Medicina,
Journal Year:
2023,
Volume and Issue:
59(3), P. 594 - 594
Published: March 17, 2023
Metabolic-dysfunction-associated
fatty
liver
disease
(MAFLD)
is
the
recent
nomenclature
designation
that
associates
condition
of
non-alcoholic
(NAFLD)
with
metabolic
dysfunction.
Its
diagnosis
has
been
debated
in
period
and
generally
associated
a
steatosis
at
least
one
pathologic
among
overweight/obesity,
type
2
diabetes
mellitus,
dysregulation.
pathogenesis
defined
by
“multiple-hit”
model
alteration
or
dysbiosis
gut
microbiota.
The
pathogenic
role
microbiota
investigated
many
diseases,
including
obesity,
NAFLD.
However,
only
few
works
correlate
it
MAFLD,
although
common
pathogenetic
links
to
these
diseases
are
suspected.
This
review
underlines
most
recurrent
changes
patients
while
also
evidencing
possible
links.
Frontiers in Microbiology,
Journal Year:
2025,
Volume and Issue:
15
Published: Jan. 7, 2025
Diabetes
mellitus
represents
a
significant
global
health
problem.
The
number
of
people
suffering
from
this
metabolic
disease
is
constantly
rising
and
although
the
incidence
heterogeneous
depending
on
region,
country,
economic
situation,
lifestyle,
diet
level
medical
care,
it
increasing
worldwide,
especially
among
youths
children,
mainly
due
to
lifestyle
environmental
changes.
pathogenesis
two
most
common
subtypes
diabetes
mellitus,
type
1
(T1DM)
2
(T2DM),
substantially
different,
so
each
form
characterized
by
different
causation,
etiology,
pathophysiology,
presentation,
treatment.
Research
in
recent
decades
increasingly
indicates
potential
role
gut
microbiome
initiation,
development,
progression
disease.
Intestinal
microbes
their
fermentation
products
have
an
important
impact
host
metabolism,
immune
system,
nutrient
digestion
absorption,
barrier
integrity
protection
against
pathogens.
This
review
summarizes
current
evidence
changes
microbial
populations
both
types
mellitus.
Attention
focused
abundance
specific
bacterial
groups
at
taxonomic
levels
humans,
shift
also
assessed
relation
geographic
location,
age,
antidiabetic
drug.
causal
relationship
between
bacteria
still
unclear,
future
studies
applying
new
methodological
approaches
broader
range
microorganisms
inhabiting
digestive
tract
are
urgently
needed.
would
not
only
provide
better
understanding
disease,
but
use
beneficial
species
probiotics
for
treatment
diabetes.
Frontiers in Nutrition,
Journal Year:
2022,
Volume and Issue:
9
Published: May 25, 2022
Whole
grains
are
a
pivotal
food
category
for
the
human
diet
and
represent
an
invaluable
source
of
carbohydrates,
proteins,
fibers,
phytocompunds,
minerals,
vitamins.
Many
studies
have
shown
that
consumption
whole
is
linked
to
reduced
risk
cancer,
cardiovascular
diseases,
type
2
diabetes
other
chronic
diseases.
However,
several
their
positive
health
effects
seem
disappear
when
consumed
in
refined
form.
Herein
we
review
available
literature
on
with
focus
molecular
composition
benefits
many
diseases
aim
offer
updated
pragmatic
reference
physicians
nutrition
professionals.
Pharmacological Research,
Journal Year:
2022,
Volume and Issue:
182, P. 106321 - 106321
Published: June 22, 2022
The
role
of
gut
microbiota
in
regulating
the
intestinal
homeostasis,
as
well
pathogenesis
severe
acute
pancreatitis-associated
lung
injury
(PALI)
is
widely
recognized.
bioactive
functions
metabolites
with
small
molecule
weight
and
detail
molecular
mechanisms
PALI
mediated
by
"gut-lung
axis"
have
gradually
raised
attentions
researchers.
Several
studies
proved
that
short-chain
fatty
acids
(SCFAs)
produced
microbiome
play
crucial
roles
varied
activities
process
PALI.
However,
relevant
reviews
reporting
SCFAs
involvement
lacking.
In
this
review,
we
firstly
introduced
synthetic
metabolic
pathways
SCFAs,
transport
signal
transduction
routes
brief.
Afterwards,
focused
on
possible
clues
to
participate
fight
against
which
referred
inhibition
pathogen
proliferation,
anti-inflammatory
effects,
enhancement
barrier
functions,
maintenance
regulation
immune
homeostasis
via
pathogen-associated
patterns
(PAMPs)
damage-associated
(DAMPs).
addition,
latest
reported
pathological
physiological
gut-lung
axis
involved
were
reviewed.
Finally,
summarized
potential
therapeutic
interventions
targeting
including
dietary
fiber
supplementation,
direct
supplementation
SCFAs/prebiotics/probiotics,
drugs
administration,
expected
provide
new
sights
for
clinical
use
future.
Molecular Medicine,
Journal Year:
2022,
Volume and Issue:
28(1)
Published: Dec. 1, 2022
Abstract
Gut
microbiota
plays
a
critical
role
in
the
maintenance
of
host
health.
As
low-cost
and
genetically
tractable
vertebrate
model,
zebrafish
have
been
widely
used
for
biological
research.
Zebrafish
humans
share
some
similarities
intestinal
physiology
function,
this
allows
to
be
surrogate
model
investigating
crosstalk
between
gut
host.
Especially,
features
such
as
high
fecundity,
external
fertilization,
early
optical
transparency.
These
enable
researchers
employ
fish
address
questions
not
easily
addressed
other
animal
models.
In
review,
we
described
intestine
structure
zebrafish.
Also,
summarized
methods
generating
gnotobiotic
factors
affecting
its
flora,
study
progress
functions
Finally,
discussed
limitations
challenges
studies.
summary,
review
established
that
is
an
attractive
research
tool
understand
mechanistic
insights
into
host-microbe
interaction.
Nutrients,
Journal Year:
2022,
Volume and Issue:
14(15), P. 3112 - 3112
Published: July 28, 2022
The
abnormal
expansion
of
body
fat
paves
the
way
for
several
metabolic
abnormalities
including
overweight,
obesity,
and
diabetes,
which
ultimately
cluster
under
umbrella
syndrome
(MetS).
Patients
with
MetS
are
at
an
increased
risk
cardiovascular
disease,
morbidity,
mortality.
coexistence
distinct
is
associated
release
pro-inflammatory
adipocytokines,
as
components
low-to-medium
grade
systemic
inflammation
oxidative
stress.
Adopting
healthy
lifestyles,
by
using
appropriate
dietary
regimens,
contributes
to
prevention
treatment
MetS.
Metabolic
can
influence
function
energetic
capacity
mitochondria,
observed
in
many
obesity-related
cardio-metabolic
disorders.
There
preclinical
studies
both
cellular
animal
models,
well
clinical
studies,
dealing
nutrients
Mediterranean
diet
(MD)
dysfunctional
mitochondria
obesity
term
"
Pharmacological Research,
Journal Year:
2023,
Volume and Issue:
192, P. 106799 - 106799
Published: May 19, 2023
Depression
is
the
most
prevalent
mental
disorder
in
world
associated
with
huge
socio-economic
consequences.
While
depressive-related
symptoms
are
well
known,
molecular
mechanisms
underlying
disease
pathophysiology
and
progression
remain
largely
unknown.
The
gut
microbiota
(GM)
emerging
as
a
key
regulator
of
central
nervous
system
homeostasis
by
exerting
fundamental
immune
metabolic
functions.
In
turn,
brain
influences
intestinal
microbial
composition
through
neuroendocrine
signals,
within
so-called
microbiota-brain
axis.
balance
this
bidirectional
crosstalk
important
to
ensure
neurogenesis,
preserve
integrity
blood-brain
barrier
avoid
neuroinflammation.
Conversely,
dysbiosis
permeability
negatively
affect
development,
behavior,
cognition.
Furthermore,
although
not
fully
defined
yet,
changes
GM
depressed
patients
reported
influence
pharmacokinetics
common
antidepressants
affecting
their
absorption,
metabolism,
activity.
Similarly,
neuropsychiatric
drugs
may
shape
turn
an
impact
on
efficacy
toxicity
pharmacological
intervention
itself.
Consequently,
strategies
aimed
at
re-establishing
correct
homeostatic
(i.e.,
prebiotics,
probiotics,
fecal
transplantation,
dietary
interventions)
represent
innovative
approach
improve
pharmacotherapy
depression.
Among
these,
probiotics
Mediterranean
diet,
alone
or
combination
standard
care,
hold
promise
for
clinical
application.
Therefore,
disclosure
intricate
network
between
depression
will
give
precious
insights
diagnostic
therapeutic
approaches
towards
depression,
profound
implications
drug
development
practice.
Nutrients,
Journal Year:
2023,
Volume and Issue:
15(2), P. 272 - 272
Published: Jan. 5, 2023
Obesity
is
a
global
public
health
issue
and
major
risk
factor
for
pathological
conditions,
including
type
2
diabetes,
dyslipidemia,
coronary
artery
disease,
hepatic
steatosis,
certain
types
of
cancer.
These
metabolic
complications
result
from
combination
genetics
environmental
influences,
thus
contributing
to
impact
whole-body
homeostasis.
Mechanistic
animal
human
studies
have
indicated
that
an
altered
gut
microbiota
can
mediate
the
development
obesity,
leading
inflammation
beyond
intestine.
Moreover,
prior
research
suggests
interaction
between
peripheral
organs
such
as
adipose
tissue
via
different
signaling
pathways;
yet,
what
degree
in
exactly
ways
this
inter-organ
crosstalk
modulates
obesity
remains
elusive.
This
review
emphasizes
influence
circulating
gut-derived
short
chain
fatty
acids
(SCFAs)
i.e.,
acetate,
propionate,
butyrate,
on
metabolism
scope
with
emphasis
adipocyte
physiology
vitro
vivo.
Furthermore,
we
discuss
some
well-established
mechanisms
which
microbial
SCFAs
exert
role
prominent
host
energy
source,
hence
regulating
overall
balance
health.
Collectively,
exploring
appears
be
promising
avenue
improve
conditions
related
obesity.