Comparative metabolomic analysis reveals shared and unique features of COVID-19 cytokine storm and surgical sepsis

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 24, 2025

The clinical manifestations of the cytokine storm (CS) associated with COVID-19 resemble acute phase sepsis. Metabolomics may contribute to understanding specific pathobiology these two syndromes. aim this study was compare serum metabolomic profiles in CS vs. septic surgery patients. In a retrospective cross-sectional study, samples from patients COVID-19, and without comorbidity, as well surgical sepsis were investigated. Targeted analysis performed on all using LC–MS/MS. Analysis revealed that similar alterations metabolome amino acid metabolism, nitrogen inflammatory status, methionine cycle glycolysis. most significant difference found for levels metabolites kynurenine synthesis, tricarboxylic cycle, gamma-aminobutyric niacinamide. metabolic pathway cysteine metabolism significantly disturbed For first time, similarities differences between investigated Northwest Russian Federation.

Language: Английский

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Dissecting inflammation in the immunemetabolomic era

Cellular and Molecular Life Sciences, Journal Year: 2025, Volume and Issue: 82(1)

Published: April 28, 2025

Abstract The role of immune metabolism, specific metabolites and cell-intrinsic -extrinsic metabolic states across the time course an inflammatory response are emerging knowledge. Targeted untargeted metabolomic analysis is essential to understand how cells adapt their program throughout response. In addition, can aid identify pathophysiological patterns in disease. Here, we discuss new findings within transition from inflammation resolution, focusing on three key programs immunity: Efferocytosis, IL-10 signaling trained immunity. Particularly tryptophan-derived metabolite kynurenine was identified as for efferocytosis resolution well a potential biomarker diverse conditions. summary, integration with transcriptomic proteomic data, high imaging spatial information unravel drivers dependencies during progression tissue-repair.

Language: Английский

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Dysregulation of glutamine/glutamate metabolism in COVID‐19 patients: A metabolism study in African population and mini meta‐analysis

Journal of Medical Virology, Journal Year: 2022, Volume and Issue: 95(1)

Published: Sept. 16, 2022

Coronavirus disease 2019 (COVID-19) remains a serious global threat. The metabolic analysis had been successfully applied in the efforts to uncover pathological mechanisms and biomarkers of severity. Here we performed quasi-targeted metabolomic on 56 COVID-19 patients from Sierra Leone western Africa, revealing profiles association with severity, which was confirmed by targeted 19 pairs patients. A meta-analysis published data verify our findings. Of 596 identified metabolites, 58 showed significant differences between severe nonsevere groups. pathway enrichment these differential metabolites revealed glutamine glutamate metabolism as most (Impact = 0.5; -log10P 1.959). Further six intergroup differences, glutamine/glutamate ratio significantly associated disease, negatively correlated 10 clinical parameters positively SPO2 (rs 0.442, p 0.005). Mini indicated elevated related increased risk infection (pooled odd [OR] 2.02; 95% confidence interval [CI]: 1.17-3.50) OR 2.28; CI: 1.14-4.56). In contrast, decreased COVID-19, pooled were 0.30 (95% 0.20-0.44), 0.44 0.19-0.98), respectively. Glutamine are severity multiple populations, might confer potential therapeutic target especially for

Language: Английский

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Using the power of innate immunoprofiling to understand vaccine design, infection, and immunity

Human Vaccines & Immunotherapeutics, Journal Year: 2023, Volume and Issue: 19(3)

Published: Oct. 26, 2023

In the field of immunology, a systems biology approach is crucial to understanding immune response infection and vaccination considering complex interplay between genetic, epigenetic, environmental factors. Significant progress has been made in innate response, including cell players critical signaling pathways, but many questions remain unanswered, how dictates host/pathogen responses vaccines. To complicate things further, it becoming increasingly clear that not linear pathway formed from networks interactions. further our crosstalk complexities, systems-level analyses expanded experimental technologies are now needed. this review, we discuss most recent immunoprofiling techniques approaches studying global landscape which will inform on development personalized medicine innovative vaccine strategies.

Language: Английский

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A metabolic readout of the urine metabolome of COVID-19 patients

Metabolomics, Journal Year: 2023, Volume and Issue: 19(2)

Published: Jan. 24, 2023

Language: Английский

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