Frontiers in Bioengineering and Biotechnology,
Journal Year:
2022,
Volume and Issue:
10
Published: July 1, 2022
Although
the
risk
of
trauma
in
space
is
low,
unpredictable
events
can
occur
that
may
require
surgical
treatment.
Hemorrhage
be
a
life-threatening
condition
while
traveling
to
another
planet
and
after
landing
on
it.
These
exploration
missions
call
for
different
approach
than
rapid
return
Earth,
which
policy
currently
adopted
International
Space
Station
(ISS)
low
Earth
orbit
(LEO).
Consequences
are
difficult
predict,
given
still
scarce
knowledge
human
physiology
such
environments.
Blood
loss
deplete
affected
astronaut’s
physiological
reserves
all
stored
crew
supplies.
In
this
review,
we
will
describe
aspects
hemorrhage
space,
by
comparison
with
terrestrial
conditions,
possible
solutions
adopted,
current
state
art.
The Journal of Physiology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 24, 2025
Abstract
Cognitive
and
physical
stress
have
significant
effects
on
brain
health,
particularly
through
their
influence
the
central
executive
network
(CEN).
The
CEN,
which
includes
regions
such
as
dorsolateral
prefrontal
cortex,
anterior
cingulate
cortex
inferior
parietal
lobe,
is
to
managing
demands
of
cognitively
challenging
motor
tasks.
Acute
can
temporarily
reduce
connectivity
within
leading
impaired
cognitive
function
emotional
states.
However
a
rebound
in
these
states
often
follows,
driven
by
motivational
signals
mesocortical
mesolimbic
pathways,
help
sustain
inhibitory
control
task
execution.
Chronic
exposure
challenges
leads
long‐term
improvements
CEN
functionality.
These
changes
are
supported
neurochemical,
structural
systemic
adaptations,
including
mechanisms
tissue
crosstalk.
Myokines,
adipokines,
anti‐inflammatory
cytokines
gut‐derived
metabolites
contribute
biochemical
environment
that
enhances
neuroplasticity,
reduces
neuroinflammation
supports
neurotransmitters
serotonin
dopamine.
processes
strengthen
connectivity,
improve
self‐regulation
enable
individuals
adopt
health‐optimizing
behaviours.
Long‐term
activity
not
only
but
also
risk
age‐related
decline
neurodegenerative
diseases.
This
review
highlights
role
progressive
exercise
practical
approach
strengthening
promoting
offering
strategy
resilience
well‐being
across
lifespan.
image
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(17), P. 9695 - 9695
Published: Sept. 7, 2024
The
research
in
neuroimmunomodulation
aims
to
shed
light
on
the
complex
relationships
that
exist
between
immune
and
neurological
systems
how
they
affect
human
body.
This
multidisciplinary
field
focuses
way
responses
are
influenced
by
brain
activity
neural
function
is
impacted
immunological
signaling.
provides
important
insights
into
a
range
of
medical
disorders.
Targeting
both
pathways,
neuroimmunomodulatory
approaches
used
clinical
pain
management
address
chronic
pain.
Pharmacological
therapies
aim
modulate
neuroimmune
interactions
reduce
inflammation.
Furthermore,
bioelectronic
techniques
like
vagus
nerve
stimulation
offer
non-invasive
control
these
systems,
while
neuromodulation
transcranial
magnetic
modify
neuronal
Within
context
aging,
analyzes
ways
which
alterations
brought
aging
contribute
cognitive
decline
neurodegenerative
illnesses.
Restoring
homeostasis
through
strategies
shows
promise
reducing
age-related
decline.
Research
mood
disorders
dysregulation
relates
illnesses
including
anxiety
depression.
Immune
system
fluctuations
increasingly
recognized
for
their
impact
function,
leading
novel
treatments
target
interactions.
review
emphasizes
interdisciplinary
cooperation
continuous
necessary
better
understand
relationship
systems.
mSystems,
Journal Year:
2023,
Volume and Issue:
unknown
Published: June 26, 2023
Short-chain
fatty
acids
(SCFAs,
especially
butyric
acid)
have
been
demonstrated
to
play
a
promising
role
in
the
development
of
autism
spectrum
disorders
(ASD).
Recently,
hypothalamic-pituitary-adrenal
(HPA)
axis
is
also
suggested
increase
risk
ASD.
However,
mechanism
underlying
SCFAs
and
HPA
ASD
remains
unknown.
Here,
we
show
that
children
with
exhibited
lower
SCFA
concentrations
higher
cortisol
levels,
which
were
recaptured
prenatal
lipopolysaccharide
(LPS)-exposed
rat
model
These
offspring
showed
decreased
SCFA-producing
bacteria
histone
acetylation
activity
as
well
impaired
corticotropin-releasing
hormone
receptor
2
(CRHR2)
expression.
Sodium
butyrate
(NaB),
can
act
deacetylases
inhibitors,
significantly
increased
at
CRHR2
promoter
vitro
normalized
corticosterone
expression
level
vivo.
Behavioral
assays
indicated
ameliorative
effects
NaB
on
anxiety
social
deficit
LPS-exposed
offspring.
Our
results
imply
treatment
improve
ASD-like
symptoms
via
epigenetic
regulation
offspring;
thus,
it
may
provide
new
insight
into
neurodevelopmental
like
IMPORTANCE
Growing
evidence
suggests
microbiota
affect
brain
function
behavior
through
"microbiome-gut-brain''
axis,
but
its
poorly
understood.
both
overactivation
axis.
bacteria,
Lactobacillus,
might
be
key
differential
between
control
Interestingly,
contributed
(such
CRHR2)
improvement
behaviors
The
potential
effect
mediated
increasing
promoter.
enhance
our
understanding
relationship
And
gut
microbiota-derived
serve
therapeutic
agent
Aquaculture Reports,
Journal Year:
2024,
Volume and Issue:
36, P. 102041 - 102041
Published: March 21, 2024
We
compared
the
performance
and
physiological
response
of
diploid
triploid
Atlantic
salmon
(Salmo
salar)
following
21
days
either
unpredictable
chronic
stress
(UCS)
or
no
disturbance
(control).
Thereafter,
all
four
groups
were
challenged
with
a
novel
acute
stressor
consisting
crowding,
netting
transfer
into
another
tank.
Growth
was
monitored
during
21-day
period,
to
challenge
assessed
by
blood
chemistry
parameters
pituitary
gene
expression.
Plasma
analyzed
before
(0)
15,
30,
45,
60,
90,
120,
240,
300
min
after
induction,
whereas
expression
at
0,
240
min.
The
results
showed:
a)
similar
growth
rate
condition
factor
reductions
from
UCS
in
triploids
diploids,
b)
higher
post-stress
plasma
Acth
cortisol
levels
c)
wider
fluctuations
most
other
for
particularly
glucose
lactate,
d)
pomca1,
pomcb,
crf-r1a
crf-r1b
mRNA
more
upregulated
control
diploids
than
triploids,
e)
only
minor
changes
both
but
noticeable
upregulation
pomca2
triploids.
Our
suggest
that
have
energy
cost
salmon.
This
can
make
them
sensitive
suboptimal
conditions
episodes
stress.
Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(3), P. 513 - 513
Published: Feb. 24, 2024
Hair
loss
is
a
common
clinical
condition
connected
with
serious
psychological
distress
and
reduced
quality
of
life.
Hormones
play
an
essential
role
in
the
regulation
hair
growth
cycle.
This
review
focuses
on
hormonal
background
loss,
including
pathophysiology,
underlying
endocrine
disorders,
possible
treatment
options
for
alopecia.
In
particular,
androgens,
dihydrotestosterone
(DHT),
testosterone
(T),
androstenedione
(A4),
dehydroepiandrosterone
(DHEA),
its
sulfate
(DHEAS),
has
been
studied
context
androgenetic
Androgen
excess
may
cause
miniaturization
follicles
(HFs)
scalp.
Moreover,
occur
case
estrogen
deficiency,
appearing
naturally
during
menopause.
Also,
thyroid
hormones
dysfunctions
are
linked
most
types
alopecia,
telogen
effluvium
(TE),
alopecia
areata
(AA),
Particular
emphasis
placed
hypothalamic–pituitary–adrenal
axis
(corticotropin-releasing
hormone,
adrenocorticotropic
hormone
(ACTH),
cortisol)
stress-induced
article
also
briefly
discusses
therapies,
5-alpha-reductase
inhibitors
(finasteride,
dutasteride),
spironolactone,
bicalutamide,
estrogens,
others.
Journal of Clinical Neurology,
Journal Year:
2024,
Volume and Issue:
20(2), P. 131 - 131
Published: Jan. 1, 2024
Epilepsy
is
a
recurrent,
transient
seizure
disorder
of
the
nervous
system
that
affects
intellectual
development,
life
and
work,
psychological
health
patients.
People
with
epilepsy
worldwide
experience
great
suffering.
Stressful
stimuli
such
as
infection,
mental
stress,
sleep
deprivation
are
important
triggers
epilepsy,
chronic
stressful
can
lead
to
frequent
seizures
comorbidities.
The
hypothalamic-pituitary-adrenal
(HPA)
axis
most
involved
in
body's
stress
response,
dysfunction
thereof
thought
be
associated
core
symptoms
related
psychopathology.
This
article
explores
intrinsic
relationships
corticotropin-releasing
hormone,
adrenocorticotropic
glucocorticoids
order
reveal
role
HPA
pathogenesis
epilepsy.
We
hope
this
information
will
yield
future
possible
directions
ideas
for
fully
understanding
developing
antiepileptic
drugs.
BIO Web of Conferences,
Journal Year:
2025,
Volume and Issue:
152, P. 01013 - 01013
Published: Jan. 1, 2025
The
effect
of
anaesthesia
on
the
immune
system
has
been
focus
research
over
last
decade,
particularly
in
cancer
patients.
Anaesthetic
procedures,
which
are
essential
surgical
management,
can
affect
body’s
response
through
direct
and
indirect
mechanisms.
Anti-tumour
immunity
is
compromised
by
local
systemic
immunosuppression,
may
ultimately
contribute
to
tumor
survival
long-term
prognosis
This
article
aims
identify
evaluate
evidence
effects
anaesthesia-induced
determine
mechanisms
affects
during
surgery,
implications
for
proliferation,
metastasis,
recurrence.
In
addition,
this
also
evaluates
type
explores
relationship
between
modulation
survival.
uses
literature
review
method
with
PICO
JBI
tools
analysis
approach
15
journals
found
database
searches
PubMed,
ScienceDirect,
EBSCO.
study
population
patients,
reviewed
provides
an
overview
into
biological
pathways
involved,
immunosuppression
associated
anaesthesia,
potential
anaesthetic
interventions
minimize
negative
impact
prognosis.
showed
a
significant
association
its
Conclusions
from
highlight
importance
appropriate
choice
improve
clinical
outcomes
