Molecular Mapping of Antifungal Mechanisms Accessing Biomaterials and New Agents to Target Oral Candidiasis DOI Open Access
Valentina Anuța, Marina-Theodora Talianu, Cristina-Elena Dinu-Pîrvu

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(14), P. 7520 - 7520

Published: July 7, 2022

Oral candidiasis has a high rate of development, especially in immunocompromised patients. Immunosuppressive and cytotoxic therapies hospitalized HIV cancer patients are known to induce the poor management adverse reactions, where local systemic become highly resistant conventional antifungal therapy. The development oral is triggered by several mechanisms that determine epithelium imbalances, resulting defense delayed immune system response. As result, pathogenic fungi colonies disseminate form biofilms, promoting serious challenges initiating proper therapeutic protocol. Hence, this study literature aimed discuss possibilities new trends through therapy for buccal drug administration. A large number studies explored activity agents or synergic components may enhance effect classic drugs. It was significant interest find connections between smart biomaterials their activity, molecular responses can conquer multidrug resistance strains, transpose them into map. Overall, attention focused on nanocolloids domain, nanoparticles, nanocomposite synthesis, design polymeric platforms satisfy sustained biocompatibility with mucosa.

Language: Английский

An Overview of Oxidative Stress, Neuroinflammation, and Neurodegenerative Diseases DOI Open Access
Daniel Mihai Teleanu, Adelina-Gabriela Niculescu, Iulia Ioana Lungu

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(11), P. 5938 - 5938

Published: May 25, 2022

Oxidative stress has been linked with a variety of diseases, being involved in the debut and/or progress several neurodegenerative disorders. This review intends to summarize some findings that correlate overproduction reactive oxygen species pathophysiology Alzheimer’s disease, Parkinson’s Huntington’s and amyotrophic lateral sclerosis. was also noted modify inflammatory response. Even though oxidative neuroinflammation are two totally different pathological events, they affect one another. Nonetheless, there still mechanisms need be understood regarding onset diseases order develop efficient therapies. As antioxidants means alter slow down symptoms these most common antioxidants, enzymatic as well non-enzymatic, have mentioned this paper therapeutic options for discussed

Language: Английский

Citations

515
Neurotransmitters—Key Factors in Neurological and Neurodegenerative Disorders of the Central Nervous System DOI Open Access
Raluca Ioana Teleanu, Adelina-Gabriela Niculescu, Eugenia Roza

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(11), P. 5954 - 5954

Published: May 25, 2022

Neurotransmitters are molecules that amplify, transmit, and convert signals in cells, having an essential role information transmission throughout the nervous system. Hundreds of such chemicals have been discovered last century, continuing to be identified studied concerning their action on brain health. These substances observed influence numerous functions, including emotions, thoughts, memories, learning, movements. Thus, disturbances neurotransmitters' homeostasis started being correlated with a plethora neurological neurodegenerative disorders. In this respect, present paper aims describe most important neurotransmitters, broadly classified into canonical (e.g., amino acids, monoamines, acetylcholine, purines, soluble gases, neuropeptides) noncanonical neurotransmitters exosomes, steroids, D-aspartic acid), explain link some relevant conditions. Moreover, brief overview recently developed detection methods is offered, followed by several considerations modulation these towards restoring homeostasis.

Language: Английский

Citations

270
Integrative Approaches in Acute Ischemic Stroke: From Symptom Recognition to Future Innovations DOI Creative Commons
Vicențiu Săceleanu, Corneliu Toader,

Horia Pleș

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(10), P. 2617 - 2617

Published: Sept. 23, 2023

Among the high prevalence of cerebrovascular diseases nowadays, acute ischemic stroke stands out, representing a significant worldwide health issue with important socio-economic implications. Prompt diagnosis and intervention are milestones for management this multifaceted pathology, making understanding various stroke-onset symptoms crucial. A key role in is emphasizing essential multi-disciplinary team, therefore, increasing efficiency recognition treatment. Neuroimaging neuroradiology have evolved dramatically over years, multiple approaches that provide higher morphological aspects as well timely cerebral artery occlusions effective therapy planning. Regarding treatment matter, pharmacological approach, particularly fibrinolytic therapy, has its merits challenges. Endovascular thrombectomy, game-changer management, witnessed advances, technologies like stent retrievers aspiration catheters playing pivotal roles. For select patients, combining endovascular strategies offers evidence-backed benefits. The aim our comprehensive study on to efficiently compare current therapies, recognize novel possibilities from literature, describe state art interdisciplinary approach stroke. As we aspire holistic patient emphasis not just medical but also physical mental health, community engagement. future holds promising innovations, artificial intelligence poised reshape diagnostics treatments. Bridging gap between groundbreaking research clinical practice remains challenge, urging continuous collaboration research.

Language: Английский

Citations

49
Microglia autophagy in ischemic stroke: A double-edged sword DOI Creative Commons
Peng Li,

Guangqiang Hu,

Qianfang Yao

et al.

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Nov. 16, 2022

Ischemic stroke (IS) is one of the major types cerebrovascular diseases causing neurological morbidity and mortality worldwide. In pathophysiological process IS, microglia play a beneficial role in tissue repair. However, it could also cause cellular damage, consequently leading to cell death. Inflammation characterized by activation microglia, increasing evidence showed that autophagy interacts with inflammation through regulating correlative mediators signaling pathways. this paper, we summarized harmful effects IS. addition, discussed interplay between ischemic inflammation, as along its application treatment We believe help provide theoretical references for further study into IS treatments future.

Language: Английский

Citations

57
Signaling Paradigms of H2S-Induced Vasodilation: A Comprehensive Review DOI Creative Commons
Constantin Munteanu, Cristina Raluca Gh. Popescu, Andreea-Iulia Vlădulescu-Trandafir

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(10), P. 1158 - 1158

Published: Sept. 25, 2024

Hydrogen sulfide (H

Language: Английский

Citations

10
PRISMA Systematic Literature Review, including with Meta-Analysis vs. Chatbot/GPT (AI) regarding Current Scientific Data on the Main Effects of the Calf Blood Deproteinized Hemoderivative Medicine (Actovegin) in Ischemic Stroke DOI Creative Commons
Aurelian Anghelescu,

Florentina Carmen Firan,

Gelu Onose

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(6), P. 1623 - 1623

Published: June 2, 2023

Stroke is a significant public health problem and leading cause of death long-term disability worldwide. Several treatments for ischemic stroke have been developed, but these limited effectiveness. One potential treatment this condition Actovegin

Language: Английский

Citations

20
Effects and mechanisms of bisphenols exposure on neurodegenerative diseases risk: A systemic review DOI

Yeqing Xu,

Jun Nie,

Chenghao Lu

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 919, P. 170670 - 170670

Published: Feb. 5, 2024

Language: Английский

Citations

7
Recent Advances in Molecular Research on Hydrogen Sulfide (H2S) Role in Diabetes Mellitus (DM)—A Systematic Review DOI Open Access
Constantin Munteanu, Mariana Rotariu, Marius Turnea

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(12), P. 6720 - 6720

Published: June 16, 2022

Abundant experimental data suggest that hydrogen sulfide (H2S) is related to the pathophysiology of Diabetes Mellitus (DM). Multiple molecular mechanisms, including receptors, membrane ion channels, signalingmolecules, enzymes, and transcription factors, are known be responsible for H2S biological actions; however, not fully documented as a gaseous signaling molecule interfering with DM vascular-linked pathology. In recent decades, multiple approaches regarding therapeutic exploitation have been identified, either based on exogenous apport or its modulated endogenous biosynthesis. This paper aims synthesize systematize, comprehensively possible, literature-related therapeutic/rehabilitative role in DM. review was conducted following “Preferred reporting items systematic reviews meta-analyses” (PRISMA) methodology, interrogating five international medically renowned databases by specific keyword combinations/“syntaxes” used contextually, over last years (2017–2021). The respective search/filtered selection methodology we applied has first step, 212 articles. After deploying next quest steps, 51 unique published papers qualified minute analysis resulted. To these bibliographic resources obtained through PRISMA order best available information coverage, added 86 were freely found direct internet search. Finally, selected connected meta-analysis eight relevant reports included 1237 human subjects elicited from clinical trial registration platforms. Numerous releasing/stimulating compounds produced, some being models. However, very few them further advanced studies, indicating development agent still at beginning.

Language: Английский

Citations

28
Rosmarinic acid Liposomes Suppress Ferroptosis in Ischemic Brain via Inhibition of TfR1 in BMECs DOI

Cui-Ling Jia,

Yujing Gou,

Yuhui Gao

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 132, P. 155835 - 155835

Published: June 28, 2024

Language: Английский

Citations

5
Considerations about Hypoxic Changes in Neuraxis Tissue Injuries and Recovery DOI Creative Commons
Simona Isabelle Stoica, Coralia Bleoţu, Vlad Ciobanu

et al.

Biomedicines, Journal Year: 2022, Volume and Issue: 10(2), P. 481 - 481

Published: Feb. 18, 2022

Hypoxia represents the temporary or longer-term decrease deprivation of oxygen in organs, tissues, and cells after supply drops its excessive consumption. can be (para)-physiological-adaptive-or pathological. Thereby, mechanisms hypoxia have many implications, such as adaptive processes normal cells, but to survival neoplastic ones, too. Ischemia differs from it means a transient permanent interruption reduction blood given region tissue consequently poor provision with energetic substratum-inflammation oxidative stress damages generating factors. Considering implications on nerve that go through different ischemic processes, this paper, we will detail molecular by which structures feel adapt hypoxia. We present hypoxic changes CNS. Also, aimed evaluate acute, subacute, chronic central nervous hypoxic-ischemic changes, hoping understand better systematize some neuro-muscular recovery methods necessary regain individual independence. To establish link between CNS hypoxia, ischemic-lesional mechanisms, neuro-motor related recovery, performed systematic literature review following the" Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA") filtering method interrogating five international medical renown databases, using, contextually, specific keywords combinations/"syntaxes", supplementation afferent documentation an amount freely discovered, also contributive, bibliographic resources. As result, 45 papers were eligible according PRISMA-inspired selection approach, thus covering information both: intimate/molecular path-physiological and, respectively, consequent clinical conditions. Such process is meant help us construct article structure skeleton giving primary objective input about assembly background approached, summarised, synthesized. The contextual search (by combination/syntaxes) fulfilled considerably reduced number obtained articles. consider warranted hypoxia's opened new perspectives understanding neuraxis tissue/cells, starting at intracellular level continuing experimental research recover clinical-functional deficits better.

Language: Английский

Citations

19