Animals,
Journal Year:
2025,
Volume and Issue:
15(2), P. 264 - 264
Published: Jan. 18, 2025
Transferrin
Receptor
2
(TfR2)
is
a
homolog
of
1
(TfR1),
involved
in
regulating
intra
and
extracellular
iron
levels.
Altered
pathways
have
been
associated
with
cancer
onset
progression;
however,
their
role
canine
tumors
remains
poorly
explored.
This
study
investigated
TfR2
immunohistochemical
expression
non-neoplastic
testis
for
the
first
time
most
common
types
testicular
tumors:
intratubular
seminomas
(ITSEMs),
diffuse
(DSEMs),
Leydig
cell
(LCTs),
Sertoli
(SCTs).
Immunohistochemical
analysis
revealed
differential
pattern
according
to
tumor
type,
high
observed
ITSEMs
DSEMs,
occasional
LCTs,
absence
SCTs.
These
results
suggest
that
may
play
relevant
seminoma
development.
Furthermore,
specific
highlights
its
potential
as
therapeutic
target,
where
regulation
possible
compensatory
mechanisms
warrant
further
investigation.
Biology,
Journal Year:
2023,
Volume and Issue:
12(7), P. 989 - 989
Published: July 11, 2023
Iron
participates
in
a
number
of
biological
processes
and
plays
crucial
role
cellular
homeostasis.
Alterations
iron
metabolism
are
considered
hallmarks
cancer
drivers
aggressive
behaviors,
such
as
uncontrolled
proliferation,
resistance
to
apoptosis,
enhanced
metastatic
ability,
increased
cell
plasticity
stemness.
Furthermore,
dysregulated
has
been
associated
with
the
development
an
adverse
tumor
microenvironment.
have
described
senescence
aging.
For
instance,
shown
accumulate
aged
tissues
age-related
diseases.
vitro
studies
demonstrate
increases
content
both
replicative
stress-induced
senescent
cells.
However,
role,
mechanisms
regulation
dysregulation
effects
on
remain
significantly
less
characterized.
In
this
review,
we
first
provide
overview
regulatory
proteins.
Then,
summarize
alterations
homeostasis
from
point
view.
Frontiers in Physiology,
Journal Year:
2024,
Volume and Issue:
15
Published: July 3, 2024
In
recent
years,
the
emerging
phenomenon
of
ferroptosis
has
garnered
significant
attention
as
a
distinctive
mode
programmed
cell
death.
Distinguished
by
its
reliance
on
iron
and
dependence
reactive
oxygen
species
(ROS),
emerged
subject
extensive
investigation.
Mechanistically,
this
intricate
process
involves
perturbations
in
homeostasis,
dampening
system
Xc-activity,
morphological
dynamics
within
mitochondria,
onset
lipid
peroxidation.
Additionally,
concomitant
ferritinophagy,
autophagic
degradation
ferritin,
assumes
pivotal
role
facilitating
liberation
ions
from
thereby
advancing
progression
ferroptosis.
This
discussion
thoroughly
examines
detailed
structures
basic
processes
behind
ferritinophagy.
Moreover,
it
scrutinizes
web
regulators
that
orchestrate
these
their
interplay
context
joint
disorders.
Against
backdrop
an
annual
increase
cases
osteoarthritis,
rheumatoid
arthritis,
gout,
narrative
sheds
light
intriguing
crossroads
pathophysiology
dissecting
interrelationships
between
diseases,
ferroptosis,
The
newfound
insights
contribute
fresh
perspectives
promising
therapeutic
avenues,
potentially
revolutionizing
landscape
disease
management.
Animals,
Journal Year:
2025,
Volume and Issue:
15(2), P. 264 - 264
Published: Jan. 18, 2025
Transferrin
Receptor
2
(TfR2)
is
a
homolog
of
1
(TfR1),
involved
in
regulating
intra
and
extracellular
iron
levels.
Altered
pathways
have
been
associated
with
cancer
onset
progression;
however,
their
role
canine
tumors
remains
poorly
explored.
This
study
investigated
TfR2
immunohistochemical
expression
non-neoplastic
testis
for
the
first
time
most
common
types
testicular
tumors:
intratubular
seminomas
(ITSEMs),
diffuse
(DSEMs),
Leydig
cell
(LCTs),
Sertoli
(SCTs).
Immunohistochemical
analysis
revealed
differential
pattern
according
to
tumor
type,
high
observed
ITSEMs
DSEMs,
occasional
LCTs,
absence
SCTs.
These
results
suggest
that
may
play
relevant
seminoma
development.
Furthermore,
specific
highlights
its
potential
as
therapeutic
target,
where
regulation
possible
compensatory
mechanisms
warrant
further
investigation.
