Journal of Cosmetic Dermatology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 4, 2024
ABSTRACT
Background
Skin
aging
is
characterized
by
an
imbalance
between
the
generation
and
degradation
of
extracellular
matrix
molecules
(ECM).
Matrix
metalloproteinases
(MMPs)
are
primary
enzymes
responsible
for
ECM
breakdown.
Intrinsic
extrinsic
stimuli
can
induce
different
MMPs.
However,
there
limited
literature
especially
on
summary
skin
MMPs
potential
inhibitors.
Objective
We
aim
to
focus
upregulation
MMP
expression
or
activity
in
cells
following
exposure
UV
radiation.
also
would
like
offer
valuable
insights
into
clinical
applications
inhibitors
mitigating
aging.
Methods
This
article
presents
prior
research,
which
involved
extensive
search
across
diverse
academic
databases
including
Web
Science
PubMed.
Results
Our
findings
a
comprehensive
insight
effects
after
irradiation,
their
substrate
preferences
distinct
roles
this
process.
Additionally,
list
natural
plant
animal
extracts,
proteins,
polypeptides,
amino
acids,
as
well
synthetic
compounds
that
serve
compiled.
Conclusion
complex
process
influenced
environmental
factors
Research
focuses
UV‐induced
damage
formation
Advanced
Glycosylation
End
Products
(AGEs),
leading
wrinkles
impaired
functionality.
Inhibiting
crucial
maintaining
youthful
skin.
Natural
sources
inhibitor
substances,
such
extracts
from
plants
animals,
safer
approach
obtain
through
dietary
supplements.
Studying
isolated
active
ingredients
contribute
developing
targeted
BMC Infectious Diseases,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: April 1, 2024
Diabetic
foot
ulcer
(DFU)
is
one
of
the
main
chronic
complications
caused
by
diabetes,
leading
to
amputation
in
severe
cases.
Bacterial
infection
affects
wound
healing
DFU.
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(4), P. 481 - 481
Published: Feb. 7, 2024
Photoaging,
the
primary
cause
of
skin
aging
damage,
results
from
chronic
ultraviolet
(UV)
exposure,
leading
to
dryness
and
wrinkle
formation.
Nutritional
intervention
has
emerged
as
a
practical
approach
for
preventing
addressing
effect
photoaging.
The
aromatic
compound
isolated
clove
oil,
isoeugenol
(IE),
antibacterial,
anti-inflammatory,
antioxidant
qualities
that
work
effectively
restrict
cancer
cell
proliferation.
This
investigation
delved
into
advantages
IE
in
alleviating
photoaging
using
UVB-irradiated
fibroblasts
female
SKH-1
hairless
mouse
models.
alleviated
UVB-induced
photodamage
Hs68
dermal
by
inhibiting
matrix
metalloproteinase
secretion
promoting
extracellular
synthesis.
In
photoaged
mice,
dietary
reduced
wrinkles,
relieved
dryness,
inhibited
epidermal
thickening,
prevented
collagen
loss.
Additionally,
intestinal
dysbiosis
caused
prolonged
UVB
exposure
was
with
an
intervention.
Spearman’s
analysis
showed
strong
correlation
between
gut
microbiota.
Given
almost
unavoidable
contemporary
living,
this
research
demonstrated
efficacy
reversing
photoaging,
presenting
promising
tackle
concerns
related
extrinsic
aging.
Journal of Wound Care,
Journal Year:
2024,
Volume and Issue:
33(6), P. 394 - 407
Published: June 2, 2024
Objective:
Hard-to-heal
(chronic)
wounds
are
common
in
patients
with
diabetes
and
associated
a
decrease
quality
of
life
(QoL).
Pathogenic
bacteria
often
colonise
hard-to-heal
hinder
the
healing
process
which
poses
high
risk
for
(systemic)
infections.
In
this
study,
we
aim
to
prove
that
probiotics
capable
displacing
human
pathogenic
bacteria,
ameliorating
inflammation
positively
influencing
microenvironment/microbiome
skin
mucosa.
Method:
pilot
duration
2–120
months
received
an
oral
multispecies
probiotic
daily
six
months.
Changes
oral,
stool
wound
microbiome
were
investigated,
effects
intervention
on
healing,
periodontitis
wound-specific
(Wound-QOL-17)
analysed
throughout
course
clinical
study.
Results:
total,
seven
20
included
unable
complete
After
intake
supplementation
five
out
remaining
13
patients,
had
healed
completely.
Most
reported
improvement
QoL,
particular
positive
pain
mobility.
Microbiome
analysis
revealed
reduction
Staphylococcus
aureus
Pseudomonas
aeruginosa,
epidermis
wounds.
Conclusion:
This
findings
study
provide
evidence
beneficial
application
over
closure,
microbial
pattern,
dental
health.
A
randomised,
placebo-controlled,
double-blinded
trial
is
required
verify
results.
Journal of Inflammation Research,
Journal Year:
2024,
Volume and Issue:
Volume 17, P. 1707 - 1720
Published: March 1, 2024
Diabetic
foot
ulcer
(DFU)
impairs
the
quality
of
life
diabetic
patients
and
overburdens
healthcare
systems
society.
It
is
crucial
to
comprehend
pathophysiology
DFU
develop
effective
treatment
strategies.
The
aim
this
study
was
evaluate
therapeutic
potential
Lactobacillus
Plantarum
(LP)
on
wound
healing
in
explore
underlying
mechanisms.
Applied and Environmental Microbiology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 28, 2025
ABSTRACT
Diabetes
is
the
third
most
common
chronic
disorder
worldwide.
Diabetic
wounds
are
a
severe
complication
that
costly
and
often
results
in
non-traumatic
lower
limb
amputation.
Recent
investigations
have
demonstrated
gut
microbiota
as
“virtual
organ”
can
regulate
metabolic
diseases
like
diabetes.
Fecal
transplantation
(FMT)
an
innovative
therapeutic
approach
for
promoting
wound
healing,
but
its
function
remains
incompletely
defined.
A
diabetes
model
was
established
by
supplying
mice
with
high-fat
diet
performing
intraperitoneal
injection
of
streptozotocin.
were
then
created,
followed
bacterial
transplantation.
The
relevant
indexes
healing
evaluated
to
verify
effect
FMT
on
diabetic
wounds.
Human
skin
keratinocytes
also
cultured,
cell
scratch
experiments
conducted
further
investigate
underlying
mechanism.
regulated
levels
specific
bacteria
helped
restore
balance
intestinal
microbes.
This
enhanced
augmenting
closure
rate,
accelerating
re-epithelialization,
boosting
collagen
deposition
Furthermore,
promoted
production
IL-17A,
which
significantly
growth
movement
human
keratinocytes.
Inhibiting
molecules
related
IL-17A–mTOR–HIF1α
signaling
axis
shown
hinder
re-epithelialization.This
study
clarifies
utilization
providing
new
method
target
IMPORTANCE
Intestinal
microbiota,
organ
largest
number
microorganisms
body,
plays
crucial
role
physiological
functions
body.
Normal
be
involved
various
such
energy
absorption,
metabolism,
immunity
imbalance
many
obesity
Diabetes,
one
world’s
three
major
diseases,
significant
health
issue
troubles
more
than
billion
people
globally.
problem
all
patients
must
confront
when
undergoing
surgery,
it
important
cause
amputations.
Exploring
wound-healing
process
offer
possibility
using
means
intervene
clinically
diseases.
Journal of Cellular and Molecular Medicine,
Journal Year:
2025,
Volume and Issue:
29(7)
Published: March 30, 2025
ABSTRACT
Diabetes
foot
ulcers
(DFU)
are
the
most
common
injuries
leading
to
lower
extremity
amputation.
Our
study
aimed
provide
first
representative
analysis
highlighting
vital
role
of
Tertiary
Lymphoid
Organs
(TLO)
inflammatory
landscape
in
diabetic
ulcers.
The
explores
mechanisms
TLO
formation
and
disease‐specific
roles
TLOs
regulating
peripheral
immune
responses.
Additionally,
comprehensive
clinical
data
from
DFU
cases,
focused
on
pathophysiology
systemic
immune‐inflammation
landscape,
is
documented,
aiming
identify
risk
factors
contributing
development
DFUs.
experimental
results
showed
very
significant
differences
were
observed
among
IL‐17
IFN‐γ
cytokine
levels
between
vs.
Control
NIDFU
(Non‐Infectious
Diabetic
Foot
Ulcers)
groups,
while
minimal
IL‐6
TNF‐α
levels.
Immunohistochemistry
staining
or
Immunophenotyping
patient‐derived
wound
samples
for
stratification
remarkable
DFU,
NIDFU,
control
groups
both
CD3
+
T
Cells
CD20
B
cells.
Overall,
our
findings
highlight
perspective
its
prudent
inflammatory‐immune
study‐related
might
be
one
important
mechanisms,
effective
unveil
a
valuable
treatment
modality
DFU‐complications.
