Endothelial dysfunction, platelet hyperactivity, hypertension, and the metabolic syndrome: molecular insights and combating strategies

Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 10

Published: Aug. 8, 2023

Metabolic syndrome (MetS) is a multifaceted condition that increases the possibility of developing atherosclerotic cardiovascular disease. MetS includes obesity, hypertension, dyslipidemia, hyperglycemia, endothelial dysfunction, and platelet hyperactivity. There concerning rise in occurrence frequency globally. The rising incidence severity need proactive, multipronged strategy for identifying treating those affected. For many patients, achieving recommended goals healthy fat intake, blood pressure control, glucose management may require combination medicine therapy, lifestyles, nutraceuticals, others. However, it essential to note lifestyle modification should be first-line therapy MetS. In addition, requires pharmacological, nutraceutical, or other interventions. This review aimed bring together etiology, molecular mechanisms, dietary strategies combat dysfunction individuals with

Language: Английский

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Endothelial Dysfunction in Obesity and Therapeutic Targets

Advances in experimental medicine and biology, Journal Year: 2024, Volume and Issue: unknown, P. 489 - 538

Published: Jan. 1, 2024

Language: Английский

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Adipose tissue adipokines and lipokines: Functions and regulatory mechanism in skeletal muscle development and homeostasis

Metabolism, Journal Year: 2022, Volume and Issue: 139, P. 155379 - 155379

Published: Dec. 17, 2022

Language: Английский

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Association between stroke and relative fat mass: a cross-sectional study based on NHANES

Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)

Published: Oct. 31, 2024

This study was aimed at investigating the correlation between occurrence of stroke and relative fat mass (RFM), a novel metric for determining total body fat.

Language: Английский

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Microvascular Skeletal-Muscle Crosstalk in Health and Disease

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(13), P. 10425 - 10425

Published: June 21, 2023

As an organ system, skeletal muscle is essential for the generation of energy that underpins contraction, plays a critical role in controlling balance and insulin-dependent glucose homeostasis, as well vascular well-being, regenerates following injury. To achieve there requirement "cross-talk" between myogenic components their regulatory factors comprise muscle. Accordingly, this review will describe following: [a] embryonic cell-signaling events important establishing cell-lineage, cross-talk endothelial cells (EC) precursors underpinning development muscle, its vasculature satellite-stem-cell (SC) pool, EC-SC maintains SC quiescence localizes ECs to SCs angio-myogenesis postnatally; [b] vascular-myocyte actions insulin on vasodilation capillary surface area uptake glucose/insulin by myofibers microvascular-myocyte dysfunction characterizes resistance, diabetes hypertension, estrogen growth adults; [c] utero fetal skeletal-muscle microvascularization myofiber hypertrophy required metabolic/vascular homeostasis after birth; [d] interactions underpin regeneration post-injury; [e] Duchenne muscular dystrophy.

Language: Английский

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Association between blood urea nitrogen-to-creatinine ratio and insulin sensitivity

Diabetes & Metabolism, Journal Year: 2024, Volume and Issue: 50(2), P. 101521 - 101521

Published: Feb. 8, 2024

Language: Английский

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Physical Exercise as a Non-Pharmacological Intervention for Attenuating Obesity-Related Complications in Children and Adolescents

International Journal of Environmental Research and Public Health, Journal Year: 2022, Volume and Issue: 19(9), P. 5046 - 5046

Published: April 21, 2022

Obesity is the most prevalent nutrition-related disorder among pediatric population [...]

Language: Английский

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Influence of Phenotypes on the Metabolic Syndrome of Women with Polycystic Ovary Syndrome over a Six-Year Follow-Up in Brazil

Biomedicines, Journal Year: 2023, Volume and Issue: 11(12), P. 3262 - 3262

Published: Dec. 9, 2023

We followed polycystic ovary syndrome (PCOS) women with metabolic (MS) over a six-year treatment period and evaluated the influence of PCOS phenotypes on MS risk for type 2 diabetes mellitus (T2DM).

Language: Английский

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Exploration of macromolecular phenotype of human skeletal muscle in diabetes using infrared spectroscopy

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: Dec. 21, 2023

Introduction The global burden of diabetes mellitus is escalating, and more efficient investigative strategies are needed for a deeper understanding underlying pathophysiological mechanisms. crucial role skeletal muscle in carbohydrate lipid metabolism makes it one the most susceptible tissues to diabetes-related metabolic disorders. In tissue studies, conventional histochemical methods have several technical limitations been shown inadequately characterise biomolecular phenotype provide holistic view pathologically altered proportions macromolecular constituents. Materials this pilot study, we examined composition five different human muscles from male donors diagnosed with type 2 non-diabetic controls. We analysed lipid, glycogen, collagen content traditional manner assays using staining techniques. This served as reference comparison unconventional analysis Fourier-transform infrared spectroscopy an alternative methodological approach. Results A thorough chemometric post-processing spectra multi-stage spectral decomposition allowed simultaneous identification various compositional details vibrational spectrum measured single experiment. obtained multifaceted information about constituents muscle, which even us distinguish protein structural properties. important steps comprehensive insight into thus set parameters identified that can be used between healthy diabetic muscles. Conclusion established framework based on detailed effectively complement or may serve assays. As study relatively small sample sets, remain cautious at stage drawing definitive conclusions changes composition. However, main focus contribution our work has alternative, simple approach purpose. confident achieved goal brought methodology level successfully transferred large-scale allows effects interrelationships alterations due investigated.

Language: Английский

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Pathophysiological and Therapeutic Roles of Fascial Hyaluronan in Obesity-Related Myofascial Disease

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(19), P. 11843 - 11843

Published: Oct. 6, 2022

Myofascial disease is an important complication associated with obesity and one of the leading causes physical disability globally. In face limited treatment options, burden myofascial disorders predicted to increase along escalating prevalence obesity. Several pathological processes in contribute modifications fascial extracellular matrix mechanical biological properties functions. Changes adipose tissue metabolism, chronic inflammatory phenotype, oxidative stress, other mechanisms may alter physiochemical biomechanical hyaluronan. Understanding pathophysiological importance hyaluronan components connective shed light on etiology inform strategies. Given its unique favorable pharmacological properties, has found a broad range clinical applications, notably orthopedic conditions such as osteoarthritis tendinopathies, which share implicated diseases. However, while existing studies uniformly affirm therapeutic value disorders, more extensive broader contexts are needed firmly validate adaptation.

Language: Английский

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