Chronobiology International,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 8
Published: Sept. 23, 2024
Circadian
rhythm
disruptions
have
been
implicated
in
numerous
health
issues,
including
cognitive
decline
and
the
exacerbation
of
neurodegenerative
diseases,
like
Alzheimer
disease
(AD).
Brain-derived
neurotrophic
factor
(BDNF),
vital
for
neuronal
plasticity
function,
is
regulated
by
circadian
clock
exerts
protective
effects
against
AD.
Thus,
we
investigated
impact
disorders
(CRDs)
on
impairment
explored
underlying
neurobiological
mechanisms
assessing
BDNF
amyloid-β
(Aβ)
levels.
We
divided
male
C57BL/6
mice
into
three
groups
(
Current Oncology,
Journal Year:
2023,
Volume and Issue:
30(2), P. 1893 - 1902
Published: Feb. 4, 2023
Outcomes
for
patients
with
high-grade
glioma
remain
poor.
Temozolomide
(TMZ)
is
the
only
drug
approved
first-line
treatment
of
glioblastoma
multiforme,
most
aggressive
form
glioma.
Chronotherapy
highlights
potential
benefit
timed
TMZ
administration.
This
based
on
pre-clinical
studies
enhanced
TMZ-induced
cytotoxicity
dependent
circadian,
oscillating
expression
key
genes
involved
in
apoptosis,
DNA
damage
repair,
and
cell-cycle
mediated
cell
death.
The
current
systematic
review’s
primary
aim
was
to
evaluate
efficacy
toxicity
chronotherapy.
A
systemic
review
literature
following
PRISMA
guidelines
looking
at
clinical
outcomes
chronotherapy
gliomas
performed.
search
English
language
included
three
databases
(PubMed,
EMBASE,
Cochrane)
five
conferences
from
1946
April
2022.
Two
independent
reviewers
undertook
screening,
data
extraction,
risk-of-bias
assessment.
descriptive
analysis
conducted
due
limited
data.
Of
269
articles
screened,
two
unique
were
eligible
underwent
abstraction
survival
findings.
Both
studies—one
a
retrospective
cohort
study
(n
=
166)
other
prospective
randomized
feasibility
35)—were
by
same
academic
group
suggested
trend
improved
overall
survival,
but
possibly
increased
when
administered
morning
(vs.
evening).
There
evidence
suggesting
possible
therapeutic
value
administering
morning,
which
may
be
consistent
observations
importance
timing
administration
vitro.
Larger,
pragmatic,
controlled
trials
are
needed
ascertain
provide
optimized
equitable
care
this
population.
Neurosciences,
Journal Year:
2025,
Volume and Issue:
30(1), P. 5 - 19
Published: Jan. 1, 2025
The
hippocampus,
noted
as
(HC),
plays
a
crucial
role
in
the
processes
of
learning,
memory
formation,
and
spatial
navigation.
Recent
research
reveals
that
this
brain
region
can
undergo
structural
functional
changes
due
to
environmental
exposures,
including
stress,
noise
pollution,
sleep
deprivation,
microgravity.
This
review
synthesizes
findings
from
animal
human
studies,
emphasizing
HC's
plasticity
response
these
factors.
It
examines
volume,
architecture,
neurogenesis,
synaptic
plasticity,
gene
expression
highlights
critical
periods
vulnerability
influences
impacting
cognition
behavior.
also
investigates
underlying
mechanisms
such
glucocorticoid
signaling,
epigenetic
alterations,
neural
circuit
adaptations.
Understanding
how
HC
reacts
various
exposures
is
vital
for
developing
strategies
enhance
cognitive
resilience
mitigate
negative
effects
on
region.
Further
needed
identify
protective
risk
factors
create
effective
interventions.
Biology,
Journal Year:
2023,
Volume and Issue:
13(1), P. 22 - 22
Published: Dec. 30, 2023
This
study
explores
the
relationship
between
light
features
of
Arctic
spring
equinox
and
circadian
rhythms,
sleep
metabolic
health.
Residents
(N
=
62)
provided
week-long
actigraphy
measures,
including
exposure,
which
were
related
to
body
mass
index
(BMI),
leptin
cortisol.
Lower
wrist
temperature
(wT)
higher
evening
blue
exposure
(BLE),
expressed
as
a
novel
index,
nocturnal
excess
(NEIbl),
most
sensitive
measures
associated
with
BMI.
A
BMI
was
linked
BLE
within
distinct
time
windows.
These
associations
present
specifically
in
carriers
MTNR1B
rs10830963
G-allele.
larger
wake-after-sleep
onset
(WASO),
smaller
24
h
amplitude
earlier
phase
activity
rhythm
leptin.
Higher
cortisol
an
M10
our
other
Daylight
Deficit
Index
light,
DDIbl.
We
also
found
sex-,
age-
population-dependent
differences
parametric
non-parametric
indices
BLE,
wT
physical
activity,
while
there
no
any
characteristics.
Overall,
this
determined
markers
predictive
health
showed
that
these
are
melatonin
receptor
polymorphism.
Journal of Pineal Research,
Journal Year:
2024,
Volume and Issue:
76(5)
Published: July 4, 2024
ABSTRACT
This
contribution
reviews
the
role
of
inbred
and
transgenic
mouse
strains
for
deciphering
mammalian
melatoninergic
circadian
system.
It
focusses
on
pineal
organ
as
melatonin
factory
two
major
targets
system,
suprachiasmatic
nuclei
(SCN)
hypophysial
pars
tuberalis
(PT).
Mammalian
pinealocytes
sharing
molecular
characteristics
with
true
retinal
photoreceptors
synthesize
secrete
into
blood
cerebrospinal
fluid
night
by
night.
Notably,
neuron‐like
connections
exist
between
deep
habenular/pretectal
region
suggesting
direct
pineal‐brain
communication.
Control
biosynthesis
in
rodents
involves
transcriptional
regulation
including
phosphorylation
CREB
upregulation
mPer1.
In
SCN,
acts
upon
MT1
MT2
receptors.
Melatonin
is
not
necessary
to
maintain
rhythm
SCN
clockwork,
but
it
has
distinct
effects
synchronization
light,
facilitates
re‐entrainment
system
phase
advances
level
clockwork
acting
receptors
plays
a
stabilizing
evidenced
from
locomotor
activity
recordings.
While
are
subtle,
essential
PT
functions.
Via
receptor
drives
PT‐intrinsic
retrograde
anterograde
output
pathways
controlling
seasonal
rhythmicity.
Although
mice
do
show
reproduction,
fully
intact
if
animals
proficient.
Thus,
only
melatonin‐proficient
suited
investigate
systems.
Biology,
Journal Year:
2023,
Volume and Issue:
12(3), P. 383 - 383
Published: Feb. 28, 2023
Most
lifeforms
on
earth
use
endogenous,
so-called
circadian
clocks
to
adapt
24-h
cycles
in
environmental
demands
driven
by
the
planet’s
rotation
around
its
axis.
Interactions
with
environment
change
over
course
of
a
lifetime,
and
so
does
regulation
clock
system.
In
this
review,
we
summarize
how
develop
humans
experimental
rodents
during
embryonic
development,
they
mature
after
birth
what
changes
occur
puberty,
adolescence
increasing
age.
Special
emphasis
is
laid
reproductive
systems
as
major
organizers
life
segments
span.
We
discuss
differences
sexes
outline
potential
areas
for
future
research.
Finally,
options
medical
applications
lifespan
chronobiology
are
discussed.
Pflügers Archiv - European Journal of Physiology,
Journal Year:
2024,
Volume and Issue:
476(3), P. 295 - 306
Published: Jan. 4, 2024
Abstract
Artificial
light
at
night
(ALAN)
affects
most
of
the
population.
Through
retinohypothalamic
tract,
ALAN
modulates
activity
central
circadian
oscillator
and,
consequently,
various
physiological
systems,
including
cardiovascular
one.
We
summarised
current
knowledge
about
effects
on
system
in
diurnal
and
nocturnal
animals.
Based
published
data,
reduces
day-night
variability
blood
pressure
heart
rate
animals
by
increasing
values
variables
decreasing
them
The
are
mainly
transmitted
through
autonomic
nervous
system.
is
also
considered
a
stress-inducing
factor,
as
glucocorticoid
glucose
level
changes
indicate.
Moreover,
rats,
increases
response
to
load.
In
addition,
induces
molecular
vessels.
Changes
significantly
depend
duration
exposure.
To
some
extent,
alterations
physical
can
explain
observed
after
Although
acts
differently
animals,
we
conclude
that
both
exhibit
weakened
coordination
among
which
risk
future
complications
ability
anticipate
stress.
Chronobiology in Medicine,
Journal Year:
2024,
Volume and Issue:
6(1), P. 10 - 14
Published: March 29, 2024
The
excessive
exposure
of
blue
light,
originated
from
electronic
gadgets
like
smartphones,
laptops,
and
tablets,
may
contribute
to
sleep
problems.
Long
blue-wavelength
light
these
devices
affects
by
suppressing
melatonin
hormone
cause
neurophysiologic
consequences.
This
literature
review
highlights
the
most
recent
findings
on
relationship
between
disruption
among
high
school
college
student
population.
A
variety
scientific
studies
have
shown
that
exposure,
especially
before
bedtime,
can
create
circadian
disruptions
inhibit
secretion
in
brain,
which
ultimately
result
deteriorated
quality
duration.
Sleep
deprivation
duration
is
reflected
negative
effects
mood,
learning
memory,
academic
performance
a
middle
college.
In
general,
accumulating
evidence
indicates
that,
promote
adolescent
young
adult
health,
it
necessary
pay
attention
impacts
modern
technologies.
ACS Chemical Neuroscience,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 17, 2025
This
study
evaluates
acetylcholinesterase
(AChE)
enzyme
activity
levels,
oxidative
stress
parameters,
histopathological
findings,
and
serum
melatonin
levels
in
rat
brain
tissue.
32
male
Wistar
Albino
rats
were
randomly
divided
into
four
groups:
Control,
Light,
Dark,
Dim
light
(n
=
8
each
group).
After
a
30
day
experiment,
tissues
collected
to
measure
AChE,
glutathione
S-transferase
(GST),
(GSH),
malondialdehyde
(MDA)
conduct
analyses.
Serum
also
measured.
In
this
study,
we
observed
significant
increase
MDA
dim
light,
dark,
groups.
AChE
α-GST
significantly
decreased
the
dark
group
compared
with
other
Additionally,
there
was
statistical
difference
between
microscope
examination
of
sections
stained
hematoxylin-eosin
from
tissue,
mild
perineuronal
edema
all
areas.
Our
is
first
compare
effects
three
groups
on
brain:
continuous
darkness,
at
night.
it
only
examine
exposure
differences
levels.
