi. HPLC results revealed that contents harmine harmaline higher than parts. A total 94 volatile organic compounds (VOCs) tentatively identified HS-SPME-GC-MS for first time. major methyl hexadecanoate, p-xylene, octane, (Z)-9-octadecanoate, ethylbenzene, octadecanoate, ethyl tetradecanoate. At concentration 800 μg·mL-1, methanol extracts showed stronger with wide spectrum, inhibiting Escherichia coli (ATCC 24433), Xanthomonas oryzae (ACCC 11602), axonopodis inhibitory rates more 90%. Furthermore, better against all bacteria. These findings indicated alkaloids from could account activity, which lead molecules development new drugs.

Language: Английский

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