Pharmaceuticals,
Journal Year:
2023,
Volume and Issue:
16(10), P. 1410 - 1410
Published: Oct. 4, 2023
Metal
nanoparticles
(NPs)
have
garnered
considerable
attention,
due
to
their
unique
physicochemical
properties,
that
render
them
promising
candidates
for
various
applications
in
medicine
and
industry.
This
article
offers
a
comprehensive
overview
of
the
most
recent
advancements
manufacturing,
characterization,
biomedical
utilization
metal
NPs,
with
primary
focus
on
silver
gold
NPs.
Their
potential
as
effective
anticancer,
anti-inflammatory,
antimicrobial
agents,
drug
delivery
systems,
imaging
agents
diagnosis
treatment
variety
disorders
is
reviewed.
Moreover,
translation
therapeutic
settings,
issue
inclusion
clinical
trials,
are
assessed
light
over
30
investigations
concentrate
administering
either
or
NPs
conditions
ranging
from
nosocomial
infections
different
types
cancers.
paper
aims
not
only
examine
biocompatibility
nanomaterials
but
also
emphasize
challenges
may
limit
safe
integration
into
healthcare
practices.
More
than
100
nanomedicines
currently
market,
which
justifies
ongoing
study
use
medicine.
Overall,
present
review
highlight
innovative
therapeutics
field
biomedicine,
citing
some
relevant
current
applications.
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(23), P. 14658 - 14658
Published: Nov. 24, 2022
Because
of
their
small
size
and
large
specific
surface
area,
nanoparticles
(NPs)
have
special
properties
that
are
different
from
bulk
materials.
In
particular,
Au/Ag
NPs
been
intensively
studied
for
a
long
time,
especially
biomedical
applications.
Thereafter,
they
played
significant
role
in
the
fields
biology,
medical
testing,
optical
imaging,
energy
catalysis,
MRI
contrast
agents,
tumor
diagnosis
treatment,
environmental
protection,
so
on.
When
synthesizing
NPs,
laser
ablation
biosynthesis
methods
very
promising
green
processes.
Therefore,
this
review
focuses
on
progress
biological
synthesis
processes
NP
generation,
fabrication
fundamentals
potential
First,
method
critically
reviewed,
including
mechanism
controlling
shape
during
using
ablation.
Second,
comprehensively
discussed,
involving
principle
process
preparing
methods.
Third,
applications
other
reviewed
to
demonstrate
value
NPs.
Finally,
discussion
surrounding
three
aspects
(similarity,
individuality,
complementarity)
two
is
presented,
necessary
outlook,
current
limitations
challenges,
suggested,
which
provides
reference
low-cost
sustainable
production
future.
Life Sciences,
Journal Year:
2024,
Volume and Issue:
352, P. 122899 - 122899
Published: July 9, 2024
This
comprehensive
review
provides
an
in-depth
analysis
of
how
nanotechnology
has
revolutionized
cancer
theragnostic,
which
combines
diagnostic
and
therapeutic
methods
to
customize
treatment.
The
study
examines
the
unique
attributes,
uses,
difficulties
linked
different
types
nanoparticles,
including
gold,
iron
oxide,
silica,
Quantum
dots,
Carbon
nanotubes,
liposomes,
in
context
In
addition,
paper
progression
nanotheranostics,
emphasizing
its
uses
precise
medication
administration,
photothermal
therapy,
sophisticated
such
as
MRI,
CT,
fluorescence
imaging.
Moreover,
article
highlights
capacity
nanoparticles
improve
effectiveness
drugs,
reduce
overall
toxicity
body,
open
up
new
possibilities
for
treating
by
releasing
drugs
a
controlled
manner
targeting
specific
areas.
Furthermore,
it
tackles
concerns
regarding
compatibility
their
potential
harmful
effects,
significance
continuous
nanotherapeutic
use
medical
treatments.
finishes
outlining
future
applications
predictive
oncology
customized
medicine.
Chemical Reviews,
Journal Year:
2023,
Volume and Issue:
123(12), P. 7782 - 7853
Published: May 15, 2023
The
high
selectivity
and
affinity
of
antibodies
toward
their
antigens
have
made
them
a
highly
valuable
tool
in
disease
therapy,
diagnosis,
basic
research.
A
plethora
chemical
genetic
approaches
been
devised
to
make
accessible
more
"undruggable"
targets
equipped
with
new
functions
illustrating
or
regulating
biological
processes
precisely.
In
this
Review,
addition
introducing
how
naked
various
antibody
conjugates
(such
as
antibody-drug
conjugates,
antibody-oligonucleotide
antibody-enzyme
etc.)
work
therapeutic
applications,
special
attention
has
paid
chemistry
tools
helped
optimize
the
outcome
(i.e.,
enhanced
efficacy
reduced
side
effects)
facilitate
multifunctionalization
antibodies,
focus
on
emerging
fields
such
targeted
protein
degradation,
real-time
live-cell
imaging,
catalytic
labeling
decaging
spatiotemporal
control
well
engagement
inside
cells.
With
advances
modern
biotechnology,
well-designed
derivatives
via
size
miniaturization
together
efficient
delivery
systems
emerged,
which
gradually
improved
our
understanding
important
paved
way
pursue
novel
for
potential
treatments
diseases.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(4), P. 2360 - 2360
Published: Feb. 17, 2024
This
review
explores
the
diverse
applications
of
gold
nanoparticles
(AuNPs)
in
neurological
diseases,
with
a
specific
focus
on
Alzheimer's
disease
(AD),
Parkinson's
(PD),
and
stroke.
The
introduction
highlights
pivotal
role
neuroinflammation
these
disorders
introduces
unique
properties
AuNPs.
review's
core
examines
mechanisms
by
which
AuNPs
exert
neuroprotection
anti-neuro-inflammatory
effects,
elucidating
various
pathways
through
they
manifest
properties.
potential
therapeutic
AD
are
discussed,
shedding
light
promising
avenues
for
therapy.
also
prospects
utilizing
PD
interventions,
presenting
hopeful
outlook
future
treatments.
Additionally,
delves
into
providing
after
strokes,
emphasizing
their
significance
mitigating
cerebrovascular
accidents'
aftermath.
Experimental
findings
from
cellular
animal
models
consolidated
to
provide
comprehensive
overview
AuNPs'
effectiveness,
offering
insights
impact
at
both
vivo
levels.
enhances
our
understanding
diseases
lays
groundwork
innovative
strategies
neurology.
Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(2), P. 176 - 176
Published: Jan. 30, 2025
Proton
therapy
represents
a
groundbreaking
advancement
in
cancer
radiotherapy,
leveraging
the
unique
spatial
energy
distribution
of
protons
to
deliver
precise,
high-dose
radiation
tumors
while
sparing
surrounding
healthy
tissues.
Despite
its
clinical
success,
proton
faces
challenges
optimizing
therapeutic
precision
and
efficacy.
Recent
research
has
highlighted
potential
gold
nanoparticles
enhance
outcomes.
Due
their
high
atomic
number
favorable
biological
properties,
act
as
radiosensitizers
by
amplifying
generation
secondary
electrons
reactive
oxygen
species
upon
irradiation.
This
enhances
DNA
damage
tumor
cells
preserving
Additionally,
functionalization
with
tumor-targeting
ligands
offers
improved
precision,
making
more
effective
against
broader
range
cancers.
review
synthesizes
current
knowledge
on
mechanisms
nanoparticle
radiosensitization,
preclinical
evidence,
technological
hurdles
that
must
be
addressed
integrate
this
promising
approach
into
practice,
aiming
advance
efficacy
accessibility
therapy.
ACS Nano,
Journal Year:
2022,
Volume and Issue:
16(3), P. 4756 - 4774
Published: March 3, 2022
Infections
caused
by
drug-resistant
bacteria,
particularly
Gram-negative
organisms,
are
increasingly
difficult
to
treat
using
antibiotics.
A
potential
alternative
is
"phage
therapy",
in
which
phages
infect
and
lyse
the
bacterial
host.
However,
phage
therapy
poses
serious
drawbacks
safety
concerns,
such
as
risk
of
genetic
transduction
antibiotic
resistance
genes,
inconsistent
pharmacokinetics,
unknown
evolutionary
potential.
In
contrast,
metallic
nanoparticles
possess
precise,
tunable
properties,
including
efficient
conversion
electronic
excitation
into
heat.
this
work,
we
demonstrate
that
engineered
phage-nanomaterial
conjugates
target
pathogen
Pseudomonas
aeruginosa
highly
effective
a
treatment
infected
wounds
mice.
Photothermal
heating,
performed
single
(15
min)
or
two
treatments
on
consecutive
days,
rapidly
reduced
load
released
Zn2+
promote
wound
healing.
The
was
significantly
more
than
systemic
standard-of-care
antibiotics,
with
>10×
greater
reduction
∼3×
faster
healing
measured
size
when
compared
fluoroquinolone
treatment.
Notably,
also
against
P.
strain
resistant
polymyxins,
last-line
therapy.
Unlike
these
showed
no
detectable
toxicity
effects
mice,
consistent
short
duration
localized
nature
Our
results
controlled
inorganic
nanomaterials
can
be
safe
antimicrobial
strategy
vivo.
Frontiers in Oncology,
Journal Year:
2022,
Volume and Issue:
11
Published: Jan. 19, 2022
In
recent
years,
the
morbidity
and
mortality
of
gastrointestinal
cancer
have
remained
high
in
China.
Due
to
deep
location
organs,
such
as
gastric
cancer,
early
symptoms
are
not
obvious.
It
is
generally
discovered
at
an
advanced
stage
with
distant
metastasis
lymph
node
infiltration,
making
it
difficult
cure.
Therefore,
there
a
significant
need
for
novel
technologies
that
can
effectively
diagnose
treat
ultimately
reducing
its
mortality.
Gold
nanoparticles
(GNPs),
type
nanocarrier
unique
optical
properties
remarkable
biocompatibility,
potential
influence
fate
by
delivering
drugs,
nucleic
acids
cells
tissues.
As
safe
reliable
visualization
agent,
GNPs
track
drugs
accurately
indicate
boundaries
opening
up
new
possibilities
treatment.
addition,
been
used
photodynamic
therapy
deliver
photosensitizers,
well
combination
photothermal
therapy.
be
effective
nanomaterial
treatment
diagnosis
cancer.
