Metabolic-Dysfunction-Associated Fatty Liver Disease and Gut Microbiota: From Fatty Liver to Dysmetabolic Syndrome DOI Creative Commons
Ludovico Abenavoli, Giuseppe Guido Maria Scarlata, Emidio Scarpellini

et al.

Medicina, Journal Year: 2023, Volume and Issue: 59(3), P. 594 - 594

Published: March 17, 2023

Metabolic-dysfunction-associated fatty liver disease (MAFLD) is the recent nomenclature designation that associates condition of non-alcoholic (NAFLD) with metabolic dysfunction. Its diagnosis has been debated in period and generally associated a steatosis at least one pathologic among overweight/obesity, type 2 diabetes mellitus, dysregulation. pathogenesis defined by “multiple-hit” model alteration or dysbiosis gut microbiota. The pathogenic role microbiota investigated many diseases, including obesity, NAFLD. However, only few works correlate it MAFLD, although common pathogenetic links to these diseases are suspected. This review underlines most recurrent changes patients while also evidencing possible links.

Language: Английский

A review on probiotics and dietary bioactives: Insights on metabolic well-being, gut microbiota, and inflammatory responses DOI Creative Commons
Alice Njolke Mafe, Great Iruoghene Edo,

Osamah S. Majeed

et al.

Food Chemistry Advances, Journal Year: 2025, Volume and Issue: 6, P. 100919 - 100919

Published: Feb. 11, 2025

Language: Английский

Citations

8
Diabetes and gut microbiome DOI Creative Commons
K. Fliegerová, Tiziana Maria Mahayri, Hana Sechovcová

et al.

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 7, 2025

Diabetes mellitus represents a significant global health problem. The number of people suffering from this metabolic disease is constantly rising and although the incidence heterogeneous depending on region, country, economic situation, lifestyle, diet level medical care, it increasing worldwide, especially among youths children, mainly due to lifestyle environmental changes. pathogenesis two most common subtypes diabetes mellitus, type 1 (T1DM) 2 (T2DM), substantially different, so each form characterized by different causation, etiology, pathophysiology, presentation, treatment. Research in recent decades increasingly indicates potential role gut microbiome initiation, development, progression disease. Intestinal microbes their fermentation products have an important impact host metabolism, immune system, nutrient digestion absorption, barrier integrity protection against pathogens. This review summarizes current evidence changes microbial populations both types mellitus. Attention focused abundance specific bacterial groups at taxonomic levels humans, shift also assessed relation geographic location, age, antidiabetic drug. causal relationship between bacteria still unclear, future studies applying new methodological approaches broader range microorganisms inhabiting digestive tract are urgently needed. would not only provide better understanding disease, but use beneficial species probiotics for treatment diabetes.

Language: Английский

Citations

4
When short-chain fatty acids meet type 2 diabetes mellitus: Revealing mechanisms, envisioning therapies DOI Creative Commons

Cong Xie,

Cong Qi,

Jianwen Zhang

et al.

Biochemical Pharmacology, Journal Year: 2025, Volume and Issue: 233, P. 116791 - 116791

Published: Feb. 1, 2025

Language: Английский

Citations

3
The Impact of Cereal Grain Composition on the Health and Disease Outcomes DOI Creative Commons
Mattia Garutti,

Gerardo Nevola,

Roberta Mazzeo

et al.

Frontiers in Nutrition, Journal Year: 2022, Volume and Issue: 9

Published: May 25, 2022

Whole grains are a pivotal food category for the human diet and represent an invaluable source of carbohydrates, proteins, fibers, phytocompunds, minerals, vitamins. Many studies have shown that consumption whole is linked to reduced risk cancer, cardiovascular diseases, type 2 diabetes other chronic diseases. However, several their positive health effects seem disappear when consumed in refined form. Herein we review available literature on with focus molecular composition benefits many diseases aim offer updated pragmatic reference physicians nutrition professionals.

Language: Английский

Citations

63
The gut-lung axis in severe acute Pancreatitis-associated lung injury: The protection by the gut microbiota through short-chain fatty acids DOI Creative Commons
Zhengjian Wang, Jin Liu, Fan Li

et al.

Pharmacological Research, Journal Year: 2022, Volume and Issue: 182, P. 106321 - 106321

Published: June 22, 2022

The role of gut microbiota in regulating the intestinal homeostasis, as well pathogenesis severe acute pancreatitis-associated lung injury (PALI) is widely recognized. bioactive functions metabolites with small molecule weight and detail molecular mechanisms PALI mediated by "gut-lung axis" have gradually raised attentions researchers. Several studies proved that short-chain fatty acids (SCFAs) produced microbiome play crucial roles varied activities process PALI. However, relevant reviews reporting SCFAs involvement lacking. In this review, we firstly introduced synthetic metabolic pathways SCFAs, transport signal transduction routes brief. Afterwards, focused on possible clues to participate fight against which referred inhibition pathogen proliferation, anti-inflammatory effects, enhancement barrier functions, maintenance regulation immune homeostasis via pathogen-associated patterns (PAMPs) damage-associated (DAMPs). addition, latest reported pathological physiological gut-lung axis involved were reviewed. Finally, summarized potential therapeutic interventions targeting including dietary fiber supplementation, direct supplementation SCFAs/prebiotics/probiotics, drugs administration, expected provide new sights for clinical use future.

Language: Английский

Citations

55
Zebrafish: an efficient vertebrate model for understanding role of gut microbiota DOI Creative Commons
Hui Xia, Huimin Chen, Xue Cheng

et al.

Molecular Medicine, Journal Year: 2022, Volume and Issue: 28(1)

Published: Dec. 1, 2022

Abstract Gut microbiota plays a critical role in the maintenance of host health. As low-cost and genetically tractable vertebrate model, zebrafish have been widely used for biological research. Zebrafish humans share some similarities intestinal physiology function, this allows to be surrogate model investigating crosstalk between gut host. Especially, features such as high fecundity, external fertilization, early optical transparency. These enable researchers employ fish address questions not easily addressed other animal models. In review, we described intestine structure zebrafish. Also, summarized methods generating gnotobiotic factors affecting its flora, study progress functions Finally, discussed limitations challenges studies. summary, review established that is an attractive research tool understand mechanistic insights into host-microbe interaction.

Language: Английский

Citations

51
The Potential of the Mediterranean Diet to Improve Mitochondrial Function in Experimental Models of Obesity and Metabolic Syndrome DOI Open Access
Mohamad Khalil, Harshitha Shanmugam,

Hala Abdallah

et al.

Nutrients, Journal Year: 2022, Volume and Issue: 14(15), P. 3112 - 3112

Published: July 28, 2022

The abnormal expansion of body fat paves the way for several metabolic abnormalities including overweight, obesity, and diabetes, which ultimately cluster under umbrella syndrome (MetS). Patients with MetS are at an increased risk cardiovascular disease, morbidity, mortality. coexistence distinct is associated release pro-inflammatory adipocytokines, as components low-to-medium grade systemic inflammation oxidative stress. Adopting healthy lifestyles, by using appropriate dietary regimens, contributes to prevention treatment MetS. Metabolic can influence function energetic capacity mitochondria, observed in many obesity-related cardio-metabolic disorders. There preclinical studies both cellular animal models, well clinical studies, dealing nutrients Mediterranean diet (MD) dysfunctional mitochondria obesity term "

Language: Английский

Citations

47
The brain-gut-microbiota interplay in depression: A key to design innovative therapeutic approaches DOI Creative Commons
Angelica Varesi, Lucrezia Irene Maria Campagnoli, Salvatore Chirumbolo

et al.

Pharmacological Research, Journal Year: 2023, Volume and Issue: 192, P. 106799 - 106799

Published: May 19, 2023

Depression is the most prevalent mental disorder in world associated with huge socio-economic consequences. While depressive-related symptoms are well known, molecular mechanisms underlying disease pathophysiology and progression remain largely unknown. The gut microbiota (GM) emerging as a key regulator of central nervous system homeostasis by exerting fundamental immune metabolic functions. In turn, brain influences intestinal microbial composition through neuroendocrine signals, within so-called microbiota-brain axis. balance this bidirectional crosstalk important to ensure neurogenesis, preserve integrity blood-brain barrier avoid neuroinflammation. Conversely, dysbiosis permeability negatively affect development, behavior, cognition. Furthermore, although not fully defined yet, changes GM depressed patients reported influence pharmacokinetics common antidepressants affecting their absorption, metabolism, activity. Similarly, neuropsychiatric drugs may shape turn an impact on efficacy toxicity pharmacological intervention itself. Consequently, strategies aimed at re-establishing correct homeostatic (i.e., prebiotics, probiotics, fecal transplantation, dietary interventions) represent innovative approach improve pharmacotherapy depression. Among these, probiotics Mediterranean diet, alone or combination standard care, hold promise for clinical application. Therefore, disclosure intricate network between depression will give precious insights diagnostic therapeutic approaches towards depression, profound implications drug development practice.

Language: Английский

Citations

40
Central and peripheral regulations mediated by short-chain fatty acids on energy homeostasis DOI Creative Commons

Pei Luo,

Kristen Lednovich, Kai Xu

et al.

Translational research, Journal Year: 2022, Volume and Issue: 248, P. 128 - 150

Published: June 7, 2022

Language: Английский

Citations

39
Gut Microbial-Derived Short Chain Fatty Acids: Impact on Adipose Tissue Physiology DOI Open Access
Karolline S. May, Laura J. den Hartigh

Nutrients, Journal Year: 2023, Volume and Issue: 15(2), P. 272 - 272

Published: Jan. 5, 2023

Obesity is a global public health issue and major risk factor for pathological conditions, including type 2 diabetes, dyslipidemia, coronary artery disease, hepatic steatosis, certain types of cancer. These metabolic complications result from combination genetics environmental influences, thus contributing to impact whole-body homeostasis. Mechanistic animal human studies have indicated that an altered gut microbiota can mediate the development obesity, leading inflammation beyond intestine. Moreover, prior research suggests interaction between peripheral organs such as adipose tissue via different signaling pathways; yet, what degree in exactly ways this inter-organ crosstalk modulates obesity remains elusive. This review emphasizes influence circulating gut-derived short chain fatty acids (SCFAs) i.e., acetate, propionate, butyrate, on metabolism scope with emphasis adipocyte physiology vitro vivo. Furthermore, we discuss some well-established mechanisms which microbial SCFAs exert role prominent host energy source, hence regulating overall balance health. Collectively, exploring appears be promising avenue improve conditions related obesity.

Language: Английский

Citations

37