Therapy-induced senescence in breast cancer: an overview DOI Creative Commons
C.S. Narayanan, Andrew J. Lindsay

Exploration of Targeted Anti-tumor Therapy, Journal Year: 2024, Volume and Issue: 5(4), P. 902 - 920

Published: July 25, 2024

Outcomes for women with breast cancer have improved dramatically in recent decades. However, many patients present intrinsic drug resistance and others are initially sensitive to anti-cancer drugs but acquire during the course of their treatment, leading recurrence and/or metastasis. Drug therapy-induced senescence (TIS) is a form characterised by induction cell cycle arrest emergence senescence-associated secretory phenotype (SASP) that can develop response chemo- targeted- therapies. A wide range anticancer interventions lead SASP induction, inducing genotoxic stress, hyperactivation signalling pathways or oxidative stress. TIS be anti-tumorigenic short-term, pro-tumorigenic long-term creating pro-inflammatory immunosuppressive microenvironment. Moreover, promote angiogenesis epithelial-mesenchymal transition neighbouring cells. In this review, we will describe characteristics detail changes accompany its induction. We also discuss strategies targeting senescent cells order prevent delay tumour recurrence.

Language: Английский

Ferroptosis mechanisms and its novel potential therapeutic targets for DLBCL DOI Open Access

Wenxia Bian,

Haoran Li, Yuhan Chen

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 173, P. 116386 - 116386

Published: March 16, 2024

Diffuse large B-cell lymphoma (DLBCL), a heterogeneous lymphoid malignancy, poses significant threat to human health. The standard therapeutic regimen for patients with DLBCL is rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP), typical cure rate of 50–70%. However, some either relapse after complete remission (CR) or exhibit resistance R-CHOP treatment. Therefore, novel approaches are imperative managing high-risk refractory DLBCL. Ferroptosis driven by iron-dependent phospholipid peroxidation, process that relies on the transition metal iron, reactive oxygen species (ROS), phospholipids containing polyunsaturated fatty acids-containing (PUFA-PLs). Research indicates ferroptosis implicated in various carcinogenic anticancer pathways. Several hematological disorders heightened sensitivity cell death induced ferroptosis. cells, particular, demonstrate an increased demand iron upregulation expression acid synthase. Additionally, there exists correlation between ferroptosis-associated genes prognosis may be promising target therapy. In this review, we elucidate mechanisms, its role DLBCL, potential targets This review offers insights into application treatment strategies

Language: Английский

Citations

11
Ferroptosis resistance in cancer cells: nanoparticles for combination therapy as a solution DOI Creative Commons

Kodzo Prosper Adzavon,

Weijian Zhao,

Xuesong He

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: June 19, 2024

Ferroptosis is a form of regulated cell death (RCD) characterized by iron-dependent lipid peroxidation. currently proposed as one the most promising means combating tumor resistance. Nevertheless, problem ferroptosis resistance in certain cancer cells has been identified. This review first, investigates mechanisms induction cells. Next, to ferroptosis, well underlying discussed. Recently discovered ferroptosis-suppressing biomarkers have described. The various types nanoparticles that can induce are also Given ability combine multiple agents, this proposes nanoparticle-based viable method circumventing suggests combining with other forms death, such apoptosis, cuproptosis and autophagy. It immunotherapy.

Language: Английский

Citations

4
Identification of TFRC as a biomarker for pulmonary arterial hypertension based on bioinformatics and experimental verification DOI Creative Commons
Chuang Yang, Yihang Liu,

Haikuo Zheng

et al.

Respiratory Research, Journal Year: 2024, Volume and Issue: 25(1)

Published: Aug. 3, 2024

Pulmonary arterial hypertension (PAH) is a life-threatening chronic cardiopulmonary disease. However, there paucity of studies that reflect the available biomarkers from separate gene expression profiles in PAH. The GSE131793 and GSE113439 datasets were combined for subsequent analyses, batch effects removed. Bioinformatic analysis was then performed to identify differentially expressed genes (DEGs). Weighted co-expression network (WGCNA) protein-protein interaction (PPI) used further filter hub genes. Functional enrichment intersection using Gene Ontology (GO), Disease (DO), Kyoto encyclopedia genomes (KEGG) set (GSEA). level diagnostic value pulmonary patients also analyzed validation GSE53408 GSE22356. In addition, target validated lungs monocrotaline (MCT)-induced (PH) rat model serum PAH patients. A total 914 (DEGs) identified, with 722 upregulated 192 downregulated key module relevant selected WGCNA. By combining DEGs WGCNA, 807 selected. Furthermore, protein–protein identified HSP90AA1, CD8A, HIF1A, CXCL8, EPRS1, POLR2B, TFRC, PTGS2 as GSE22356 evaluate which showed robust value. According GSEA analysis, PAH-relevant biological functions pathways enriched high TFRC levels. found be lung tissues our experimental PH compared those controls, same conclusion reached bioinformatics observed increase tissue human patients, indicated by transcriptomic data, consistent alterations rodent models. These data suggest may serve potential biomarker

Language: Английский

Citations

4
Anticancer Diiron Aminocarbyne Complexes with Labile N-Donor Ligands DOI
Sara Stocchetti, Ján Vančo, Giulio Bresciani

et al.

European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 286, P. 117304 - 117304

Published: Jan. 21, 2025

Language: Английский

Citations

0
The Role of Glial Cell Senescence in Alzheimer's Disease DOI Creative Commons
Fadhl Al‐Shaebi, Alessia Sciortino, Rakez Kayed

et al.

Journal of Neurochemistry, Journal Year: 2025, Volume and Issue: 169(3)

Published: March 1, 2025

Glial cell senescence, characterized by the irreversible arrest of division and a pro-inflammatory secretory phenotype, has emerged as critical player in pathogenesis Alzheimer's disease (ad). While much attention been devoted to role neurons ad, growing evidence suggests that glial cells, including astrocytes, microglia, oligodendrocytes, contribute significantly progression through senescence. In this review, we explore molecular mechanisms underlying senescence focusing on cellular signaling pathways, DNA damage response accumulation senescence-associated phenotypes (SASP). We also examine how senescent cells exacerbate neuroinflammation, disrupt synaptic function, promote neuronal death ad. Moreover, discuss emerging therapeutic strategies aimed at targeting mitigate neurodegenerative processes By providing comprehensive overview current research disease, review highlights its potential novel target fight against

Language: Английский

Citations

0
Lactoferrin—A Regulator of Iron Homeostasis and Its Implications in Cancer DOI Creative Commons
Izabela Bolesławska,

Natasza Bolesławska-Król,

Karol Jakubowski

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(7), P. 1507 - 1507

Published: March 28, 2025

Cancer is a global health challenge, and its development closely linked to iron metabolism. cells have an increased demand for this element, which promotes their proliferation, invasion, metastasis. Excess catalyzes the formation of reactive oxygen species (ROS), can both induce ferroptosis initiate oncogenic signaling pathways. The deregulation metabolism in cancer patients leads anemia or toxic overload also affects gut microbiota. Lactoferrin (LF), glycoprotein with strong chelating properties, regulate availability cells, thereby limiting growth progression. By free Fe ions, LF reduces oxidative stress inhibits mechanisms that promote carcinogenesis. Additionally, it exhibits immunomodulatory anti-inflammatory effects may enhance body’s anti-tumor response. This review analyses action lactoferrin context cancer, particular focus on chelating, antioxidant, properties. multidirectional make promising component preventive therapeutic strategies, requiring further clinical studies.

Language: Английский

Citations

0
Integration of Transcriptomic and Single-Cell Data to Uncover Senescence- and Ferroptosis-Associated Biomarkers in Sepsis DOI Creative Commons
Xiangqian Zhang, Yiran Zhou, Hang Li

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(4), P. 942 - 942

Published: April 11, 2025

Background: Sepsis is a life-threatening condition characterized by organ dysfunction due to an imbalanced immune response infection, with high mortality. Ferroptosis, iron-dependent cell death process, and cellular senescence, which exacerbates inflammation, have recently been implicated in sepsis pathophysiology. Methods: Weighted gene co-expression network analysis (WGCNA) was used identify ferroptosis- senescence-related modules sepsis. Differentially expressed genes (DEGs) were analyzed using public datasets (GSE57065, GSE65682, GSE26378). Receiver operating characteristic (ROC) performed evaluate their diagnostic potential, while single-cell RNA sequencing (scRNA-seq) assess immune-cell-specific expression. Molecular docking conducted predict drug interactions key proteins. Results: Five (CD82, MAPK14, NEDD4, TXN, WIPI1) significantly upregulated patients highly correlated infiltration. MAPK14 TXN exhibited strong potential (AUC = 0.983, 0.978). suggested therapeutic diclofenac, flurbiprofen, N-acetyl-L-cysteine. Conclusions: This study highlights ferroptosis senescence as critical mechanisms identifies promising biomarkers for diagnosis targeted therapy. Future studies should focus on clinical validation precision medicine applications.

Language: Английский

Citations

0
Anemia of inflammation and iron metabolism in chronic diseases DOI

Susana Díez,

Ricardo de las Cuevas Allende,

Eulogio Conde García

et al.

Revista Clínica Española (English Edition), Journal Year: 2024, Volume and Issue: 224(9), P. 598 - 608

Published: Sept. 3, 2024

Language: Английский

Citations

3
Anemia de la inflamación y metabolismo del hierro en las enfermedades crónicas DOI

Susana Díez,

Ricardo de las Cuevas Allende,

Eulogio Conde García

et al.

Revista Clínica Española, Journal Year: 2024, Volume and Issue: 224(9), P. 598 - 608

Published: Sept. 3, 2024

Citations

2
Role of Nutraceuticals in Counteracting Inflammation in In Vitro Macrophages Obtained from Childhood Cancer Survivors DOI Open Access
Alessandra Di Paola,

Maria Maddalena Marrapodi,

Elvira Pota

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(4), P. 714 - 714

Published: Feb. 8, 2024

The advancement of anti-cancer therapies has markedly improved the survival rate children with cancer, making them long-term childhood cancer survivors (CCS). Nevertheless, these treatments cause a low-grade inflammatory state, determining inflamm-aging and, thus, favoring early onset chronic diseases normally associated old age. Identification novel and safer therapeutic strategies is needed to counteract prevent inflamm-aging. Macrophages are cells involved in immune responses, pivotal role iron metabolism, which related inflammation. We obtained macrophages from CCS patients evaluated their phenotype markers, states, metabolism by Western blotting, ELISA, assays. observed strong increase classically activated markers (M1) alteration CCS, an intracellular concentration markers. These results suggest that prevalence M1 could be worsening inflammation CCS. Therefore, we propose as targets To avoid toxic regimens, tested some nutraceuticals (resveratrol, curcumin, oil-enriched lycopene), already known exert anti-inflammatory properties. After administration, macrophage switch towards M2, well reductions pro-inflammatory cytokines concentration. suggest—for first time—that reduce through mechanism action, modulating metabolism.

Language: Английский

Citations

2