Acetyl-CoA synthesis in the skin is a key determinant of systemic lipid homeostasis DOI Creative Commons
Phuong Nguyen,

Michael H.I. Shiue,

Nina Kuprasertkul

et al.

Cell Reports, Journal Year: 2025, Volume and Issue: 44(2), P. 115284 - 115284

Published: Feb. 1, 2025

ATP-citrate lyase (ACLY) generates cytosolic acetyl-coenzyme A (acetyl-CoA) for lipid synthesis and is a promising therapeutic target in diseases with altered metabolism. Here, we developed inducible whole-body Acly-knockout mice to determine the requirement ACLY normal tissue functions, uncovering its crucial role skin homeostasis. ACLY-deficient upregulates acetyl-CoA synthetase ACSS2; deletion of both Acly Acss2 from exacerbates abnormalities, differential effects on two major lipid-producing compartments. While epidermis depleted barrier lipids, sebaceous glands increase production sebum, supplied at least part by circulating fatty acids coinciding adipose lipolysis fat depletion. Dietary supplementation further boosts sebum partially rescues lipoatrophy aberrant phenotypes. The data establish critical maintaining integrity highlight as key organ systemic regulation.

Language: Английский

Skin, gut, and lung barrier: Physiological interface and target of intervention for preventing and treating allergic diseases DOI Creative Commons
Roberto Berni Canani, Marco Caminati, Laura R. Carucci

et al.

Allergy, Journal Year: 2024, Volume and Issue: 79(6), P. 1485 - 1500

Published: March 4, 2024

The epithelial barriers of the skin, gut, and respiratory tract are critical interfaces between environment host, they orchestrate both homeostatic pathogenic immune responses. mechanisms underlying barrier dysfunction in allergic inflammatory conditions, such as atopic dermatitis, food allergy, eosinophilic oesophagitis, rhinitis, chronic rhinosinusitis, asthma, complex influenced by exposome, microbiome, individual genetics, epigenetics. Here, we review role digestive tract, airways maintaining homeostasis, how influence occurrence progression current treatments target epithelium to improve symptoms these disorders, what unmet needs identification treatment disorders.

Language: Английский

Citations

20
Skin Cleansing without or with Compromise: Soaps and Syndets DOI Creative Commons
Dalibor Mijaljica, Fabrizio Spada, Ian P. Harrison

et al.

Molecules, Journal Year: 2022, Volume and Issue: 27(6), P. 2010 - 2010

Published: March 21, 2022

Products designed to cleanse the skin commonly do so through surfactant action, which leads lowering of surface tension facilitate removal dirt from its surface. Skin cleansers generally come in one two types: soap-based and synthetic detergents, or syndets. While latter can effectively maintain native structure, function integrity, former tends negatively affect by causing barrier disruption, lipid dissolution pH alteration. Despite this, soap is still often preferred, possibly due negative connotations around anything that not perceived as ‘natural’. It is, therefore, important science behind cleansers, especially those for maintenance healthy management common conditions such eczema, be understood both formulators end-users. Here, we carefully weigh advantages disadvantages different types surfactant—the key ingredient(s) cleansers—and provide insight into surfactants’ physicochemical properties, biological activity potential effects. Fine-tuning complex characteristics surfactants successfully lead an ‘optimal’ cleanser simultaneously milder nature, highly effective beneficial, offer minimal interference environmental impact.

Language: Английский

Citations

62
Recapitulating Antioxidant and Antibacterial Compounds into a Package for Tissue Regeneration: Dual Function Materials with Synergistic Effect DOI

Minmin Shao,

Ashkan Bigham, Satar Yousefiasl

et al.

Small, Journal Year: 2023, Volume and Issue: 19(19)

Published: Feb. 12, 2023

Abstract Oxidative damage and infection can prevent or delay tissue repair. Moreover, reinforces reactive oxygen species (ROS) formation, which makes the wound's condition even worse. Therefore, need for antioxidant antibacterial agents is felt regeneration. There are emerging up‐and‐coming biomaterials that recapitulate both properties into a package, offering an effective solution to turn wound back healing state. In this article, principles of activity summarized. The review starts with biological aspects, getting readers familiarize themselves barriers against infection. This followed by chemistry mechanism action materials (dual function). Eventually, outlook challenges underlined provide where dual‐function they going in future. It expected present article inspires designing more advanced levels providing fundamentals comparative points view paving clinical way these materials.

Language: Английский

Citations

33
Spatial multi-omics of human skin reveals KRAS and inflammatory responses to spaceflight DOI Creative Commons
Jiwoon Park, Eliah Overbey, S Narayanan

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: June 11, 2024

Abstract Spaceflight can change metabolic, immunological, and biological homeostasis cause skin rashes irritation, yet the molecular basis remains unclear. To investigate impact of short-duration spaceflight on skin, we conducted biopsies Inspiration4 crew members before (L-44) after (R + 1) flight. Leveraging multi-omics assays including GeoMx™ Digital Spatial Profiler, single-cell RNA/ATAC-seq, metagenomics/metatranscriptomics, assessed spatial gene expressions associated microbial immune changes across 95 regions in four compartments: outer epidermis, inner dermis, vasculature. Post-flight samples showed significant up-regulation genes related to inflammation KRAS signaling all regions. These spaceflight-associated mapped specific cellular responses, altered interferon DNA damage, epithelial barrier disruptions, T-cell migration, hindered regeneration were located primarily tissue compartments. We also linked disruption shifts swab cell activity PBMC data from same timepoints. Our findings present inaugural collection examination astronaut offering insights for future space missions response countermeasures.

Language: Английский

Citations

15
Inflammatory Skin Diseases: Focus on the Role of Suppressors of Cytokine Signaling (SOCS) Proteins DOI Creative Commons
Antonia Cianciulli, Rosa Calvello, Chiara Porro

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(6), P. 505 - 505

Published: March 13, 2024

Inflammatory skin diseases include a series of disorders characterized by strong activation the innate and adaptive immune system in which proinflammatory cytokines play fundamental role supporting inflammation. Skin inflammation is complex process influenced various factors, including genetic environmental dysfunction both non-immune cells. Psoriasis (PS) atopic dermatitis (AD) are most common chronic inflammatory conditions whose pathogeneses very multifactorial. Both an immunological involving predominance Th1 Th17 cells PS Th2 AD. Suppressor cytokine signaling (SOCS) proteins intracellular that control responses regulating pathways activated cytokines. SOCS involved regulation progression skin-resident non-resident cells, recent data suggest these negative modulators dysregulated such as This review focuses on current understanding about modulating activity mediators implicated pathogenesis

Language: Английский

Citations

10
New Insights into the Role of PPARγ in Skin Physiopathology DOI Creative Commons
Stefania Briganti, Sarah Mosca, Anna Di Nardo

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(6), P. 728 - 728

Published: June 19, 2024

Peroxisome proliferator-activated receptor gamma (PPARγ) is a transcription factor expressed in many tissues, including skin, where it essential for maintaining skin barrier permeability, regulating cell proliferation/differentiation, and modulating antioxidant inflammatory responses upon ligand binding. Therefore, PPARγ activation has important implications homeostasis. Over the past 20 years, with increasing interest role of PPARs physiopathology, considerable effort been devoted to development ligands as therapeutic option disorders. In addition, also regulates sebocyte differentiation lipid production, making potential target sebaceous disorders such acne. A large number studies suggest that acts tumor suppressor both melanoma non-melanoma cancers, but its tumorigenesis remains controversial. this review, we have summarized current state research into health disease how may provide starting point more potent selective low toxicity profile, thereby reducing unwanted side effects.

Language: Английский

Citations

9
Vortex Fluidic Mediated Generation of Fatty Acid Ethyl Esters from Vegetable Oils for Applications in Cosmetic Emulsions DOI Creative Commons
Xuejiao Cao, Xuan Luo, Amir Heydari

et al.

Journal of Cleaner Production, Journal Year: 2025, Volume and Issue: unknown, P. 145006 - 145006

Published: Feb. 1, 2025

Language: Английский

Citations

1
The Role of Keratinocytes in Skin Health and Disease DOI Open Access
Mohammed Saleh Al‐Dhubaibi, Ghada Farouk Mohammed, Saleh Salem Bahaj

et al.

Dermatological Reviews, Journal Year: 2025, Volume and Issue: 6(2)

Published: March 24, 2025

ABSTRACT Aim This study aims to provide a comprehensive analysis of keratinocytes, the predominant cell type in epidermis, by examining their structural, functional, and regulatory roles skin biology. The explores intricate processes keratinocyte differentiation, proliferation, immune interactions, emphasizing essential contributions homeostasis, wound healing, barrier integrity. Additionally, it investigates involvement keratinocytes dermatological disorders such as psoriasis, atopic dermatitis, cancer, highlighting pathological alterations molecular mechanisms. Methods review covers broad range studies, including vitro vivo research on biology, interactions with growth factors, inflammatory responses skin. It also discusses therapeutic advancements biologics gene therapy that focus restoring function diseases. Results highlights play pivotal role inflammation regulation factors promote healing regeneration. Dysregulation is linked several diseases, need for targeted approaches. Recent treatments, biologics, offer promising outcomes managing conditions driven dysfunction. Conclusion primary aim this an in‐depth overview functions particularly health, inflammation, disease development. highlight latest strategies targeting treatment

Language: Английский

Citations

1
Nanoencapsulation of Tea Catechins for Enhancing Skin Absorption and Therapeutic Efficacy DOI

Ibrahim A. Aljuffali,

Chih-Hung Lin,

Shih-Chun Yang

et al.

AAPS PharmSciTech, Journal Year: 2022, Volume and Issue: 23(6)

Published: July 7, 2022

Language: Английский

Citations

36
Epidermal barrier function in dry, flaky and sensitive skin: A narrative review DOI Creative Commons
Joachim W. Fluhr, David J. Moore, Majella E. Lane

et al.

Journal of the European Academy of Dermatology and Venereology, Journal Year: 2023, Volume and Issue: 38(5), P. 812 - 820

Published: Dec. 22, 2023

Abstract The stratum corneum (SC)—the outermost layer of the epidermis—is principal permeability and protective barrier skin. Different components SC, including corneocytes, natural moisturizing factor, a variety enzymes their inhibitors, antimicrobial peptides lipids, work interactively to maintain function. main properties SC are limitation water loss prevention infection contact with potentially harmful exogenous factors. Although functions consistently as throughout body, variations in morphology occur across body sites age skin type. Healthy function also depends on interplay between chemosensory barrier, skin's microbiome innate immune system. Dysregulation can lead development disorders, such dry, flaky or sensitive skin, but complete underlying pathophysiology these not fully understood. This review provides insight into current literature emerging themes related epidermal changes that context Additional studies needed further elucidate aetiology provide tailored treatment.

Language: Английский

Citations

22