Published: Aug. 15, 2022
CCTcarcinoma de células transicionais cDNA DNA codificante CFSE
Critical Reviews in Oncology/Hematology, Journal Year: 2022, Volume and Issue: 179, P. 103803 - 103803
Published: Sept. 1, 2022
Language: Английский
Citations
5
Frontiers in Oncology, Journal Year: 2022, Volume and Issue: 12
Published: Nov. 15, 2022
To investigate the short-term efficacy and radiotoxicity 3.543of chronoradiotherapy in patients with cervical cancer. We also examined overall symptom score quality of life (QOL) who underwent morning radiotherapy evening radiotherapy.We conducted a multicenter randomized controlled trial to compare effects (9:00-11:00 AM) (7:00-9:00 PM) cancer receiving radiotherapy. From November 2021 June 2022, 114 admitted eight center hospitals Tianjin, Chongqing, Hubei, Shanxi, Shandong, Shaanxi, Hebei, Cangzhou were randomly divided into group (MG; N = 61) (EG; 53). The on at different time points occurrence explored after had undergone radiotherapy.The total effective response (partial remission [PR] + complete [CR]) rate was similar across two groups (93.5% vs. 96.3%, p > 0.05). However, incidence bone marrow suppression intestinal reaction significantly (p < MG higher Anderson scores than EG (21.64 ± 7.916 18.53 4.098, In terms physical activity, functional status, QOL, lower No other measures showed significant difference between groups.The effect consistent that EG. radiation enteritis diarrhea EG; however, blood toxicity more serious MG. Because small sample size study, we only Therefore, further clinical trials are needed verify side chronoradiotherapy.http://www.chictr.org.cn/searchproj.aspx, Registration Number: ChiCTR2100047140.
Language: Английский
Citations
5
Frontiers in Oncology, Journal Year: 2023, Volume and Issue: 13
Published: Feb. 15, 2023
EDITORIAL article Front. Oncol., 15 February 2023Sec. Radiation Oncology Volume 13 - 2023 | https://doi.org/10.3389/fonc.2023.1144797
Language: Английский
Citations
2
FEBS Letters, Journal Year: 2023, Volume and Issue: unknown
Published: Dec. 23, 2023
Redox and metabolic processes are tightly coupled in both physiological pathological conditions. In cancer, their integration occurs at multiple levels is characterized by synchronized reprogramming the tumor tissue its specific but heterogeneous microenvironment. breast principal microenvironment cancer‐associated adipose (CAAT). Understanding how redox‐metabolic becomes coordinated human cancer imperative for prevention establishment of new therapeutic approaches. This review aims to provide an overview current knowledge redox profiles regulation intermediary metabolism while considering CAAT as a unique Warburg's pseudo‐organ. As now recognized systemic disease, we have paid particular attention cell‐specific roles estrogen receptors circadian rhythms, well crosstalk development, growth, progression, prognosis cancer.
Language: Английский
Citations
2
Journal of Proteomics, Journal Year: 2022, Volume and Issue: 265, P. 104660 - 104660
Published: June 18, 2022
Language: Английский
Citations
3
Clocks & Sleep, Journal Year: 2024, Volume and Issue: 6(1), P. 200 - 210
Published: March 21, 2024
The circadian system, a vital temporal regulator influencing physiological processes, has implications for cancer development and treatment response. Our study assessed timing’s impact on whole-brain radiotherapy outcomes in brain metastases personalized therapy insights. aim of the was to evaluate influence radiation timing its correlation with clinical identify patient populations benefiting from interventions synchronizing rhythms, considering subgroup differences potential disparities. An IRB-approved retrospective analysis 237 patients undergoing (2017–2021), receiving over 80% treatments morning or afternoon, performed. Survival analyses utilized Kaplan–Meier curves. This single-institution involving radiotherapy. Demographic, disease, socioeconomic parameters electronic medical records were collected. Morning (n = 158) showed trend toward improved overall survival vs. afternoon 79); median 158 79 days (p 0.20, HR 0.84, CI95% 0.84–0.91). Subgroup benefits females 0.04) trends controlled primary disease 0.11) breast 0.08) observed. Black exhibited diminished influence. present emphasized chronobiological factors’ relevance therapy. correlated survival, particularly specific subgroups. Potential disparities identified, laying foundation rhythms enhanced efficacy.
Language: Английский
Citations
0
Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 71 - 94
Published: Jan. 1, 2024
Citations
0
Journal of Biosciences, Journal Year: 2024, Volume and Issue: 49(3)
Published: Aug. 22, 2024
Language: Английский
Citations
0
Integrative Biology, Journal Year: 2024, Volume and Issue: 16
Published: Jan. 1, 2024
Abstract Recent findings in cancer research have pointed towards the bidirectional interaction between circadian and hypoxia pathways. However, little is known about their crosstalk mechanism. In this work, we aimed to investigate at a network level utilizing omics information of gallbladder cancer. Differential gene expression pathway enrichment analysis were used for selecting crucial genes from both pathways, followed by construction logical model using GINsim. Functional circuit identification node perturbations then performed. Significant combinations temporal behavior through MaBoSS. Lastly, was validated published vitro experimentations. Four new positive circuits axis viz. BMAL1/ HIF1αβ/ NANOG, responsible stemness identified. Through triple viz.a. BMAL:CLOCK (KO or E1) + P53 (E1) HIF1α (KO); b. (KO) MYC (E1); c. EGFR (KO), able inhibit growth maintain homeostatic condition. This work provides an architecture drug simulation entrainment rhythm experiments chronotherapy-related studies. Insight Box. Circadian are key dysregulated processes which fuels-up growth. present developed (GBC) specific Boolean model, RNASeq data GBC dataset tissue interactions. adequately models nature interactions previously illustrated experimental papers showing effect on dysregulation influence disruption progression metastasis. dynamical study its response different perturbations, report novel that can be targeted efficiently reduce as generalized framework pathways linked with progression.
Language: Английский
Citations
0
Highlights in Science Engineering and Technology, Journal Year: 2023, Volume and Issue: 54, P. 321 - 327
Published: July 4, 2023
The intricate set of molecular and cellular activities known as the circadian clock controls a number physiological processes. These processes are essential for maintaining homeostasis coordinating biological rhythms with environment. Recent research has shown that disruption is related to various diseases, including metabolic disorders, cardiovascular cancer, neurological diseases. In particular, such diabetes, gained significant attention due alarming increase in individuals diabetes worldwide. Since animal models have an interruption results decreased glucose tolerance insulin sensitivity, it imperative comprehend mechanisms underlying rhythm's role metabolism glucose. By highlighting importance start illness, recent revealed clock's connection regulation cardiac activity. As result disturbance being linked increased risk cancer poor prognosis patients, on also drawn context cancer. A deeper understanding rhythm its disease etiology may lead new treatment strategies interventions.
Language: Английский
Citations
1