Crystals,
Journal Year:
2022,
Volume and Issue:
12(6), P. 774 - 774
Published: May 26, 2022
The
high
incidence
of
fungal
resistance
to
antifungal
drugs
represents
a
global
concern,
contributing
levels
morbidity
and
mortality,
especially
among
immunocompromised
patients.
Moreover,
conventional
medications
have
poor
therapeutic
outcomes,
as
well
possible
toxicities
resulting
from
long-term
administration.
Accordingly,
the
aim
present
study
was
investigate
effectiveness
biogenic
zinc
oxide
nanoparticles
(ZnO
NPs)
against
multidrug-resistant
candidal
strains.
Biogenic
ZnO
NPs
were
characterized
using
physicochemical
methods,
such
UV-vis
spectroscopy,
transmission
electron
microscopy
(TEM),
energy-dispersive
X
ray
(EDX)
FTIR
(Fourier
transform
infrared)
spectroscopy
X-ray
powder
diffraction
(XRD)
analysis.
UV
spectral
analysis
revealed
formation
two
absorption
peaks
at
367
506
nm,
which
preliminarily
indicated
successful
synthesis
NPs,
whereas
TEM
showed
that
exhibited
an
average
particle
size
22.84
nm.
EDX
spectrum
confirmed
free
impurities.
biosynthesized
different
3427.99,
1707.86,
1621.50,
1424.16,
1325.22,
1224.67,
1178.22,
1067.69,
861.22,
752.97
574.11
cm−1,
corresponding
various
functional
groups.
zeta
potential
value
−7.45
mV.
XRD
presence
six
2θ
=
31.94,
34.66,
36.42,
56.42,
69.54
76.94°.
(100
µg/disk)
potent
activity
C.
albicans,
glabrata
tropicalis
strains,
with
suppressive
zone
diameters
24.18
±
0.32,
20.17
0.56
26.35
0.16
mm,
respectively.
minimal
inhibitory
concentration
(MIC)
strain
found
be
10
μg/mL,
fungicidal
(MFC)
20
μg/mL.
synergistic
efficiency
fluconazole,
nystatin
clotrimazole
albicans
strain,
terbinafine,
itraconazole
synergism
strain.
In
conclusion,
pomegranate
peel
extract
mediated
green
features
antimicrobial
activity.
could
utilized
for
formulation
novel
drug
combinations
boost
commonly
used
agents.
Pharmacological Research - Modern Chinese Medicine,
Journal Year:
2023,
Volume and Issue:
7, P. 100262 - 100262
Published: May 20, 2023
Secondary
metabolites,
also
called
specialized
are
essential
in
defense
and
cell-to-cell
communication
that
play
a
significant
role
pharmacotherapy.
plant
or
microbial
metabolites
played
an
important
alleviating
infectious
diseases
traditional
Chinese
medicine
(TCM)
folk
uses.
Natural
products
considerable
roles
TCM,
as
their
biological
activities
related
to
TCM
efficacy
provide
chemical
diversity
for
drug
discovery.
This
paper
summarizes
the
literature
describing
anti-fungal
natural
against
fungal
pathogens
semi-synthetic
compounds
with
improved
properties,
which
will
be
included.
The
mechanisms
targets
of
drugs
may
differ
among
different
compounds,
discovered
divided
into
groups,
structures,
sources,
effects,
summarized
detail
around
series
anabolic
disorders,
signaling
pathway
intracellular
substance
transport
abnormalities
caused
by
cells.
More
than
eighty
derivatives
were
summarized,
classified
eight
main
groups
according
antifungal
mechanism
action,
types
illustrated,
mode
action
some
additional
unreported
unknown.
showed
activity
animal
pathogenic
fungi
origins
addition
being
active
fungi.
In
this
review,
we
wish
draw
readers'
attention
rapidly
evolving
recognition
plants
microorganisms
produce
increasing
number
products,
highlighting
underlying
modes
actions,
discussing
key
opportunities
Journal of Immunology Research,
Journal Year:
2022,
Volume and Issue:
2022, P. 1 - 10
Published: Oct. 7, 2022
Airborne
fungi
are
one
of
the
most
ubiquitous
kinds
inhalant
allergens
which
can
result
in
allergic
diseases.
Fungi
tend
to
grow
warm
and
humid
environments
with
regional
seasonal
variations.
Their
nomenclature
taxonomy
related
sensitization
immunoglobulin
E
(IgE).
Allergic
cross-reactivity
among
different
fungal
species
appears
be
widely
existing.
Fungus-related
foods,
such
as
edible
mushrooms,
mycoprotein,
fermented
foods
by
fungi,
often
induce
fungus
food
allergy
syndrome
(FFAS)
airborne
fungi.
FFAS
may
involve
or
more
target
organs,
including
oral
mucosa,
skin,
gastrointestinal
respiratory
tracts,
cardiovascular
system,
various
symptoms
ranging
from
(OAS)
severe
anaphylaxis.
This
article
reviews
current
knowledge
on
field
between
well
diagnosis
treatment
FFAS.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(8), P. 3424 - 3424
Published: April 13, 2023
Fungal
microbes
are
important
in
the
creation
of
new
drugs,
given
their
unique
genetic
and
metabolic
diversity.
As
one
most
commonly
found
fungi
nature,
Fusarium
spp.
has
been
well
regarded
as
a
prolific
source
secondary
metabolites
(SMs)
with
diverse
chemical
structures
broad
spectrum
biological
properties.
However,
little
information
is
available
concerning
derived
SMs
antimicrobial
effects.
By
extensive
literature
search
data
analysis,
many
185
natural
products
had
discovered
from
strains
by
end
2022.
This
review
first
provides
comprehensive
analysis
these
substances
terms
various
effects,
including
antibacterial,
antifungal,
antiviral,
antiparasitic.
Future
prospects
for
efficient
discovery
bioactive
also
proposed.
Journal of Agricultural and Food Chemistry,
Journal Year:
2023,
Volume and Issue:
71(16), P. 6236 - 6248
Published: April 16, 2023
Natural
products
are
important
sources
for
the
discovery
of
new
pesticides.
Chemical
synthesis
and
structural
modification
can
lead
to
Despite
abundant
research
in
fungicide
crop
protection,
there
is
an
emerging
need
development
novel
antifungal
agrochemicals.
Herein,
39
diversified
griseofulvin
derivatives
were
effectively
synthesized
from
natural
product
by
diversity-oriented
through
reactions
demethylation,
ammonolysis,
methylation,
nitration,
acylation,
reduction,
chlorination.
Among
them,
31
novel.
All
structures
characterized
1H
NMR,
13C
high-resolution
mass
spectrometry
(HR-MS),
activity
was
investigated
against
five
phytopathogenic
fungi.
Compounds
5h
5l
had
excellent
Botrytis
cinerea
(5h,
IC50
=
17.29
±
0.64
μg/mL)
Alternaria
solani
(5l,
22.52
0.79
μg/mL),
respectively.
Compound
9
exhibited
more
promising
activities
three
target
fungi,
especially
Colletotrichum
gloeosporioides
(IC50
7.24
0.66
which
obviously
better
than
positive
control
hymexazol,
thifluzamide,
parent
compound
griseofulvin.
In
addition,
10
showed
significant
extensive
four
fungi
Cytospora
sp.
18.72
0.35
C.
31.39
1.48
A.
40.82
1.04
Fusarium
36.81
0.82
μg/mL).
Unexpectedly,
11
12,
chlorinated
9,
most
4.48
0.54
μg/mL
11,
2.24
0.76
12).
Furthermore,
12
remarkable
5.85
0.72
Additionally,
vivo
gloeosporioides,
homology
modeling,
docking
analysis
conducted.
results
indicated
that
potency
as
agents
modifications
2′
4′
positions
should
be
further
explored
higher-activity
compounds
or
potential
agricultural
fungicides.
Journal of Fungi,
Journal Year:
2024,
Volume and Issue:
10(5), P. 334 - 334
Published: May 5, 2024
Fungi
are
eukaryotic
organisms
with
relatively
few
pathogenic
members
dangerous
for
humans,
usually
acting
as
opportunistic
infections.
In
the
last
decades,
several
life-threatening
fungal
infections
have
risen
mostly
associated
worldwide
extension
of
chronic
diseases
and
immunosuppression.
The
available
antifungal
therapies
cannot
combat
this
challenge
because
arsenal
compounds
is
scarce
displays
low
selective
action,
significant
adverse
effects,
increasing
resistance.
A
growing
isolation
outbreaks
triggered
by
species
formerly
considered
innocuous
being
recorded.
From
ancient
times,
natural
substances
harvested
from
plants
been
applied
to
folk
medicine
some
them
recently
emerged
promising
antifungals.
most
used
briefly
revised
herein.
Combinations
chemotherapeutic
drugs
products
obtain
more
efficient
gentle
treatments
also
revised.
Nevertheless,
considerable
research
work
still
necessary
before
their
clinical
use
can
be
generally
accepted.
Many
a
highly
complex
chemical
composition,
active
principles
partially
unknown.
Here,
we
survey
field
underlying
lights
shadows
both
groups.
More
studies
involving
strains
necessary,
but
illustrate
matter
discussing
potential
applications
combined
carnosic
acid
plus
propolis
formulations.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: June 22, 2024
Frequent
and
variant
infections
are
caused
by
the
virtue
of
opportunistic
fungi
pathogens.
Candidiasis,
aspergillosis,
mucormycosis
pathogenic
microorganisms
that
give
rise
to
vast
fungal
diseases
alternate
between
moderate
fatal
in
severity.
The
use
fluconazole
as
an
antifungal
drug
was
limited
due
acquired
resistance
some
types
Candida
other
species.
This
study
aims
consolidate
fluconazole's
biological
effectiveness
against
several
fungi.
Six
active
monoterpenes
(MTs)
carvacrol,
linalool,
geraniol,
α-terpinene,
citronellal,
nerolidol
were
selected
encapsulated
nanostructure
lipid
carrier
(NLC)
with
(NLC-Flu-MTs)
and/without
(NLC-MTs)
one
nanoformulation
determine
if
they
will
act
synergistically
or
not?
synthesized
NLC-Flu-MTs
NLC-MTs
exhibited
very
good
particle
size
144.5
nm
138.6
for
zeta
potential
values
(-
23.5
mV)
20.3
mV),
respectively.
Transmission
electron
microscope
investigation
confirmed
NLCs
have
regular
spherical
shape.
abundance
concentration
six
released
determined,
a
novel
approach,
using
GC-MS
results
validity.
In-vitro
screening
done
before
after
nano
co-delivery
seven
pathogenic,
aggressive
tropicalis,
krusei,
glabrata,
Geotrichum
Candidum,
Candidaalbicans,
Aspergillus
Niger,
mucor
circinelloides.
Inhibition
Zone
diameter
(IZD)
minimum
inhibitory
(MIC)
measured.
Nanoformulations
manifested
unique
susceptibility
all
tested
reduced
values,
especially
Tropicalis
(MIC
=
0.97
µg/ml)
which
represents
16-fold
value
shown
15.6
64-fold
free
62.5
µg/ml).
efficiency
nanomaterials,
particularly
NLC-Flu-MTs,
has
become
evident
diminishing
MIC
affirmed
synergism
monoterpenes.
