Chrono-Endocrinology in Clinical Practice: A Journey from Pathophysiological to Therapeutic Aspects DOI Creative Commons

Silvia Mercadante,

Antonio Bellastella

Life, Journal Year: 2024, Volume and Issue: 14(5), P. 546 - 546

Published: April 24, 2024

This review was aimed at collecting the knowledge on pathophysiological and clinical aspects of endocrine rhythms their implications in practice, derived from published literature some personal experiences this topic. We chose to review, according PRISMA guidelines, results original observational studies, reviews, meta-analyses case reports up March 2024. Thus, after summarizing general biological rhythms, we will describe characteristics several consequences disruption, paying particular attention practice. Rhythmic secretions, like other physiological are genetically determined regulated by a central hypothalamic CLOCK located suprachiasmatic nucleus, which links timing independent clocks, hierarchical organization for regulation physiology behavior. However, environmental factors, such as daily cycles light/darkness, sleep/wake, food intake, may influence rhythm characteristics. Endocrine involved important processes disruption cause disorders also cancer. it is very prevent disruptions restore previously altered an early corrective chronotherapy.

Language: Английский

Early Life Stress and Major Depressive Disorder—An Update on Molecular Mechanisms and Synaptic Impairments DOI
Amanda Gollo Bertollo, Agatha Carina Leite Galvan, Claudia Dallagnol

et al.

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: 61(9), P. 6469 - 6483

Published: Feb. 3, 2024

Language: Английский

Citations

10
Improving brain health via the central executive network DOI Open Access
Marcelo Bigliassi, Danylo F. Cabral, Amanda C. Evans

et al.

The Journal of Physiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 24, 2025

Abstract Cognitive and physical stress have significant effects on brain health, particularly through their influence the central executive network (CEN). The CEN, which includes regions such as dorsolateral prefrontal cortex, anterior cingulate cortex inferior parietal lobe, is to managing demands of cognitively challenging motor tasks. Acute can temporarily reduce connectivity within leading impaired cognitive function emotional states. However a rebound in these states often follows, driven by motivational signals mesocortical mesolimbic pathways, help sustain inhibitory control task execution. Chronic exposure challenges leads long‐term improvements CEN functionality. These changes are supported neurochemical, structural systemic adaptations, including mechanisms tissue crosstalk. Myokines, adipokines, anti‐inflammatory cytokines gut‐derived metabolites contribute biochemical environment that enhances neuroplasticity, reduces neuroinflammation supports neurotransmitters serotonin dopamine. processes strengthen connectivity, improve self‐regulation enable individuals adopt health‐optimizing behaviours. Long‐term activity not only but also risk age‐related decline neurodegenerative diseases. This review highlights role progressive exercise practical approach strengthening promoting offering strategy resilience well‐being across lifespan. image

Language: Английский

Citations

1
T cell-mediated skin-brain axis: Bridging the gap between psoriasis and psychiatric comorbidities DOI

Juexi Yang,

Zhang Song,

Qixuan Wu

et al.

Journal of Autoimmunity, Journal Year: 2024, Volume and Issue: 144, P. 103176 - 103176

Published: Feb. 15, 2024

Language: Английский

Citations

7
Navigating the Neuroimmunomodulation Frontier: Pioneering Approaches and Promising Horizons—A Comprehensive Review DOI Open Access

Antea Kršek,

Leona Ostojić,

Dorotea Zivalj

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9695 - 9695

Published: Sept. 7, 2024

The research in neuroimmunomodulation aims to shed light on the complex relationships that exist between immune and neurological systems how they affect human body. This multidisciplinary field focuses way responses are influenced by brain activity neural function is impacted immunological signaling. provides important insights into a range of medical disorders. Targeting both pathways, neuroimmunomodulatory approaches used clinical pain management address chronic pain. Pharmacological therapies aim modulate neuroimmune interactions reduce inflammation. Furthermore, bioelectronic techniques like vagus nerve stimulation offer non-invasive control these systems, while neuromodulation transcranial magnetic modify neuronal Within context aging, analyzes ways which alterations brought aging contribute cognitive decline neurodegenerative illnesses. Restoring homeostasis through strategies shows promise reducing age-related decline. Research mood disorders dysregulation relates illnesses including anxiety depression. Immune system fluctuations increasingly recognized for their impact function, leading novel treatments target interactions. review emphasizes interdisciplinary cooperation continuous necessary better understand relationship systems.

Language: Английский

Citations

7
Sodium butyrate facilitates CRHR2 expression to alleviate HPA axis hyperactivity in autism-like rats induced by prenatal lipopolysaccharides through histone deacetylase inhibition DOI Creative Commons

Xinyuan Wang,

Zhujun Sun,

Ting Yang

et al.

mSystems, Journal Year: 2023, Volume and Issue: unknown

Published: June 26, 2023

Short-chain fatty acids (SCFAs, especially butyric acid) have been demonstrated to play a promising role in the development of autism spectrum disorders (ASD). Recently, hypothalamic-pituitary-adrenal (HPA) axis is also suggested increase risk ASD. However, mechanism underlying SCFAs and HPA ASD remains unknown. Here, we show that children with exhibited lower SCFA concentrations higher cortisol levels, which were recaptured prenatal lipopolysaccharide (LPS)-exposed rat model These offspring showed decreased SCFA-producing bacteria histone acetylation activity as well impaired corticotropin-releasing hormone receptor 2 (CRHR2) expression. Sodium butyrate (NaB), can act deacetylases inhibitors, significantly increased at CRHR2 promoter vitro normalized corticosterone expression level vivo. Behavioral assays indicated ameliorative effects NaB on anxiety social deficit LPS-exposed offspring. Our results imply treatment improve ASD-like symptoms via epigenetic regulation offspring; thus, it may provide new insight into neurodevelopmental like IMPORTANCE Growing evidence suggests microbiota affect brain function behavior through "microbiome-gut-brain'' axis, but its poorly understood. both overactivation axis. bacteria, Lactobacillus, might be key differential between control Interestingly, contributed (such CRHR2) improvement behaviors The potential effect mediated increasing promoter. enhance our understanding relationship And gut microbiota-derived serve therapeutic agent

Language: Английский

Citations

15
Comparing physiological responses of acute and chronically stressed diploid and triploid Atlantic salmon (Salmo salar) DOI Creative Commons
Angelico Madaro, Floriana Lai, Per Gunnar Fjelldal

et al.

Aquaculture Reports, Journal Year: 2024, Volume and Issue: 36, P. 102041 - 102041

Published: March 21, 2024

We compared the performance and physiological response of diploid triploid Atlantic salmon (Salmo salar) following 21 days either unpredictable chronic stress (UCS) or no disturbance (control). Thereafter, all four groups were challenged with a novel acute stressor consisting crowding, netting transfer into another tank. Growth was monitored during 21-day period, to challenge assessed by blood chemistry parameters pituitary gene expression. Plasma analyzed before (0) 15, 30, 45, 60, 90, 120, 240, 300 min after induction, whereas expression at 0, 240 min. The results showed: a) similar growth rate condition factor reductions from UCS in triploids diploids, b) higher post-stress plasma Acth cortisol levels c) wider fluctuations most other for particularly glucose lactate, d) pomca1, pomcb, crf-r1a crf-r1b mRNA more upregulated control diploids than triploids, e) only minor changes both but noticeable upregulation pomca2 triploids. Our suggest that have energy cost salmon. This can make them sensitive suboptimal conditions episodes stress.

Language: Английский

Citations

5
Menstrual disturbances following COVID-19 vaccination: A probable puzzle about the role of endocrine and immune pathways DOI Open Access
Farima Rahimi Mansour, Amirreza Keyvanfar, Hanieh Najafiarab

et al.

Journal of Reproductive Immunology, Journal Year: 2023, Volume and Issue: 158, P. 103952 - 103952

Published: May 12, 2023

Language: Английский

Citations

13
The Hormonal Background of Hair Loss in Non-Scarring Alopecias DOI Creative Commons

Barbara Owecka,

Anna Tomaszewska, Krzysztof Dobrzeniecki

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(3), P. 513 - 513

Published: Feb. 24, 2024

Hair loss is a common clinical condition connected with serious psychological distress and reduced quality of life. Hormones play an essential role in the regulation hair growth cycle. This review focuses on hormonal background loss, including pathophysiology, underlying endocrine disorders, possible treatment options for alopecia. In particular, androgens, dihydrotestosterone (DHT), testosterone (T), androstenedione (A4), dehydroepiandrosterone (DHEA), its sulfate (DHEAS), has been studied context androgenetic Androgen excess may cause miniaturization follicles (HFs) scalp. Moreover, occur case estrogen deficiency, appearing naturally during menopause. Also, thyroid hormones dysfunctions are linked most types alopecia, telogen effluvium (TE), alopecia areata (AA), Particular emphasis placed hypothalamic–pituitary–adrenal axis (corticotropin-releasing hormone, adrenocorticotropic hormone (ACTH), cortisol) stress-induced article also briefly discusses therapies, 5-alpha-reductase inhibitors (finasteride, dutasteride), spironolactone, bicalutamide, estrogens, others.

Language: Английский

Citations

4
Hypothalamic-Pituitary-Adrenal Axis and Epilepsy DOI Creative Commons
X. Bian, Wenxian Yang,

Jiannan Lin

et al.

Journal of Clinical Neurology, Journal Year: 2024, Volume and Issue: 20(2), P. 131 - 131

Published: Jan. 1, 2024

Epilepsy is a recurrent, transient seizure disorder of the nervous system that affects intellectual development, life and work, psychological health patients. People with epilepsy worldwide experience great suffering. Stressful stimuli such as infection, mental stress, sleep deprivation are important triggers epilepsy, chronic stressful can lead to frequent seizures comorbidities. The hypothalamic-pituitary-adrenal (HPA) axis most involved in body's stress response, dysfunction thereof thought be associated core symptoms related psychopathology. This article explores intrinsic relationships corticotropin-releasing hormone, adrenocorticotropic glucocorticoids order reveal role HPA pathogenesis epilepsy. We hope this information will yield future possible directions ideas for fully understanding developing antiepileptic drugs.

Language: Английский

Citations

4
Brain-Heart Axis and the Inflammatory Response: Connecting Stroke and Cardiac Dysfunction DOI Creative Commons
Xiaosheng Chen,

Jiajie Gu,

Xiaojia Zhang

et al.

Cardiology, Journal Year: 2024, Volume and Issue: 149(4), P. 369 - 382

Published: Jan. 1, 2024

In recent years, the mechanistic interaction between brain and heart has been explored in detail, which explains effects of injuries on those cardiac dysfunction brain. Brain are predominant cause post-stroke deaths, is second leading mortality after stroke onset.

Language: Английский

Citations

4